{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:23:22Z","timestamp":1790011402932,"version":"4.0.1"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"name":"Olistic"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dermatol Ther (Heidelb)"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1007\/s13555-026-01739-5","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T11:38:44Z","timestamp":1775129924000},"page":"2857-2869","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hair Aging Revisited: An Expert Delphi Consensus on Pathogenesis, Clinical Features, and Future Therapies"],"prefix":"10.1007","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6315-5462","authenticated-orcid":false,"given":"David","family":"Saceda-Corralo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Paus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Starace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"S\u00e1ez Moya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Va\u00f1\u00f3-Galv\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca Maria","family":"Piraccini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,2]]},"reference":[{"key":"1739_CR1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-02636-2_15","author":"RM Tr\u00fceb","year":"2010","unstructured":"Tr\u00fceb RM. Age-related general problems affecting the condition of hair. Aging Hair [Internet]. 2010. https:\/\/doi.org\/10.1007\/978-3-642-02636-2_15.","journal-title":"Aging Hair [Internet]"},{"key":"1739_CR2","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1111\/J.1600-0846.2010.00466.X","volume":"17","author":"KH Jeong","year":"2011","unstructured":"Jeong KH, Kim KS, Lee GJ, Choi SJ, Jeong TJ, Shin MK, et\u00a0al. Investigation of aging effects in human hair using atomic force microscopy. Skin Res Technol [Internet]. 2011;17:63\u20138. https:\/\/doi.org\/10.1111\/J.1600-0846.2010.00466.X.","journal-title":"Skin Res Technol [Internet]"},{"key":"1739_CR3","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1111\/J.1365-2133.2012.11010.X","volume":"167","author":"C Robbins","year":"2012","unstructured":"Robbins C, Mirmirani P, Messenger AG, Birch MP, Youngquist RS, Tamura M, et\u00a0al. What women want\u2014Quantifying the perception of hair amount: an analysis of hair diameter and density changes with age in Caucasian women. Br J Dermatol [Internet]. 2012;167:324\u201332. https:\/\/doi.org\/10.1111\/J.1365-2133.2012.11010.X.","journal-title":"Br J Dermatol [Internet]."},{"key":"1739_CR4","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1096\/fj.05-4039fje","volume":"20","author":"PC Arck","year":"2006","unstructured":"Arck PC, Overall R, Spatz K, Liezman C, Handjiski B, Klapp BF, et\u00a0al. Towards a \u201cfree radical theory of graying\u201d: melanocyte apoptosis in the aging human hair follicle is an indicator of oxidative stress induced tissue damage. FASEB J. 2006;20:1567\u20139. https:\/\/doi.org\/10.1096\/fj.05-4039fje. (Wiley).","journal-title":"FASEB J"},{"issue":"Suppl 2","key":"1739_CR5","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1111\/JDV.17246","volume":"35","author":"V Turlier","year":"2021","unstructured":"Turlier V, Mengeaud V, Lauze C, Kottner J, Blume-Peytavi U. Quantitative and physical characterization of normal hair ageing in White European women: a single-centre study. J Eur Acad Dermatol Venereol [Internet]. 2021;35(Suppl 2):21\u20133. https:\/\/doi.org\/10.1111\/JDV.17246.","journal-title":"J Eur Acad Dermatol Venereol [Internet]"},{"key":"1739_CR6","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1111\/J.1468-2494.2010.00580_5.X","volume":"60","author":"S Nagase","year":"2009","unstructured":"Nagase S, Kajiura Y, Mamada A, Hiroko ABE, Shibuichi S, Satoh N, et\u00a0al. Changes in structure and geometric properties of human hair by aging. J Cosmet Sci [Internet]. 2009;60:637\u201348. https:\/\/doi.org\/10.1111\/J.1468-2494.2010.00580_5.X.","journal-title":"J Cosmet Sci [Internet]"},{"key":"1739_CR7","first-page":"317","volume":"59","author":"S Nagase","year":"2008","unstructured":"Nagase S, Tsuchiya M, Matsui T, Shibuichi S, Tsujimura H, Masukawa Y, et\u00a0al. Characterization of curved hair of Japanese women with reference to internal structures and amino acid composition. J Cosmet Sci [Internet]. 2008;59:317\u201332.","journal-title":"J Cosmet Sci [Internet]"},{"key":"1739_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/J.FSIGEN.2020.102309","volume":"47","author":"TJ Plott","year":"2020","unstructured":"Plott TJ, Karim N, Durbin-Johnson BP, Swift DP, Scott Youngquist R, Salemi M, et\u00a0al. Age-related changes in hair shaft protein profiling and genetically variant peptides. Forensic Sci Int Genet [Internet]. 2020;47:102309. https:\/\/doi.org\/10.1016\/J.FSIGEN.2020.102309.","journal-title":"Forensic Sci Int Genet [Internet]"},{"issue":"4","key":"1739_CR9","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1111\/JOCD.12960","volume":"18","author":"J Ahluwalia","year":"2019","unstructured":"Ahluwalia J, Fabi SG. The psychological and aesthetic impact of age-related hair changes in females. J Cosmet Dermatol [Internet]. 2019;18(4):1161\u20139. https:\/\/doi.org\/10.1111\/JOCD.12960.","journal-title":"J Cosmet Dermatol [Internet]"},{"key":"1739_CR10","first-page":"38","volume":"14","author":"MBC Maymone","year":"2021","unstructured":"Maymone MBC, Laughter M, Pollock S, Khan I, Marques T, Abdat R, et\u00a0al. Hair aging in different races and ethnicities. J Clin Aesthet Dermatol [Internet]. 2021;14:38.","journal-title":"J Clin Aesthet Dermatol [Internet]"},{"key":"1739_CR11","doi-asserted-by":"publisher","DOI":"10.7759\/CUREUS.58261","author":"EY Chow","year":"2024","unstructured":"Chow EY, Salopek TG. Acitretin-induced repigmentation of gray hair: a case report. Cureus [Internet]. 2024. https:\/\/doi.org\/10.7759\/CUREUS.58261.","journal-title":"Cureus [Internet]"},{"key":"1739_CR12","doi-asserted-by":"publisher","DOI":"10.7759\/CUREUS.65612","author":"O Alomari","year":"2024","unstructured":"Alomari O, Kara\u00e7elik A, Rana-Tatar E, Ulya Durmus B, Keskin O. Unveiling the link between celiac disease and premature graying of hair: a case report and discussion on the potential implications for diagnosis and management. Cureus [Internet]. 2024. https:\/\/doi.org\/10.7759\/CUREUS.65612.","journal-title":"Cureus [Internet]."},{"key":"1739_CR13","doi-asserted-by":"publisher","first-page":"4588","DOI":"10.7150\/IJBS.86911","volume":"19","author":"Z Feng","year":"2023","unstructured":"Feng Z, Qin Y, Jiang G. Reversing gray hair: inspiring the development of new therapies through research on hair pigmentation and repigmentation progress. Int J Biol Sci Internet. 2023;19:4588\u2013607. https:\/\/doi.org\/10.7150\/IJBS.86911.","journal-title":"Int J Biol Sci Internet."},{"key":"1739_CR14","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1126\/SCIENCE.1099593","volume":"307","author":"EK Nishimura","year":"2005","unstructured":"Nishimura EK, Granter SR, Fisher DE. Mechanisms of hair graying: incomplete melanocyte stem cell maintenance in the niche. Science [Internet]. 2005;307:720\u20134. https:\/\/doi.org\/10.1126\/SCIENCE.1099593.","journal-title":"Science [Internet]"},{"key":"1739_CR15","doi-asserted-by":"publisher","DOI":"10.1152\/PHYSREV.00005.2024","author":"S Altendorf","year":"2025","unstructured":"Altendorf S, Bertolini M, Le RA, Tosti A, Paus R. Frontiers in the physiology of male pattern androgenetic alopecia: beyond the androgen horizon. Physiol Rev [Internet]. 2025. https:\/\/doi.org\/10.1152\/PHYSREV.00005.2024.","journal-title":"Physiol Rev [Internet]"},{"key":"1739_CR16","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1016\/j.jid.2016.03.032","volume":"136","author":"EGY Chew","year":"2016","unstructured":"Chew EGY, Tan JHJ, Bahta AW, Ho BSY, Liu X, Lim TC, et\u00a0al. Differential expression between human dermal papilla cells from balding and non-balding scalps reveals new candidate genes for androgenetic alopecia. J Investig Dermatol [Internet]. 2016;136:1559\u201367. https:\/\/doi.org\/10.1016\/j.jid.2016.03.032.","journal-title":"J Investig Dermatol [Internet]"},{"key":"1739_CR17","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1111\/EXD.14536","volume":"31","author":"EGY Chew","year":"2022","unstructured":"Chew EGY, Lim TC, Leong MF, Liu X, Sia YY, Leong ST, et\u00a0al. Observations that suggest a contribution of altered dermal papilla mitochondrial function to androgenetic alopecia. Exp Dermatol [Internet]. 2022;31:906\u201317. https:\/\/doi.org\/10.1111\/EXD.14536.","journal-title":"Exp Dermatol [Internet]"},{"key":"1739_CR18","doi-asserted-by":"publisher","DOI":"10.1111\/EXD.14948","author":"F Liu","year":"2024","unstructured":"Liu F, Liu S, Luo X, Fan Z, Huang S, Deng F, et\u00a0al. Combatting ageing in dermal papilla cells and promoting hair follicle regeneration using exosomes from human hair follicle dermal sheath cup cells. Exp Dermatol [Internet]. 2024. https:\/\/doi.org\/10.1111\/EXD.14948.","journal-title":"Exp Dermatol [Internet]."},{"key":"1739_CR19","doi-asserted-by":"publisher","DOI":"10.3390\/JCM14061894","author":"GE Westgate","year":"2025","unstructured":"Westgate GE, Grohmann D, S\u00e1ez Moya M. Hair longevity-evidence for a multifactorial holistic approach to managing hair aging changes. J Clin Med [Internet]. 2025. https:\/\/doi.org\/10.3390\/JCM14061894.","journal-title":"J Clin Med [Internet]"},{"key":"1739_CR20","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/J.JDERMSCI.2013.06.017","volume":"72","author":"P Karnik","year":"2013","unstructured":"Karnik P, Shah S, Dvorkin-Wininger Y, Oshtory S, Mirmirani P. Microarray analysis of androgenetic and senescent alopecia: comparison of gene expression shows two distinct profiles. J Dermatol Sci [Internet]. 2013;72:183. https:\/\/doi.org\/10.1016\/J.JDERMSCI.2013.06.017.","journal-title":"J Dermatol Sci [Internet]."},{"key":"1739_CR21","doi-asserted-by":"publisher","first-page":"e0287207","DOI":"10.1371\/JOURNAL.PONE.0287207","volume":"18","author":"T Jayawardhana","year":"2023","unstructured":"Jayawardhana T, Jayathilaka R, Nimnadi T, Anuththara S, Karadanaarachchi R, Galappaththi K, et\u00a0al. The cost of aging: economic growth perspectives for Europe. PLoS One [Internet]. 2023;18:e0287207. https:\/\/doi.org\/10.1371\/JOURNAL.PONE.0287207.","journal-title":"PLoS One [Internet]."},{"key":"1739_CR22","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1586\/17469872.2.5.607","volume":"2","author":"RM Tr\u00fceb","year":"2007","unstructured":"Tr\u00fceb RM. Hair aging and anti-aging. Expert Rev Dermatol [Internet]. 2007;2:607\u201317. https:\/\/doi.org\/10.1586\/17469872.2.5.607.","journal-title":"Expert Rev Dermatol [Internet]"},{"issue":"2","key":"1739_CR23","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/S0738-081X(00)00127-9","volume":"19","author":"TF Cash","year":"2001","unstructured":"Cash TF. The psychology of hair loss and its implications for patient care. Clin Dermatol [Internet]. 2001;19(2):161\u20136. https:\/\/doi.org\/10.1016\/S0738-081X(00)00127-9.","journal-title":"Clin Dermatol [Internet]"},{"key":"1739_CR24","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1111\/jocd.15652","volume":"22","author":"X Zhang","year":"2023","unstructured":"Zhang X, Zhu J, Zhang J, Zhao H. Melanocyte stem cells and hair graying. J Cosmet Dermatol. 2023;22:1720\u20133. https:\/\/doi.org\/10.1111\/jocd.15652.","journal-title":"J Cosmet Dermatol"},{"issue":"2","key":"1739_CR25","doi-asserted-by":"publisher","first-page":"83","DOI":"10.4103\/0974-7753.58550","volume":"1","author":"DJ Tobin","year":"2009","unstructured":"Tobin DJ. Aging of the hair follicle pigmentation system. Int J Trichol [Internet]. 2009;1(2):83\u201393. https:\/\/doi.org\/10.4103\/0974-7753.58550.","journal-title":"Int J Trichol [Internet]"},{"issue":"1","key":"1739_CR26","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1111\/BRV.12648","volume":"96","author":"JDB O\u2019Sullivan","year":"2021","unstructured":"O\u2019Sullivan JDB, Nicu C, Picard M, Ch\u00e9ret J, Bedogni B, Tobin DJ, et\u00a0al. The biology of human hair greying. Biol Rev Camb Philos Soc [Internet]. 2021;96(1):107\u201328. https:\/\/doi.org\/10.1111\/BRV.12648.","journal-title":"Biol Rev Camb Philos Soc [Internet]"},{"key":"1739_CR27","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1016\/J.JID.2023.09.276","volume":"144","author":"R Paus","year":"2024","unstructured":"Paus R, Sevilla A, Grichnik JM. Human hair graying revisited: principles, misconceptions, and key research frontiers. J Invest Dermatol. 2024;144:474\u201391. https:\/\/doi.org\/10.1016\/J.JID.2023.09.276. (Elsevier).","journal-title":"J Invest Dermatol"},{"key":"1739_CR28","doi-asserted-by":"publisher","DOI":"10.7554\/ELIFE.67437","author":"AM Rosenberg","year":"2021","unstructured":"Rosenberg AM, Rausser S, Ren J, Mosharov EV, Sturm G, Ogden RT, et\u00a0al. Quantitative mapping of human hair greying and reversal in relation to life stress. Elife [Internet]. 2021. https:\/\/doi.org\/10.7554\/ELIFE.67437.","journal-title":"Elife [Internet]"},{"key":"1739_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/J.YFRNE.2022.101008","author":"JDB O\u2019Sullivan","year":"2022","unstructured":"O\u2019Sullivan JDB, Peters EMJ, Amer Y, Atuluru P, Ch\u00e9ret J, Rosenberg AM, et\u00a0al. The impact of perceived stress on the hair follicle: towards solving a psychoneuroendocrine and neuroimmunological puzzle. Front Neuroendocrinol [Internet]. 2022. https:\/\/doi.org\/10.1016\/J.YFRNE.2022.101008.","journal-title":"Front Neuroendocrinol [Internet]"},{"key":"1739_CR30","doi-asserted-by":"publisher","first-page":"2065","DOI":"10.1096\/FJ.08-125435","volume":"23","author":"JM Wood","year":"2009","unstructured":"Wood JM, Decker H, Hartmann H, Chavan B, Rokos H, Spencer JD, et\u00a0al. Senile hair graying: H2O2-mediated oxidative stress affects human hair color by blunting methionine sulfoxide repair. FASEB J [Internet]. 2009;23:2065\u201375. https:\/\/doi.org\/10.1096\/FJ.08-125435.","journal-title":"FASEB J [Internet]"},{"key":"1739_CR31","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1111\/ICS.12700","volume":"43","author":"R Vyumvuhore","year":"2021","unstructured":"Vyumvuhore R, Verzeaux L, Gilardeau S, Bordes S, Aymard E, Manfait M, et\u00a0al. Investigation of the molecular signature of greying hair shafts. Int J Cosmet Sci [Internet]. 2021;43:332\u201340. https:\/\/doi.org\/10.1111\/ICS.12700.","journal-title":"Int J Cosmet Sci [Internet]"},{"key":"1739_CR32","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1046\/J.1365-2133.2004.05787.X","volume":"150","author":"S Commo","year":"2004","unstructured":"Commo S, Gaillard O, Bernard BA. Human hair greying is linked to a specific depletion of hair follicle melanocytes affecting both the bulb and the outer root sheath. Br J Dermatol [Internet]. 2004;150:435\u201343. https:\/\/doi.org\/10.1046\/J.1365-2133.2004.05787.X.","journal-title":"Br J Dermatol [Internet]"},{"issue":"2","key":"1739_CR33","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.stem.2009.12.010","volume":"6","author":"EK Nishimura","year":"2010","unstructured":"Nishimura EK, Suzuki M, Igras V, Du J, Lonning S, Miyachi Y, et\u00a0al. Key roles for transforming growth factor \u03b2 in melanocyte stem cell maintenance. Cell Stem Cell [Internet]. 2010;6(2):130\u201340. https:\/\/doi.org\/10.1016\/j.stem.2009.12.010.","journal-title":"Cell Stem Cell [Internet]"},{"key":"1739_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000504414","volume":"6","author":"K Yale","year":"2020","unstructured":"Yale K, Juhasz M, Atanaskova Mesinkovska N. Medication-induced repigmentation of gray hair: a systematic review. Skin Appendage Disord [Internet]. 2020;6:1\u201310. https:\/\/doi.org\/10.1159\/000504414.","journal-title":"Skin Appendage Disord [Internet]"},{"issue":"2","key":"1739_CR35","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1111\/J.1473-2165.2005.40203.X","volume":"4","author":"R Tr\u00fceb","year":"2005","unstructured":"Tr\u00fceb R, Hoffmann R. Aging of hair. J Cosmet Dermatol [Internet]. 2005;4(2):697\u2013708. https:\/\/doi.org\/10.1111\/J.1473-2165.2005.40203.X.","journal-title":"J Cosmet Dermatol [Internet]"},{"issue":"2","key":"1739_CR36","doi-asserted-by":"publisher","first-page":"94","DOI":"10.4103\/0974-7753.58551","volume":"1","author":"WS Lee","year":"2009","unstructured":"Lee WS. Photoaggravation of hair aging. Int J Trichol [Internet]. 2009;1(2):94\u20139. https:\/\/doi.org\/10.4103\/0974-7753.58551.","journal-title":"Int J Trichol [Internet]"},{"key":"1739_CR37","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1111\/EXD.14109","volume":"29","author":"R Williams","year":"2020","unstructured":"Williams R, Pawlus AD, Thornton MJ. Getting under the skin of hair aging: the impact of the hair follicle environment. Exp Dermatol [Internet]. 2020;29:588\u201397. https:\/\/doi.org\/10.1111\/EXD.14109.","journal-title":"Exp Dermatol [Internet]"},{"key":"1739_CR38","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1016\/J.JID.2020.11.009","volume":"141","author":"R Williams","year":"2021","unstructured":"Williams R, Westgate GE, Pawlus AD, Sikkink SK, Thornton MJ. Age-related changes in female scalp dermal sheath and dermal fibroblasts: how the hair follicle environment impacts hair aging. J Invest Dermatol. 2021;141:1041\u201351. https:\/\/doi.org\/10.1016\/J.JID.2020.11.009. (Elsevier).","journal-title":"J Invest Dermatol"},{"key":"1739_CR39","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/0738-081X(88)90074-0","volume":"6","author":"AM Kligman","year":"1988","unstructured":"Kligman AM. The comparative histopathology of male-pattern baldness and senescent baldness. Clin Dermatol. 1988;6:108\u201318. https:\/\/doi.org\/10.1016\/0738-081X(88)90074-0. (Elsevier).","journal-title":"Clin Dermatol"},{"key":"1739_CR40","doi-asserted-by":"publisher","DOI":"10.15252\/EMBJ.2019101982","author":"S Victorelli","year":"2019","unstructured":"Victorelli S, Lagnado A, Halim J, Moore W, Talbot D, Barrett K, et\u00a0al. Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction. EMBO J [Internet]. 2019. https:\/\/doi.org\/10.15252\/EMBJ.2019101982.","journal-title":"EMBO J [Internet]"},{"key":"1739_CR41","doi-asserted-by":"publisher","DOI":"10.1111\/DTH.13990","volume":"33","author":"S Mahendiratta","year":"2020","unstructured":"Mahendiratta S, Sarma P, Kaur H, Kaur S, Kaur H, Bansal S, et\u00a0al. Premature graying of hair: risk factors, co-morbid conditions, pharmacotherapy and reversal\u2014A systematic review and meta-analysis. Dermatol Ther [Internet]. 2020;33:e13990. https:\/\/doi.org\/10.1111\/DTH.13990.","journal-title":"Dermatol Ther [Internet]"},{"key":"1739_CR42","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/J.CLINDERMATOL.2010.07.007","volume":"29","author":"DA Whiting","year":"2011","unstructured":"Whiting DA. How real is senescent alopecia? A histopathologic approach. Clin Dermatol [Internet]. 2011;29:49\u201353. https:\/\/doi.org\/10.1016\/J.CLINDERMATOL.2010.07.007.","journal-title":"Clin Dermatol [Internet]"},{"issue":"4","key":"1739_CR43","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1111\/J.1365-2133.2005.06310.X","volume":"152","author":"R Sinclair","year":"2005","unstructured":"Sinclair R, Chapman A, Magee J. The lack of significant changes in scalp hair follicle density with advancing age. Br J Dermatol [Internet]. 2005;152(4):646\u20139. https:\/\/doi.org\/10.1111\/J.1365-2133.2005.06310.X.","journal-title":"Br J Dermatol [Internet]"},{"key":"1739_CR44","unstructured":"Lidia R, Malgorzata O, Adriana R. Atlas of trichoscopy: dermoscopy in hair and scalp disease. Springer; 2012; https:\/\/books.google.com\/books\/about\/Atlas_of_Trichoscopy.html?hl=es&id=oNdm2o19jG0C. Accessed 12 Sept 2025."},{"key":"1739_CR45","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1111\/exd.14839","volume":"32","author":"LC Redmond","year":"2023","unstructured":"Redmond LC, Limbu S, Farjo B, Messenger AG, Higgins CA. Male pattern hair loss: can developmental origins explain the pattern? Exp Dermatol [Internet]. 2023;32:1174\u201381. https:\/\/doi.org\/10.1111\/exd.14839.","journal-title":"Exp Dermatol [Internet]"},{"key":"1739_CR46","doi-asserted-by":"publisher","first-page":"121","DOI":"10.2147\/CIIA.2006.1.2.121","volume":"1","author":"RM Tr\u00fceb","year":"2006","unstructured":"Tr\u00fceb RM. Pharmacologic interventions in aging hair. Clin Interv Aging. 2006;1:121\u20139. https:\/\/doi.org\/10.2147\/CIIA.2006.1.2.121.","journal-title":"Clin Interv Aging"},{"key":"1739_CR47","doi-asserted-by":"publisher","DOI":"10.2340\/ACTADV.V104.24213","author":"AA Zeltzer","year":"2024","unstructured":"Zeltzer AA, Keren A, Paus R, Gilhar A. Topical minoxidil rejuvenates hair follicles from men with androgenetic alopecia in vivo. Acta Derm Venereol [Internet]. 2024. https:\/\/doi.org\/10.2340\/ACTADV.V104.24213.","journal-title":"Acta Derm Venereol [Internet]"},{"key":"1739_CR48","doi-asserted-by":"publisher","DOI":"10.2340\/ACTADV.V103.12320","volume":"103","author":"A Gilhar","year":"2023","unstructured":"Gilhar A, Keren A, Paus R. Vellus-to-terminal hair follicle reconversion occurs in male pattern balding and is promoted by minoxidil and platelet-rich plasma: in vivo evidence from a new humanized mouse model of androgenetic alopecia. Acta Derm Venereol [Internet]. 2023;103:12320. https:\/\/doi.org\/10.2340\/ACTADV.V103.12320.","journal-title":"Acta Derm Venereol [Internet]"},{"issue":"25","key":"1739_CR49","doi-asserted-by":"publisher","DOI":"10.1126\/SCIADV.ABM6756","volume":"8","author":"A Keren","year":"2022","unstructured":"Keren A, Bertolini M, Keren Y, Ullmann Y, Paus R, Gilhar A. Human organ rejuvenation by VEGF-A: lessons from the skin. Sci Adv [Internet]. 2022;8(25):6756. https:\/\/doi.org\/10.1126\/SCIADV.ABM6756.","journal-title":"Sci Adv [Internet]"},{"key":"1739_CR50","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1109\/JSTQE.2016.2561201","volume":"22","author":"LF De Freitas","year":"2016","unstructured":"De Freitas LF, Hamblin MR. Proposed mechanisms of photobiomodulation or low-level light therapy. IEEE J Sel Top Quantum Electron. 2016;22:348\u201364. https:\/\/doi.org\/10.1109\/JSTQE.2016.2561201.","journal-title":"IEEE J Sel Top Quantum Electron"},{"key":"1739_CR51","doi-asserted-by":"publisher","unstructured":"Ahn JH, Park YE, Kim B, Park CW, Sim TH, Lee TK, et\u00a0al. Hair growth is promoted in mouse dorsal skin by a mixture of Platycladus orientalis (L) Franco leaf extract and alpha-terpineol by increasing growth factors and wnt3\/\u03b2-catenin. Nat Prod Commun [Internet]. 2020. https:\/\/doi.org\/10.1177\/1934578X20951433\/ASSET\/IMAGES\/LARGE\/10.1177_1934578X20951433-FIG4.JPEG.","DOI":"10.1177\/1934578X20951433\/ASSET\/IMAGES\/LARGE\/10.1177_1934578X20951433-FIG4.JPEG"},{"key":"1739_CR52","doi-asserted-by":"publisher","DOI":"10.1186\/S12929-022-00863-6","author":"O Salhab","year":"2022","unstructured":"Salhab O, Khayat L, Alaaeddine N. Stem cell secretome as a mechanism for restoring hair loss due to stress, particularly alopecia areata: narrative review. J Biomed Sci [Internet]. 2022. https:\/\/doi.org\/10.1186\/S12929-022-00863-6.","journal-title":"J Biomed Sci [Internet]"},{"key":"1739_CR53","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/J.JAAD.2020.02.033","volume":"83","author":"R Tsuboi","year":"2020","unstructured":"Tsuboi R, Niiyama S, Irisawa R, Harada K, Nakazawa Y, Kishimoto J. Autologous cell-based therapy for male and female pattern hair loss using dermal sheath cup cells: a randomized placebo-controlled double-blinded dose-finding clinical study. J Am Acad Dermatol [Internet]. 2020;83:109\u201316. https:\/\/doi.org\/10.1016\/J.JAAD.2020.02.033.","journal-title":"J Am Acad Dermatol [Internet]"},{"key":"1739_CR54","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/J.JDERMSCI.2023.11.003","volume":"113","author":"Y Ishimatsu-Tsuji","year":"2024","unstructured":"Ishimatsu-Tsuji Y, Niiyama S, Irisawa R, Harada K, Kishimoto J, Tsuboi R. High migratory activity of dermal sheath cup cells associated with the clinical efficacy of autologous cell-based therapy for pattern hair loss. J Dermatol Sci [Internet]. 2024;113:26\u201333. https:\/\/doi.org\/10.1016\/J.JDERMSCI.2023.11.003.","journal-title":"J Dermatol Sci [Internet]"},{"key":"1739_CR55","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/J.BBRC.2016.02.099","volume":"472","author":"M Sasaki","year":"2016","unstructured":"Sasaki M, Shinozaki S, Shimokado K. Sulforaphane promotes murine hair growth by accelerating the degradation of dihydrotestosterone. Biochem Biophys Res Commun [Internet]. 2016;472:250\u20134. https:\/\/doi.org\/10.1016\/J.BBRC.2016.02.099.","journal-title":"Biochem Biophys Res Commun [Internet]"},{"issue":"3","key":"1739_CR56","doi-asserted-by":"publisher","first-page":"245","DOI":"10.4161\/DERM.22344","volume":"4","author":"K Kleszczynski","year":"2012","unstructured":"Kleszczynski K, Fischer TW. Melatonin and human skin aging. Dermatoendocrinology [Internet]. 2012;4(3):245\u201352. https:\/\/doi.org\/10.4161\/DERM.22344.","journal-title":"Dermatoendocrinology [Internet]"},{"key":"1739_CR57","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1111\/JOCD.12127","volume":"14","author":"C Le Floc\u2019h","year":"2015","unstructured":"Le Floc\u2019h C, Cheniti A, Conn\u00e9table S, Piccardi N, Vincenzi C, Tosti A. Effect of a nutritional supplement on hair loss in women. J Cosmet Dermatol [Internet]. 2015;14:76\u201382. https:\/\/doi.org\/10.1111\/JOCD.12127.","journal-title":"J Cosmet Dermatol [Internet]"},{"key":"1739_CR58","doi-asserted-by":"publisher","first-page":"2179","DOI":"10.1111\/JOCD.13815","volume":"20","author":"M Honda Igarashi","year":"2021","unstructured":"Honda Igarashi M, da Silva SG, Mercuri M, Zuardi FMdeON, Facchini G, da Silva GH, et\u00a0al. Novel complex of cosmetic ingredients with promising action in preventing hair loss and follicular aging through mechanism involving enrichment of WNT\/signaling, mitochondrial activity, and stem cells maintenance. J Cosmet Dermatol [Internet]. 2021;20:2179\u201389. https:\/\/doi.org\/10.1111\/JOCD.13815.","journal-title":"J Cosmet Dermatol [Internet]"},{"key":"1739_CR59","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1016\/j.freeradbiomed.2025.05.427","volume":"237","author":"H Wang","year":"2025","unstructured":"Wang H, Wang Y, Li X, Ma J, Hu Z, Qu Q, et\u00a0al. Ergothioneine regulates the paracrine of dermal papilla cells through SIRT1\/Nrf2 pathway to antagonize oxidative stress and natural hair follicle aging. Free Radic Biol Med [Internet]. 2025;237:570\u201384. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2025.05.427.","journal-title":"Free Radic Biol Med [Internet]"}],"container-title":["Dermatology and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13555-026-01739-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13555-026-01739-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13555-026-01739-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T14:53:24Z","timestamp":1780584804000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13555-026-01739-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,2]]},"references-count":59,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["1739"],"URL":"https:\/\/doi.org\/10.1007\/s13555-026-01739-5","relation":{},"ISSN":["2193-8210","2190-9172"],"issn-type":[{"value":"2193-8210","type":"print"},{"value":"2190-9172","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,2]]},"assertion":[{"value":"2 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"David Saceda-Corralo is an investigator in clinical trials and\/or affiliated with (Presentations\/Advisory boards) for Eli Lilly and Company, L\u2019Oreal, Pfizer Inc., ISDIN, Cantabria Labs. Vice president of the Spanish Hair Research Society (2023 to present). David Saceda-Corralo is an Editorial Board member of\n                      Dermatology and Therapy\n                      . David Saceda-Corralo was not involved in the selection of peer reviewers for the manuscript nor any of the subsequent editorial decisions. Ralf Paus serves on the Scientific Advisory Board of Olistic, Spain, and DermaliQ, USA, and is an employee of CUTANEON, Germany. Michela Starace has no conflicts of interest. Sergio Va\u00f1\u00f3-Galv\u00e1n is advisor and speaker of Lilly, Pfizer, Pierre Fabre, Loreal and Cantabria Labs. Bianca Maria Piraccini is advisor of Lilly and Sun Pharma, and speaker of Lilly. Manuel S\u00e1ez has no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"The study adhered to the ethical principles outlined in the Declaration of Helsinki and was approved by the Research Ethics Committee of Hospital Universitario Ram\u00f3n y Cajal (Madrid, Spain); CEIm number 82\/26. No patient data was collected or analyzed.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}