{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T12:56:39Z","timestamp":1774443399847,"version":"3.50.1"},"reference-count":90,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2018,6,6]],"date-time":"2018-06-06T00:00:00Z","timestamp":1528243200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"JSPS KAKENHI","award":["JP23390329"],"award-info":[{"award-number":["JP23390329"]}]},{"name":"JSPS KAKENHI","award":["JP18H02883"],"award-info":[{"award-number":["JP18H02883"]}]},{"name":"Strategic Research Fund of Osaka City University"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Human Cell"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1007\/s13577-018-0211-4","type":"journal-article","created":{"date-parts":[[2018,6,6]],"date-time":"2018-06-06T03:52:31Z","timestamp":1528257151000},"page":"271-281","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The significance of scirrhous gastric cancer cell lines: the molecular characterization using cell lines and mouse models"],"prefix":"10.1007","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5743-7228","authenticated-orcid":false,"given":"Masakazu","family":"Yashiro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tasuku","family":"Matsuoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaichi","family":"Ohira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,6,6]]},"reference":[{"key":"211_CR1","doi-asserted-by":"publisher","first-page":"E359","DOI":"10.1002\/ijc.29210","volume":"136","author":"J Ferlay","year":"2015","unstructured":"Ferlay J, Soerjomataram I, Dikshit R, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136:E359\u201386.","journal-title":"Int J Cancer"},{"key":"211_CR2","doi-asserted-by":"publisher","first-page":"74","DOI":"10.3322\/canjclin.55.2.74","volume":"55","author":"DM Parkin","year":"2005","unstructured":"Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin. 2005;55:74\u2013108.","journal-title":"CA Cancer J Clin"},{"key":"211_CR3","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1007\/s12307-010-0036-5","volume":"3","author":"M Yashiro","year":"2010","unstructured":"Yashiro M, Hirakawa K. Cancer-stromal interactions in scirrhous gastric carcinoma. Cancer Microenviron. 2010;3:127\u201335.","journal-title":"Cancer Microenviron"},{"issue":"1","key":"211_CR4","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/s101200100010","volume":"4","author":"M Kurihara","year":"2001","unstructured":"Kurihara M, Aiko T, Japanese Gastric Cancer Association. The new Japanese classification of gastric carcinoma: revised explanation of \u201cresponse assessment of chemotherapy and radiotherapy for gastric carcinoma\u201d. Gastric Cancer. 2001;4(1):9\u201313.","journal-title":"Gastric Cancer."},{"key":"211_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10120-012-0163-4","volume":"16","author":"A Nashimoto","year":"2013","unstructured":"Nashimoto A, Akazawa K, Isobe Y, et al. Gastric cancer treated in 2002 in Japan: 2009 annual report of the JGCA nationwide registry. Gastric Cancer. 2013;16:1\u201327.","journal-title":"Gastric Cancer"},{"key":"211_CR6","doi-asserted-by":"publisher","first-page":"2397","DOI":"10.1016\/j.ejca.2006.03.024","volume":"42","author":"M Yashiro","year":"2006","unstructured":"Yashiro M, Nishioka N, Hirakawa K. Decreased expression of the adhesion molecule desmoglein-2 is associated with diffuse-type gastric carcinoma. Eur J Cancer. 2006;42:2397\u2013403.","journal-title":"Eur J Cancer"},{"key":"211_CR7","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1002\/ijc.24763","volume":"126","author":"M Yashiro","year":"2010","unstructured":"Yashiro M, Shinto O, Nakamura K, et al. Synergistic antitumor effects of FGFR2 inhibitor with 5-fluorouracil on scirrhous gastric carcinoma. Int J Cancer. 2010;126:1004\u201316.","journal-title":"Int J Cancer"},{"key":"211_CR8","doi-asserted-by":"publisher","first-page":"3718","DOI":"10.1245\/s10434-011-1768-2","volume":"18","author":"S Noda","year":"2011","unstructured":"Noda S, Yashiro M, Toyokawa T, et al. Borrmann\u2019s macroscopic criteria and p-Smad2 expression are useful predictive prognostic markers for cytology-positive gastric cancer patients without overt peritoneal metastasis. Ann Surg Oncol. 2011;18:3718\u201325.","journal-title":"Ann Surg Oncol"},{"key":"211_CR9","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1097\/00004836-198103000-00004","volume":"3","author":"Y Kohli","year":"1981","unstructured":"Kohli Y, Takeda S, Kawai K. Earlier diagnosis of gastric infiltrating carcinoma (scirrhous cancer). J Clin Gastroenterol. 1981;3:17\u201320.","journal-title":"J Clin Gastroenterol"},{"key":"211_CR10","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/BF00157685","volume":"14","author":"M Yashiro","year":"1996","unstructured":"Yashiro M, Chung YS, Nishimura S, Inoue T, Sowa M. Peritoneal metastatic model for human scirrhous gastric carcinoma in nude mice. Clin Exp Metastasis. 1996;14:43\u201354.","journal-title":"Clin Exp Metastasis"},{"key":"211_CR11","first-page":"61","volume":"48","author":"M Sekiguchi","year":"1978","unstructured":"Sekiguchi M, Sakakibara K, Fujii G. Establishment of cultured cell lines derived from a human gastric carcinoma. Jpn J Exp Med. 1978;48:61\u20138.","journal-title":"Jpn J Exp Med"},{"key":"211_CR12","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/0006-291X(92)91548-5","volume":"189","author":"H Kuniyasu","year":"1992","unstructured":"Kuniyasu H, Yasui W, Kitadai Y, Yokozaki H, Ito H, Tahara E. Frequent amplification of the c-met gene in scirrhous type stomach cancer. Biochem Biophys Res Commun. 1992;189:227\u201332.","journal-title":"Biochem Biophys Res Commun"},{"key":"211_CR13","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.jss.2004.09.020","volume":"124","author":"M Yashiro","year":"2005","unstructured":"Yashiro M, Nishioka N, Hirakawa K. K-ras mutation influences macroscopic features of gastric carcinoma. J Surg Res. 2005;124:74\u20138.","journal-title":"J Surg Res"},{"key":"211_CR14","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1007\/BF00294705","volume":"19","author":"E Tahara","year":"1995","unstructured":"Tahara E. Molecular biology of gastric cancer. World J Surg. 1995;19:484\u20138. (discussion 89\u201390).","journal-title":"World J Surg"},{"key":"211_CR15","first-page":"1015","volume":"64","author":"H Nomura","year":"1980","unstructured":"Nomura H, Tokumitsu SI, Takeuchi T. Ultrastructural, cytochemical, and biochemical characterization of alpha-amylase produced by human gastric cancer cells in vitro. J Natl Cancer Inst. 1980;64:1015\u201324.","journal-title":"J Natl Cancer Inst"},{"key":"211_CR16","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1007\/BF02471470","volume":"18","author":"S Akiyama","year":"1988","unstructured":"Akiyama S, Amo H, Watanabe T, et al. Characteristics of three human gastric cancer cell lines, NU-GC-2, NU-GC-3 and NU-GC-4. Jpn J Surg. 1988;18:438\u201346.","journal-title":"Jpn J Surg"},{"key":"211_CR17","first-page":"1451","volume":"92","author":"T Kubo","year":"1991","unstructured":"Kubo T. Establishment and characterization of a new gastric cancer cell line (OCUM-1), derived from Borrmann type IV tumor. Nihon Geka Gakkai Zasshi. 1991;92:1451\u201360.","journal-title":"Nihon Geka Gakkai Zasshi"},{"key":"211_CR18","first-page":"307","volume":"2","author":"A Terano","year":"1989","unstructured":"Terano A, Nakada R, Mutoh H, et al. [Establishment and characterization of a tumor marker producing cell line (JR-1) derived from a gastric scirrhous cancer]. Hum Cell. 1989;2:307\u20139.","journal-title":"Hum Cell"},{"key":"211_CR19","first-page":"71","volume":"4","author":"M Nozue","year":"1991","unstructured":"Nozue M, Nishida M, Todoroki T, Iwasaki Y. Establishment and characterization of a human scirrhus type gastric cancer cell line, GCIY, producing CA19-9. Hum Cell. 1991;4:71\u20135.","journal-title":"Hum Cell"},{"key":"211_CR20","first-page":"67","volume":"4","author":"A Arimura","year":"1991","unstructured":"Arimura A, Nakamura Y, Shimizu A, Harada M, Yanoma S. Establishment and characterization of a CA19-9 producing human gastric cancer cell line, STKM-1. Hum Cell. 1991;4:67\u201370.","journal-title":"Hum Cell"},{"key":"211_CR21","first-page":"381","volume":"51","author":"K Yanagihara","year":"1991","unstructured":"Yanagihara K, Seyama T, Tsumuraya M, Kamada N, Yokoro K. Establishment and characterization of human signet ring cell gastric carcinoma cell lines with amplification of the c-myc oncogene. Cancer Res. 1991;51:381\u20136.","journal-title":"Cancer Res"},{"key":"211_CR22","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/BF02779502","volume":"26","author":"A Terano","year":"1991","unstructured":"Terano A, Nakada R, Mutoh H, et al. Characterization of a newly established cell line (JR-St) derived from human gastric signet ring cell cancer, producing tumor markers. Gastroenterol Jpn. 1991;26:7\u201313.","journal-title":"Gastroenterol Jpn"},{"key":"211_CR23","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1002\/ijc.2910540207","volume":"54","author":"K Yanagihara","year":"1993","unstructured":"Yanagihara K, Kamada N, Tsumuraya M, Amano F. Establishment and characterization of a human gastric scirrhous carcinoma cell line in serum-free chemically defined medium. Int J Cancer. 1993;54:200\u20137.","journal-title":"Int J Cancer"},{"key":"211_CR24","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1038\/bjc.1995.486","volume":"72","author":"M Yashiro","year":"1995","unstructured":"Yashiro M, Chung YS, Nishimura S, Inoue T, Sowa M. Establishment of two new scirrhous gastric cancer cell lines: analysis of factors associated with disseminated metastasis. Br J Cancer. 1995;72:1200\u201310.","journal-title":"Br J Cancer"},{"key":"211_CR25","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1111\/j.1349-7006.2004.tb02199.x","volume":"95","author":"S Takemura","year":"2004","unstructured":"Takemura S, Yashiro M, Sunami T, Tendo M, Hirakawa K. Novel models for human scirrhous gastric carcinoma in vivo. Cancer Sci. 2004;95:893\u2013900.","journal-title":"Cancer Sci"},{"key":"211_CR26","first-page":"5815","volume":"53","author":"K Yanagihara","year":"1993","unstructured":"Yanagihara K, Ito A, Toge T, Numoto M. Antiproliferative effects of isoflavones on human cancer cell lines established from the gastrointestinal tract. Cancer Res. 1993;53:5815\u201321.","journal-title":"Cancer Res"},{"key":"211_CR27","first-page":"1029","volume":"19","author":"K Murahashi","year":"2001","unstructured":"Murahashi K, Yashiro M, Takenaka C, Matsuoka T, Ohira M, Chung KH. Establishment of a new scirrhous gastric cancer cell line with loss of heterozygosity at E-cadherin locus. Int J Oncol. 2001;19:1029\u201333.","journal-title":"Int J Oncol"},{"key":"211_CR28","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1111\/j.1349-7006.2004.tb02489.x","volume":"95","author":"K Yanagihara","year":"2004","unstructured":"Yanagihara K, Tanaka H, Takigahira M, et al. Establishment of two cell lines from human gastric scirrhous carcinoma that possess the potential to metastasize spontaneously in nude mice. Cancer Sci. 2004;95:575\u201382.","journal-title":"Cancer Sci"},{"key":"211_CR29","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1038\/sj.bjc.6605543","volume":"102","author":"Y Kato","year":"2010","unstructured":"Kato Y, Yashiro M, Noda S, et al. Establishment and characterization of a new hypoxia-resistant cancer cell line, OCUM-12\/Hypo, derived from a scirrhous gastric carcinoma. Br J Cancer. 2010;102:898\u2013907.","journal-title":"Br J Cancer"},{"key":"211_CR30","first-page":"4459","volume":"30","author":"Y Kuramitsu","year":"2010","unstructured":"Kuramitsu Y, Baron B, Yoshino S, et al. Proteomic differential display analysis shows up-regulation of 14-3-3 sigma protein in human scirrhous-type gastric carcinoma cells. Anticancer Res. 2010;30:4459\u201365.","journal-title":"Anticancer Res"},{"key":"211_CR31","first-page":"8848","volume":"63","author":"K Nakazawa","year":"2003","unstructured":"Nakazawa K, Yashiro M, Hirakawa K. Keratinocyte growth factor produced by gastric fibroblasts specifically stimulates proliferation of cancer cells from scirrhous gastric carcinoma. Cancer Res. 2003;63:8848\u201352.","journal-title":"Cancer Res"},{"key":"211_CR32","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1038\/bjc.2014.61","volume":"110","author":"YJ Liu","year":"2014","unstructured":"Liu YJ, Shen D, Yin X, et al. HER2, MET and FGFR2 oncogenic driver alterations define distinct molecular segments for targeted therapies in gastric carcinoma. Br J Cancer. 2014;110:1169\u201378.","journal-title":"Br J Cancer"},{"key":"211_CR33","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1126\/science.1846706","volume":"251","author":"DP Bottaro","year":"1991","unstructured":"Bottaro DP, Rubin JS, Faletto DL, et al. Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. Science. 1991;251:802\u20134.","journal-title":"Science"},{"key":"211_CR34","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1006\/excr.1999.4686","volume":"253","author":"CV Dang","year":"1999","unstructured":"Dang CV, Resar LM, Emison E, et al. Function of the c-Myc oncogenic transcription factor. Exp Cell Res. 1999;253:63\u201377.","journal-title":"Exp Cell Res"},{"key":"211_CR35","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1046\/j.1440-1827.2000.01117.x","volume":"50","author":"H Yokozaki","year":"2000","unstructured":"Yokozaki H. Molecular characteristics of eight gastric cancer cell lines established in Japan. Pathol Int. 2000;50:767\u201377.","journal-title":"Pathol Int"},{"key":"211_CR36","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1038\/nature01646","volume":"423","author":"K Takahashi","year":"2003","unstructured":"Takahashi K, Mitsui K, Yamanaka S. Role of ERas in promoting tumour-like properties in mouse embryonic stem cells. Nature. 2003;423:541\u20135.","journal-title":"Nature"},{"key":"211_CR37","doi-asserted-by":"publisher","first-page":"997","DOI":"10.3892\/ijo_00000414","volume":"35","author":"M Yashiro","year":"2009","unstructured":"Yashiro M, Yasuda K, Nishii T, et al. Epigenetic regulation of the embryonic oncogene ERas in gastric cancer cells. Int J Oncol. 2009;35:997\u20131003.","journal-title":"Int J Oncol"},{"key":"211_CR38","first-page":"2189","volume":"29","author":"R Kaizaki","year":"2009","unstructured":"Kaizaki R, Yashiro M, Shinto O, et al. Expression of ERas oncogene in gastric carcinoma. Anticancer Res. 2009;29:2189\u201393.","journal-title":"Anticancer Res"},{"key":"211_CR39","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1111\/j.1349-7006.1996.tb02106.x","volume":"87","author":"Y Akama","year":"1996","unstructured":"Akama Y, Yasui W, Kuniyasu H, et al. Genetic status and expression of the cyclin-dependent kinase inhibitors in human gastric carcinoma cell lines. Jpn J Cancer Res. 1996;87:824\u201330.","journal-title":"Jpn J Cancer Res"},{"key":"211_CR40","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1002\/ijc.2910530108","volume":"53","author":"W Yasui","year":"1993","unstructured":"Yasui W, Ayhan A, Kitadai Y, et al. Increased expression of p34cdc2 and its kinase activity in human gastric and colonic carcinomas. Int J Cancer. 1993;53:36\u201341.","journal-title":"Int J Cancer"},{"key":"211_CR41","doi-asserted-by":"publisher","first-page":"14","DOI":"10.2353\/ajpath.2008.070942","volume":"173","author":"MR Schneider","year":"2008","unstructured":"Schneider MR, Werner S, Paus R, Wolf E. Beyond wavy hairs: the epidermal growth factor receptor and its ligands in skin biology and pathology. Am J Pathol. 2008;173:14\u201324.","journal-title":"Am J Pathol"},{"key":"211_CR42","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1038\/sj.onc.1206256","volume":"22","author":"M Kobayashi","year":"2003","unstructured":"Kobayashi M, Iwamatsu A, Shinohara-Kanda A, Ihara S, Fukui Y. Activation of ErbB3-PI3-kinase pathway is correlated with malignant phenotypes of adenocarcinomas. Oncogene. 2003;22:1294\u2013301.","journal-title":"Oncogene"},{"key":"211_CR43","doi-asserted-by":"publisher","first-page":"e0170298","DOI":"10.1371\/journal.pone.0170298","volume":"12","author":"X Shan","year":"2017","unstructured":"Shan X, Wen W, Zhu D, et al. miR 1296-5p inhibits the migration and invasion of gastric cancer cells by repressing ERBB2 expression. PLoS One. 2017;12:e0170298.","journal-title":"PLoS One"},{"key":"211_CR44","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1038\/bjc.1994.147","volume":"69","author":"K Mahara","year":"1994","unstructured":"Mahara K, Kato J, Terui T, et al. Transforming growth factor beta 1 secreted from scirrhous gastric cancer cells is associated with excess collagen deposition in the tissue. Br J Cancer. 1994;69:777\u201383.","journal-title":"Br J Cancer"},{"key":"211_CR45","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1038\/sj.bjc.6605561","volume":"102","author":"O Shinto","year":"2010","unstructured":"Shinto O, Yashiro M, Kawajiri H, et al. Inhibitory effect of a TGFbeta receptor type-I inhibitor, Ki26894, on invasiveness of scirrhous gastric cancer cells. Br J Cancer. 2010;102:844\u201351.","journal-title":"Br J Cancer"},{"key":"211_CR46","first-page":"1061","volume":"12","author":"Y Shitara","year":"1998","unstructured":"Shitara Y, Yokozaki H, Yasui W, Takenoshita S, Nagamachi Y, Tahara E. Mutation of the transforming growth factor-beta type II receptor gene is a rare event in human sporadic gastric carcinomas. Int J Oncol. 1998;12:1061\u20135.","journal-title":"Int J Oncol"},{"key":"211_CR47","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1093\/jnci\/djp058","volume":"101","author":"A Komuro","year":"2009","unstructured":"Komuro A, Yashiro M, Iwata C, et al. Diffuse-type gastric carcinoma: progression, angiogenesis, and transforming growth factor beta signaling. J Natl Cancer Inst. 2009;101:592\u2013604.","journal-title":"J Natl Cancer Inst"},{"key":"211_CR48","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1038\/nri887","volume":"2","author":"A Richmond","year":"2002","unstructured":"Richmond A. Nf-kappa B, chemokine gene transcription and tumour growth. Nat Rev Immunol. 2002;2:664\u201374.","journal-title":"Nat Rev Immunol"},{"key":"211_CR49","doi-asserted-by":"publisher","first-page":"1858","DOI":"10.1073\/pnas.91.5.1858","volume":"91","author":"T Oda","year":"1994","unstructured":"Oda T, Kanai Y, Oyama T, et al. E-cadherin gene mutations in human gastric carcinoma cell lines. Proc Natl Acad Sci USA. 1994;91:1858\u201362.","journal-title":"Proc Natl Acad Sci USA"},{"key":"211_CR50","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1128\/MCB.15.3.1175","volume":"15","author":"J Kawanishi","year":"1995","unstructured":"Kawanishi J, Kato J, Sasaki K, Fujii S, Watanabe N, Niitsu Y. Loss of E-cadherin-dependent cell-cell adhesion due to mutation of the beta-catenin gene in a human cancer cell line, HSC-39. Mol Cell Biol. 1995;15:1175\u201381.","journal-title":"Mol Cell Biol"},{"key":"211_CR51","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1038\/bjc.2012.107","volume":"106","author":"T Matsuoka","year":"2012","unstructured":"Matsuoka T, Yashiro M, Nishioka N, Hirakawa K, Olden K, Roberts JD. PI3K\/Akt signalling is required for the attachment and spreading, and growth in vivo of metastatic scirrhous gastric carcinoma. Br J Cancer. 2012;106:1535\u201342.","journal-title":"Br J Cancer"},{"key":"211_CR52","first-page":"293","volume":"17","author":"T Nakashio","year":"1997","unstructured":"Nakashio T, Narita T, Sato M, et al. The association of metastasis with the expression of adhesion molecules in cell lines derived from human gastric cancer. Anticancer Res. 1997;17:293\u20139.","journal-title":"Anticancer Res"},{"key":"211_CR53","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1038\/nrc1877","volume":"6","author":"R Kalluri","year":"2006","unstructured":"Kalluri R, Zeisberg M. Fibroblasts in cancer. Nat Rev Cancer. 2006;6:392\u2013401.","journal-title":"Nat Rev Cancer"},{"key":"211_CR54","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1111\/cas.12329","volume":"105","author":"Y Naito","year":"2014","unstructured":"Naito Y, Sakamoto N, Oue N, et al. MicroRNA-143 regulates collagen type III expression in stromal fibroblasts of scirrhous type gastric cancer. Cancer Sci. 2014;105:228\u201335.","journal-title":"Cancer Sci"},{"key":"211_CR55","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.3892\/ijmm.2015.2337","volume":"36","author":"L Wu","year":"2015","unstructured":"Wu L, Zhu Y. The function and mechanisms of action of LOXL2 in cancer (review). Int J Mol Med. 2015;36:1200\u20134.","journal-title":"Int J Mol Med"},{"key":"211_CR56","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.canlet.2014.08.014","volume":"354","author":"H Kasashima","year":"2014","unstructured":"Kasashima H, Yashiro M, Kinoshita H, et al. Lysyl oxidase-like 2 (LOXL2) from stromal fibroblasts stimulates the progression of gastric cancer. Cancer Lett. 2014;354:438\u201346.","journal-title":"Cancer Lett"},{"key":"211_CR57","doi-asserted-by":"publisher","first-page":"1588","DOI":"10.2353\/ajpath.2009.080545","volume":"174","author":"MW Klymkowsky","year":"2009","unstructured":"Klymkowsky MW, Savagner P. Epithelial-mesenchymal transition: a cancer researcher\u2019s conceptual friend and foe. Am J Pathol. 2009;174:1588\u201393.","journal-title":"Am J Pathol"},{"key":"211_CR58","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1172\/JCI39104","volume":"119","author":"R Kalluri","year":"2009","unstructured":"Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest. 2009;119:1420\u20138.","journal-title":"J Clin Invest"},{"key":"211_CR59","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.3892\/ijo.27.6.1677","volume":"27","author":"M Katoh","year":"2005","unstructured":"Katoh M. Epithelial-mesenchymal transition in gastric cancer (review). Int J Oncol. 2005;27:1677\u201383.","journal-title":"Int J Oncol"},{"key":"211_CR60","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1242\/jcs.114.15.2713","volume":"114","author":"AJ Ridley","year":"2001","unstructured":"Ridley AJ. Rho GTPases and cell migration. J Cell Sci. 2001;114:2713\u201322.","journal-title":"J Cell Sci"},{"key":"211_CR61","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1007\/s10585-011-9396-6","volume":"28","author":"T Matsuoka","year":"2011","unstructured":"Matsuoka T, Yashiro M, Kato Y, Shinto O, Kashiwagi S, Hirakawa K. RhoA\/ROCK signaling mediates plasticity of scirrhous gastric carcinoma motility. Clin Exp Metastasis. 2011;28:627\u201336.","journal-title":"Clin Exp Metastasis"},{"key":"211_CR62","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1038\/nature03096","volume":"432","author":"NA Bhowmick","year":"2004","unstructured":"Bhowmick NA, Neilson EG, Moses HL. Stromal fibroblasts in cancer initiation and progression. Nature. 2004;432:332\u20137.","journal-title":"Nature"},{"key":"211_CR63","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1111\/j.1349-7006.1994.tb02963.x","volume":"85","author":"M Yashiro","year":"1994","unstructured":"Yashiro M, Chung YS, Sowa M. Role of orthotopic fibroblasts in the development of scirrhous gastric carcinoma. Jpn J Cancer Res. 1994;85:883\u20136.","journal-title":"Jpn J Cancer Res"},{"key":"211_CR64","doi-asserted-by":"publisher","first-page":"1530","DOI":"10.1053\/j.gastro.2006.08.030","volume":"131","author":"K Nakamura","year":"2006","unstructured":"Nakamura K, Yashiro M, Matsuoka T, et al. A novel molecular targeting compound as K-samII\/FGF-R2 phosphorylation inhibitor, Ki23057, for Scirrhous gastric cancer. Gastroenterology. 2006;131:1530\u201341.","journal-title":"Gastroenterology"},{"key":"211_CR65","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1111\/j.1349-7006.2012.02209.x","volume":"103","author":"Y Fuyuhiro","year":"2012","unstructured":"Fuyuhiro Y, Yashiro M, Noda S, et al. Cancer-associated orthotopic myofibroblasts stimulates the motility of gastric carcinoma cells. Cancer Sci. 2012;103:797\u2013805.","journal-title":"Cancer Sci"},{"key":"211_CR66","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1038\/sj.bjc.6605309","volume":"101","author":"S Semba","year":"2009","unstructured":"Semba S, Kodama Y, Ohnuma K, et al. Direct cancer-stromal interaction increases fibroblast proliferation and enhances invasive properties of scirrhous-type gastric carcinoma cells. Br J Cancer. 2009;101:1365\u201373.","journal-title":"Br J Cancer"},{"key":"211_CR67","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1002\/ijc.28520","volume":"134","author":"T Hasegawa","year":"2014","unstructured":"Hasegawa T, Yashiro M, Nishii T, et al. Cancer-associated fibroblasts might sustain the stemness of scirrhous gastric cancer cells via transforming growth factor-beta signaling. Int J Cancer. 2014;134:1785\u201395.","journal-title":"Int J Cancer"},{"key":"211_CR68","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1038\/bjc.2011.330","volume":"105","author":"Y Fuyuhiro","year":"2011","unstructured":"Fuyuhiro Y, Yashiro M, Noda S, et al. Upregulation of cancer-associated myofibroblasts by TGF-beta from scirrhous gastric carcinoma cells. Br J Cancer. 2011;105:996\u20131001.","journal-title":"Br J Cancer"},{"key":"211_CR69","first-page":"3550","volume":"51","author":"H Ura","year":"1991","unstructured":"Ura H, Obara T, Yokota K, Shibata Y, Okamura K, Namiki M. Effects of transforming growth factor-beta released from gastric carcinoma cells on the contraction of collagen-matrix gels containing fibroblasts. Cancer Res. 1991;51:3550\u20134.","journal-title":"Cancer Res"},{"key":"211_CR70","doi-asserted-by":"publisher","first-page":"e85485","DOI":"10.1371\/journal.pone.0085485","volume":"9","author":"H Yamaguchi","year":"2014","unstructured":"Yamaguchi H, Yoshida N, Takanashi M, et al. Stromal fibroblasts mediate extracellular matrix remodeling and invasion of scirrhous gastric carcinoma cells. PLoS One. 2014;9:e85485.","journal-title":"PLoS One"},{"key":"211_CR71","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.1126\/science.1099513","volume":"306","author":"J Houghton","year":"2004","unstructured":"Houghton J, Stoicov C, Nomura S, et al. Gastric cancer originating from bone marrow-derived cells. Science. 2004;306:1568\u201371.","journal-title":"Science"},{"key":"211_CR72","doi-asserted-by":"publisher","first-page":"3028","DOI":"10.1016\/j.ajpath.2016.07.024","volume":"186","author":"H Kasashima","year":"2016","unstructured":"Kasashima H, Yashiro M, Nakamae H, et al. CXCL1-chemokine (C-X-C Motif) receptor 2 signaling stimulates the recruitment of bone marrow-derived mesenchymal cells into diffuse-type gastric cancer stroma. Am J Pathol. 2016;186:3028\u201339.","journal-title":"Am J Pathol"},{"key":"211_CR73","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1038\/nri3902","volume":"15","author":"SJ Turley","year":"2015","unstructured":"Turley SJ, Cremasco V, Astarita JL. Immunological hallmarks of stromal cells in the tumour microenvironment. Nat Rev Immunol. 2015;15:669\u201382.","journal-title":"Nat Rev Immunol"},{"key":"211_CR74","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1111\/imm.12117","volume":"140","author":"M Collin","year":"2013","unstructured":"Collin M, McGovern N, Haniffa M. Human dendritic cell subsets. Immunology. 2013;140:22\u201330.","journal-title":"Immunology"},{"key":"211_CR75","first-page":"1637","volume":"24","author":"H Tanaka","year":"2010","unstructured":"Tanaka H, Shinto O, Yashiro M, et al. Transforming growth factor beta signaling inhibitor, SB-431542, induces maturation of dendritic cells and enhances anti-tumor activity. Oncol Rep. 2010;24:1637\u201343.","journal-title":"Oncol Rep"},{"key":"211_CR76","doi-asserted-by":"publisher","first-page":"1668","DOI":"10.1038\/bjc.2012.141","volume":"106","author":"M Yoshii","year":"2012","unstructured":"Yoshii M, Tanaka H, Ohira M, et al. Expression of Forkhead box P3 in tumour cells causes immunoregulatory function of signet ring cell carcinoma of the stomach. Br J Cancer. 2012;106:1668\u201374.","journal-title":"Br J Cancer"},{"key":"211_CR77","doi-asserted-by":"publisher","first-page":"75","DOI":"10.3389\/fphys.2014.00075","volume":"5","author":"V Riabov","year":"2014","unstructured":"Riabov V, Gudima A, Wang N, Mickley A, Orekhov A, Kzhyshkowska J. Role of tumor associated macrophages in tumor angiogenesis and lymphangiogenesis. Front Physiol. 2014;5:75.","journal-title":"Front Physiol"},{"key":"211_CR78","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1111\/cas.12977","volume":"107","author":"Y Tauchi","year":"2016","unstructured":"Tauchi Y, Tanaka H, Kumamoto K, et al. Tumor-associated macrophages induce capillary morphogenesis of lymphatic endothelial cells derived from human gastric cancer. Cancer Sci. 2016;107:1101\u20139.","journal-title":"Cancer Sci"},{"key":"211_CR79","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1136\/gutjnl-2011-300050","volume":"61","author":"S Shimada","year":"2012","unstructured":"Shimada S, Mimata A, Sekine M, et al. Synergistic tumour suppressor activity of E-cadherin and p53 in a conditional mouse model for metastatic diffuse-type gastric cancer. Gut. 2012;61:344\u201353.","journal-title":"Gut"},{"key":"211_CR80","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1158\/1541-7786.MCR-14-0192-T","volume":"12","author":"JW Park","year":"2014","unstructured":"Park JW, Jang SH, Park DM, et al. Cooperativity of E-cadherin and Smad4 loss to promote diffuse-type gastric adenocarcinoma and metastasis. Mol Cancer Res. 2014;12:1088\u201399.","journal-title":"Mol Cancer Res"},{"key":"211_CR81","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1111\/j.1349-7006.2011.01890.x","volume":"102","author":"A Mimata","year":"2011","unstructured":"Mimata A, Fukamachi H, Eishi Y, Yuasa Y. Loss of E-cadherin in mouse gastric epithelial cells induces signet ring-like cells, a possible precursor lesion of diffuse gastric cancer. Cancer Sci. 2011;102:942\u201350.","journal-title":"Cancer Sci"},{"key":"211_CR82","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/BF00049529","volume":"5","author":"IJ Fidler","year":"1986","unstructured":"Fidler IJ. Rationale and methods for the use of nude mice to study the biology and therapy of human cancer metastasis. Cancer Metastasis Rev. 1986;5:29\u201349.","journal-title":"Cancer Metastasis Rev"},{"key":"211_CR83","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1111\/j.1349-7006.1996.tb03138.x","volume":"87","author":"S Nishimura","year":"1996","unstructured":"Nishimura S, Chung YS, Yashiro M, Inoue T, Sowa M. CD44H plays an important role in peritoneal dissemination of scirrhous gastric cancer cells. Jpn J Cancer Res. 1996;87:1235\u201344.","journal-title":"Jpn J Cancer Res"},{"key":"211_CR84","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1002\/cam4.1274","volume":"7","author":"N Charalampakis","year":"2018","unstructured":"Charalampakis N, Economopoulou P, Kotsantis I, et al. Medical management of gastric cancer: a 2017 update. Cancer Med. 2018;7:123\u201333.","journal-title":"Cancer Med"},{"key":"211_CR85","first-page":"895","volume":"17","author":"M Yashiro","year":"1997","unstructured":"Yashiro M, Chung YS, Sowa M. Tranilast [N-(3,4-dimethoxycinnamoyl) anthranilic acid] down-regulates the growth of scirrhous gastric cancer. Anticancer Res. 1997;17:895\u2013900.","journal-title":"Anticancer Res"},{"key":"211_CR86","doi-asserted-by":"publisher","first-page":"2850","DOI":"10.1158\/1078-0432.CCR-07-1634","volume":"14","author":"H Kawajiri","year":"2008","unstructured":"Kawajiri H, Yashiro M, Shinto O, et al. A novel transforming growth factor beta receptor kinase inhibitor, A-77, prevents the peritoneal dissemination of scirrhous gastric carcinoma. Clin Cancer Res. 2008;14:2850\u201360.","journal-title":"Clin Cancer Res"},{"key":"211_CR87","doi-asserted-by":"publisher","first-page":"979","DOI":"10.21873\/anticanres.11407","volume":"37","author":"X Dai","year":"2017","unstructured":"Dai X, Liu D, Liu M, et al. Anti-metastatic efficacy of traditional chinese medicine (TCM) ginsenoside conjugated to a VEFGR-3 antibody on human gastric cancer in an orthotopic mouse model. Anticancer Res. 2017;37:979\u201386.","journal-title":"Anticancer Res"},{"key":"211_CR88","first-page":"637","volume":"27","author":"N Ohashi","year":"2005","unstructured":"Ohashi N, Kodera Y, Nakanishi H, et al. Efficacy of intraperitoneal chemotherapy with paclitaxel targeting peritoneal micrometastasis as revealed by GFP-tagged human gastric cancer cell lines in nude mice. Int J Oncol. 2005;27:637\u201344.","journal-title":"Int J Oncol"},{"key":"211_CR89","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1158\/1078-0432.CCR-05-1963","volume":"12","author":"H Yokoyama","year":"2006","unstructured":"Yokoyama H, Nakanishi H, Kodera Y, et al. Biological significance of isolated tumor cells and micrometastasis in lymph nodes evaluated using a green fluorescent protein-tagged human gastric cancer cell line. Clin Cancer Res. 2006;12:361\u20138.","journal-title":"Clin Cancer Res"},{"key":"211_CR90","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1016\/S0959-8049(98)00077-X","volume":"34","author":"Y Kato","year":"1998","unstructured":"Kato Y, Nagashima Y, Koshikawa N, Miyagi Y, Yasumitsu H, Miyazaki K. Production of trypsins by human gastric cancer cells correlates with their malignant phenotype. Eur J Cancer. 1998;34:1117\u201323.","journal-title":"Eur J Cancer"}],"container-title":["Human Cell"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13577-018-0211-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13577-018-0211-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13577-018-0211-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T00:15:17Z","timestamp":1751674517000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13577-018-0211-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,6]]},"references-count":90,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["211"],"URL":"https:\/\/doi.org\/10.1007\/s13577-018-0211-4","relation":{},"ISSN":["1749-0774"],"issn-type":[{"value":"1749-0774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,6]]},"assertion":[{"value":"15 March 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 May 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"There are not any financial or other interests with regard to the submitted manuscript that might be construed as a conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}