{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:04:30Z","timestamp":1786982670019,"version":"build-2736575974"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2013,12,10]],"date-time":"2013-12-10T00:00:00Z","timestamp":1386633600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Cell"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1007\/s13577-013-0083-6","type":"journal-article","created":{"date-parts":[[2013,12,9]],"date-time":"2013-12-09T00:42:39Z","timestamp":1386549759000},"page":"68-77","source":"Crossref","is-referenced-by-count":26,"title":["Carnosol, rosemary ingredient, induces apoptosis in adult T-cell leukemia\/lymphoma cells via glutathione depletion: proteomic approach using fluorescent two-dimensional differential gel electrophoresis"],"prefix":"10.1007","volume":"27","author":[{"given":"Yo-ichi","family":"Ishida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Yamasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chizuko","family":"Yukizaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Nishiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirohito","family":"Tsubouchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Okayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Kataoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,12,10]]},"reference":[{"key":"83_CR1","doi-asserted-by":"crossref","first-page":"6476","DOI":"10.1073\/pnas.78.10.6476","volume":"78","author":"Y Hinuma","year":"1981","unstructured":"Hinuma Y, Nagata K, Hanaoka M, et al. Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera. Proc Natl Acad Sci USA. 1981;78:6476\u201380.","journal-title":"Proc Natl Acad Sci USA"},{"key":"83_CR2","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1182\/blood-2009-12-257410","volume":"116","author":"M Iwanaga","year":"2010","unstructured":"Iwanaga M, Watanabe T, Utsunomiya A, et al. Human T-cell leukemia virus type I (HTLV-1) proviral load and disease progression in asymptomatic HTLV-1 carriers: a nationwide prospective study in Japan. Blood. 2010;116:1211\u20139.","journal-title":"Blood"},{"key":"83_CR3","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1046\/j.1365-2141.2001.02737.x","volume":"113","author":"Y Yamada","year":"2001","unstructured":"Yamada Y, Tomonaga M, Fukuda H, et al. A new G-CSF-supported combination chemotherapy, LSG15, for adult T-cell leukemia-lymphoma: Japan clinical oncology group study 9303. Br J Haematol. 2001;113:375\u201382.","journal-title":"Br J Haematol"},{"key":"83_CR4","first-page":"113","volume":"14","author":"J Yasunaga","year":"2007","unstructured":"Yasunaga J, Matsuoka M. Human T-cell leukemia virus type 1 induces adult T-cell leukemia: from clinical aspects to molecular mechanisms. Can Con. 2007;14:113\u201340.","journal-title":"Can Con"},{"key":"83_CR5","doi-asserted-by":"crossref","first-page":"284S","DOI":"10.1093\/ajcn\/81.1.284S","volume":"81","author":"JD Lambert","year":"2005","unstructured":"Lambert JD, Hong J, Yang G, Liao J, Yang CS. Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations. Am J Clin Nutr. 2005;81:284S\u201391S.","journal-title":"Am J Clin Nutr"},{"key":"83_CR6","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/mnfr.200700326","volume":"52","author":"S Ramos","year":"2008","unstructured":"Ramos S. Cancer chemoprevention and chemotherapy: dietary polyphenols and signaling pathways. Mol Nutr Food Res. 2008;52:507\u201326.","journal-title":"Mol Nutr Food Res"},{"key":"83_CR7","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1349-7006.2000.tb00857.x","volume":"91","author":"HC Li","year":"2000","unstructured":"Li HC, Yashiki S, Sonoda J, et al. Green tea polyphenols induce apoptosis in vitro in peripheral blood T lymphocytes of adult T-cell leukemia patients. Jpn J Can Res. 2000;91:34\u201340.","journal-title":"Jpn J Can Res"},{"key":"83_CR8","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0145-2126(02)00164-9","volume":"27","author":"J Zhang","year":"2003","unstructured":"Zhang J, Nagasaki M, Tanaka Y, Morikawa S. Capsaicin inhibits growth of adult T-cell leukemia cells. Leuk Res. 2003;27:275\u201383.","journal-title":"Leuk Res"},{"key":"83_CR9","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1111\/j.1349-7006.2007.00595.x","volume":"98","author":"M Yamasaki","year":"2007","unstructured":"Yamasaki M, Fujita S, Ishiyama E, et al. Soy-derived isoflavones inhibit the growth of adult T-cell leukemia cells in vitro and in vivo. Can Sci. 2007;98:1740\u20136.","journal-title":"Can Sci"},{"key":"83_CR10","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1002\/cbin.10101","volume":"37","author":"M Yamasaki","year":"2013","unstructured":"Yamasaki M, Mine Y, Nishimura M, et al. Genistein induces apoptotic cell death associated with inhibition of NF-\u03baB pathway in adult T-cell leukemia cells. Cell Biol Int. 2013;37:742\u20137.","journal-title":"Cell Biol Int"},{"key":"83_CR11","doi-asserted-by":"crossref","first-page":"3034S","DOI":"10.1093\/jn\/131.11.3034S","volume":"131","author":"MJ Wargovich","year":"2001","unstructured":"Wargovich MJ, Woods C, Hollis DM, Zander ME. Herbals, cancer prevention and health. J Nutr. 2001;131:3034S\u20136S.","journal-title":"J Nutr"},{"key":"83_CR12","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.jnutbio.2007.11.003","volume":"19","author":"CM Kaefer","year":"2008","unstructured":"Kaefer CM, Milner JA. The role of herbs and spices in cancer prevention. J Nutr Biochem. 2008;19:347\u201361.","journal-title":"J Nutr Biochem"},{"key":"83_CR13","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0304-3835(01)00549-3","volume":"170","author":"J D\u00f6rrie","year":"2001","unstructured":"D\u00f6rrie J, Sapala K, Zunino SJ. Carnosol-induced apoptosis and downregulation of Bcl-2 in B-lineage leukemia cells. Can Lett. 2001;170:33\u20139.","journal-title":"Can Lett"},{"key":"83_CR14","doi-asserted-by":"crossref","first-page":"21165","DOI":"10.1074\/jbc.M109.004945","volume":"284","author":"M Takeshita","year":"2009","unstructured":"Takeshita M, Ishida Y, Akamatsu E, et al. Proanthocyanidin from blueberry leaves suppresses expression of sub-genomic hepatitis C virus RNA. J Biol Chem. 2009;284:21165\u201376.","journal-title":"J Biol Chem"},{"key":"83_CR15","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1182\/blood-2004-03-1222","volume":"105","author":"H Sasaki","year":"2005","unstructured":"Sasaki H, Nishikata I, Shiraga T, et al. Overexpression of a cell adhesion molecule, TSLC1, as a possible molecular marker for acute-type adult T-cell leukemia. Blood. 2005;105:1204\u201313.","journal-title":"Blood"},{"key":"83_CR16","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1159\/000065865","volume":"45","author":"Y Ishida","year":"2002","unstructured":"Ishida Y, Hiraki A, Hirayama E, Koga Y, Kim J. Temperature-sensitive viral infection: inhibition of hemagglutinating virus of Japan (Sendai virus) infection at 41 degrees. Intervirology. 2002;45:125\u201335.","journal-title":"Intervirology"},{"key":"83_CR17","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.chroma.2006.02.056","volume":"1102","author":"L Almela","year":"2006","unstructured":"Almela L, S\u00e1nchez-Mu\u00f1oz B, Fern\u00e1ndez-L\u00f3pez JA, Roca MJ, Rabe V. Liquid chromatograpic-mass spectrometric analysis of phenolics and free radical scavenging activity of rosemary extract from different raw material. J Chromatogr A. 2006;1102:221\u20139.","journal-title":"J Chromatogr A"},{"key":"83_CR18","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1586\/14789450.2.2.215","volume":"2","author":"PG Righetti","year":"2005","unstructured":"Righetti PG, Castagna A, Antonioli P, Cecconi D, Campostrini N, Righetti SC. Proteomic approaches for studying chemoresistance in cancer. Exp Rev Prot. 2005;2:215\u201328.","journal-title":"Exp Rev Prot"},{"key":"83_CR19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/jbiol63","volume":"7","author":"CM Grant","year":"2008","unstructured":"Grant CM. Metabolic reconfiguration is a regulated response to oxidative stress. J Biol. 2008;7:1.","journal-title":"J Biol"},{"key":"83_CR20","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/S0891-5849(99)00177-X","volume":"27","author":"H Sies","year":"1999","unstructured":"Sies H. Glutathione and its role in cellular functions. Free Rad Biol Med. 1999;27:916\u201321.","journal-title":"Free Rad Biol Med"},{"key":"83_CR21","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1093\/jn\/134.3.489","volume":"134","author":"G Wu","year":"2004","unstructured":"Wu G, Fang YZ, Yang S, Lupton JR, Turner ND. Glutathione metabolism and its implications for health. J Nutr. 2004;134:489\u201392.","journal-title":"J Nutr"},{"key":"83_CR22","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1021\/jf026162r","volume":"51","author":"RH Liu","year":"2003","unstructured":"Liu RH, Sun J. Anti-proliferative activity of apples is not due to phenolic-induced hydrogen peroxide formation. J Agric Food Chem. 2003;51:1718\u201323.","journal-title":"J Agric Food Chem"},{"key":"83_CR23","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1021\/jf0486040","volume":"53","author":"KW Lee","year":"2005","unstructured":"Lee KW, Hur HJ, Lee HJ, Lee CY. Anti-proliferative effects of dietary phenolic substances and hydrogen peroxide. J Agric Food Chem. 2005;53:1990\u20135.","journal-title":"J Agric Food Chem"},{"key":"83_CR24","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1002\/ijc.22733","volume":"121","author":"P Nangia-Makker","year":"2007","unstructured":"Nangia-Makker P, Tait L, Shekhar MP, et al. Inhibition of breast tumor growth and angiogenesis by a medicinal herb: ocimum gratissimum. Int J Can. 2007;121:884\u201394.","journal-title":"Int J Can"},{"key":"83_CR25","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.1182\/blood-2006-06-032250","volume":"109","author":"GB Zhou","year":"2007","unstructured":"Zhou GB, Kang H, Wang L, et al. Oridonin, a diterpenoid extracted from medicinal herbs, targets AML1-ETO fusion protein and shows potent antitumor activity with low adverse effects on t(8;21) leukemia in vitro and in vivo. Blood. 2007;109:3441\u201350.","journal-title":"Blood"},{"key":"83_CR26","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.canlet.2005.05.045","volume":"237","author":"JM Visanji","year":"2006","unstructured":"Visanji JM, Thompson DG, Padfield PJ. Induction of G2\/M phase cell cycle arrest by carnosol and carnosic acid is associated with alteration of cyclin A and cyclin B1 levels. Can Lett. 2006;237:130\u20136.","journal-title":"Can Lett"},{"key":"83_CR27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2011.02.005","volume":"305","author":"JJ Johnson","year":"2011","unstructured":"Johnson JJ. Carnosol: a promising anti-cancer and anti-inflammatory agent. Can Lett. 2011;305:1\u20137.","journal-title":"Can Lett"},{"key":"83_CR28","doi-asserted-by":"crossref","first-page":"19402","DOI":"10.1074\/jbc.M111053200","volume":"277","author":"JM Pullar","year":"2002","unstructured":"Pullar JM, Hampton MB. Diphenyleneiodonium triggers the efflux of glutathione from cultured cells. J Biol Chem. 2002;277:19402\u20137.","journal-title":"J Biol Chem"},{"key":"83_CR29","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/j.1582-4934.2004.tb00470.x","volume":"8","author":"Y Higuchi","year":"2004","unstructured":"Higuchi Y. Glutathione depletion-induced chromosomal DNA fragmentation associated with apoptosis and necrosis. J Cell Mol Med. 2004;8:455\u201364.","journal-title":"J Cell Mol Med"},{"key":"83_CR30","doi-asserted-by":"crossref","first-page":"39591","DOI":"10.1074\/jbc.M303753200","volume":"278","author":"A Ortega","year":"2003","unstructured":"Ortega A, Ferrer P, Carretero J, et al. Down-regulation of glutathione and Bcl-2 synthesis in mouse B16 melanoma cells avoids their survival during interaction with the vascular endothelium. J Biol Chem. 2003;278:39591\u20139.","journal-title":"J Biol Chem"},{"key":"83_CR31","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1179\/135100005X70224","volume":"10","author":"K England","year":"2005","unstructured":"England K, Cotter TG. Direct oxidative modifications of signaling proteins in mammalian cells and their effects on apoptosis. Redox Rep. 2005;10:237\u201345.","journal-title":"Redox Rep"},{"key":"83_CR32","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1093\/emboj\/17.9.2596","volume":"17","author":"M Saitoh","year":"1998","unstructured":"Saitoh M, Nishitoh H, Fujii M, et al. Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1. EMBO J. 1998;17:2596\u2013606.","journal-title":"EMBO J"},{"key":"83_CR33","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/sj.cdd.4401625","volume":"12","author":"H Masutani","year":"2005","unstructured":"Masutani H, Ueda S, Yodoi J. The thioredoxin system in retroviral infection and apoptosis. Cell Death Diff. 2005;12:991\u20138.","journal-title":"Cell Death Diff"},{"key":"83_CR34","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0304-3835(95)04082-X","volume":"100","author":"KW Singletary","year":"1996","unstructured":"Singletary KW. Rosemary extract and carnosol stimulate rat liver glutathione-s-transferase and quinone reductase activities. Can Lett. 1996;100:139\u201344.","journal-title":"Can Lett"},{"key":"83_CR35","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0304-3835(97)04680-6","volume":"114","author":"EA Offord","year":"1997","unstructured":"Offord EA, Mac\u00e9 K, Avanti O, Pfeifer AM. Mechanisms involved in the chemo-protective effects of rosemary extract studied in human liver and bronchial cells. Can Lett. 1997;114:275\u201381.","journal-title":"Can Lett"},{"key":"83_CR36","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0378-8741(02)00090-9","volume":"81","author":"JI Sotelo-F\u00e9lix","year":"2002","unstructured":"Sotelo-F\u00e9lix JI, Martinez-Fong D, Muriel P, Santill\u00e1n RL, Castillo D, Yahuaca P. Evaluation of the effectiveness of Rosmarinus officinalis (Lamiaceae) in the alleviation of carbon tetrachloride-induced acute hepatotoxicity in the rat. J Ethnopharmacol. 2002;81:145\u201354.","journal-title":"J Ethnopharmacol"},{"key":"83_CR37","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1055\/s-0029-1240622","volume":"76","author":"Y Tamaki","year":"2010","unstructured":"Tamaki Y, Tabuchi T, Takahashi T, Kosaka K, Satoh T. Activated glutathione metabolism participates in protective effects of carnosic acid against oxidative stress in neuronal HT22 cells. Planta Med. 2010;76:683\u20138.","journal-title":"Planta Med"},{"key":"83_CR38","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0076-6879(05)01019-0","volume":"401","author":"DM Townsend","year":"2005","unstructured":"Townsend DM, Findlay VL, Tew KD. Glutathione S-transferases as regulators of kinase pathways and anticancer drug targets. Meth Enzymol. 2005;401:287\u2013307.","journal-title":"Meth Enzymol"},{"key":"83_CR39","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.2174\/092986706776872934","volume":"13","author":"G Zhao","year":"2006","unstructured":"Zhao G, Wang X. Advance in antitumor agents targeting glutathione-s-transferase. Curr Med Chem. 2006;13:1461\u201371.","journal-title":"Curr Med Chem"},{"key":"83_CR40","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1517\/17425250903427980","volume":"6","author":"G Pietro Di","year":"2010","unstructured":"Di Pietro G, Magno LA, Rios-Santos F. Glutathione S-transferases: an overview in cancer research. Exp Opin Drug Metab Toxicol. 2010;6:153\u201370.","journal-title":"Exp Opin Drug Metab Toxicol"}],"container-title":["Human Cell"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13577-013-0083-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13577-013-0083-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13577-013-0083-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,4]],"date-time":"2019-08-04T13:22:26Z","timestamp":1564924946000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13577-013-0083-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,10]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["83"],"URL":"https:\/\/doi.org\/10.1007\/s13577-013-0083-6","relation":{},"ISSN":["1749-0774"],"issn-type":[{"value":"1749-0774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,10]]}}}