{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:25:17Z","timestamp":1790115917956,"version":"4.0.1"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T00:00:00Z","timestamp":1649116800000},"content-version":"vor","delay-in-days":4,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dermatol Ther (Heidelb)"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1007\/s13555-022-00710-4","type":"journal-article","created":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T16:04:39Z","timestamp":1649174679000},"page":"1027-1040","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Economic Burden and Healthcare Resource Use of Alopecia Areata in an Insured Population in the USA"],"prefix":"10.1007","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6084-5617","authenticated-orcid":false,"given":"Arash","family":"Mostaghimi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Xenakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aster","family":"Meche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy W.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Gruben","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanja","family":"Sikirica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,4,5]]},"reference":[{"issue":"2","key":"710_CR1","doi-asserted-by":"publisher","first-page":"51","DOI":"10.4103\/ijt.ijt_99_17","volume":"10","author":"E Darwin","year":"2018","unstructured":"Darwin E, Hirt PA, Fertig R, Doliner B, Delcanto G, Jimenez JJ. Alopecia areata: review of epidemiology, clinical features, pathogenesis, and new treatment options. Int J Trichology. 2018;10(2):51\u201360.","journal-title":"Int J Trichology"},{"issue":"4","key":"710_CR2","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.ebiom.2015.02.015","volume":"2","author":"A Jabbari","year":"2015","unstructured":"Jabbari A, Dai Z, Xing L, Cerise JE, Ramot Y, Berkun Y, et\u00a0al. Reversal of alopecia areata following treatment with the JAK1\/2 inhibitor baricitinib. EBioMedicine. 2015;2(4):351\u20135.","journal-title":"EBioMedicine"},{"issue":"4","key":"710_CR3","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/j.jaad.2009.04.031","volume":"61","author":"N Barahmani","year":"2009","unstructured":"Barahmani N, Schabath MB, Duvic M. National Alopecia Areata Registry. History of atopy or autoimmunity increases risk of alopecia areata. J Am Acad Dermatol. 2009;61(4):581\u201391.","journal-title":"J Am Acad Dermatol"},{"issue":"1","key":"710_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jaad.2017.04.1141","volume":"78","author":"LC Strazzulla","year":"2018","unstructured":"Strazzulla LC, Wang EHC, Avila L, Lo Sicco K, Brinster N, Christiano AM, et\u00a0al. Alopecia areata: disease characteristics, clinical evaluation, and new perspectives on pathogenesis. J Am Acad Dermatol. 2018;78(1):1\u201312.","journal-title":"J Am Acad Dermatol"},{"issue":"7","key":"710_CR5","doi-asserted-by":"publisher","first-page":"628","DOI":"10.4065\/70.7.628","volume":"70","author":"KH Safavi","year":"1995","unstructured":"Safavi KH, Muller SA, Suman VJ, Moshell AN, Melton LJ III. Incidence of alopecia areata in Olmsted County, Minnesota, 1975 through 1989. Mayo Clin Proc. 1995;70(7):628\u201333.","journal-title":"Mayo Clin Proc"},{"issue":"3","key":"710_CR6","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1111\/j.1529-8019.2011.01411.x","volume":"24","author":"L Petukhova","year":"2011","unstructured":"Petukhova L, Cabral RM, Mackay-Wiggan J, Clynes R, Christiano AM. The genetics of alopecia areata: what\u2019s new and how will it help our patients? Dermatol Ther. 2011;24(3):326\u201336.","journal-title":"Dermatol Ther"},{"key":"710_CR7","doi-asserted-by":"publisher","first-page":"259","DOI":"10.2147\/CCID.S245649","volume":"13","author":"M Benigno","year":"2020","unstructured":"Benigno M, Anastassopoulos KP, Mostaghimi A, Udall M, Daniel SR, Cappelleri JC, et\u00a0al. A large cross-sectional survey study of the prevalence of alopecia areata in the United States. Clin Cosmet Investig Dermatol. 2020;13:259\u201366.","journal-title":"Clin Cosmet Investig Dermatol"},{"issue":"1","key":"710_CR8","doi-asserted-by":"publisher","first-page":"S13","DOI":"10.1038\/jidsymp.2013.4","volume":"16","author":"MK Hordinsky","year":"2013","unstructured":"Hordinsky MK. Overview of alopecia areata. J Investig Dermatol Symp Proc. 2013;16(1):S13\u20135.","journal-title":"J Investig Dermatol Symp Proc"},{"issue":"1764","key":"710_CR9","first-page":"29","volume":"257","author":"KJ MacLean","year":"2013","unstructured":"MacLean KJ, Tidman MJ. Alopecia areata: more than skin deep. Practitioner. 2013;257(1764):29\u201332, 3.","journal-title":"Practitioner"},{"issue":"1","key":"710_CR10","doi-asserted-by":"publisher","first-page":"S42","DOI":"10.1038\/jidsymp.2013.14","volume":"16","author":"J Shapiro","year":"2013","unstructured":"Shapiro J. Current treatment of alopecia areata. J Investig Dermatol Symp Proc. 2013;16(1):S42\u20134.","journal-title":"J Investig Dermatol Symp Proc"},{"issue":"1","key":"710_CR11","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.jaad.2020.03.004","volume":"83","author":"N Meah","year":"2020","unstructured":"Meah N, Wall D, York K, Bhoyrul B, Bokhari L, Sigall DA, et\u00a0al. The Alopecia Areata Consensus of Experts (ACE) study: results of an international expert opinion on treatments for alopecia areata. J Am Acad Dermatol. 2020;83(1):123\u201330.","journal-title":"J Am Acad Dermatol"},{"key":"710_CR12","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.jaad.2021.08.043","volume":"86","author":"BA King","year":"2022","unstructured":"King BA, Mesinkovska NA, Craiglow B, Kindred C, Ko J, McMichael A, et\u00a0al. Development of the alopecia areata scale for clinical use: results of an academic-industry collaborative effort. J Am Acad Dermatol. 2022;86:359\u201364.","journal-title":"J Am Acad Dermatol"},{"key":"710_CR13","doi-asserted-by":"publisher","first-page":"c3671","DOI":"10.1136\/bmj.c3671","volume":"341","author":"MJ Harries","year":"2010","unstructured":"Harries MJ, Sun J, Paus R, King LE Jr. Management of alopecia areata. BMJ. 2010;341:c3671.","journal-title":"BMJ"},{"issue":"9","key":"710_CR14","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1001\/jamadermatol.2014.709","volume":"150","author":"C Karimkhani","year":"2014","unstructured":"Karimkhani C, Boyers LN, Prescott L, Welch V, Delamere FM, Nasser M, et\u00a0al. Global burden of skin disease as reflected in Cochrane Database of Systematic Reviews. JAMA Dermatol. 2014;150(9):945\u201351.","journal-title":"JAMA Dermatol"},{"issue":"7522","key":"710_CR15","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1136\/bmj.331.7522.951","volume":"331","author":"N Hunt","year":"2005","unstructured":"Hunt N, McHale S. The psychological impact of alopecia. BMJ. 2005;331(7522):951\u20133.","journal-title":"BMJ"},{"issue":"2","key":"710_CR16","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1111\/jdv.15927","volume":"34","author":"G Titeca","year":"2020","unstructured":"Titeca G, Goudetsidis L, Francq B, Sampogna F, Gieler U, Tomas-Aragones L, et\u00a0al. \u201cThe psychosocial burden of alopecia areata and androgenetica\u201d: a cross-sectional multicentre study among dermatological out-patients in 13 European countries. J Eur Acad Dermatol Venereol. 2020;34(2):406\u201311.","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"19","key":"710_CR17","first-page":"30890","volume":"S0190\u20139622","author":"JP Okhovat","year":"2019","unstructured":"Okhovat JP, Marks DH, Manatis-Lornell A, Hagigeorges D, Locascio JJ, Senna MM. Association between alopecia areata, anxiety, and depression: a systematic review and meta-analysis. J Am Acad Dermatol. 2019;S0190\u20139622(19):30890\u20134.","journal-title":"J Am Acad Dermatol"},{"issue":"2","key":"710_CR18","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.jaad.2018.07.013","volume":"80","author":"S Lee","year":"2019","unstructured":"Lee S, Lee H, Lee CH, Lee WS. Comorbidities in alopecia areata: a systematic review and meta-analysis. J Am Acad Dermatol. 2019;80(2):466\u201377.e16.","journal-title":"J Am Acad Dermatol"},{"issue":"4","key":"710_CR19","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/j.jaad.2016.12.007","volume":"76","author":"RZ Conic","year":"2017","unstructured":"Conic RZ, Miller R, Piliang M, Bergfeld W, Atanaskova MN. Comorbidities in patients with alopecia areata. J Am Acad Dermatol. 2017;76(4):755\u20137.","journal-title":"J Am Acad Dermatol"},{"key":"710_CR20","unstructured":"IQVIA. IQVIA PharMetrics Plus: Fact Sheet; 2020. https:\/\/www.iqvia.com\/library\/fact-sheets\/iqvia-pharmetrics-plus. Accessed Jan 11, 2021."},{"issue":"6","key":"710_CR21","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1093\/aje\/kwq433","volume":"173","author":"H Quan","year":"2011","unstructured":"Quan H, Li B, Couris CM, Fushimi K, Graham P, Hider P, et\u00a0al. Updating and validating the Charlson comorbidity index and score for risk adjustment in hospital discharge abstracts using data from 6 countries. Am J Epidemiol. 2011;173(6):676\u201382.","journal-title":"Am J Epidemiol"},{"issue":"5","key":"710_CR22","doi-asserted-by":"publisher","first-page":"234","DOI":"10.4103\/ijt.ijt_67_20","volume":"12","author":"J Lavian","year":"2020","unstructured":"Lavian J, Li SJ, Lee EY, Bordone LA, Polubriaginof FCG, Christiano AM, et\u00a0al. Validation of case identification for alopecia areata using International Classification of Diseases Coding. Int J Trichology. 2020;12(5):234\u20137.","journal-title":"Int J Trichology"},{"key":"710_CR23","first-page":"103","volume-title":"Principles of international finance and open economy macroeconomics","author":"TC The","year":"2015","unstructured":"The TC, Rate ERE. Principles of international finance and open economy macroeconomics. Waltham: Academic Press; 2015. p. 103\u201343."},{"issue":"1","key":"710_CR24","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s40413-018-0205-4","volume":"11","author":"\u00c1 Fl\u00f3rez-Tanus","year":"2018","unstructured":"Fl\u00f3rez-Tanus \u00c1, Parra D, Zakzuk J, Caraballo L, Alvis-Guzm\u00e1n N. Health care costs and resource utilization for different asthma severity stages in Colombia: a claims data analysis. World Allergy Organ J. 2018;11(1):26.","journal-title":"World Allergy Organ J"},{"issue":"9","key":"710_CR25","doi-asserted-by":"publisher","first-page":"4646","DOI":"10.1007\/s12325-021-01845-0","volume":"38","author":"M Senna","year":"2021","unstructured":"Senna M, Ko J, Tosti A, Edson-Heredia E, Fenske DC, Ellinwood AK, et\u00a0al. Alopecia areata treatment patterns, healthcare resource utilization, and comorbidities in the US population using insurance claims. Adv Ther. 2021;38(9):4646\u201358.","journal-title":"Adv Ther"},{"issue":"4","key":"710_CR26","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1007\/s13555-020-00413-8","volume":"10","author":"LF Eichenfield","year":"2020","unstructured":"Eichenfield LF, DiBonaventura M, Xenakis J, Lafeuille MH, Duh MS, Fakih I, et\u00a0al. Costs and treatment patterns among patients with atopic dermatitis using advanced therapies in the United States: analysis of a retrospective claims database. Dermatol Ther (Heidelb). 2020;10(4):791\u2013806.","journal-title":"Dermatol Ther (Heidelb)"},{"issue":"6","key":"710_CR27","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1016\/j.jaad.2015.02.1099","volume":"72","author":"J Vanderpuye-Orgle","year":"2015","unstructured":"Vanderpuye-Orgle J, Zhao Y, Lu J, Shrestha A, Sexton A, Seabury S, et\u00a0al. Evaluating the economic burden of psoriasis in the United States. J Am Acad Dermatol. 2015;72(6):961\u20137.e5.","journal-title":"J Am Acad Dermatol"},{"issue":"7","key":"710_CR28","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1001\/jamadermatol.2013.3049","volume":"149","author":"KP Huang","year":"2013","unstructured":"Huang KP, Mullangi S, Guo Y, Qureshi AA. Autoimmune, atopic, and mental health comorbid conditions associated with alopecia areata in the United States. JAMA Dermatol. 2013;149(7):789\u201394.","journal-title":"JAMA Dermatol"},{"issue":"1","key":"710_CR29","doi-asserted-by":"publisher","first-page":"S57","DOI":"10.1016\/j.jisp.2017.10.006","volume":"19","author":"CP Lim","year":"2018","unstructured":"Lim CP, Severin RK, Petukhova L. Big data reveal insights into alopecia areata comorbidities. J Investig Dermatol Symp Proc. 2018;19(1):S57\u201361.","journal-title":"J Investig Dermatol Symp Proc"},{"issue":"7","key":"710_CR30","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1001\/jamadermatol.2020.1133","volume":"156","author":"JW Shin","year":"2020","unstructured":"Shin JW, Kang T, Lee JS, Kang MJ, Huh CH, Kim MS, et\u00a0al. Time-dependent risk of acute myocardial infarction in patients with alopecia areata in Korea. JAMA Dermatol. 2020;156(7):763\u201371.","journal-title":"JAMA Dermatol"},{"issue":"1","key":"710_CR31","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.jaad.2016.02.1234","volume":"75","author":"KP Huang","year":"2016","unstructured":"Huang KP, Joyce CJ, Topaz M, Guo Y, Mostaghimi A. Cardiovascular risk in patients with alopecia areata (AA): a propensity-matched retrospective analysis. J Am Acad Dermatol. 2016;75(1):151\u20134.","journal-title":"J Am Acad Dermatol"},{"issue":"1","key":"710_CR32","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1111\/ced.14425","volume":"46","author":"R El-Sayed Mahmoud Marie","year":"2021","unstructured":"El-Sayed Mahmoud Marie R, El-Sayed GAK, Attia FM, Gomaa AHA. Evaluation of serum cardiac troponin I and N-terminal pro-B-type natriuretic peptide levels in patients with alopecia areata. Clin Exp Dermatol. 2021;46(1):153\u20136.","journal-title":"Clin Exp Dermatol"},{"issue":"2","key":"710_CR33","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/j.jaad.2020.04.138","volume":"84","author":"JW Glickman","year":"2021","unstructured":"Glickman JW, Dubin C, Renert-Yuval Y, Dahabreh D, Kimmel GW, Auyeung K, et\u00a0al. Cross-sectional study of blood biomarkers of patients with moderate to severe alopecia areata reveals systemic immune and cardiovascular biomarker dysregulation. J Am Acad Dermatol. 2021;84(2):370\u201380.","journal-title":"J Am Acad Dermatol"},{"issue":"8","key":"710_CR34","doi-asserted-by":"publisher","first-page":"776","DOI":"10.2340\/00015555-2964","volume":"98","author":"EH Wang","year":"2018","unstructured":"Wang EH, Santos L, Li XY, Tran A, Kim SSY, Woo K, et\u00a0al. Alopecia areata is associated with increased expression of heart disease biomarker cardiac troponin I. Acta Derm Venereol. 2018;98(8):776\u201382.","journal-title":"Acta Derm Venereol"},{"issue":"1","key":"710_CR35","doi-asserted-by":"publisher","first-page":"9748","DOI":"10.1038\/s41598-018-28142-1","volume":"8","author":"JH Lee","year":"2018","unstructured":"Lee JH, Song Y, Do Han K, Park YM, Lee JY, Park YG, et\u00a0al. Cancer risk by the subtype of alopecia. Sci Rep. 2018;8(1):9748.","journal-title":"Sci Rep"},{"issue":"5","key":"710_CR36","doi-asserted-by":"publisher","first-page":"2153","DOI":"10.1002\/cam4.1448","volume":"7","author":"CC Chen","year":"2018","unstructured":"Chen CC, Chang YT, Liu HN, Chen YJ. Cancer risk in patients with alopecia areata: a nationwide population-based matched cohort study. Cancer Med. 2018;7(5):2153\u20139.","journal-title":"Cancer Med"},{"issue":"2","key":"710_CR37","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1590\/abd1806-4841.20153084","volume":"90","author":"LB Ribeiro","year":"2015","unstructured":"Ribeiro LB, Rego JC, Estrada BD, Bastos PR, Pineiro Maceira JM, Sodre CT. Alopecia secondary to anti-tumor necrosis factor-alpha therapy. An Bras Dermatol. 2015;90(2):232\u20135.","journal-title":"An Bras Dermatol"},{"issue":"1","key":"710_CR38","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/0165-3806(89)90014-X","volume":"45","author":"OP Mishra","year":"1989","unstructured":"Mishra OP, Delivoria-Papadopoulos M. Lipid peroxidation in developing fetal guinea pig brain during normoxia and hypoxia. Brain Res Dev Brain Res. 1989;45(1):129\u201335.","journal-title":"Brain Res Dev Brain Res"},{"issue":"10","key":"710_CR39","doi-asserted-by":"publisher","first-page":"2751","DOI":"10.1007\/s10067-018-4187-y","volume":"37","author":"JF Merola","year":"2018","unstructured":"Merola JF, Herrera V, Palmer JB. Direct healthcare costs and comorbidity burden among patients with psoriatic arthritis in the USA. Clin Rheumatol. 2018;37(10):2751\u201361.","journal-title":"Clin Rheumatol"},{"issue":"2","key":"710_CR40","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1007\/s40257-017-0253-5","volume":"18","author":"SR Feldman","year":"2017","unstructured":"Feldman SR, Vrijens B, Gieler U, Piaserico S, Puig L, van de Kerkhof P. Treatment adherence intervention studies in dermatology and guidance on how to support adherence. Am J Clin Dermatol. 2017;18(2):253\u201371.","journal-title":"Am J Clin Dermatol"}],"container-title":["Dermatology and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13555-022-00710-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13555-022-00710-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13555-022-00710-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T10:07:47Z","timestamp":1650535667000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13555-022-00710-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["710"],"URL":"https:\/\/doi.org\/10.1007\/s13555-022-00710-4","relation":{},"ISSN":["2193-8210","2190-9172"],"issn-type":[{"value":"2193-8210","type":"print"},{"value":"2190-9172","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"14 December 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 March 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 April 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}