{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T14:58:12Z","timestamp":1783090692510,"version":"3.54.6"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T00:00:00Z","timestamp":1659571200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T00:00:00Z","timestamp":1659571200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"DOI":"10.13039\/501100017596","name":"Natural Science Basic Research Program of Shaanxi Province","doi-asserted-by":"publisher","award":["Program No. 2021JM278"],"award-info":[{"award-number":["Program No. 2021JM278"]}],"id":[{"id":"10.13039\/501100017596","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dermatol Ther (Heidelb)"],"DOI":"10.1007\/s13555-022-00784-0","type":"journal-article","created":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T10:03:03Z","timestamp":1659607383000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Botulinum Toxin A Alleviates Persistent Erythema and Flushing in Patients with Erythema Telangiectasia Rosacea"],"prefix":"10.1007","author":[{"given":"Rongli","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenli","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jintian","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoli","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5184-7496","authenticated-orcid":false,"given":"Xin","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,8,4]]},"reference":[{"issue":"2","key":"784_CR1","first-page":"282","volume":"179","author":"L Gether","year":"2018","unstructured":"Gether L, et al. Incidence and prevalence of rosacea: a systematic review and meta-analysis. Br J Dermatol. 2018;179(2):282\u20139.","journal-title":"Br J Dermatol"},{"issue":"5","key":"784_CR2","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1111\/bjd.18420","volume":"182","author":"M Schaller","year":"2020","unstructured":"Schaller M, et al. Recommendations for rosacea diagnosis, classification and management: update from the global ROSacea COnsensus 2019 panel. Br J Dermatol. 2020;182(5):1269\u201376.","journal-title":"Br J Dermatol"},{"issue":"6","key":"784_CR3","first-page":"348","volume":"6","author":"TT Huynh","year":"2013","unstructured":"Huynh TT. Burden of disease: the psychosocial impact of rosacea on a patient\u2019s quality of life. Am Health Drug Benefits. 2013;6(6):348\u201354.","journal-title":"Am Health Drug Benefits"},{"issue":"Suppl 6","key":"784_CR4","first-page":"38","volume":"14","author":"MA Hofmann","year":"2016","unstructured":"Hofmann MA, Lehmann P. Physical modalities for the treatment of rosacea. J Dtsch Dermatol Ges. 2016;14(Suppl 6):38\u201343.","journal-title":"J Dtsch Dermatol Ges"},{"issue":"1","key":"784_CR5","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1080\/09546634.2019.1580669","volume":"31","author":"Y Zhang","year":"2020","unstructured":"Zhang Y, et al. A decade retrospective study of light\/laser devices in treating nasal rosacea. J Dermatolog Treat. 2020;31(1):84\u201390.","journal-title":"J Dermatolog Treat"},{"issue":"1","key":"784_CR6","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1111\/bjd.17590","volume":"181","author":"EJ van Zuuren","year":"2019","unstructured":"van Zuuren EJ, et al. Interventions for rosacea based on the phenotype approach: an updated systematic review including GRADE assessments. Br J Dermatol. 2019;181(1):65\u201379.","journal-title":"Br J Dermatol"},{"issue":"14","key":"784_CR7","doi-asserted-by":"publisher","first-page":"407","DOI":"10.2147\/CCID.S307013","volume":"30","author":"H Zhang","year":"2021","unstructured":"Zhang H, Tang K, Wang Y, Fang R, Sun Q. Use of botulinum toxin in treating rosacea: a systematic review. Clin Cosmet Investig Dermatol. 2021;30(14):407\u201317.","journal-title":"Clin Cosmet Investig Dermatol"},{"issue":"18","key":"784_CR8","doi-asserted-by":"publisher","first-page":"2985","DOI":"10.3889\/oamjms.2019.784","volume":"7","author":"J Scala","year":"2019","unstructured":"Scala J, Vojvodic A, Vojvodic P, Vlaskovic-Jovicevic T, Peric-Hajzler Z, Matovic D, Dimitrijevic S, Vojvodic J, Sijan G, Stepic N, Wollina U, Tirant M, Thuong NV, Fioranelli M, Lotti T. Botulin toxin use in rosacea and facial flushing treatment. Open Access Maced J Med Sci. 2019;7(18):2985\u20137.","journal-title":"Open Access Maced J Med Sci"},{"issue":"Suppl 1","key":"784_CR9","doi-asserted-by":"publisher","first-page":"S9","DOI":"10.1097\/DSS.0000000000000277","volume":"41","author":"BS Bloom","year":"2015","unstructured":"Bloom BS, et al. Impact of intradermal abobotulinumtoxinA on facial erythema of rosacea. Dermatol Surg. 2015;41(Suppl 1):S9-16.","journal-title":"Dermatol Surg"},{"issue":"7","key":"784_CR10","first-page":"454","volume":"54","author":"G Eshghi","year":"2016","unstructured":"Eshghi G, Khezrian L, Alirezaei P. Botulinum toxin A in treatment of facial flushing. Acta Med Iran. 2016;54(7):454\u20137.","journal-title":"Acta Med Iran"},{"issue":"6","key":"784_CR11","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13976","volume":"33","author":"F Al-Niaimi","year":"2020","unstructured":"Al-Niaimi F, Glagoleva E, Araviiskaia E. Pulsed dye laser followed by intradermal botulinum toxin type-A in the treatment of rosacea-associated erythema and flushing. Dermatol Ther. 2020;33(6): e13976.","journal-title":"Dermatol Ther"},{"key":"784_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.05.014","author":"J Bharti","year":"2018","unstructured":"Bharti J, Sonthalia S, Jakhar D. Mesotherapy with botulinum toxin for the treatment of refractory vascular and papulopustular rosacea. J Am Acad Dermatol. 2018. https:\/\/doi.org\/10.1016\/j.jaad.2018.05.014.","journal-title":"J Am Acad Dermatol"},{"issue":"4","key":"784_CR13","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1002\/lsm.23023","volume":"51","author":"O Friedman","year":"2019","unstructured":"Friedman O, et al. The toxic edge-A novel treatment for refractory erythema and flushing of rosacea. Lasers Surg Med. 2019;51(4):325\u201331.","journal-title":"Lasers Surg Med"},{"issue":"1","key":"784_CR14","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.jaad.2017.08.037","volume":"78","author":"RL Gallo","year":"2018","unstructured":"Gallo RL, et al. Standard classification and pathophysiology of rosacea: the 2017 update by the National Rosacea Society Expert Committee. J Am Acad Dermatol. 2018;78(1):148\u201355.","journal-title":"J Am Acad Dermatol"},{"issue":"4","key":"784_CR15","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1016\/j.jaad.2014.05.044","volume":"71","author":"J Tan","year":"2014","unstructured":"Tan J, et al. Reliability of clinician erythema assessment grading scale. J Am Acad Dermatol. 2014;71(4):760\u20133.","journal-title":"J Am Acad Dermatol"},{"issue":"7","key":"784_CR16","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1185\/030079907X199637","volume":"23","author":"JM Norquist","year":"2007","unstructured":"Norquist JM, et al. Validation of a questionnaire to assess niacin-induced cutaneous flushing. Curr Med Res Opin. 2007;23(7):1549\u201360.","journal-title":"Curr Med Res Opin"},{"issue":"3","key":"784_CR17","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1111\/j.1365-2230.1994.tb01167.x","volume":"19","author":"AY Finlay","year":"1994","unstructured":"Finlay AY, Khan GK. Dermatology Life Quality Index (DLQI)\u2014a simple practical measure for routine clinical use. Clin Exp Dermatol. 1994;19(3):210\u20136.","journal-title":"Clin Exp Dermatol"},{"issue":"1\u20132","key":"784_CR18","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1080\/14764172.2021.1957114","volume":"23","author":"A Ballan","year":"2021","unstructured":"Ballan A, Nasr M, Jabbour S. An unusual tell sign of botulinum toxin injection in patients with facial flushing: incorporating a new questionnaire in the evaluation of botulinum toxin patients. J Cosmet Laser Ther. 2021;23(1\u20132):24\u20135.","journal-title":"J Cosmet Laser Ther"},{"issue":"2","key":"784_CR19","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/0738-081X(93)90057-J","volume":"11","author":"JK Wilkin","year":"1993","unstructured":"Wilkin JK. The red face: flushing disorders. Clin Dermatol. 1993;11(2):211\u201323.","journal-title":"Clin Dermatol"},{"key":"784_CR20","unstructured":"Gu H, et al. Guidelines for the diagnosis and treatment of rosacea in China (2021 edition). Int J Dermatol Venereol. 2021;4."},{"issue":"2","key":"784_CR21","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/s00403-011-1177-1","volume":"304","author":"PD Drummond","year":"2012","unstructured":"Drummond PD, Su D. Endothelial and axon reflex vasodilatation to acetylcholine in rosacea-affected skin. Arch Dermatol Res. 2012;304(2):133\u20137.","journal-title":"Arch Dermatol Res"},{"issue":"10","key":"784_CR22","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.1152\/japplphysiol.00859.2012","volume":"113","author":"DJ Kellogg","year":"2012","unstructured":"Kellogg DJ, et al. Nitric oxide and receptors for VIP and PACAP in cutaneous active vasodilation during heat stress in humans. J Appl Physiol. 2012;113(10):1512\u20138.","journal-title":"J Appl Physiol"}],"updated-by":[{"DOI":"10.1007\/s13555-022-00798-8","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T00:00:00Z","timestamp":1663027200000}}],"container-title":["Dermatology and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13555-022-00784-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13555-022-00784-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13555-022-00784-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T15:36:12Z","timestamp":1664984172000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13555-022-00784-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,4]]},"references-count":22,"alternative-id":["784"],"URL":"https:\/\/doi.org\/10.1007\/s13555-022-00784-0","relation":{"correction":[{"id-type":"doi","id":"10.1007\/s13555-022-00798-8","asserted-by":"object"}]},"ISSN":["2193-8210","2190-9172"],"issn-type":[{"value":"2193-8210","type":"print"},{"value":"2190-9172","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,4]]},"assertion":[{"value":"19 April 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 July 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 August 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 September 2022","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s13555-022-00798-8","URL":"https:\/\/doi.org\/10.1007\/s13555-022-00798-8","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}}]}}