{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T15:17:08Z","timestamp":1778253428455,"version":"3.51.4"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2017,3,4]],"date-time":"2017-03-04T00:00:00Z","timestamp":1488585600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Human Cell"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1007\/s13577-017-0165-y","type":"journal-article","created":{"date-parts":[[2017,3,4]],"date-time":"2017-03-04T15:45:56Z","timestamp":1488642356000},"page":"319-326","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Establishment and characterization of a squamous cell carcinoma cell line, designated hZK-1, derived from a metastatic lymph node tumor of the tongue"],"prefix":"10.1007","volume":"30","author":[{"given":"Tetsuya","family":"Hirabayashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruka","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miho","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiaki","family":"Tachibana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,3,4]]},"reference":[{"key":"165_CR1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.tripleo.2005.07.038","volume":"102","author":"J Massano","year":"2006","unstructured":"Massano J, Regateiro F, Januario G, Ferreira A. Oral squamous cell carcinoma: review of prognostic and predictive factors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;102:67\u201376.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"165_CR2","first-page":"961","volume":"158","author":"PM Som","year":"1992","unstructured":"Som PM. Detection of metastasis in cervical lymph nodes: CT and MRI criteria and differential diagnosis. Am J Radiol. 1992;158:961\u20139.","journal-title":"Am J Radiol"},{"key":"165_CR3","doi-asserted-by":"crossref","first-page":"27","DOI":"10.2485\/jhtb.19.27","volume":"19","author":"A Yasui","year":"2010","unstructured":"Yasui A, Okada Y, Mataga I, Katagiri M. An analysis of distant metastasis in oral squamous cell carcinoma. J Hard Tissue Biol. 2010;19:27\u201332.","journal-title":"J Hard Tissue Biol"},{"key":"165_CR4","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1016\/0277-5379(88)90335-5","volume":"24","author":"J Gioanni","year":"1988","unstructured":"Gioanni J, Fischel JL, Lambert JC, et al. Two new human tumor cell lines derived from squamous cell carcinomas of the tongue: establishment, characterization and response to cytotoxic treatment. Eur J Cancer Clin Oncol. 1988;24:1445\u201355.","journal-title":"Eur J Cancer Clin Oncol"},{"key":"165_CR5","first-page":"1627","volume":"12","author":"EC Chew","year":"1992","unstructured":"Chew EC, King WK, Hou HJ, Yam HF. Establishment and characterization of two new cell lines derived from squamous cell carcinoma of the tongue in Chinese patients. Anticancer Res. 1992;12:1627\u201334.","journal-title":"Anticancer Res"},{"key":"165_CR6","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1365-2273.1995.tb00005.x","volume":"20","author":"WWK King","year":"1995","unstructured":"King WWK, Lam PK, Huang DWSP, Liew CT, Li AKC. Establishment and characterization of a human cell line from a squamous carcinoma of the tongue. Clin Otolaryngol. 1995;20:15\u201320.","journal-title":"Clin Otolaryngol"},{"key":"165_CR7","doi-asserted-by":"publisher","unstructured":"Kim KM, Park EJ, Yeo YH, Cho KJ, Kim MS. Establishment of a novel HPV-negative and radiosensitive head and neck squamous cell carcinoma cell line. Head Neck. 2015. doi: 10.1002\/hed.24037 .","DOI":"10.1002\/hed.24037"},{"key":"165_CR8","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s13577-014-0107-x","volume":"28","author":"H Takahashi","year":"2015","unstructured":"Takahashi H, Ishikawa H, Mataga I, et al. Establishment and characterization of human lingual squamous cell carcinoma cell lines designated Nialym derived from metastatic foci of lymph node, and Nialymx derived from transplanted tumor of Nialym cells. Hum Cell. 2015;28:143\u201353.","journal-title":"Hum Cell"},{"key":"165_CR9","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1758-3284-1-27","volume":"1","author":"J Han","year":"2009","unstructured":"Han J, Kioi M, Chu WS, et al. Identification of potential therapeutic targets in human head and neck aquamous cell carcinoma. Head Neck Oncol. 2009;1:27.","journal-title":"Head Neck Oncol"},{"key":"165_CR10","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1007\/s10856-006-9684-x","volume":"17","author":"S Koch","year":"2006","unstructured":"Koch S, Yao C, Grieb G, Prevel P, Noah EM, Steffens GCM. Enhancing angiogenesis in collagen matrices by vovalent incorporation of VEGF. J Mater Sci Mater Med. 2006;17:735\u201341.","journal-title":"J Mater Sci Mater Med"},{"key":"165_CR11","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0002-9440(10)65284-4","volume":"154","author":"JE Nor","year":"1999","unstructured":"Nor JE, Christensen J, Mooney DJ, Polverini PJ. Vascular endothelial growth factor (VEGF)-mediated angiogenesis is associated with enhanced endothelial cell survival and induction of Bcl-2 expression. Am J Pathol. 1999;154:375\u201384.","journal-title":"Am J Pathol"},{"key":"165_CR12","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1242\/dev.125.9.1591","volume":"125","author":"LE Benjamin","year":"1998","unstructured":"Benjamin LE, Hemo I, Keshet E. A plasticity window for blood vessel remodeling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF. Development. 1998;125:1591\u20138.","journal-title":"Development."},{"key":"165_CR13","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1006\/mvre.2001.2383","volume":"63","author":"HC Haspel","year":"2002","unstructured":"Haspel HC, Scicli GM, MaMahon G, Scicli GM. Inhibition of vascular endothelial growth factor-associated tyrosine kinase activity with SU5416 blocks sprouting in the microvascular endothelial cell spheloid model of angiogenesis. Microvasc Res. 2002;63:304\u201315.","journal-title":"Microvasc Res"},{"key":"165_CR14","doi-asserted-by":"crossref","first-page":"4604","DOI":"10.1128\/MCB.16.9.4604","volume":"16","author":"JA Forsythe","year":"1996","unstructured":"Forsythe JA, Jiang BH, Lyer NV, et al. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mil Cell Biol. 1996;16:4604\u201313.","journal-title":"Mil Cell Biol"},{"key":"165_CR15","doi-asserted-by":"crossref","first-page":"5510","DOI":"10.1073\/pnas.92.12.5510","volume":"92","author":"GL Wong","year":"1995","unstructured":"Wong GL, Jiang BH, Rue EA, Semenza GL. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cell OXYGEN tension. Proc Natl Acad Sci. 1995;92:5510\u20134.","journal-title":"Proc Natl Acad Sci"},{"key":"165_CR16","doi-asserted-by":"publisher","unstructured":"Identity crisis. Nature. 2009;457 (7232):935\u20136. doi: 10.1038\/457935b .","DOI":"10.1038\/457935b"},{"issue":"5814","key":"165_CR17","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1126\/science.315.5814.928","volume":"315","author":"R Chatterjee","year":"2007","unstructured":"Chatterjee R. Cell biology. Cases of mistaken identity. Science. 2007;315(5814):928\u201331.","journal-title":"Science"},{"issue":"1\u20132","key":"165_CR18","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0166-0934(03)00186-1","volume":"112","author":"Patti E Gravitt","year":"2003","unstructured":"Gravitt Patti E, Peyton Cheri, Wheeler Cosette, Apple Raymond, Higuchi Russell, Shah Keerti V. Reproducibility of HPV 16 and HPV 18 viral load quantitation using TaqMan real-time PCR assays. J Virol Methods. 2003;112(1\u20132):23\u201333.","journal-title":"J Virol Methods"},{"issue":"9","key":"165_CR19","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1002\/1097-0142(19910501)67:9<2327::AID-CNCR2820670919>3.0.CO;2-F","volume":"67","author":"H Ichimura","year":"1991","unstructured":"Ichimura H, Yamasaki M, Tamura I, et al. Establishment and characterization of a new cell line TC-YIK originating from argyrophil small cell carcinoma of the uterine cervix integrating HPV16 DNA. Cancer. 1991;67(9):2327\u201332.","journal-title":"Cancer"},{"key":"165_CR20","first-page":"3","volume":"12","author":"Y Amano","year":"1999","unstructured":"Amano Y, Okumura C, Yoshida M, et al. Measuring respiration of cultured cell with oxygen electrode as a metabolic indicator for drug screening. Hum Cell. 1999;12:3\u201310.","journal-title":"Hum Cell"},{"key":"165_CR21","first-page":"7","volume":"7","author":"K Uesu","year":"2005","unstructured":"Uesu K, Ishikawa H. Analysis of an in vitro susceptibility test of anticancer drugs using new yupes of oxygen electrodes. Bull Edu Res Nihon Univ Sch Dent Matsudo. 2005;7:7\u201321.","journal-title":"Bull Edu Res Nihon Univ Sch Dent Matsudo."},{"key":"165_CR22","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1097\/00029330-200810010-00007","volume":"121","author":"R Sun","year":"2008","unstructured":"Sun R, Zhang JG, Guo CB. Establishment of cervical lymph node metastasis model of squamous cell carcinoma in the oral cavity in mice. Chin Med J. 2008;121:1891\u20135.","journal-title":"Chin Med J"},{"key":"165_CR23","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/j.1600-0714.1989.tb01570.x","volume":"18","author":"F Monose","year":"1989","unstructured":"Monose F, Araida T, Negishi A, Ichijo S, Sasaki S. Variant sublines with different metastatic potentials selected in nude mice from human oral squamous cell carcinomas. J Oral Pathol Med. 1989;18:391\u20135.","journal-title":"J Oral Pathol Med"},{"key":"165_CR24","first-page":"43","volume":"23","author":"T Yokoi","year":"1988","unstructured":"Yokoi T, Yamaguchi A, Odajima T, Furukawa K. Establishment and characterization of a human cell line derived from a squamous cell carcinoma of the tongue. Tumor Res. 1988;23:43\u201357.","journal-title":"Tumor Res"},{"key":"165_CR25","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1182\/blood-2004-07-2958","volume":"105","author":"DJ Manalo","year":"2005","unstructured":"Manalo DJ, Rowan A, Lavoie T, et al. Transcriptional regulation of vascular endothelial call responses to hypoxia. Blood. 2005;105:659\u201369.","journal-title":"Blood."},{"key":"165_CR26","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1002\/lary.23888","volume":"123","author":"J Dunkel","year":"2013","unstructured":"Dunkel J, Vaittinen S, Gr\u00e9nman R, et al. Prognostic markers in stage I oral cavity squamous cell carcinoma. Laryngoscope. 2013;123:2435\u201343.","journal-title":"Laryngoscope"},{"key":"165_CR27","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12476","author":"S Kazakydasan","year":"2016","unstructured":"Kazakydasan S, Rahman ZA, Ismail SM, et al. Prognostic significance of VEGF-C in predicting micrometastasis and isolated tumour cells in NO oral squamous cell carcinoma. J Oral Pathol Med. 2016;. doi: 10.1111\/jop.12476 .","journal-title":"J Oral Pathol Med."},{"key":"165_CR28","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1016\/j.ejca.2008.07.013","volume":"44","author":"A Bozec","year":"2008","unstructured":"Bozec A, Gros FX, Penault-Llorca F, et al. Vertical VEGF targeting: a combination of ligand blockade with receptor tyrosine kinase inhibition. Eur J Cancer. 2008;44:1922\u201330.","journal-title":"Eur J Cancer"},{"issue":"33","key":"165_CR29","doi-asserted-by":"crossref","first-page":"7415","DOI":"10.3748\/wjg.v22.i33.7415","volume":"22","author":"D Bucchi","year":"2016","unstructured":"Bucchi D, Stracci F, Buonoraet N, et al. Human papilloma virus and gastrointestinal cancer: a review. World J Gastroenterol. 2016;22(33):7415\u201330.","journal-title":"World J Gastroenterol"}],"container-title":["Human Cell"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13577-017-0165-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13577-017-0165-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13577-017-0165-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T13:28:54Z","timestamp":1692710934000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13577-017-0165-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,4]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["165"],"URL":"https:\/\/doi.org\/10.1007\/s13577-017-0165-y","relation":{},"ISSN":["1749-0774"],"issn-type":[{"value":"1749-0774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,4]]}}}