{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T16:07:12Z","timestamp":1784909232097,"version":"3.55.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T00:00:00Z","timestamp":1687564800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T00:00:00Z","timestamp":1687564800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"name":"Pfizer Gulf FZ LLC"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dermatol Ther (Heidelb)"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1007\/s13555-023-00963-7","type":"journal-article","created":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T12:31:22Z","timestamp":1687609882000},"page":"1801-1815","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Treatment Patterns and Unmet Needs in the Management of Alopecia Areata: Results of a Physician\u2019s Survey in the Middle East"],"prefix":"10.1007","volume":"13","author":[{"given":"Alfred","family":"Ammoury","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rehab","family":"Hegazy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saad","family":"Al Talhab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Ameen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nehal","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5994-0497","authenticated-orcid":false,"given":"Marcelle","family":"Ghoubar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,6,24]]},"reference":[{"issue":"2","key":"963_CR1","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.autrev.2014.10.014","volume":"14","author":"N Islam","year":"2015","unstructured":"Islam N, Leung PS, Huntley AC, Gershwin ME. The autoimmune basis of alopecia areata: a comprehensive review. Autoimmun Rev. 2015;14(2):81\u20139. https:\/\/doi.org\/10.1016\/j.autrev.2014.10.014.","journal-title":"Autoimmun Rev"},{"issue":"7","key":"963_CR2","doi-asserted-by":"publisher","first-page":"628","DOI":"10.4065\/70.7.628","volume":"70","author":"KH Safavi","year":"1995","unstructured":"Safavi KH, Muller SA, Suman VJ, Moshell AN, Melton LJ. Incidence of alopecia Areata in Olmsted county, Minnesota, 1975 through 1989. Mayo Clin Proc. 1995;70(7):628\u201333. https:\/\/doi.org\/10.4065\/70.7.628.","journal-title":"Mayo Clin Proc"},{"issue":"3","key":"963_CR3","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.jaad.2006.05.008","volume":"55","author":"A Tosti","year":"2006","unstructured":"Tosti A, Bellavista S, Iorizzo M. Alopecia areata: a long term follow-up study of 191 patients. J Am Acad Dermatol. 2006;55(3):438\u201341. https:\/\/doi.org\/10.1016\/j.jaad.2006.05.008.","journal-title":"J Am Acad Dermatol"},{"issue":"2","key":"963_CR4","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1111\/ajd.12941","volume":"60","author":"WC Cranwell","year":"2019","unstructured":"Cranwell WC, Lai VW, Photiou L, et al. Treatment of alopecia areata: an Australian expert consensus statement. Australas J Dermatol. 2019;60(2):163\u201370. https:\/\/doi.org\/10.1111\/ajd.12941.","journal-title":"Australas J Dermatol"},{"key":"963_CR5","doi-asserted-by":"publisher","unstructured":"Pratt CH, King LE Jr, Messenger AG, Christiano AM, Sundberg JP. Alopecia areata. Nat Rev Dis Primers. 2017;3:17011. https:\/\/doi.org\/10.1038\/nrdp.2017.11.","DOI":"10.1038\/nrdp.2017.11"},{"issue":"3","key":"963_CR6","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.jaad.2019.08.032","volume":"82","author":"HH Lee","year":"2020","unstructured":"Lee HH, Gwillim E, Patel KR, et al. Epidemiology of alopecia areata, ophiasis, totalis, and universalis: a systematic review and meta-analysis. J Am Acad Dermatol. 2020;82(3):675\u201382. https:\/\/doi.org\/10.1016\/j.jaad.2019.08.032.","journal-title":"J Am Acad Dermatol"},{"issue":"16","key":"963_CR7","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.1056\/NEJMra1103442","volume":"366","author":"A Gilhar","year":"2012","unstructured":"Gilhar A, Etzioni A, Paus R. Alopecia areata. N Engl J Med. 2012;366(16):1515\u201325. https:\/\/doi.org\/10.1056\/NEJMra1103442.","journal-title":"N Engl J Med"},{"issue":"9","key":"963_CR8","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1111\/j.1468-3083.2006.01676.x","volume":"20","author":"C Goh","year":"2006","unstructured":"Goh C, Finkel M, Christos PJ, Sinha AA. Profile of 513 patients with alopecia areata: associations of disease subtypes with atopy, autoimmune disease and positive family history. J Eur Acad Dermatol Venereol. 2006;20(9):1055\u201360. https:\/\/doi.org\/10.1111\/j.1468-3083.2006.01676.x.","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"963_CR9","doi-asserted-by":"publisher","unstructured":"Aldhouse NVJ, Kitchen H, Knight S, et al. \u201cYou lose your hair, what\u2019s the big deal?\u2019 I was so embarrassed, I was so self-conscious, I was so depressed:\u201d a qualitative interview study to understand the psychosocial burden of alopecia areata. J Patient Rep Outcomes. 2020;4(1):76. https:\/\/doi.org\/10.1186\/s41687-020-00240-7.","DOI":"10.1186\/s41687-020-00240-7"},{"issue":"3","key":"963_CR10","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/j.jaad.2018.01.048","volume":"79","author":"LY Liu","year":"2018","unstructured":"Liu LY, King BA, Craiglow BG. Alopecia areata is associated with impaired health-related quality of life: A survey of affected adults and children and their families. J Am Acad Dermatol. 2018;79(3):556-558.e1. https:\/\/doi.org\/10.1016\/j.jaad.2018.01.048.","journal-title":"J Am Acad Dermatol"},{"key":"963_CR11","doi-asserted-by":"publisher","first-page":"8879343","DOI":"10.1155\/2020\/8879343","volume":"2020","author":"S Marahatta","year":"2020","unstructured":"Marahatta S, Agrawal S, Adhikari BR. Psychological impact of alopecia areata. Dermatol Res Pract. 2020;2020:8879343. https:\/\/doi.org\/10.1155\/2020\/8879343.","journal-title":"Dermatol Res Pract"},{"issue":"1","key":"963_CR12","doi-asserted-by":"publisher","first-page":"S62","DOI":"10.1016\/j.jisp.2020.05.007","volume":"20","author":"N Mesinkovska","year":"2020","unstructured":"Mesinkovska N, King B, Mirmirani P, Ko J, Cassella J. Burden of illness in alopecia areata: a cross-sectional online survey study. J Investig Dermatol Symp Proc. 2020;20(1):S62-s68. https:\/\/doi.org\/10.1016\/j.jisp.2020.05.007.","journal-title":"J Investig Dermatol Symp Proc"},{"issue":"3","key":"963_CR13","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1007\/s13555-021-00512-0","volume":"11","author":"A Mostaghimi","year":"2021","unstructured":"Mostaghimi A, Napatalung L, Sikirica V, et al. Patient perspectives of the social, emotional and functional impact of alopecia areata: a systematic literature review. Dermatol Ther (Heidelb). 2021;11(3):867\u201383. https:\/\/doi.org\/10.1007\/s13555-021-00512-0.","journal-title":"Dermatol Ther (Heidelb)"},{"key":"963_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.05.086","author":"JP Okhovat","year":"2023","unstructured":"Okhovat JP, Marks DH, Manatis-Lornell A, Hagigeorges D, Locascio JJ, Senna MM. Association between alopecia areata, anxiety, and depression: a systematic review and meta-analysis. J Am Acad Dermatol. 2023;88(5):1040-50. https:\/\/doi.org\/10.1016\/j.jaad.2019.05.086.","journal-title":"J Am Acad Dermatol."},{"issue":"1","key":"963_CR15","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.jaad.2020.06.047","volume":"85","author":"A Toussi","year":"2021","unstructured":"Toussi A, Barton VR, Le ST, Agbai ON, Kiuru M. Psychosocial and psychiatric comorbidities and health-related quality of life in alopecia areata: a systematic review. J Am Acad Dermatol. 2021;85(1):162\u201375. https:\/\/doi.org\/10.1016\/j.jaad.2020.06.047.","journal-title":"J Am Acad Dermatol"},{"key":"963_CR16","unstructured":"United States Food and Drug Administration. Patient-focused drug development public meeting for alopecia areata. 2017. https:\/\/www.fda.gov\/ForIndustry\/UserFees\/PrescriptionDrugUserFee\/ucm554443.htm. Accessed 21 June 2023"},{"issue":"7","key":"963_CR17","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1001\/jamadermatol.2013.3049","volume":"149","author":"KP Huang","year":"2013","unstructured":"Huang KP, Mullangi S, Guo Y, Qureshi AA. Autoimmune, atopic, and mental health comorbid conditions associated with alopecia areata in the United States. JAMA Dermatol. 2013;149(7):789\u201394. https:\/\/doi.org\/10.1001\/jamadermatol.2013.3049.","journal-title":"JAMA Dermatol"},{"key":"963_CR18","doi-asserted-by":"publisher","first-page":"2323","DOI":"10.2147\/dddt.s172638","volume":"12","author":"K Triyangkulsri","year":"2018","unstructured":"Triyangkulsri K, Suchonwanit P. Role of janus kinase inhibitors in the treatment of alopecia areata. Drug Des Devel Ther. 2018;12:2323\u201335. https:\/\/doi.org\/10.2147\/dddt.s172638.","journal-title":"Drug Des Devel Ther"},{"issue":"6","key":"963_CR19","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1159\/000501940","volume":"5","author":"AK Gupta","year":"2019","unstructured":"Gupta AK, Carviel JL, Foley KA, et al. Monotherapy for alopecia areata: a systematic review and network meta-analysis. Skin Appendage Disord. 2019;5(6):331\u20137. https:\/\/doi.org\/10.1159\/000501940.","journal-title":"Skin Appendage Disord"},{"issue":"10387","key":"963_CR20","doi-asserted-by":"publisher","first-page":"1518","DOI":"10.1016\/S0140-6736(23)00222-2","volume":"401","author":"B King","year":"2023","unstructured":"King B, Zhang X, Gubelin Harcha W, et al. Efficacy and safety of ritlecitinib in adults and adolescents with alopecia areata: a randomised, double-blind, multicentre phase 2b\/3 trial. Lancet. 2023;401(10387):1518\u201329.","journal-title":"Lancet"},{"issue":"2","key":"963_CR21","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.jaad.2021.03.050","volume":"85","author":"B King","year":"2021","unstructured":"King B, Guttman-Yassky E, Peeva E, et al. A phase 2a randomized, placebo-controlled study to evaluate the efficacy and safety of the oral Janus kinase inhibitors ritlecitinib and brepocitinib in alopecia areata: 24-week results. J Am Acad Dermatol. 2021;85(2):379\u201387. https:\/\/doi.org\/10.1016\/j.jaad.2021.03.050.","journal-title":"J Am Acad Dermatol."},{"key":"963_CR22","doi-asserted-by":"publisher","first-page":"363","DOI":"10.2147\/DDDT.S334727","volume":"16","author":"HA Ram\u00edrez-Mar\u00edn","year":"2022","unstructured":"Ram\u00edrez-Mar\u00edn HA, Tosti A. Evaluating the therapeutic potential of ritlecitinib for the treatment of alopecia areata. Drug Des Devel Ther. 2022;16:363\u201374. https:\/\/doi.org\/10.2147\/DDDT.S334727.","journal-title":"Drug Des Devel Ther"},{"key":"963_CR23","doi-asserted-by":"publisher","first-page":"691","DOI":"10.2147\/CCID.S309215","volume":"14","author":"KL Dillon","year":"2021","unstructured":"Dillon KL. A Comprehensive literature review of JAK inhibitors in treatment of alopecia areata. Clin Cosmet Investig Dermatol. 2021;14:691\u2013714. https:\/\/doi.org\/10.2147\/CCID.S309215.","journal-title":"Clin Cosmet Investig Dermatol"},{"issue":"18","key":"963_CR24","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1056\/NEJMoa2110343","volume":"386","author":"B King","year":"2022","unstructured":"King B, Ohyama M, Kwon O, et al. Two phase 3 trials of baricitinib for alopecia areata. N Engl J Med. 2022;386(18):1687\u201399. https:\/\/doi.org\/10.1056\/NEJMoa2110343.","journal-title":"N Engl J Med."},{"key":"963_CR25","unstructured":"United States Food and Drug Administration. FDA approves first systemic treatment for alopecia areata. 2022. https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-approves-first-systemic-treatment-alopecia-areata. Accessed 21 June 2023."},{"key":"963_CR26","unstructured":"European Medicines Agency. Olumiant (baricitinib). https:\/\/www.ema.europa.eu\/en\/medicines\/human\/EPAR\/olumiant. Accessed 21 June 2023."},{"key":"963_CR27","unstructured":"Oluminant (baricitinib). Prescribing Information. 2022. https:\/\/pi.lilly.com\/us\/olumiant-uspi.pdf. Accessed 21 June 2023."},{"issue":"10","key":"963_CR28","doi-asserted-by":"publisher","first-page":"3851","DOI":"10.4103\/jfmpc.jfmpc_1070_21","volume":"10","author":"AR Alomaish","year":"2021","unstructured":"Alomaish AR, Gosadi IM, Dallak FH, et al. Prevalence of alopecia and its contributing factors among primary healthcare attendees in the Jazan region, Saudi Arabia. J Family Med Prim Care. 2021;10(10):3851\u20136. https:\/\/doi.org\/10.4103\/jfmpc.jfmpc_1070_21.","journal-title":"J Family Med Prim Care"},{"key":"963_CR29","doi-asserted-by":"publisher","first-page":"7194270","DOI":"10.1155\/2020\/7194270","volume":"2020","author":"AA Alshahrani","year":"2020","unstructured":"Alshahrani AA, Al-Tuwaijri R, Abuoliat ZA, Alyabsi M, AlJasser MI, Alkhodair R. Prevalence and clinical characteristics of alopecia Areata at a tertiary care center in Saudi Arabia. Dermatol Res Pract. 2020;2020:7194270. https:\/\/doi.org\/10.1155\/2020\/7194270.","journal-title":"Dermatol Res Pract"},{"issue":"6","key":"963_CR30","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1001\/jamainternmed.2021.0269","volume":"181","author":"DJ Morgan","year":"2021","unstructured":"Morgan DJ, Pineles L, Owczarzak J, et al. Accuracy of practitioner estimates of probability of diagnosis before and after testing. JAMA Intern Med. 2021;181(6):747\u201355. https:\/\/doi.org\/10.1001\/jamainternmed.2021.0269.","journal-title":"JAMA Intern Med"},{"issue":"4","key":"963_CR31","doi-asserted-by":"publisher","first-page":"404","DOI":"10.4103\/0378-6323.174421","volume":"82","author":"H Gopinath","year":"2016","unstructured":"Gopinath H, Upadya GM. Metabolic syndrome in androgenic alopecia. Indian J Dermatol Venereol Leprol. 2016;82(4):404\u20138. https:\/\/doi.org\/10.4103\/0378-6323.174421.","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"963_CR32","doi-asserted-by":"publisher","unstructured":"Stefanadi EC, Dimitrakakis G, Antoniou CK, et al. Metabolic syndrome and the skin: a more than superficial association. Reviewing the association between skin diseases and metabolic syndrome and a clinical decision algorithm for high risk patients. Diabetol Metab Syndr. 2018;10:9. https:\/\/doi.org\/10.1186\/s13098-018-0311-z","DOI":"10.1186\/s13098-018-0311-z"},{"key":"963_CR33","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.jdin.2022.05.011","volume":"8","author":"AB Kim","year":"2022","unstructured":"Kim AB, Cheng BT, Hassan S. Association of mental health outcomes and lower patient satisfaction among adults with alopecia: a cross-sectional population-based study. JAAD Int. 2022;8:82\u20138. https:\/\/doi.org\/10.1016\/j.jdin.2022.05.011.","journal-title":"JAAD Int"},{"issue":"7522","key":"963_CR34","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1136\/bmj.331.7522.951","volume":"331","author":"N Hunt","year":"2005","unstructured":"Hunt N, McHale S. The psychological impact of alopecia. BMJ. 2005;331(7522):951\u20133. https:\/\/doi.org\/10.1136\/bmj.331.7522.951.","journal-title":"BMJ"},{"issue":"10","key":"963_CR35","doi-asserted-by":"publisher","first-page":"2646","DOI":"10.1016\/j.jid.2022.02.019","volume":"142","author":"M Senna","year":"2022","unstructured":"Senna M, Ko J, Glashofer M, Edison-Heredia E, Zhu B, Shapiro J. Predictors of QOL in patients with alopecia areata. J Investig Dermatol. 2022;142(10):2646\u201350. https:\/\/doi.org\/10.1016\/j.jid.2022.02.019.","journal-title":"J Investig Dermatol"},{"issue":"1","key":"963_CR36","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.jaad.2020.03.004","volume":"83","author":"N Meah","year":"2020","unstructured":"Meah N, Wall D, York K, et al. The Alopecia Areata Consensus of Experts (ACE) study: results of an international expert opinion on treatments for alopecia areata. J Am Acad Dermatol. 2020;83(1):123\u201330. https:\/\/doi.org\/10.1016\/j.jaad.2020.03.004.","journal-title":"J Am Acad Dermatol"},{"issue":"6","key":"963_CR37","doi-asserted-by":"publisher","first-page":"609","DOI":"10.23736\/S0392-0488.19.06458-7","volume":"154","author":"A Rossi","year":"2019","unstructured":"Rossi A, Muscianese M, Piraccini BM, et al. Italian Guidelines in diagnosis and treatment of alopecia areata. G Ital Dermatol Venereol. 2019;154(6):609\u201323. https:\/\/doi.org\/10.23736\/S0392-0488.19.06458-7.","journal-title":"G Ital Dermatol Venereol"},{"issue":"4","key":"963_CR38","doi-asserted-by":"publisher","first-page":"160","DOI":"10.4103\/ijt.ijt_53_17","volume":"9","author":"ST Hussain","year":"2017","unstructured":"Hussain ST, Mostaghimi A, Barr PJ, Brown JR, Joyce C, Huang KP. Utilization of mental health resources and complementary and alternative therapies for alopecia areata: A U.S. survey. Int J Trichology. 2017;9(4):160\u20134. https:\/\/doi.org\/10.4103\/ijt.ijt_53_17.","journal-title":"Int J Trichology."},{"key":"963_CR39","unstructured":"ClinicalTrials.gov. Long-Term PF-06651600 for the Treatment of Alopecia Areata (ALLEGRO-LT). https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04006457. Accessed 21 June 2023."}],"container-title":["Dermatology and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13555-023-00963-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13555-023-00963-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13555-023-00963-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T09:15:35Z","timestamp":1690190135000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13555-023-00963-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,24]]},"references-count":39,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["963"],"URL":"https:\/\/doi.org\/10.1007\/s13555-023-00963-7","relation":{},"ISSN":["2193-8210","2190-9172"],"issn-type":[{"value":"2193-8210","type":"print"},{"value":"2190-9172","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,24]]},"assertion":[{"value":"15 March 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 June 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}