{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:23:56Z","timestamp":1790396636086,"version":"4.1.0"},"reference-count":69,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dermatol Ther (Heidelb)"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1007\/s13555-025-01585-x","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T09:51:52Z","timestamp":1764064312000},"page":"521-534","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy and Safety of a Drinkable Nutraceutical in Premenopausal Women with Telogen Effluvium: A 6-Month, Randomized, Multicenter, Double-Blind, Placebo-Controlled Study"],"prefix":"10.1007","volume":"16","clinical-trial-number":[{"clinical-trial-number":"nct07111312","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Claudia","family":"Bern\u00e1rdez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Podlipnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian E.","family":"Westgate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Paus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Zamfir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Grohmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1293-4822","authenticated-orcid":false,"given":"Manuel","family":"S\u00e1ez Moya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,25]]},"reference":[{"key":"1585_CR1","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1111\/jdv.13455","volume":"30","author":"M Harries","year":"2016","unstructured":"Harries M, Tosti A, Bergfeld W, et al. Towards a consensus on how to diagnose and quantify female pattern hair loss\u2014the \u201cfemale pattern hair loss severity index (FPHL-SI).\u201d J Eur Acad Dermatol Venereol. 2016;30:667\u201376.","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"1585_CR2","volume-title":"Disorders of the hair and nail: diagnosis and treatment","author":"A Tosti","year":"2024","unstructured":"Tosti A, Piraccini BM. Disorders of the hair and nail: diagnosis and treatment. New York: McGraw Hill; 2024."},{"key":"1585_CR3","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1080\/13548506.2023.2242049","volume":"29","author":"H Frith","year":"2024","unstructured":"Frith H, Jankowski GS. Psychosocial impact of androgenetic alopecia on men: a systematic review and meta-analysis. Psychol Health Med. 2024;29:822\u201342.","journal-title":"Psychol Health Med"},{"key":"1585_CR4","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26083461","author":"J Kim","year":"2025","unstructured":"Kim J, Song SY, Sung JH. Recent advances in drug development for hair loss. Int J Mol Sci. 2025. https:\/\/doi.org\/10.3390\/ijms26083461.","journal-title":"Int J Mol Sci"},{"key":"1585_CR5","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12030513","author":"B Owecka","year":"2024","unstructured":"Owecka B, Tomaszewska A, Dobrzeniecki K, Owecki M. The hormonal background of hair loss in non-scarring alopecias. Biomedicines. 2024. https:\/\/doi.org\/10.3390\/biomedicines12030513.","journal-title":"Biomedicines"},{"key":"1585_CR6","doi-asserted-by":"publisher","first-page":"S20","DOI":"10.1016\/j.jaad.2023.04.022","volume":"89","author":"L Alhanshali","year":"2023","unstructured":"Alhanshali L, Buontempo M, Shapiro J, Lo Sicco K. Medication-induced hair loss: an update. J Am Acad Dermatol. 2023;89:S20\u20138.","journal-title":"J Am Acad Dermatol"},{"key":"1585_CR7","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16512","author":"IN Durusu Turkoglu","year":"2024","unstructured":"Durusu Turkoglu IN, Turkoglu AK, Soylu S, Gencer G, Duman R. A comprehensive investigation of biochemical status in patients with telogen effluvium: analysis of Hb, ferritin, vitamin\u00a0B12, vitamin\u00a0D, thyroid function tests, zinc, copper, biotin, and selenium levels. J Cosmet Dermatol. 2024. https:\/\/doi.org\/10.1111\/jocd.16512.","journal-title":"J Cosmet Dermatol"},{"key":"1585_CR8","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1159\/000216832","volume":"219","author":"M Kunz","year":"2009","unstructured":"Kunz M, Seifert B, Tr\u00fceb RM. Seasonality of hair shedding in healthy women complaining of hair loss. Dermatology. 2009;219:105\u201310.","journal-title":"Dermatology"},{"key":"1585_CR9","doi-asserted-by":"publisher","first-page":"e1458","DOI":"10.1111\/jdv.19364","volume":"37","author":"MG Buontempo","year":"2023","unstructured":"Buontempo MG, Ingrassia JP, Shapiro J, Lo Sicco K. Seasonal trends in hair loss: a big data analysis of Google search patterns and their association with seasonal factors. J Eur Acad Dermatol Venereol. 2023;37:e1458\u201360.","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"1585_CR10","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1080\/13697137.2022.2050206","volume":"25","author":"CC Zouboulis","year":"2022","unstructured":"Zouboulis CC, Blume-Peytavi U, Kosmadaki M, et al. Skin, hair and beyond: the impact of menopause. Climacteric. 2022;25:434\u201342.","journal-title":"Climacteric"},{"key":"1585_CR11","first-page":"3","volume":"35","author":"SK Henne","year":"2023","unstructured":"Henne SK, N\u00f6then MM, Heilmann-Heimbach S. Male-pattern hair loss: comprehensive identification of the associated genes as a basis for understanding pathophysiology. Med Genet. 2023;35:3\u201314.","journal-title":"Med Genet"},{"key":"1585_CR12","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1111\/jdv.12914","volume":"30","author":"A Rebora","year":"2016","unstructured":"Rebora A, Guarrera M, Drago F. Postpartum telogen effluvium. J Eur Acad Dermatol Venereol. 2016;30:518.","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"1585_CR13","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1111\/j.1365-2133.1991.tb00423.x","volume":"124","author":"VA Randall","year":"1991","unstructured":"Randall VA, Ebling FJ. Seasonal changes in human hair growth. Br J Dermatol. 1991;124:146\u201351.","journal-title":"Br J Dermatol"},{"key":"1585_CR14","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1056\/NEJM199908123410706","volume":"341","author":"R Paus","year":"1999","unstructured":"Paus R, Cotsarelis G. The biology of hair follicles. N Engl J Med. 1999;341:491\u20137.","journal-title":"N Engl J Med"},{"key":"1585_CR15","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a013615","author":"J Qi","year":"2014","unstructured":"Qi J, Garza LA. An overview of alopecias. Cold Spring Harb Perspect Med. 2014. https:\/\/doi.org\/10.1101\/cshperspect.a013615.","journal-title":"Cold Spring Harb Perspect Med"},{"key":"1585_CR16","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1159\/000211279","volume":"7","author":"M Courtois","year":"1994","unstructured":"Courtois M, Loussouarn G, Hourseau C, Grollier JF. Hair cycle and alopecia. Skin Pharmacol. 1994;7:84\u20139.","journal-title":"Skin Pharmacol."},{"key":"1585_CR17","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.8320","author":"F Asghar","year":"2020","unstructured":"Asghar F, Shamim N, Farooque U, Sheikh H, Aqeel R. Telogen effluvium: a review of the literature. Cureus. 2020. https:\/\/doi.org\/10.7759\/cureus.8320.","journal-title":"Cureus"},{"key":"1585_CR18","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12030893","author":"N Natarelli","year":"2023","unstructured":"Natarelli N, Gahoonia N, Sivamani RK. Integrative and mechanistic approach to the hair growth cycle and hair loss. J Clin Med. 2023. https:\/\/doi.org\/10.3390\/jcm12030893.","journal-title":"J Clin Med"},{"key":"1585_CR19","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1007\/s40257-023-00760-0","volume":"24","author":"A Daunton","year":"2023","unstructured":"Daunton A, Harries M, Sinclair R, Paus R, Tosti A, Messenger A. Chronic telogen effluvium: is it a distinct condition? A systematic review. Am J Clin Dermatol. 2023;24:513\u201320.","journal-title":"Am J Clin Dermatol"},{"key":"1585_CR20","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.jdermsci.2021.01.007","volume":"101","author":"GO Chien Yin","year":"2021","unstructured":"Chien Yin GO, Siong-See JL, Wang ECE. Telogen effluvium - a review of the science and current obstacles. J Dermatol Sci. 2021;101:156\u201363.","journal-title":"J Dermatol Sci"},{"key":"1585_CR21","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.2147\/PPA.S282399","volume":"15","author":"K Thadanipon","year":"2021","unstructured":"Thadanipon K, Suchonwanit P. Measuring patient quality of life following treatment for alopecia. Patient Prefer Adherence. 2021;15:1601\u201310.","journal-title":"Patient Prefer Adherence"},{"key":"1585_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2021.100978","author":"PR Feldman","year":"2021","unstructured":"Feldman PR, Fiebig KM, Piwko C, et al. Safety and efficacy of ALRV5XR in women with androgenetic alopecia or telogen effluvium: a randomised, double-blinded, placebo-controlled clinical trial. EClinMed. 2021. https:\/\/doi.org\/10.1016\/j.eclinm.2021.100978.","journal-title":"EClinMed"},{"key":"1585_CR23","doi-asserted-by":"publisher","first-page":"661","DOI":"10.36849\/JDD.8421","volume":"23","author":"RK Sivamani","year":"2024","unstructured":"Sivamani RK, Ablon G, Nong Y, Maloh J, Hazan A, Raymond I. A prospective, multi-center study to evaluate the safety and efficacy of a vegan nutraceutical to improve hair growth and quality in females following a plant-based diet. J Drugs Dermatol. 2024;23:661\u20138.","journal-title":"J Drugs Dermatol"},{"key":"1585_CR24","doi-asserted-by":"publisher","unstructured":"Bhatia N, Ablon G, Farris PK, Hazan A, Raymond I. A randomized, double-blind, placebo-controlled study to evaluate the safety and efficacy of a nutraceutical supplement with standardized botanicals in males with thinning hair. J Cosmet Dermatol. 2025. https:\/\/doi.org\/10.1111\/jocd.16778.","DOI":"10.1111\/jocd.16778"},{"key":"1585_CR25","doi-asserted-by":"publisher","unstructured":"Lee J, Jin Y, Zhang X, et al. Therapeutic potential of Gynostemma pentaphyllum extract for hair health enhancement: a randomized, double-blind, placebo-controlled clinical trial. Nutrients. 2025. https:\/\/doi.org\/10.3390\/nu17050767.","DOI":"10.3390\/nu17050767"},{"key":"1585_CR26","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16778","volume":"24","author":"N Bhatia","year":"2025","unstructured":"Bhatia N, Ablon G, Farris PK, Hazan A, Raymond I. A randomized, double-blind, placebo-controlled study to evaluate the safety and efficacy of a nutraceutical supplement with standardized botanicals in males with thinning hair. J Cosmet Dermatol. 2025;24:e16778.","journal-title":"J Cosmet Dermatol"},{"key":"1585_CR27","first-page":"558","volume":"17","author":"G Ablon","year":"2018","unstructured":"Ablon G, Kogan S. A six-month, randomized, double-blind, placebo-controlled study evaluating the safety and efficacy of a nutraceutical supplement for promoting hair growth in women with self-perceived thinning hair. J Drugs Dermatol. 2018;17:558\u201365.","journal-title":"J Drugs Dermatol"},{"key":"1585_CR28","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1111\/exd.12164","volume":"22","author":"M Guarrera","year":"2013","unstructured":"Guarrera M, Fiorucci MC, Rebora A. Methods of hair loss evaluation: a comparison of TrichoScan\u00ae with the modified wash test. Exp Dermatol. 2013;22:482\u20134.","journal-title":"Exp Dermatol"},{"key":"1585_CR29","doi-asserted-by":"crossref","unstructured":"Guarrera M, Rebora A. Hair evaluation method: pull test and wash test. In: Humbert P, Fanian F, Maibach HI, Agache P, editors. Agache\u2019s measuring the skin: non-invasive investigations, physiology, normal constants, 2nd ed. Cham: Springer; 2017. pp. 827\u2013830.","DOI":"10.1007\/978-3-319-32383-1_115"},{"key":"1585_CR30","doi-asserted-by":"publisher","first-page":"2168","DOI":"10.1016\/j.bpj.2022.04.029","volume":"121","author":"DP Harland","year":"2022","unstructured":"Harland DP, Popescu C, Richena M, et al. The susceptibility of disulfide bonds to modification in keratin fibers undergoing tensile stress. Biophys J. 2022;121:2168\u201379.","journal-title":"Biophys J"},{"key":"1585_CR31","doi-asserted-by":"publisher","first-page":"56S","DOI":"10.1016\/0022-202X(93)90501-8","volume":"101","author":"J Yu","year":"1993","unstructured":"Yu J, Yu D-W, Checkla DM, Freedberg IM, Bertolino AP. Human hair keratins. J Invest Dermatol. 1993;101:56S-59S.","journal-title":"J Invest Dermatol"},{"key":"1585_CR32","doi-asserted-by":"publisher","first-page":"4221","DOI":"10.1242\/jcs.089516","volume":"124","author":"P Strnad","year":"2011","unstructured":"Strnad P, Usachov V, Debes C, Gr\u00e4ter F, Parry DAD, Omary MB. Unique amino acid signatures that are evolutionarily conserved distinguish simple-type, epidermal and hair keratins. J Cell Sci. 2011;124:4221\u201332.","journal-title":"J Cell Sci"},{"key":"1585_CR33","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/s13555-018-0278-6","volume":"9","author":"HM Almohanna","year":"2019","unstructured":"Almohanna HM, Ahmed AA, Tsatalis JP, Tosti A. The role of vitamins and minerals in hair loss: a review. Dermatol Ther (Heidelb). 2019;9:51\u201370.","journal-title":"Dermatol Ther (Heidelb)"},{"key":"1585_CR34","doi-asserted-by":"publisher","DOI":"10.3390\/nu14163357","author":"I Piccini","year":"2022","unstructured":"Piccini I, Sousa M, Altendorf S, et al. Intermediate hair follicles from patients with female pattern hair loss are associated with nutrient insufficiency and a quiescent metabolic phenotype. Nutrients. 2022. https:\/\/doi.org\/10.3390\/nu14163357.","journal-title":"Nutrients"},{"key":"1585_CR35","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1046\/j.1365-2230.2002.01076.x","volume":"27","author":"DH Rushton","year":"2002","unstructured":"Rushton DH. Nutritional factors and hair loss. Clin Exp Dermatol. 2002;27:396\u2013404.","journal-title":"Clin Exp Dermatol"},{"key":"1585_CR36","doi-asserted-by":"publisher","first-page":"2455","DOI":"10.1080\/09546634.2022.2062282","volume":"33","author":"T Searle","year":"2022","unstructured":"Searle T, Faisal RA, Al-Niaimi F. Zinc in dermatology. J Dermatolog Treat. 2022;33:2455\u20138.","journal-title":"J Dermatolog Treat"},{"key":"1585_CR37","doi-asserted-by":"publisher","first-page":"168","DOI":"10.4103\/ijt.ijt_124_19","volume":"12","author":"HRA Ashtiani","year":"2020","unstructured":"Ashtiani HRA, Dadgar A, Akaberi M. Improvement of cell proliferation and antioxidant activity of silymarin in hair follicles dermal papillae isolated from the human scalp: comparison with vitamin\u00a0C effects. Int J Trichology. 2020;12:168\u201375.","journal-title":"Int J Trichology"},{"key":"1585_CR38","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1146\/annurev.nutr.24.012003.132446","volume":"25","author":"U Singh","year":"2005","unstructured":"Singh U, Devaraj S, Jialal I. Vitamin\u00a0e, oxidative stress, and inflammation. Annu Rev Nutr. 2005;25:151\u201374.","journal-title":"Annu Rev Nutr"},{"key":"1585_CR39","doi-asserted-by":"publisher","first-page":"2125","DOI":"10.1016\/j.biocel.2009.06.003","volume":"41","author":"FZ Marques","year":"2009","unstructured":"Marques FZ, Markus MA, Morris BJ. Resveratrol: cellular actions of a potent natural chemical that confers a diversity of health benefits. Int J Biochem Cell Biol. 2009;41:2125\u20138.","journal-title":"Int J Biochem Cell Biol"},{"key":"1585_CR40","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252212001","author":"I Sadowska-Bartosz","year":"2024","unstructured":"Sadowska-Bartosz I, Bartosz G. Antioxidant activity of anthocyanins and anthocyanidins: a critical review. Int J Mol Sci. 2024. https:\/\/doi.org\/10.3390\/ijms252212001.","journal-title":"Int J Mol Sci"},{"key":"1585_CR41","doi-asserted-by":"publisher","DOI":"10.3390\/nu10040522","author":"S Davinelli","year":"2018","unstructured":"Davinelli S, Nielsen ME, Scapagnini G. Astaxanthin in skin health, repair, and disease: a comprehensive review. Nutrients. 2018. https:\/\/doi.org\/10.3390\/nu10040522.","journal-title":"Nutrients"},{"key":"1585_CR42","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2023.156144","volume":"164","author":"MJ Dehzad","year":"2023","unstructured":"Dehzad MJ, Ghalandari H, Nouri M, Askarpour M. Antioxidant and anti-inflammatory effects of curcumin\/turmeric supplementation in adults: a GRADE-assessed systematic review and dose\u2013response meta-analysis of randomized controlled trials. Cytokine. 2023;164:156144.","journal-title":"Cytokine"},{"key":"1585_CR43","doi-asserted-by":"publisher","DOI":"10.3390\/nu13061784","author":"MA Hannan","year":"2021","unstructured":"Hannan MA, Rahman MA, Sohag AAM, et al. Black cumin (Nigella sativa L.): a comprehensive review on phytochemistry, health benefits, molecular pharmacology, and safety. Nutrients. 2021. https:\/\/doi.org\/10.3390\/nu13061784.","journal-title":"Nutrients"},{"key":"1585_CR44","first-page":"1404","volume":"10","author":"CM Magro","year":"2011","unstructured":"Magro CM, Rossi A, Poe J, Manhas-Bhutani S, Sadick N. The role of inflammation and immunity in the pathogenesis of androgenetic alopecia. J Drugs Dermatol. 2011;10:1404\u201311.","journal-title":"J Drugs Dermatol"},{"key":"1585_CR45","doi-asserted-by":"publisher","DOI":"10.3390\/nu16091293","author":"S Pandit","year":"2024","unstructured":"Pandit S, Srivastav AK, Sur TK, Chaudhuri S, Wang Y, Biswas TK. Effects of Withania somnifera extract in chronically stressed adults: a randomized controlled trial. Nutrients. 2024. https:\/\/doi.org\/10.3390\/nu16091293.","journal-title":"Nutrients"},{"key":"1585_CR46","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2024.149564","volume":"699","author":"W Liang","year":"2024","unstructured":"Liang W, Zhao Y, Cai B, et al. Psychological stress induces hair regenerative disorders through corticotropin-releasing hormone-mediated autophagy inhibition. Biochem Biophys Res Commun. 2024;699:149564.","journal-title":"Biochem Biophys Res Commun"},{"key":"1585_CR47","volume":"72","author":"Y Feng","year":"2024","unstructured":"Feng Y. Exploring clues pointing toward the existence of a brain-gut microbiota-hair follicle axis. Curr Res Transl Med. 2024;72:103408.","journal-title":"Curr Res Transl Med"},{"key":"1585_CR48","first-page":"59","volume":"16","author":"AE Carrington","year":"2023","unstructured":"Carrington AE, Maloh J, Nong Y, Agbai ON, Bodemer AA, Sivamani RK. The gut and skin microbiome in alopecia: associations and interventions. J Clin Aesthet Dermatol. 2023;16:59\u201364.","journal-title":"J Clin Aesthet Dermatol"},{"key":"1585_CR49","doi-asserted-by":"publisher","first-page":"1095555","DOI":"10.3389\/fmicb.2023.1095555","volume":"14","author":"Z Yu","year":"2023","unstructured":"Yu Z, Chen J, Liu Y, et al. The role of potential probiotic strains Lactobacillus reuteri in various intestinal diseases: new roles for an old player. Front Microbiol. 2023;14:1095555.","journal-title":"Front Microbiol"},{"key":"1585_CR50","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.878808","volume":"9","author":"S Ren","year":"2022","unstructured":"Ren S, Wang C, Chen A, Lv W, Gao R. The probiotic Lactobacillus paracasei ameliorates diarrhea cause by Escherichia coli O8 via gut microbiota modulation. Front Nutr. 2022;9:878808.","journal-title":"Front Nutr"},{"key":"1585_CR51","doi-asserted-by":"publisher","first-page":"1953","DOI":"10.3389\/fmicb.2018.01953","volume":"9","author":"J Wang","year":"2018","unstructured":"Wang J, Ji H, Wang S, et al. Probiotic Lactobacillus plantarum promotes intestinal barrier function by strengthening the epithelium and modulating gut microbiota. Front Microbiol. 2018;9:1953.","journal-title":"Front Microbiol"},{"key":"1585_CR52","doi-asserted-by":"publisher","DOI":"10.3390\/life12111856","author":"DW Shin","year":"2022","unstructured":"Shin DW. The molecular mechanism of natural products activating Wnt\/\u03b2-catenin signaling pathway for improving hair loss. Life (Basel). 2022. https:\/\/doi.org\/10.3390\/life12111856.","journal-title":"Life (Basel)"},{"key":"1585_CR53","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21144915","author":"BY Choi","year":"2020","unstructured":"Choi BY. Targeting Wnt\/\u03b2-catenin pathway for developing therapies for hair loss. Int J Mol Sci. 2020. https:\/\/doi.org\/10.3390\/ijms21144915.","journal-title":"Int J Mol Sci"},{"key":"1585_CR54","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/j.devcel.2010.01.016","volume":"18","author":"D Enshell-Seijffers","year":"2010","unstructured":"Enshell-Seijffers D, Lindon C, Kashiwagi M, Morgan BA. Beta-catenin activity in the dermal papilla regulates morphogenesis and regeneration of hair. Dev Cell. 2010;18:633\u201342.","journal-title":"Dev Cell"},{"key":"1585_CR55","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1159\/000509905","volume":"6","author":"E Evron","year":"2020","unstructured":"Evron E, Juhasz M, Babadjouni A, Mesinkovska NA. Natural hair supplement: friend or foe? Saw palmetto, a systematic review in alopecia. Skin Appendage Disord. 2020;6:329\u201337.","journal-title":"Skin Appendage Disord"},{"key":"1585_CR56","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1023\/A:1009058232389","volume":"3","author":"EJ Moon","year":"1999","unstructured":"Moon EJ, Lee YM, Lee OH, et al. A novel angiogenic factor derived from Aloe vera gel: beta-sitosterol, a plant sterol. Angiogenesis. 1999;3:117\u201323.","journal-title":"Angiogenesis"},{"key":"1585_CR57","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1046\/j.1365-2133.2001.04018.x","volume":"144","author":"MP Birch","year":"2001","unstructured":"Birch MP, Messenger JF, Messenger AG. Hair density, hair diameter and the prevalence of female pattern hair loss. Br J Dermatol. 2001;144:297\u2013304.","journal-title":"Br J Dermatol"},{"key":"1585_CR58","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1111\/j.1365-2133.2006.07409.x","volume":"155","author":"AG Messenger","year":"2006","unstructured":"Messenger AG, Sinclair R. Follicular miniaturization in female pattern hair loss: clinicopathological correlations. Br J Dermatol. 2006;155:926\u201330.","journal-title":"Br J Dermatol"},{"key":"1585_CR59","doi-asserted-by":"publisher","DOI":"10.1111\/exd.70001","volume":"33","author":"F Jimenez","year":"2024","unstructured":"Jimenez F, Alam M. The proportion of catagen and telogen hair follicles in occipital scalp of male androgenetic alopecia patients: challenging the established dogma. Exp Dermatol. 2024;33:e70001.","journal-title":"Exp Dermatol"},{"key":"1585_CR60","doi-asserted-by":"publisher","first-page":"583","DOI":"10.2147\/CCID.S200471","volume":"12","author":"A Rebora","year":"2019","unstructured":"Rebora A. Telogen effluvium: a comprehensive review. Clin Cosmet Investig Dermatol. 2019;12:583\u201390.","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"1585_CR61","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1089\/jwh.2004.13.872","volume":"13","author":"BD Johnson","year":"2004","unstructured":"Johnson BD, Merz CNB, Braunstein GD, et al. Determination of menopausal status in women: the NHLBI-sponsored women\u2019s ischemia syndrome evaluation (WISE) study. J Womens Health (Larchmt). 2004;13:872\u201387.","journal-title":"J Womens Health (Larchmt)"},{"key":"1585_CR62","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/j.ogc.2018.07.003","volume":"45","author":"SD Harlow","year":"2018","unstructured":"Harlow SD. Menstrual cycle changes as women approach the final menses: what matters? Obstet Gynecol Clin North Am. 2018;45:599\u2013611.","journal-title":"Obstet Gynecol Clin North Am"},{"key":"1585_CR63","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/957432","volume":"2013","author":"C Pi\u00e9rard-Franchimont","year":"2013","unstructured":"Pi\u00e9rard-Franchimont C, Pi\u00e9rard GE. Alterations in hair follicle dynamics in women. Biomed Res Int. 2013;2013:957432.","journal-title":"Biomed Res Int"},{"issue":"Suppl 3","key":"1585_CR64","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1111\/j.1365-2133.2011.10629.x","volume":"165","author":"P Mirmirani","year":"2011","unstructured":"Mirmirani P. Hormonal changes in menopause: do they contribute to a \u201cmidlife hair crisis\u201d in women? Br J Dermatol. 2011;165(Suppl 3):7\u201311.","journal-title":"Br J Dermatol"},{"issue":"7","key":"1585_CR65","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1111\/jdv.12188","volume":"28","author":"S Gizlenti","year":"2014","unstructured":"Gizlenti S, Ekmekci TR. The changes in the hair cycle during gestation and the post-partum period. J Eur Acad Dermatol Venereol. 2014;28(7):878\u201381.","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"1585_CR66","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1111\/ics.12929","volume":"46","author":"S Dudonn\u00e9","year":"2024","unstructured":"Dudonn\u00e9 S, Kern C, Garcia C. Efficacy of a wheat polar lipid complex in reducing hair loss and improving hair growth in healthy women: a randomized, double-blind, placebo-controlled clinical study. Int J Cosmet Sci. 2024;46:284\u201396.","journal-title":"Int J Cosmet Sci"},{"key":"1585_CR67","doi-asserted-by":"crossref","unstructured":"Maria Borr\u00e1s J, Piqu\u00e9 N, Nieto C, Gonz\u00e1lez J. Efficacy and safety of a dietary supplement containing a lipid co-extract from Serenoa repens and Pygeum africanum for the treatment of androgenetic alopecia (AGA) in women. Results of a randomized, double-blind, placebo-controlled clinical trial. M\u00e1s Dermatol. 2016;25:5\u201314.","DOI":"10.5538\/1887-5181.2016.25.5"},{"key":"1585_CR68","doi-asserted-by":"publisher","first-page":"393","DOI":"10.2147\/CCID.S377009","volume":"18","author":"F Flament","year":"2025","unstructured":"Flament F, Maudet A, Barbarat P, et al. Types and characteristics of hair across the globe: results of a multinational study on 19,461 individuals. Clin Cosmet Investig Dermatol. 2025;18:393\u2013404.","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"1585_CR69","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1684\/ejd.2015.2726","volume":"26","author":"G Loussouarn","year":"2016","unstructured":"Loussouarn G, Lozano I, Panhard S, Collaudin C, El Rawadi C, Genain G. Diversity in human hair growth, diameter, colour and shape. An in vivo study on young adults from 24 different ethnic groups observed in the five continents. Eur J Dermatol. 2016;26:144\u201354.","journal-title":"Eur J Dermatol"}],"container-title":["Dermatology and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13555-025-01585-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13555-025-01585-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13555-025-01585-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T08:02:34Z","timestamp":1770192154000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13555-025-01585-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,25]]},"references-count":69,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["1585"],"URL":"https:\/\/doi.org\/10.1007\/s13555-025-01585-x","relation":{},"ISSN":["2193-8210","2190-9172"],"issn-type":[{"value":"2193-8210","type":"print"},{"value":"2190-9172","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,25]]},"assertion":[{"value":"23 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Claudia Bern\u00e1rdez, Sebastian Podlipnik, Gillian E Westgate and Ralf Paus work as consultants for Olistic Research Labs S.L. Laura Zamfir, Daniela Grohmann and Manuel S\u00e1ez Moya work as employees for Olistic Research Labs S.L.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"This study was reviewed and approved (approval number 20230918-EC48.23) by the Comit\u00e9 de \u00c9tica de la Investigaci\u00f3n con medicamentos (CEIm) Regional de la Comunidad de Madrid in Madrid, Spain. It followed all applicable ethical guidelines, including those set by the institutional and national research committees, the Declaration of Helsinki (1964) and its later updates, as well as Good Clinical Practice standards (ICH E6 R2, EMA\/CHMP\/ICH\/135\/1995, Directive 2001\/20\/CE). All human participants provided written informed consent prior to their inclusion in the study. Furthermore, they also agreed to the publication of any information that could potentially identify them, if included in the manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}