{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T06:12:32Z","timestamp":1793686352813,"version":"4.5.1"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"DOI":"10.13039\/501100009687","name":"Uniwersytet Medyczny im. Piast\u00f3w Slaskich we Wroclawiu","doi-asserted-by":"publisher","award":["SUBZ.L010.25.053"],"award-info":[{"award-number":["SUBZ.L010.25.053"]}],"id":[{"id":"10.13039\/501100009687","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dermatol Ther (Heidelb)"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1007\/s13555-025-01566-0","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T16:21:47Z","timestamp":1760718107000},"page":"155-169","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Cardiovascular Disease and Psoriasis"],"prefix":"10.1007","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0679-676X","authenticated-orcid":false,"given":"Ma\u0142gorzata","family":"Ponikowska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5232-0936","authenticated-orcid":false,"given":"Loreena","family":"Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2510-4071","authenticated-orcid":false,"given":"Christopher S.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4224-8779","authenticated-orcid":false,"given":"Michela","family":"Barisone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3391-7064","authenticated-orcid":false,"given":"Piotr","family":"Ponikowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8842-6169","authenticated-orcid":false,"given":"Heba M.","family":"Aldossary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7208-3509","authenticated-orcid":false,"given":"Maria","family":"J\u0119drzejczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1229-0650","authenticated-orcid":false,"given":"Grzegorz","family":"Kubielas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5452-0210","authenticated-orcid":false,"given":"Izabella","family":"Uchmanowicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,17]]},"reference":[{"issue":"2","key":"1566_CR1","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1038\/jid.2012.339","volume":"133","author":"R Parisi","year":"2013","unstructured":"Parisi R, Symmons DPM, Griffiths CEM, Ashcroft DM. Global epidemiology of psoriasis: a systematic review of incidence and prevalence. J Investig Dermatol. 2013;133(2):377\u201385.","journal-title":"J Investig Dermatol"},{"issue":"11","key":"1566_CR2","doi-asserted-by":"publisher","first-page":"2461","DOI":"10.1111\/jdv.16915","volume":"34","author":"A Nast","year":"2020","unstructured":"Nast A, Smith C, Spuls PI, Avila Valle G, Bata-Cs\u00f6rg\u00f6 Z, Boonen H, et al. Euroguiderm guideline on the systemic treatment of Psoriasis vulgaris\u2014part 1: treatment and monitoring recommendations. J Eur Acad Dermatol Venereol. 2020;34(11):2461\u201398.","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"5","key":"1566_CR3","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1136\/annrheumdis-2012-201497","volume":"72","author":"L Eder","year":"2013","unstructured":"Eder L, Jayakar J, Shanmugarajah S, Thavaneswaran A, Pereira D, Chandran V, et al. The burden of carotid artery plaques is higher in patients with psoriatic arthritis compared with those with psoriasis alone. Ann Rheum Dis. 2013;72(5):715\u201320.","journal-title":"Ann Rheum Dis"},{"issue":"25","key":"1566_CR4","doi-asserted-by":"publisher","first-page":"3133","DOI":"10.1161\/01.CIR.0000077913.60364.D2","volume":"107","author":"ES Chung","year":"2003","unstructured":"Chung ES, Packer M, Lo KH, Fasanmade AA, Willerson JT. Randomized, double-blind, placebo-controlled, pilot trial of Infliximab, a chimeric monoclonal antibody to tumor necrosis factor-\u03b1, in patients with moderate-to-severe heart failure: results of the anti-TNF therapy against congestive heart failure (ATTACH) trial. Circulation. 2003;107(25):3133\u201340.","journal-title":"Circulation"},{"issue":"3","key":"1566_CR5","doi-asserted-by":"publisher","first-page":"269","DOI":"10.5301\/jn.5000174","volume":"25","author":"EJ Hoorn","year":"2012","unstructured":"Hoorn EJ, Walsh SB, McCormick JA, Zietse R, Unwin RJ, Ellison DH. Pathogenesis of calcineurin inhibitor-induced hypertension. J Nephrol. 2012;25(3):269\u201375.","journal-title":"J Nephrol"},{"issue":"s2","key":"1566_CR6","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1111\/j.1468-3083.2011.03991.x","volume":"25","author":"H Montaudi\u00e9","year":"2011","unstructured":"Montaudi\u00e9 H, Sbidian E, Paul C, Maza A, Gallini A, Aractingi S, et al. Methotrexate in psoriasis: a systematic review of treatment modalities, incidence, risk factors and monitoring of liver toxicity. J Eur Acad Dermatol Venereol. 2011;25(s2):12\u20138.","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"10","key":"1566_CR7","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1016\/j.jid.2023.02.037","volume":"143","author":"S Piaserico","year":"2023","unstructured":"Piaserico S, Papadavid E, Cecere A, Orlando G, Theodoropoulos K, Katsimbri P, et al. Coronary microvascular dysfunction in asymptomatic patients with severe psoriasis. J Invest Dermatol. 2023;143(10):1929-1936.e2.","journal-title":"J Invest Dermatol"},{"key":"1566_CR8","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000677","author":"DK Arnett","year":"2019","unstructured":"Arnett DK, Blumenthal RS, Albert MA, Buroker AB, Goldberger ZD, Hahn EJ, et al. 2019 ACC\/AHA guideline on the primary prevention of cardiovascular disease: executive summary: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines. Circulation [Internet]. 2019. https:\/\/doi.org\/10.1161\/CIR.0000000000000677.","journal-title":"Circulation [Internet]."},{"key":"1566_CR9","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000659","author":"EJ Benjamin","year":"2019","unstructured":"Benjamin EJ, Muntner P, Alonso A, Bittencourt MS, Callaway CW, Carson AP, et al. Heart disease and stroke statistics\u20142019 update: a report From the American Heart Association. Circulation [Internet]. 2019. https:\/\/doi.org\/10.1161\/CIR.0000000000000659.","journal-title":"Circulation [Internet]."},{"issue":"18","key":"1566_CR10","doi-asserted-by":"publisher","first-page":"e016956","DOI":"10.1161\/JAHA.120.016956","volume":"9","author":"S Karbach","year":"2020","unstructured":"Karbach S, Hobohm L, Wild J, M\u00fcnzel T, Gori T, Wegner J, et al. Impact of psoriasis on mortality rate and outcome in myocardial infarction. J Am Heart Assoc. 2020;9(18):e016956.","journal-title":"J Am Heart Assoc"},{"issue":"6","key":"1566_CR11","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1016\/j.jaad.2013.06.053","volume":"69","author":"IM Miller","year":"2013","unstructured":"Miller IM, Ellervik C, Yazdanyar S, Jemec GBE. Meta-analysis of psoriasis, cardiovascular disease, and associated risk factors. J Am Acad Dermatol. 2013;69(6):1014\u201324.","journal-title":"J Am Acad Dermatol"},{"issue":"10","key":"1566_CR12","doi-asserted-by":"publisher","first-page":"2340","DOI":"10.1038\/jid.2013.149","volume":"133","author":"EJ Samarasekera","year":"2013","unstructured":"Samarasekera EJ, Neilson JM, Warren RB, Parnham J, Smith CH. Incidence of cardiovascular disease in individuals with psoriasis: a systematic review and meta-analysis. J Investig Dermatol. 2013;133(10):2340\u20136.","journal-title":"J Investig Dermatol"},{"issue":"9","key":"1566_CR13","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.829709","volume":"25","author":"L Liu","year":"2022","unstructured":"Liu L, Cui S, Liu M, Huo X, Zhang G, Wang N. Psoriasis increased the risk of adverse cardiovascular outcomes: a new systematic review and meta-analysis of cohort study. Front Cardiovasc Med. 2022;25(9):829709.","journal-title":"Front Cardiovasc Med"},{"issue":"7","key":"1566_CR14","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1002\/ejhf.113","volume":"16","author":"U Khalid","year":"2014","unstructured":"Khalid U, Ahlehoff O, Gislason GH, Kristensen SL, Skov L, Torp-Pedersen C, et al. Psoriasis and risk of heart failure: a nationwide cohort study. Eur J Heart Fail. 2014;16(7):743\u20138.","journal-title":"Eur J Heart Fail"},{"issue":"11","key":"1566_CR15","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1001\/jamadermatol.2016.2907","volume":"152","author":"B Mansouri","year":"2016","unstructured":"Mansouri B, Kivelevitch D, Natarajan B, Joshi AA, Ryan C, Benjegerdes K, et al. Comparison of coronary artery calcium scores between patients with psoriasis and type 2 diabetes. JAMA Dermatol. 2016;152(11):1244.","journal-title":"JAMA Dermatol"},{"issue":"3","key":"1566_CR16","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1161\/CIRCULATIONAHA.116.026859","volume":"136","author":"JB Lerman","year":"2017","unstructured":"Lerman JB, Joshi AA, Chaturvedi A, Aberra TM, Dey AK, Rodante JA, et al. Coronary plaque characterization in psoriasis reveals high-risk features that improve after treatment in a prospective observational study. Circulation. 2017;136(3):263\u201376.","journal-title":"Circulation"},{"issue":"2","key":"1566_CR17","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1111\/j.1365-2796.2010.02310.x","volume":"270","author":"O Ahlehoff","year":"2011","unstructured":"Ahlehoff O, Gislason GH, Charlot M, J\u00f8rgensen CH, Lindhardsen J, Olesen JB, et al. Psoriasis is associated with clinically significant cardiovascular risk: a Danish nationwide cohort study: Psoriasis and cardiovascular risk. J Intern Med. 2011;270(2):147\u201357.","journal-title":"J Intern Med"},{"issue":"1","key":"1566_CR18","doi-asserted-by":"publisher","first-page":"13831","DOI":"10.1038\/s41598-017-14365-1","volume":"7","author":"NN Mehta","year":"2017","unstructured":"Mehta NN, Teague HL, Swindell WR, Baumer Y, Ward NL, Xing X, et al. IFN-\u03b3 and TNF-\u03b1 synergism may provide a link between psoriasis and inflammatory atherogenesis. Sci Rep. 2017;7(1):13831.","journal-title":"Sci Rep"},{"issue":"4","key":"1566_CR19","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1161\/ATVBAHA.118.312246","volume":"39","author":"MS Garshick","year":"2019","unstructured":"Garshick MS, Barrett TJ, Wechter T, Azarchi S, Scher JU, Neimann A, et al. Inflammasome signaling and impaired vascular health in psoriasis. Arterioscler Thromb Vasc Biol. 2019;39(4):787\u201398.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"5","key":"1566_CR20","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1161\/ATVBAHA.119.314008","volume":"40","author":"MS Garshick","year":"2020","unstructured":"Garshick MS, Tawil M, Barrett TJ, Salud-Gnilo CM, Eppler M, Lee A, et al. Activated platelets induce endothelial cell inflammatory response in psoriasis via COX-1. Arterioscler Thromb Vasc Biol. 2020;40(5):1340\u201351.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"5","key":"1566_CR21","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1016\/j.jid.2018.10.042","volume":"139","author":"E Von Stebut","year":"2019","unstructured":"Von Stebut E, Reich K, Tha\u00e7i D, Koenig W, Pinter A, K\u00f6rber A, et al. Impact of secukinumab on endothelial dysfunction and other cardiovascular disease parameters in psoriasis patients over 52 weeks. J Investig Dermatol. 2019;139(5):1054\u201362.","journal-title":"J Investig Dermatol"},{"issue":"1","key":"1566_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jacbts.2018.10.008","volume":"4","author":"HL Teague","year":"2019","unstructured":"Teague HL, Varghese NJ, Tsoi LC, Dey AK, Garshick MS, Silverman JI, et al. Neutrophil subsets, platelets, and vascular disease in psoriasis. JACC Basic Transl Sci. 2019;4(1):1\u201314.","journal-title":"JACC Basic Transl Sci"},{"issue":"5","key":"1566_CR23","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1111\/1523-1747.ep12491695","volume":"97","author":"L Vila","year":"1991","unstructured":"Vila L, Cullar\u00e9 C, Sol\u00e1 J, Puig L, De Castellarnau C, De Moragas JM. Cyclooxygenase activity is increased in platelets from psoriatic patients. J Investig Dermatol. 1991;97(5):922\u20136.","journal-title":"J Investig Dermatol."},{"issue":"2","key":"1566_CR24","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.jdermsci.2015.08.002","volume":"80","author":"M Keermann","year":"2015","unstructured":"Keermann M, K\u00f5ks S, Reimann E, Abram K, Erm T, Silm H, et al. Expression of IL-36 family cytokines and IL-37 but not IL-38 is altered in psoriatic skin. J Dermatol Sci. 2015;80(2):150\u20132.","journal-title":"J Dermatol Sci"},{"issue":"11","key":"1566_CR25","doi-asserted-by":"publisher","first-page":"2909","DOI":"10.1016\/j.jid.2022.05.1085","volume":"142","author":"AR Berg","year":"2022","unstructured":"Berg AR, Hong CG, Svirydava M, Li H, Parel PM, Florida E, et al. Association of S100A8\/A9 with lipid-rich necrotic core and treatment with biologic therapy in patients with psoriasis: results from an observational cohort study. J Investig Dermatol. 2022;142(11):2909\u201319.","journal-title":"J Investig Dermatol"},{"issue":"1","key":"1566_CR26","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-015-1508-2","volume":"16","author":"M Keermann","year":"2015","unstructured":"Keermann M, K\u00f5ks S, Reimann E, Prans E, Abram K, Kingo K. Transcriptional landscape of psoriasis identifies the involvement of IL36 and IL36RN. BMC Genom. 2015;16(1):322.","journal-title":"BMC Genom"},{"issue":"11","key":"1566_CR27","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1177\/1535370217703977","volume":"242","author":"S K\u00f5ks","year":"2017","unstructured":"K\u00f5ks S, K\u00f5ks G. Activation of GPR15 and its involvement in the biological effects of smoking. Exp Biol Med. 2017;242(11):1207\u201312.","journal-title":"Exp Biol Med"},{"issue":"23","key":"1566_CR28","doi-asserted-by":"publisher","first-page":"16725","DOI":"10.3390\/ijms242316725","volume":"24","author":"VS Krishnan","year":"2023","unstructured":"Krishnan VS, K\u00f5ks S. Transcriptional landscape of repetitive elements in psoriatic skin from large cohort studies: relevance to psoriasis pathophysiology. Int J Mol Sci. 2023;24(23):16725.","journal-title":"Int J Mol Sci"},{"issue":"1","key":"1566_CR29","doi-asserted-by":"publisher","first-page":"4358","DOI":"10.1038\/s41598-018-22734-7","volume":"8","author":"F L\u00e4ttekivi","year":"2018","unstructured":"L\u00e4ttekivi F, K\u00f5ks S, Keermann M, Reimann E, Prans E, Abram K, et al. Transcriptional landscape of human endogenous retroviruses (HERVs) and other repetitive elements in psoriatic skin. Sci Rep. 2018;8(1):4358.","journal-title":"Sci Rep"},{"key":"1566_CR30","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2016.00046\/full","author":"S K\u00f5ks","year":"2016","unstructured":"K\u00f5ks S, Keermann M, Reimann E, Prans E, Abram K, Silm H, et al. Psoriasis-specific RNA isoforms identified by RNA-Seq analysis of 173,446 transcripts. Front Med [Internet]. 2016. https:\/\/doi.org\/10.3389\/fmed.2016.00046\/full.","journal-title":"Front Med [Internet]."},{"issue":"1","key":"1566_CR31","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.jaad.2011.06.035","volume":"67","author":"AB Kimball","year":"2012","unstructured":"Kimball AB, Szapary P, Mrowietz U, Reich K, Langley RG, You Y, et al. Underdiagnosis and undertreatment of cardiovascular risk factors in patients with moderate to severe psoriasis. J Am Acad Dermatol. 2012;67(1):76\u201385.","journal-title":"J Am Acad Dermatol"},{"issue":"7","key":"1566_CR32","doi-asserted-by":"publisher","first-page":"972","DOI":"10.2340\/00015555-2434","volume":"96","author":"L Cea-Calvo","year":"2016","unstructured":"Cea-Calvo L, Vanaclocha F, Belinch\u00f3n I, Rinc\u00f3n \u00d3, Juli\u00e1 B, Puig L. Underdiagnosis of cardiovascular risk factors in outpatients with psoriasis followed at hospital dermatology offices: the PSO-RISK study. Acta Derm Venereol. 2016;96(7):972\u20133.","journal-title":"Acta Derm Venereol"},{"issue":"1","key":"1566_CR33","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.atherosclerosis.2012.06.068","volume":"224","author":"NN Mehta","year":"2012","unstructured":"Mehta NN, Li R, Krishnamoorthy P, Yu Y, Farver W, Rodrigues A, et al. Abnormal lipoprotein particles and cholesterol efflux capacity in patients with psoriasis. Atherosclerosis. 2012;224(1):218\u201321.","journal-title":"Atherosclerosis"},{"issue":"8","key":"1566_CR34","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.1194\/jlr.M027367","volume":"53","author":"M Holzer","year":"2012","unstructured":"Holzer M, Wolf P, Curcic S, Birner-Gruenberger R, Weger W, Inzinger M, et al. Psoriasis alters HDL composition and cholesterol efflux capacity. J Lipid Res. 2012;53(8):1618\u201324.","journal-title":"J Lipid Res"},{"issue":"11","key":"1566_CR35","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1161\/CIRCRESAHA.118.313608","volume":"123","author":"AV Sorokin","year":"2018","unstructured":"Sorokin AV, Kotani K, Elnabawi YA, Dey AK, Sajja AP, Yamada S, et al. Association between oxidation-modified lipoproteins and coronary plaque in psoriasis: an observational cohort study. Circ Res. 2018;123(11):1244\u201354.","journal-title":"Circ Res"},{"issue":"11","key":"1566_CR36","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1001\/archdermatol.2012.2502","volume":"148","author":"JJ Wu","year":"2012","unstructured":"Wu JJ, Poon KYT, Channual JC, Shen AYJ. Association between tumor necrosis factor inhibitor therapy and myocardial infarction risk in patients with psoriasis. Arch Dermatol. 2012;148(11):1244.","journal-title":"Arch Dermatol"},{"issue":"8","key":"1566_CR37","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1007\/s40261-017-0533-0","volume":"37","author":"WC Ports","year":"2017","unstructured":"Ports WC, Fayyad R, DeMicco DA, Laskey R, Wolk R. Effectiveness of lipid-lowering statin therapy in patients with and without psoriasis. Clin Drug Investig. 2017;37(8):775\u201385.","journal-title":"Clin Drug Investig"},{"issue":"2","key":"1566_CR38","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.jid.2020.05.115","volume":"141","author":"MS Garshick","year":"2021","unstructured":"Garshick MS, Baumer Y, Dey AK, Grattan R, Ng Q, Teague HL, et al. Characterization of PCSK9 in the blood and skin of psoriasis. J Investig Dermatol. 2021;141(2):308\u201315.","journal-title":"J Investig Dermatol"},{"issue":"2","key":"1566_CR39","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1001\/jamadermatol.2014.2094","volume":"151","author":"J Takeshita","year":"2015","unstructured":"Takeshita J, Wang S, Shin DB, Mehta NN, Kimmel SE, Margolis DJ, et al. Effect of psoriasis severity on hypertension control: a population-based study in the United Kingdom. JAMA Dermatol. 2015;151(2):161.","journal-title":"JAMA Dermatol"},{"issue":"12","key":"1566_CR40","doi-asserted-by":"publisher","first-page":"2658","DOI":"10.1161\/ATVBAHA.114.304108","volume":"34","author":"S Karbach","year":"2014","unstructured":"Karbach S, Croxford AL, Oelze M, Sch\u00fcler R, Minwegen D, Wegner J, et al. Interleukin 17 drives vascular inflammation, endothelial dysfunction, and arterial hypertension in psoriasis-like skin disease. Arterioscler Thromb Vasc Biol. 2014;34(12):2658\u201368.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"3","key":"1566_CR41","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1038\/jid.2011.365","volume":"132","author":"SM Langan","year":"2012","unstructured":"Langan SM, Seminara NM, Shin DB, Troxel AB, Kimmel SE, Mehta NN, et al. Prevalence of metabolic syndrome in patients with psoriasis: a population-based study in the United Kingdom. J Investig Dermatol. 2012;132(3):556\u201362.","journal-title":"J Investig Dermatol"},{"issue":"4","key":"1566_CR42","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1016\/j.jaad.2018.11.058","volume":"80","author":"CA Elmets","year":"2019","unstructured":"Elmets CA, Leonardi CL, Davis DMR, Gelfand JM, Lichten J, Mehta NN, et al. Joint AAD-NPF guidelines of care for the management and treatment of psoriasis with awareness and attention to comorbidities. J Am Acad Dermatol. 2019;80(4):1073\u2013113.","journal-title":"J Am Acad Dermatol"},{"issue":"11","key":"1566_CR43","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1161\/CIRCRESAHA.116.309637","volume":"119","author":"AA Joshi","year":"2016","unstructured":"Joshi AA, Lerman JB, Aberra TM, Afshar M, Teague HL, Rodante JA, et al. GlycA Is a novel biomarker of inflammation and subclinical cardiovascular disease in psoriasis. Circ Res. 2016;119(11):1242\u201353.","journal-title":"Circ Res"},{"issue":"12","key":"1566_CR44","doi-asserted-by":"publisher","first-page":"2667","DOI":"10.1161\/ATVBAHA.115.306460","volume":"35","author":"HB Naik","year":"2015","unstructured":"Naik HB, Natarajan B, Stansky E, Ahlman MA, Teague H, Salahuddin T, et al. Severity of psoriasis associates with aortic vascular inflammation detected by FDG PET\/CT and neutrophil activation in a prospective observational study. Arterioscler Thromb Vasc Biol. 2015;35(12):2667\u201376.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"13","key":"1566_CR45","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.2340\/00015555-3337","volume":"99","author":"E Reimann","year":"2019","unstructured":"Reimann E, L\u00e4ttekivi F, Keermann M, Abram K, K\u00f5ks S, Kingo K, et al. Multicomponent biomarker approach improves the accuracy of diagnostic biomarkers for psoriasis vulgaris. Acta Derm Venereol. 2019;99(13):1258\u201365.","journal-title":"Acta Derm Venereol"},{"issue":"13","key":"1566_CR46","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1016\/j.jacc.2021.02.009","volume":"77","author":"MS Garshick","year":"2021","unstructured":"Garshick MS, Ward NL, Krueger JG, Berger JS. Cardiovascular risk in patients with psoriasis. J Am Coll Cardiol. 2021;77(13):1670\u201380.","journal-title":"J Am Coll Cardiol"},{"issue":"8","key":"1566_CR47","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1038\/ijo.2015.64","volume":"39","author":"S Upala","year":"2015","unstructured":"Upala S, Sanguankeo A. Effect of lifestyle weight loss intervention on disease severity in patients with psoriasis: a systematic review and meta-analysis. Int J Obes. 2015;39(8):1197\u2013202.","journal-title":"Int J Obes"},{"issue":"8","key":"1566_CR48","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1001\/jamadermatol.2018.1412","volume":"154","author":"AR Ford","year":"2018","unstructured":"Ford AR, Siegel M, Bagel J, Cordoro KM, Garg A, Gottlieb A, et al. Dietary recommendations for adults with psoriasis or psoriatic arthritis from the medical board of the national psoriasis foundation: a systematic review. JAMA Dermatol. 2018;154(8):934.","journal-title":"JAMA Dermatol"},{"issue":"9","key":"1566_CR49","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1001\/jamacardio.2017.1213","volume":"2","author":"AK Dey","year":"2017","unstructured":"Dey AK, Joshi AA, Chaturvedi A, Lerman JB, Aberra TM, Rodante JA, et al. Association between skin and aortic vascular inflammation in patients with psoriasis: a case-cohort study using positron emission tomography\/computed tomography. JAMA Cardiol. 2017;2(9):1013.","journal-title":"JAMA Cardiol."},{"issue":"4","key":"1566_CR50","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1093\/cvr\/cvz009","volume":"115","author":"YA Elnabawi","year":"2019","unstructured":"Elnabawi YA, Dey AK, Goyal A, Groenendyk JW, Chung JH, Belur AD, et al. Coronary artery plaque characteristics and treatment with biologic therapy in severe psoriasis: results from a prospective observational study. Cardiovasc Res. 2019;115(4):721\u20138.","journal-title":"Cardiovasc Res"},{"issue":"6","key":"1566_CR51","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.117.007394","volume":"11","author":"NN Mehta","year":"2018","unstructured":"Mehta NN, Shin DB, Joshi AA, Dey AK, Armstrong AW, Duffin KC, et al. Effect of 2 psoriasis treatments on vascular inflammation and novel inflammatory cardiovascular biomarkers: a randomized placebo-controlled trial. Circ Cardiovasc Imaging. 2018;11(6):e007394.","journal-title":"Circ Cardiovasc Imaging"},{"issue":"9","key":"1566_CR52","doi-asserted-by":"publisher","first-page":"1784","DOI":"10.1016\/j.jid.2020.01.025","volume":"140","author":"JM Gelfand","year":"2020","unstructured":"Gelfand JM, Shin DB, Duffin KC, Armstrong AW, Blauvelt A, Tyring SK, et al. A randomized placebo-controlled trial of Secukinumab on aortic vascular inflammation in moderate-to-severe plaque psoriasis (VIP-S). J Investig Dermatol. 2020;140(9):1784-1793.e2.","journal-title":"J Investig Dermatol"},{"key":"1566_CR53","unstructured":"Penn Medicine [Internet]. 2024 [access 2025 July 3]. Program can identify and manage risk of cardiovascular disease in patients with psoriatic disease. https:\/\/www.pennmedicine.org\/news\/program-for-psoriasis-patients-finds-cardiovascular-disease-risk."},{"issue":"2","key":"1566_CR54","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000062","volume":"2","author":"EJ Armstrong","year":"2013","unstructured":"Armstrong EJ, Harskamp CT, Armstrong AW. Psoriasis and major adverse cardiovascular events: a systematic review and meta-analysis of observational studies. J Am Heart Assoc. 2013;2(2):e000062.","journal-title":"J Am Heart Assoc"},{"issue":"1","key":"1566_CR55","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-015-0752-0","volume":"15","author":"A Mustonen","year":"2015","unstructured":"Mustonen A, Mattila K, Leino M, Koulu L, Tuominen R. How much of the productivity losses among psoriasis patients are due to psoriasis? BMC Health Serv Res. 2015;15(1):87.","journal-title":"BMC Health Serv Res"},{"issue":"1","key":"1566_CR56","doi-asserted-by":"publisher","first-page":"2247106","DOI":"10.1080\/09546634.2023.2247106","volume":"34","author":"S Min","year":"2023","unstructured":"Min S, Wang D, Xia J, Lin X, Jiang G. The economic burden and quality of life of patients with psoriasis treated with biologics in China. J Dermatol Treat. 2023;34(1):2247106.","journal-title":"J Dermatol Treat"},{"issue":"2","key":"1566_CR57","doi-asserted-by":"publisher","DOI":"10.2196\/jmir.3703","volume":"17","author":"CS Kruse","year":"2015","unstructured":"Kruse CS, Argueta DA, Lopez L, Nair A. Patient and provider attitudes toward the use of patient portals for the management of chronic disease: a systematic review. J Med Internet Res. 2015;17(2):e40.","journal-title":"J Med Internet Res"},{"key":"1566_CR58","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001431.pub6","author":"D Stacey","year":"2024","unstructured":"Stacey D, Lewis KB, Smith M, Carley M, Volk R, Douglas EE, et al. Decision aids for people facing health treatment or screening decisions. Cochrane Consumers and Communication Group, editor. Cochrane Database Syst Rev [Internet]. 2024. https:\/\/doi.org\/10.1002\/14651858.CD001431.pub6.","journal-title":"Cochrane Database Syst Rev [Internet]."},{"issue":"4","key":"1566_CR59","doi-asserted-by":"publisher","first-page":"e187","DOI":"10.1111\/ajd.14436","volume":"66","author":"A Smith","year":"2025","unstructured":"Smith A, Lai B, Zaman S, et al. Improving cardiovascular outcomes in the psoriasis cohort. Psoriasis and cardiovascular disease-clinician knowledge, practice and perceptions. Australas J Dermatol. 2025;66(4):e187\u201396. https:\/\/doi.org\/10.1111\/ajd.14436.","journal-title":"Australas J Dermatol"},{"issue":"3","key":"1566_CR60","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1177\/247553031700200307","volume":"2","author":"L Afifi","year":"2017","unstructured":"Afifi L, Shankle L, Armstrong AW, Boas M, Bridges A, Chiguil V, et al. National Psoriasis Foundation priorities for patient-centered research: proceedings from the 2016 conference. J Psoriasis Psoriatic Arthritis. 2017;2(3):73\u201380.","journal-title":"J Psoriasis Psoriatic Arthritis"}],"container-title":["Dermatology and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13555-025-01566-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13555-025-01566-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13555-025-01566-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T08:02:24Z","timestamp":1770192144000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13555-025-01566-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,17]]},"references-count":60,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["1566"],"URL":"https:\/\/doi.org\/10.1007\/s13555-025-01566-0","relation":{},"ISSN":["2193-8210","2190-9172"],"issn-type":[{"value":"2193-8210","type":"print"},{"value":"2190-9172","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,17]]},"assertion":[{"value":"5 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ma\u0142gorzata Ponikowska has nothing to disclose. Loreena Hill has nothing to disclose. Christopher S. Lee has nothing to disclose. Michela Barisone has nothing to disclose. Piotr Ponikowski has nothing to disclose. Heba Aldossary has nothing to disclose. Maria J\u0119drzejczyk has nothing to disclose. Grzegorz Kubielas has nothing to disclose. Izabella Uchmanowicz has nothing to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"This article is based on previously conducted studies and does not contain any new studies with human participants or animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}