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Recent evidence suggests that, besides the antineoplastic effect, tirbanibulin may also confer substantial cosmetic benefits to patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>We report a single-center retrospective study of patients affected by solar lentigines (SLs) and AKs in the context of field cancerization treated with tirbanibulin 1% ointment.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Among 42 patients, 35% (<jats:italic>n<\/jats:italic>\u2009=\u200915) experienced complete clearance of SLs, while partial clearance was observed in 50% (<jats:italic>n<\/jats:italic>\u2009=\u200921) of patients. Regarding AKs, complete and partial clearance were observed in 52% (<jats:italic>n<\/jats:italic>\u2009=\u200922) and 40% (<jats:italic>n<\/jats:italic>\u2009=\u200917) of patients, respectively. Major study limitations are the small sample size and the absence of a control group.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Our results suggest that tirbanibulin 1% ointment may offer the dual benefit of treating AKs while simultaneously lightening aesthetically bothersome and difficult-to-treat lesions like SLs with just 5 days of application.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s13555-024-01310-0","type":"journal-article","created":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T07:03:24Z","timestamp":1732950204000},"page":"95-110","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Skin-Lightening Power of Tirbanibulin 1% Ointment"],"prefix":"10.1007","volume":"15","author":[{"given":"Federica","family":"Li Pomi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"d\u2019Aloja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelangelo","family":"Rottura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Vaccaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3515-8441","authenticated-orcid":false,"given":"Francesco","family":"Borgia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,30]]},"reference":[{"key":"1310_CR1","doi-asserted-by":"publisher","first-page":"e209","DOI":"10.1016\/j.jaad.2021.02.082","volume":"85","author":"DB Eisen","year":"2021","unstructured":"Eisen DB, Asgari MM, Bennett DD, Connolly SM, Dellavalle RP, Freeman EE, Goldenberg G, Leffell DJ, Peschin S, Sligh JE, et al. 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The study was approved by the local ethical committee. Written informed consent was obtained from all patients for their photographs and medical information to be published. Patients\u2019 names, initials, or hospital numbers have not been used.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}