{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T21:17:35Z","timestamp":1774387055714,"version":"3.50.1"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T00:00:00Z","timestamp":1772841600000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dermatol Ther (Heidelb)"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1007\/s13555-026-01682-5","type":"journal-article","created":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T18:34:56Z","timestamp":1772908496000},"page":"1831-1839","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Conceptual Disease Model of Symptoms and Impacts in Adults with Prurigo Nodularis: A Qualitative and Literature-Informed Study"],"prefix":"10.1007","volume":"16","author":[{"given":"Shawn G.","family":"Kwatra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1135-6999","authenticated-orcid":false,"given":"Danielle","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Dias-Barbosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"Piketty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajesh","family":"Rout","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramkumar","family":"Subramanian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Puelles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,7]]},"reference":[{"issue":"5 Suppl","key":"1682_CR1","first-page":"S63","volume":"29","author":"SS Chisolm","year":"2023","unstructured":"Chisolm SS. A review of the current management and burden of prurigo nodularis in the United States. Am J Manag Care. 2023;29(5 Suppl):S63\u201372.","journal-title":"Am J Manag Care"},{"issue":"6","key":"1682_CR2","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1093\/bjd\/ljae052","volume":"190","author":"V Liao","year":"2024","unstructured":"Liao V, Cornman HL, Ma E, Kwatra SG. Prurigo nodularis: new insights into pathogenesis and novel therapeutics. Br J Dermatol. 2024;190(6):798\u2013810.","journal-title":"Br J Dermatol"},{"key":"1682_CR3","unstructured":"National organization for rare diseases. Prurigo nodularis. RAre disease database 2025 [Available from: https:\/\/rarediseases.org\/rare-diseases\/prurigo-nodularis\/."},{"key":"1682_CR4","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.jdin.2023.12.013","volume":"18","author":"SG Kwatra","year":"2024","unstructured":"Kwatra SG, Puelles J, Tran O, et al. Prevalence of prurigo nodularis in the United States. JAAD Int. 2024;18:134\u20136.","journal-title":"JAAD Int"},{"issue":"2","key":"1682_CR5","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/j.jid.2019.07.697","volume":"140","author":"AH Huang","year":"2020","unstructured":"Huang AH, Canner JK, Khanna R, Kang S, Kwatra SG. Real-world prevalence of prurigo nodularis and burden of associated diseases. J Invest Dermatol. 2020;140(2):480-3 e4.","journal-title":"J Invest Dermatol"},{"key":"1682_CR6","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.jdin.2020.10.009","volume":"2","author":"S St\u00e4nder","year":"2021","unstructured":"St\u00e4nder S, Augustin M, Berger T, et al. Prevalence of prurigo nodularis in the United States of America: a retrospective database analysis. JAAD Int. 2021;2:28\u201330.","journal-title":"JAAD Int"},{"issue":"7","key":"1682_CR7","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1111\/ced.14722","volume":"46","author":"P Aggarwal","year":"2021","unstructured":"Aggarwal P, Choi J, Sutaria N, et al. Clinical characteristics and disease burden in prurigo nodularis. Clin Exp Dermatol. 2021;46(7):1277\u201384.","journal-title":"Clin Exp Dermatol"},{"issue":"3","key":"1682_CR8","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/j.jaad.2021.05.036","volume":"86","author":"KA Whang","year":"2022","unstructured":"Whang KA, Le TK, Khanna R, et al. Health-related quality of life and economic burden of prurigo nodularis. J Am Acad Dermatol. 2022;86(3):573\u201380.","journal-title":"J Am Acad Dermatol"},{"issue":"3","key":"1682_CR9","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/j.jaad.2020.07.025","volume":"84","author":"S Elmariah","year":"2021","unstructured":"Elmariah S, Kim B, Berger T, et al. Practical approaches for diagnosis and management of prurigo nodularis: United States expert panel consensus. J Am Acad Dermatol. 2021;84(3):747\u201360.","journal-title":"J Am Acad Dermatol"},{"key":"1682_CR10","doi-asserted-by":"crossref","unstructured":"Elmariah SB, Tao L, Valdes-Rodriguez R, Laquer V. Management of Prurigo Nodularis. J Drugs Dermatol. 2023;22(12):SF365502s15-SFs22.","DOI":"10.36849\/JDD.SF365502"},{"key":"1682_CR11","doi-asserted-by":"publisher","first-page":"11","DOI":"10.2147\/ITT.S316602","volume":"11","author":"A Labib","year":"2022","unstructured":"Labib A, Ju T, Does AV, Yosipovitch G. Immunotargets and therapy for prurigo nodularis. Immunotargets Ther. 2022;11:11\u201321.","journal-title":"Immunotargets Ther"},{"key":"1682_CR12","doi-asserted-by":"crossref","unstructured":"St\u00e4nder S, Pereira MP, Berger T, et al. IFSI-guideline on chronic prurigo including prurigo nodularis. Itch. 2020;5(4).","DOI":"10.1097\/itx.0000000000000042"},{"key":"1682_CR13","unstructured":"U.S. Food & Drug Administration. FDA approves first treatment for prurigo nodularis [Internet] 2022 [Available from: https:\/\/www.fda.gov\/drugs\/news-events-human-drugs\/fda-approves-first-treatment-prurigo-nodularis."},{"key":"1682_CR14","unstructured":"U.S. Food & Drug Administration. NEMLUVIO (nemolizumab-ilto) Prescribing Information 2024 [Available from: https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2024\/761390s000lbl.pdf."},{"key":"1682_CR15","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25105164","author":"HJ Yook","year":"2024","unstructured":"Yook HJ, Lee JH. Prurigo nodularis: pathogenesis and the horizon of potential therapeutics. Int J Mol Sci. 2024. https:\/\/doi.org\/10.3390\/ijms25105164.","journal-title":"Int J Mol Sci"},{"key":"1682_CR16","unstructured":"U.S. Food & Drug Administration. FDA-led Patient-Focused Drug Development (PFDD) Public Meetings 2025 [Available from: https:\/\/www.fda.gov\/industry\/prescription-drug-user-fee-amendments\/fda-led-patient-focused-drug-development-pfdd-public-meetings."},{"key":"1682_CR17","unstructured":"U.S. Food & Drug Administration. FDA patient-focused drug development guidance series for enhancing the incorporation of the patient\u2019s voice in medical product development and regulatory decision making 2025. [Available from: https:\/\/www.fda.gov\/drugs\/development-approval-process-drugs\/fda-patient-focused-drug-development-guidance-series-enhancing-incorporation-patients-voice-medical."},{"issue":"1","key":"1682_CR18","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1001\/jama.1995.03520250075037","volume":"273","author":"IB Wilson","year":"1995","unstructured":"Wilson IB, Cleary PD. Linking clinical variables with health-related quality of life. A conceptual model of patient outcomes. JAMA. 1995;273(1):59\u201365.","journal-title":"JAMA"},{"issue":"11","key":"1682_CR19","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1001\/jamadermatol.2023.3251","volume":"159","author":"D Rodriguez","year":"2023","unstructured":"Rodriguez D, Kwatra SG, Dias-Barbosa C, et al. Patient perspectives on living with severe prurigo nodularis. JAMA Dermatol. 2023;159(11):1205\u201312.","journal-title":"JAMA Dermatol"},{"issue":"5","key":"1682_CR20","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1007\/s40257-018-0381-6","volume":"19","author":"JI Silverberg","year":"2018","unstructured":"Silverberg JI, Kantor RW, Dalal P, et al. A comprehensive conceptual model of the experience of chronic itch in adults. Am J Clin Dermatol. 2018;19(5):759\u201369.","journal-title":"Am J Clin Dermatol"},{"issue":"4","key":"1682_CR21","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1097\/DER.0000000000000486","volume":"30","author":"L Grant","year":"2019","unstructured":"Grant L, Seiding Larsen L, Trennery C, et al. Conceptual model to illustrate the symptom experience and humanistic burden associated with atopic dermatitis in adults and adolescents. Dermatitis. 2019;30(4):247\u201354.","journal-title":"Dermatitis"},{"key":"1682_CR22","doi-asserted-by":"publisher","DOI":"10.2340\/actadv.v104.40677","volume":"104","author":"W Jiang","year":"2024","unstructured":"Jiang W, Chen J, Li N, Wang X, Li C. Depression, anxiety and suicidal ideation in prurigo nodularis: a systematic review and meta-analysis. Acta Derm Venereol. 2024;104:adv40677.","journal-title":"Acta Derm Venereol"},{"issue":"12","key":"1682_CR23","first-page":"SF365502s6","volume":"22","author":"NT Issa","year":"2023","unstructured":"Issa NT, Riva H, Jafferany M. Individual article: prurigo nodularis: current clinicopathologic overview and psychodermatological perspectives. J Drugs Dermatol. 2023;22(12):SF365502s6-SF365511.","journal-title":"J Drugs Dermatol"},{"issue":"12","key":"1682_CR24","first-page":"SF365502s12","volume":"22","author":"SG Kwatra","year":"2023","unstructured":"Kwatra SG, Chisolm SS, Puerta Durango KS, Mollanazar NK. Patient journey and the burden of systemic comorbidities and sequalae in prurigo nodularis. J Drugs Dermatol. 2023;22(12):SF365502s12-SF365514.","journal-title":"J Drugs Dermatol"},{"issue":"4","key":"1682_CR25","first-page":"97","volume":"6","author":"CD Kwon","year":"2019","unstructured":"Kwon CD, Khanna R, Williams KA, Kwatra MM, Kwatra SG. Diagnostic workup and evaluation of patients with prurigo nodularis. Medicines (Basel). 2019;6(4):97.","journal-title":"Medicines (Basel)"},{"issue":"2","key":"1682_CR26","doi-asserted-by":"publisher","first-page":"173","DOI":"10.2340\/00015555-2774","volume":"98","author":"C Zeidler","year":"2018","unstructured":"Zeidler C, Tsianakas A, Pereira M, et al. Chronic prurigo of nodular type: a review. Acta Derm Venereol. 2018;98(2):173\u20139.","journal-title":"Acta Derm Venereol"},{"issue":"6","key":"1682_CR27","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1016\/j.jaad.2024.11.081","volume":"92","author":"AJ D'Amiano","year":"2025","unstructured":"D\u2019Amiano AJ, Madan V, Ma E, et al. Patient perspectives on the lived experience of prurigo nodularis: a qualitative approach. J Am Acad Dermatol. 2025;92(6):1370\u20132.","journal-title":"J Am Acad Dermatol"},{"issue":"5","key":"1682_CR28","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1016\/j.jaad.2024.12.043","volume":"92","author":"AS Ficheux","year":"2025","unstructured":"Ficheux AS, Brenaut E, Schut C, et al. Predictors of perceived stress, perceived stigmatization, and body dysmorphia in patients with chronic prurigo\/prurigo nodularis: results from an observational cross-sectional multicenter European study in 17 countries. J Am Acad Dermatol. 2025;92(5):1056\u201363.","journal-title":"J Am Acad Dermatol"},{"issue":"4","key":"1682_CR29","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1093\/bjd\/ljae453","volume":"192","author":"W Lu","year":"2025","unstructured":"Lu W, Yossef SM, Ma EZ, et al. Association of sleep disturbance and itch intensity with quality-of-life impairment and disease severity in prurigo nodularis. Br J Dermatol. 2025;192(4):755\u20137.","journal-title":"Br J Dermatol"},{"issue":"4","key":"1682_CR30","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1093\/bjd\/ljad500","volume":"190","author":"HL Cornman","year":"2024","unstructured":"Cornman HL, Whang KA, Ma E, et al. Severity, impact on quality of life and mental health burden of pruritus in prurigo nodularis: a cross-sectional study of a diverse patient cohort. Br J Dermatol. 2024;190(4):571\u20132.","journal-title":"Br J Dermatol"},{"issue":"2","key":"1682_CR31","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1111\/1346-8138.17045","volume":"51","author":"H Murota","year":"2024","unstructured":"Murota H, Arima K, Yoshida T, Fujita H. Disease burden and treatment satisfaction in patients with prurigo nodularis in Japan. J Dermatol. 2024;51(2):223\u201333.","journal-title":"J Dermatol"},{"issue":"11","key":"1682_CR32","doi-asserted-by":"publisher","first-page":"e984","DOI":"10.1111\/jdv.20038","volume":"38","author":"MP Pereira","year":"2024","unstructured":"Pereira MP, Gutsche A, Weisshaar E, et al. Chronic nodular prurigo: Association between comorbidities, itch and quality of life. J Eur Acad Dermatol Venereol. 2024;38(11):e984\u20138.","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"5","key":"1682_CR33","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1093\/bjd\/ljae274","volume":"191","author":"L Schielein","year":"2024","unstructured":"Schielein L, Ziehfreund S, Biedermann T, Zink A. \u201cWhen you do not feel comfortable in your skin, you cannot get out of it\u201d; a qualitative interview study exploring psychosocial impact and coping strategies among patients with prurigo nodularis. Br J Dermatol. 2024;191(5):845\u20136.","journal-title":"Br J Dermatol"},{"key":"1682_CR34","doi-asserted-by":"crossref","unstructured":"Misery L, Patras de Campaigno C, Taieb C, et al. Impact of chronic prurigo nodularis on daily life and stigmatization. J Eur Acad Dermatol Venereol. 2023;37(7):e908-e9.","DOI":"10.1111\/jdv.19013"},{"issue":"10","key":"1682_CR35","doi-asserted-by":"publisher","first-page":"2373","DOI":"10.1111\/jdv.16309","volume":"34","author":"MP Pereira","year":"2020","unstructured":"Pereira MP, Hoffmann V, Weisshaar E, et al. Chronic nodular prurigo: clinical profile and burden. A European cross-sectional study. J Eur Acad Dermatol Venereol. 2020;34(10):2373\u201383.","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"12","key":"1682_CR36","doi-asserted-by":"publisher","first-page":"2224","DOI":"10.1111\/jdv.15107","volume":"32","author":"MP Pereira","year":"2018","unstructured":"Pereira MP, Basta S, Moore J, Stander S. Prurigo nodularis: a physician survey to evaluate current perceptions of its classification, clinical experience and unmet need. J Eur Acad Dermatol Venereol. 2018;32(12):2224\u20139.","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"1682_CR37","doi-asserted-by":"crossref","unstructured":"Steinke S, Zeidler C, Riepe C, et al. Humanistic burden of chronic pruritus in patients with inflammatory dermatoses: results of the european academy of dermatology and venereology network on assessment of severity and burden of pruritus (PruNet) cross-sectional trial. J Am Acad Dermatol. 2018;79(3):457\u201363 e5.","DOI":"10.1016\/j.jaad.2018.04.044"},{"issue":"5","key":"1682_CR38","doi-asserted-by":"publisher","first-page":"318","DOI":"10.4103\/idoj.IDOJ_324_17","volume":"9","author":"L Dhawan","year":"2018","unstructured":"Dhawan L, Singh SM, Avasthi A, Kumaran MS, Narang T. The prevalence of psychiatric comorbidity in patients with prurigo nodularis. Indian Dermatol Online J. 2018;9(5):318\u201321.","journal-title":"Indian Dermatol Online J"},{"issue":"6","key":"1682_CR39","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1111\/1346-8138.12844","volume":"42","author":"E Errichetti","year":"2015","unstructured":"Errichetti E, Piccirillo A, Stinco G. Dermoscopy of prurigo nodularis. J Dermatol. 2015;42(6):632\u20134.","journal-title":"J Dermatol"},{"key":"1682_CR40","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.ajp.2015.07.010","volume":"17","author":"D Konda","year":"2015","unstructured":"Konda D, Chandrashekar L, Rajappa M, et al. Serotonin and interleukin-6: Association with pruritus severity, sleep quality and depression severity in Prurigo Nodularis. Asian J Psychiatr. 2015;17:24\u20138.","journal-title":"Asian J Psychiatr"},{"issue":"5","key":"1682_CR41","doi-asserted-by":"publisher","first-page":"525","DOI":"10.4103\/0019-5154.164451","volume":"60","author":"CC Oh","year":"2015","unstructured":"Oh CC, Li H, Lee W, Tey HL. Biopsychosocial factors associated with prurigo nodularis in endogenous eczema. Indian J Dermatol. 2015;60(5):525.","journal-title":"Indian J Dermatol"},{"issue":"4","key":"1682_CR42","doi-asserted-by":"publisher","first-page":"211","DOI":"10.3109\/09546631003674321","volume":"22","author":"C Dazzi","year":"2011","unstructured":"Dazzi C, Erma D, Piccinno R, Veraldi S, Caccialanza M. Psychological factors involved in prurigo nodularis: a pilot study. J Dermatolog Treat. 2011;22(4):211\u20134.","journal-title":"J Dermatolog Treat"},{"key":"1682_CR43","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2025.03.015","author":"D Frankel","year":"2025","unstructured":"Frankel D, Ma E, Gage D, et al. Cross-sectional analysis of mental health comorbidities in patients with prurigo nodularis. J Am Acad Dermatol. 2025. https:\/\/doi.org\/10.1016\/j.jaad.2025.03.015.","journal-title":"J Am Acad Dermatol"},{"issue":"2","key":"1682_CR44","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1177\/12034754241227808","volume":"28","author":"D Taghaddos","year":"2024","unstructured":"Taghaddos D, Savinova I, Abu-Hilal M. Clinical characteristics and treatment outcomes of prurigo nodularis: a retrospective study. J Cutan Med Surg. 2024;28(2):141\u20135.","journal-title":"J Cutan Med Surg"},{"issue":"6","key":"1682_CR45","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1177\/12034754241269153","volume":"28","author":"G Xiong","year":"2024","unstructured":"Xiong G, Abu-Hilal M. Itch and Insomnia in Patients With Prurigo Nodularis and Other Dermatologic Conditions. J Cutan Med Surg. 2024;28(6):591\u20132.","journal-title":"J Cutan Med Surg"},{"key":"1682_CR46","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.jdin.2023.07.009","volume":"13","author":"MZ Joel","year":"2023","unstructured":"Joel MZ, Taylor MT, Cornman HL, et al. Risk of incident sleep disorders in patients with prurigo nodularis: a population-level analysis using The Health Improvement Network. JAAD Int. 2023;13:39\u201345.","journal-title":"JAAD Int"},{"issue":"6","key":"1682_CR47","first-page":"53","volume":"15","author":"J Han","year":"2022","unstructured":"Han J, Palomino A, Estupinan B, Wozniak A, Swan J. Psychiatric Comorbidity in Prurigo Nodularis and the Impact of Socioeconomic Status. J Clin Aesthet Dermatol. 2022;15(6):53\u20138.","journal-title":"J Clin Aesthet Dermatol"},{"issue":"5","key":"1682_CR48","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1590\/abd1806-4841.20187127","volume":"93","author":"S Akarsu","year":"2018","unstructured":"Akarsu S, Ozbagcivan O, Ilknur T, et al. Xerosis cutis and associated co-factors in women with prurigo nodularis. An Bras Dermatol. 2018;93(5):671\u20139.","journal-title":"An Bras Dermatol"},{"issue":"2","key":"1682_CR49","doi-asserted-by":"publisher","first-page":"e106","DOI":"10.1111\/jdv.13827","volume":"31","author":"KM Jorgensen","year":"2017","unstructured":"Jorgensen KM, Egeberg A, Gislason GH, Skov L, Thyssen JP. Anxiety, depression and suicide in patients with prurigo nodularis. J Eur Acad Dermatol Venereol. 2017;31(2):e106\u20137.","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"3","key":"1682_CR50","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-3778","volume":"101","author":"EC Gwillim","year":"2021","unstructured":"Gwillim EC, Nattkemper L, Yosipovitch G. Impact of itch on sleep disturbance in patients with prurigo nodularis. Acta Derm Venereol. 2021;101(3):adv00424.","journal-title":"Acta Derm Venereol"},{"issue":"3","key":"1682_CR51","first-page":"70","volume":"17","author":"SG Kwatra","year":"2023","unstructured":"Kwatra SG, Dias-Barbosa C, Rodriguez D, et al. Development of a patient-centered conceptual disease model for prurigo nodularis: a qualitative content analysis. J Dermatol Physician Assist. 2023;17(3):70\u20131.","journal-title":"J Dermatol Physician Assist"},{"key":"1682_CR52","unstructured":"Acquadro M, Zikos E, Dias-Barbosa C, et al. Understanding the experiences of people living with chronic pruritus of unknown origin: Development of a disease conceptual model. ISPOR Europe 2024; 17\u201320 Nov 2024; Cophenhagen, Denmark2024."},{"issue":"5","key":"1682_CR53","doi-asserted-by":"publisher","DOI":"10.1002\/ski2.262","volume":"3","author":"L Cesnakova","year":"2023","unstructured":"Cesnakova L, Meadows K, Avey S, et al. A patient-centred conceptual model of nocturnal scratch and its impact in atopic dermatitis: a mixed-methods study supporting the development of novel digital measurements. Skin Health Disease. 2023;3(5):e262.","journal-title":"Skin Health Disease"},{"issue":"1","key":"1682_CR54","doi-asserted-by":"publisher","DOI":"10.1186\/s41687-024-00764-2","volume":"8","author":"A Rams","year":"2024","unstructured":"Rams A, Baldasaro J, Bunod L, et al. Sleep-loss related to itch in atopic dermatitis: assessing content validity and psychometric properties of a patient-reported sleep-loss rating scale. J Patient Rep Outcomes. 2024;8(1):77.","journal-title":"J Patient Rep Outcomes"}],"container-title":["Dermatology and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13555-026-01682-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13555-026-01682-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13555-026-01682-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T18:02:44Z","timestamp":1774375364000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13555-026-01682-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":54,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["1682"],"URL":"https:\/\/doi.org\/10.1007\/s13555-026-01682-5","relation":{},"ISSN":["2193-8210","2190-9172"],"issn-type":[{"value":"2193-8210","type":"print"},{"value":"2190-9172","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"18 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Carla Dias-Barbosa and Danielle Rodriguez are employees of Evidera, which was paid by Galderma for work relating to this study. Shawn G. Kwatra has received grants as a consultant and\/or advisory board member for Galderma. Christophe Piketty Rajesh Rout, Ramkumar Subramanian, and Jorge Puelles are employees of Galderma and hold company stock.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"Studies involving human participants (the concept elicitation\/cognitive debriefing interviews) were conducted in accordance with the principles of the Declaration of Helsinki and received ethical approval from an institutional review board and\/or ethics committee. This article is based on previously conducted studies and does not contain any new studies with human participants or animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}