{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T05:59:08Z","timestamp":1767851948516,"version":"3.49.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T00:00:00Z","timestamp":1542067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Human Cell"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1007\/s13577-018-0221-2","type":"journal-article","created":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T12:04:47Z","timestamp":1542110687000},"page":"41-50","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["LRRC8A potentiates temozolomide sensitivity in glioma cells via activating mitochondria-dependent apoptotic pathway"],"prefix":"10.1007","volume":"32","author":[{"given":"Chao","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Longshuang","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaofei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeqian","family":"Ning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhibai","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,11,13]]},"reference":[{"issue":"4","key":"221_CR1","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1158\/1078-0432.CCR-12-3002","volume":"19","author":"H Ohgaki","year":"2013","unstructured":"Ohgaki H, Kleihues P. The Definition of Primary and Secondary Glioblastoma. Clin Cancer Res. 2013;19(4):764\u201372. \n                    https:\/\/doi.org\/10.1158\/1078-0432.Ccr-12-3002\n                    \n                  .","journal-title":"Clin Cancer Res"},{"issue":"3","key":"221_CR2","doi-asserted-by":"publisher","first-page":"166","DOI":"10.3322\/caac.20069","volume":"60","author":"EG Meir Van","year":"2010","unstructured":"Van Meir EG, Hadjipanayis CG, Norden AD, Shu HK, Wen PY, Olson JJ. Exciting New Advances in Neuro-oncology the avenue to a cure for malignant glioma. Ca Cancer J Clin. 2010;60(3):166\u201393.","journal-title":"Ca Cancer J Clin"},{"issue":"2","key":"221_CR3","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1038\/sj.onc.1209785","volume":"26","author":"WP Roos","year":"2007","unstructured":"Roos WP, Batista LF, Naumann SC, Wick W, Weller M, Menck CF, et al. Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanine. Oncogene. 2007;26(2):186\u201397. \n                    https:\/\/doi.org\/10.1038\/sj.onc.1209785\n                    \n                  .","journal-title":"Oncogene"},{"key":"221_CR4","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.pharmthera.2017.10.017","volume":"184","author":"S Hombach-Klonisch","year":"2018","unstructured":"Hombach-Klonisch S, Mehrpour M, Shojaei S, Harlos C, Pitz M, Hamai A, et al. Glioblastoma and chemoresistance to alkylating agents: Involvement of apoptosis, autophagy, and unfolded protein response. Pharmacol Ther. 2018;184:13\u201341. \n                    https:\/\/doi.org\/10.1016\/j.pharmthera.2017.10.017\n                    \n                  .","journal-title":"Pharmacol Ther"},{"issue":"2","key":"221_CR5","first-page":"172","volume":"1806","author":"B Koberle","year":"2010","unstructured":"Koberle B, Tomicic MT, Usanova S, Kaina B. Cisplatin resistance: Preclinical findings and clinical implications. Bba-Rev Cancer. 2010;1806(2):172\u201382.","journal-title":"Bba-Rev Cancer"},{"issue":"1","key":"221_CR6","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/nrm3722","volume":"15","author":"PE Czabotar","year":"2014","unstructured":"Czabotar PE, Lessene G, Strasser A, Adams JM. Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy. Nat Rev Mol Cell Biol. 2014;15(1):49\u201363. \n                    https:\/\/doi.org\/10.1038\/nrm3722\n                    \n                  .","journal-title":"Nat Rev Mol Cell Biol"},{"key":"221_CR7","doi-asserted-by":"crossref","unstructured":"Hoffmann EK, Lambert IH. Ion channels and transporters in the development of drug resistance in cancer cells. Philos T R Soc B. 2014;369(1638).","DOI":"10.1098\/rstb.2013.0109"},{"issue":"1","key":"221_CR8","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1152\/physrev.00037.2007","volume":"89","author":"EK Hoffmann","year":"2009","unstructured":"Hoffmann EK, Lambert IH, Pedersen SF. Physiology of cell volume regulation in vertebrates. Physiol Rev. 2009;89(1):193\u2013277.","journal-title":"Physiol Rev"},{"issue":"1","key":"221_CR9","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.drup.2010.12.002","volume":"14","author":"H Burger","year":"2011","unstructured":"Burger H, Loos WJ, Eechoute K, Verweij J, Mathijssen RHJ, Wiemer EAC. Drug transporters of platinum-based anticancer agents and their clinical significance. Drug Resist Update. 2011;14(1):22\u201334.","journal-title":"Drug Resist Update"},{"issue":"2","key":"221_CR10","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.cell.2014.03.024","volume":"157","author":"ZZ Qiu","year":"2014","unstructured":"Qiu ZZ, Dubin AE, Mathur J, Tu B, Reddy K, Miraglia LJ, et al. SWELL1, a plasma membrane protein, is an essential component of volume-regulated anion channel. Cell. 2014;157(2):447\u201358.","journal-title":"Cell"},{"issue":"1","key":"221_CR11","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1093\/cvr\/cvt156","volume":"100","author":"LY Zheng","year":"2013","unstructured":"Zheng LY, Li L, Ma MM, Liu Y, Wang GL, Tang YB, et al. Deficiency of volume-regulated ClC-3 chloride channel attenuates cerebrovascular remodelling in DOCA-salt hypertension. Cardiovasc Res. 2013;100(1):134\u201342. \n                    https:\/\/doi.org\/10.1093\/cvr\/cvt156\n                    \n                  .","journal-title":"Cardiovasc Res"},{"issue":"10","key":"221_CR12","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1007\/s10495-013-0881-z","volume":"18","author":"J Liu","year":"2013","unstructured":"Liu J, Zhang FF, Li L, Yang J, Liu J, Guan YY, et al. ClC-3 deficiency prevents apoptosis induced by angiotensin II in endothelial progenitor cells via inhibition of NADPH oxidase. Apoptosis. 2013;18(10):1262\u201373. \n                    https:\/\/doi.org\/10.1007\/s10495-013-0881-z\n                    \n                  .","journal-title":"Apoptosis"},{"issue":"2","key":"221_CR13","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.cell.2014.03.024","volume":"157","author":"Z Qiu","year":"2014","unstructured":"Qiu Z, Dubin AE, Mathur J, Tu B, Reddy K, Miraglia LJ, et al. SWELL1, a plasma membrane protein, is an essential component of volume-regulated anion channel. Cell. 2014;157(2):447\u201358. \n                    https:\/\/doi.org\/10.1016\/j.cell.2014.03.024\n                    \n                  .","journal-title":"Cell"},{"issue":"6184","key":"221_CR14","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1126\/science.1252826","volume":"344","author":"FK Voss","year":"2014","unstructured":"Voss FK, Ullrich F, Munch J, Lazarow K, Lutter D, Mah N, et al. Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC. Science. 2014;344(6184):634\u20138. \n                    https:\/\/doi.org\/10.1126\/science.1252826\n                    \n                  .","journal-title":"Science"},{"issue":"12","key":"221_CR15","doi-asserted-by":"publisher","first-page":"C1071-C80","DOI":"10.1152\/ajpcell.00274.2014","volume":"307","author":"BH Sorensen","year":"2014","unstructured":"Sorensen BH, Thorsteinsdottir UA, Lambert IH. Acquired cisplatin resistance in human ovarian A2780 cancer cells correlates with shift in taurine homeostasis and ability to volume regulate. Am J Physiol Cell Physiol. 2014;307(12):C1071-C80.","journal-title":"Am J Physiol Cell Physiol"},{"issue":"22","key":"221_CR16","doi-asserted-by":"publisher","first-page":"4855","DOI":"10.1113\/jphysiol.2014.278887","volume":"592","author":"MC Hyzinski-Garcia","year":"2014","unstructured":"Hyzinski-Garcia MC, Rudkouskaya A, Mongin AA. LRRC8A protein is indispensable for swelling-activated and ATP-induced release of excitatory amino acids in rat astrocytes. J Physiol Lond. 2014;592(22):4855\u201362.","journal-title":"J Physiol Lond"},{"issue":"11","key":"221_CR17","doi-asserted-by":"publisher","first-page":"C857-73","DOI":"10.1152\/ajpcell.00256.2015","volume":"310","author":"BH Sorensen","year":"2016","unstructured":"Sorensen BH, Nielsen D, Thorsteinsdottir UA, Hoffmann EK, Lambert IH. Downregulation of LRRC8A protects human ovarian and alveolar carcinoma cells against Cisplatin-induced expression of p53, MDM2, p21Waf1\/Cip1, and Caspase-9\/-3 activation. Am J Physiol Cell Physiol. 2016;310(11):C857-73. \n                    https:\/\/doi.org\/10.1152\/ajpcell.00256.2015\n                    \n                  .","journal-title":"Am J Physiol Cell Physiol"},{"key":"221_CR18","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.jinorgbio.2016.04.004","volume":"160","author":"BH Sorensen","year":"2016","unstructured":"Sorensen BH, Dam CS, Sturup S, Lambert IH. Dual role of LRRC8A-containing transporters on cisplatin resistance in human ovarian cancer cells. J Inorg Biochem. 2016;160:287\u201395. \n                    https:\/\/doi.org\/10.1016\/j.jinorgbio.2016.04.004\n                    \n                  .","journal-title":"J Inorg Biochem"},{"issue":"1","key":"221_CR19","doi-asserted-by":"publisher","first-page":"C14","DOI":"10.1152\/ajpcell.00654.2008","volume":"298","author":"KA Poulsen","year":"2010","unstructured":"Poulsen KA, Andersen EC, Hansen CF, Klausen TK, Hougaard C, Lambert IH, et al. Deregulation of apoptotic volume decrease and ionic movements in multidrug-resistant tumor cells: role of chloride channels. Am J Physiol-Cell Physiol. 2010;298(1):C14\u201325.","journal-title":"Am J Physiol-Cell Physiol"},{"issue":"6","key":"221_CR20","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1038\/s41419-018-0677-8","volume":"9","author":"XY Liu","year":"2018","unstructured":"Liu XY, Zhang FR, Shang JY, Liu YY, Lv XF, Yuan JN, et al. Renal inhibition of miR-181a ameliorates 5-fluorouracil-induced mesangial cell apoptosis and nephrotoxicity. Cell Death Dis. 2018;9(6):610. \n                    https:\/\/doi.org\/10.1038\/s41419-018-0677-8\n                    \n                  .","journal-title":"Cell Death Dis"},{"issue":"5","key":"221_CR21","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1161\/HYPERTENSIONAHA.112.198648","volume":"60","author":"H Yang","year":"2012","unstructured":"Yang H, Huang LY, Zeng DY, Huang EW, Liang SJ, Tang YB, et al. Decrease of intracellular chloride concentration promotes endothelial cell inflammation by activating nuclear factor-kappaB pathway. Hypertension. 2012;60(5):1287\u201393. \n                    https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.112.198648\n                    \n                  .","journal-title":"Hypertension"},{"issue":"9","key":"221_CR22","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1038\/nrm2952","volume":"11","author":"SW Tait","year":"2010","unstructured":"Tait SW, Green DR. Mitochondria and cell death: outer membrane permeabilization and beyond. Nat Rev Mol Cell Biol. 2010;11(9):621\u201332. \n                    https:\/\/doi.org\/10.1038\/nrm2952\n                    \n                  .","journal-title":"Nat Rev Mol Cell Biol"},{"key":"221_CR23","doi-asserted-by":"publisher","first-page":"e909","DOI":"10.1038\/cddis.2013.436","volume":"4","author":"M Kvansakul","year":"2013","unstructured":"Kvansakul M, Hinds MG. Structural biology of the Bcl-2 family and its mimicry by viral proteins. Cell Death Dis. 2013;4:e909. \n                    https:\/\/doi.org\/10.1038\/cddis.2013.436\n                    \n                  .","journal-title":"Cell Death Dis"},{"issue":"10","key":"221_CR24","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1136\/gutjnl-2013-305168","volume":"63","author":"LY Huang","year":"2014","unstructured":"Huang LY, He Q, Liang SJ, Su YX, Xiong LX, Wu QQ, et al. ClC-3 chloride channel\/antiporter defect contributes to inflammatory bowel disease in humans and mice. Gut. 2014;63(10):1587\u201395. \n                    https:\/\/doi.org\/10.1136\/gutjnl-2013-305168\n                    \n                  .","journal-title":"Gut"},{"issue":"6","key":"221_CR25","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/j.jacc.2015.06.007","volume":"66","author":"JL Grodin","year":"2015","unstructured":"Grodin JL, Simon J, Hachamovitch R, Wu Y, Jackson G, Halkar M, et al. Prognostic role of serum chloride levels in acute decompensated heart failure. J Am Coll Cardiol. 2015;66(6):659\u201366. \n                    https:\/\/doi.org\/10.1016\/j.jacc.2015.06.007\n                    \n                  .","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"221_CR26","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1253\/circj.CJ-15-1209","volume":"80","author":"QQ Wu","year":"2016","unstructured":"Wu QQ, Liu XY, Xiong LX, Shang JY, Mai XY, Pang RP, et al. Reduction of intracellular chloride concentration promotes foam cell formation. Circ J. 2016;80(4):1024\u201333. \n                    https:\/\/doi.org\/10.1253\/circj.CJ-15-1209\n                    \n                  .","journal-title":"Circ J"},{"key":"221_CR27","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.yjmcc.2015.09.002","volume":"87","author":"J Tao","year":"2015","unstructured":"Tao J, Liu CZ, Yang J, Xie ZZ, Ma MM, Li XY, et al. ClC-3 deficiency prevents atherosclerotic lesion development in ApoE-\/- mice. J Mol Cell Cardiol. 2015;87:237\u201347. \n                    https:\/\/doi.org\/10.1016\/j.yjmcc.2015.09.002\n                    \n                  .","journal-title":"J Mol Cell Cardiol"},{"issue":"24","key":"221_CR28","doi-asserted-by":"publisher","first-page":"2993","DOI":"10.15252\/embj.201592409","volume":"34","author":"R Planells-Cases","year":"2015","unstructured":"Planells-Cases R, Lutter D, Guyader C, Gerhards NM, Ullrich F, Elger DA, et al. Subunit composition of VRAC channels determines substrate specificity and cellular resistance to Pt-based anti-cancer drugs. Embo J. 2015;34(24):2993\u20133008.","journal-title":"Embo J"},{"issue":"5","key":"221_CR29","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1111\/jcmm.13029","volume":"21","author":"BD Tang","year":"2017","unstructured":"Tang BD, Xia X, Lv XF, Yu BX, Yuan JN, Mai XY, et al. Inhibition of Orai1-mediated Ca(2+) entry enhances chemosensitivity of HepG2 hepatocarcinoma cells to 5-fluorouracil. J Cell Mol Med. 2017;21(5):904\u201315. \n                    https:\/\/doi.org\/10.1111\/jcmm.13029\n                    \n                  .","journal-title":"J Cell Mol Med"},{"issue":"2","key":"221_CR30","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1038\/s41419-017-0059-7","volume":"9","author":"G Mattia","year":"2018","unstructured":"Mattia G, Puglisi R, Ascione B, Malorni W, Care A, Matarrese P. Cell death-based treatments of melanoma:conventional treatments and new therapeutic strategies. Cell Death Dis. 2018;9(2):112. \n                    https:\/\/doi.org\/10.1038\/s41419-017-0059-7\n                    \n                  .","journal-title":"Cell Death Dis"},{"key":"221_CR31","doi-asserted-by":"publisher","first-page":"e1675","DOI":"10.1038\/cddis.2015.20","volume":"6","author":"V Labi","year":"2015","unstructured":"Labi V, Erlacher M. How cell death shapes cancer. Cell Death Dis. 2015;6:e1675. \n                    https:\/\/doi.org\/10.1038\/cddis.2015.20\n                    \n                  .","journal-title":"Cell Death Dis"},{"key":"221_CR32","doi-asserted-by":"publisher","first-page":"e1257","DOI":"10.1038\/cddis.2013.428","volume":"5","author":"L Galluzzi","year":"2014","unstructured":"Galluzzi L, Vitale I, Michels J, Brenner C, Szabadkai G, Harel-Bellan A, et al. Systems biology of cisplatin resistance: past, present and future. Cell Death Dis. 2014;5:e1257. \n                    https:\/\/doi.org\/10.1038\/cddis.2013.428\n                    \n                  .","journal-title":"Cell Death Dis"},{"issue":"8","key":"221_CR33","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1007\/s10495-009-0341-y","volume":"14","author":"VI Rasheva","year":"2009","unstructured":"Rasheva VI, Domingos PM. Cellular responses to endoplasmic reticulum stress and apoptosis. Apoptosis. 2009;14(8):996\u20131007. \n                    https:\/\/doi.org\/10.1007\/s10495-009-0341-y\n                    \n                  .","journal-title":"Apoptosis"},{"issue":"3","key":"221_CR34","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1038\/s41419-017-0237-7","volume":"9","author":"D Martinvalet","year":"2018","unstructured":"Martinvalet D. The role of the mitochondria and the endoplasmic reticulum contact sites in the development of the immune responses. Cell Death Dis. 2018;9(3):336. \n                    https:\/\/doi.org\/10.1038\/s41419-017-0237-7\n                    \n                  .","journal-title":"Cell Death Dis"}],"container-title":["Human Cell"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13577-018-0221-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13577-018-0221-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13577-018-0221-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T00:36:59Z","timestamp":1573605419000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13577-018-0221-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,13]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["221"],"URL":"https:\/\/doi.org\/10.1007\/s13577-018-0221-2","relation":{},"ISSN":["1749-0774"],"issn-type":[{"value":"1749-0774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,13]]},"assertion":[{"value":"27 June 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 November 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}