{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T21:12:59Z","timestamp":1768079579221,"version":"3.49.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,7,19]],"date-time":"2020-07-19T00:00:00Z","timestamp":1595116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,7,19]],"date-time":"2020-07-19T00:00:00Z","timestamp":1595116800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100007338","name":"All-India Institute of Medical Sciences","doi-asserted-by":"publisher","award":["Intramural research grant (IRG)"],"award-info":[{"award-number":["Intramural research grant (IRG)"]}],"id":[{"id":"10.13039\/501100007338","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Human Cell"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1007\/s13577-020-00397-9","type":"journal-article","created":{"date-parts":[[2020,7,19]],"date-time":"2020-07-19T07:04:30Z","timestamp":1595142270000},"page":"1264-1272","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Prognostic impact of HERC2 protein and pink-eyed dilution protein in uveal melanoma"],"prefix":"10.1007","volume":"33","author":[{"given":"Seema","family":"Kashyap","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mithalesh Kumar","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayanti","family":"Jha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lata","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neelam","family":"Pushker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seema","family":"Sen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pradeep","family":"Venkatesh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachna","family":"Meel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neiwete","family":"Lomi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,7,19]]},"reference":[{"key":"397_CR1","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/s40487-018-0056-8","volume":"6","author":"S Manni","year":"2018","unstructured":"Manni S, Durairaj P, Yeung J. Uveal melanoma: a review of the literature. Oncol Ther. 2018;6:87\u2013104.","journal-title":"Oncol Ther"},{"key":"397_CR2","first-page":"3","volume":"34","author":"JH Francis","year":"2016","unstructured":"Francis JH, Shoushtari AN, Barker CA, Abramson DH. Uveal melanoma: diagnosis, prognosis and current treatments for primary and metastatic disease. Melanoma Lett. 2016;34:3.","journal-title":"Melanoma Lett"},{"key":"397_CR3","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1016\/j.ajo.2005.05.034","volume":"140","author":"DN Hu","year":"2005","unstructured":"Hu DN, Yu GP, McCormick SA, Schneider S, Finger PT. Population-based incidence of uveal melanoma in various races and ethnic groups. Am J Ophthalmol. 2005;140:612\u20137.","journal-title":"Am J Ophthalmol"},{"key":"397_CR4","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1136\/bjo.88.1.39","volume":"88","author":"JW Harbour","year":"2004","unstructured":"Harbour JW, Brantley MA, Hollingsworth H, Gordon M. Association between choroidal pigmentation and posterior uveal melanoma in a white population. Br J Ophthalmol. 2004;88:39\u2013433.","journal-title":"Br J Ophthalmol"},{"key":"397_CR5","doi-asserted-by":"publisher","first-page":"17844","DOI":"10.18632\/oncotarget.7528","volume":"7","author":"AA Bro\u017cyna","year":"2016","unstructured":"Bro\u017cyna AA, Jozwicki W, Roszkowski K, Filipiak J, Slominsk AT. Melanin content in melanoma metastases affects the outcome of radiotherapy. Oncotarget. 2016;7:17844\u201353.","journal-title":"Oncotarget"},{"key":"397_CR6","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1152\/physrev.00044.2003","volume":"84","author":"A Slominski","year":"2004","unstructured":"Slominski A, Tobin DJ, Shibahara S, Wortsman J. Melanin pigmentation in mammalian skin and its hormonal regulation. Physiol Rev. 2004;84:1155\u2013228.","journal-title":"Physiol Rev"},{"key":"397_CR7","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.preteyeres.2012.10.002","volume":"33","author":"M Mochizuki","year":"2013","unstructured":"Mochizuki M, Sugita S, Kamoi K. Immunological homeostasis of the eye. Progress Retinal Eye Res. 2013;33:10\u201327.","journal-title":"Progress Retinal Eye Res"},{"key":"397_CR8","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1038\/eye.2012.253","volume":"27","author":"IH Bronkhorst","year":"2013","unstructured":"Bronkhorst IH, Jager MJ. Inflammation in uveal melanoma. Eye. 2013;27:217\u201323.","journal-title":"Eye"},{"key":"397_CR9","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1016\/S0002-9394(98)00040-3","volume":"125","author":"COMS report no. 6","year":"1998","unstructured":"COMS report no. 6. Histopathologic characteristics of uveal melanomas in eyes enucleated from the Collaborative Ocular Melanoma Study. Am J Ophthalmol. 1998;125:745\u201366.","journal-title":"Am J Ophthalmol"},{"key":"397_CR10","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1046\/j.1523-1747.2001.01224.x","volume":"116","author":"NF Box","year":"2001","unstructured":"Box NF, Chen W, Sturm RA, et al. Melanocortin-1 receptor genotype is a risk factor for basal and squamous cell carcinoma. J Investig Dermatol. 2001;116:224\u20139.","journal-title":"J Investig Dermatol"},{"key":"397_CR11","doi-asserted-by":"publisher","first-page":"110","DOI":"10.4103\/0301-4738.154373","volume":"63","author":"P Rishi","year":"2015","unstructured":"Rishi P, Koundanya V, Shields CL. Using risk factors for detection and prognostication of uveal melanoma. Indian J Ophthalmol. 2015;63:110\u20136.","journal-title":"Indian J Ophthalmol"},{"issue":"82","key":"397_CR12","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.ajhg.2007.10.003","volume":"8","author":"M Kayser","year":"2008","unstructured":"Kayser M, Liu F, Janssens AC, Rivadeneira F, Lao O, van Duijn K, Vermeulen M, Arp P, Jhamai MM, van IJcken WF, den Dunnen JT. Three genome-wide association studies and a linkage analysis identify HERC2 as a human iris color gene. Am J Hum Genet. 2008;8(82):411\u201323.","journal-title":"Am J Hum Genet"},{"key":"397_CR13","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1034\/j.1600-0749.2001.140203.x","volume":"14","author":"MH Brilliant","year":"2001","unstructured":"Brilliant MH. The mouse p (pink-eyed dilution) and human P genes, oculocutaneous albinism type 2 (OCA2), and melanosomal pH. Pigment Cell Res. 2001;14:86\u201393.","journal-title":"Pigment Cell Res"},{"key":"397_CR14","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1007\/s00439-007-0460-x","volume":"123","author":"H Eiberg","year":"2008","unstructured":"Eiberg H, Troelsen J, Nielsen M, et al. Blue eye color in humans may be caused by a perfectly associated founder mutation in a regulatory element located within the HERC2 gene inhibiting OCA2 expression. Hum Genet. 2008;123:177\u201387.","journal-title":"Hum Genet"},{"key":"397_CR15","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1101\/gr.128652.111","volume":"22","author":"M Visser","year":"2012","unstructured":"Visser M, Kayser M, Palstra RJ. HERC2 rs12913832 modulates human pigmentation by attenuating chromatin-loop formation between a long-range enhancer and the OCA2 promoter. Genome Res. 2012;22:446\u201355.","journal-title":"Genome Res"},{"key":"397_CR16","doi-asserted-by":"publisher","first-page":"31191","DOI":"10.1038\/srep31191","volume":"6","author":"R Ferguson","year":"2016","unstructured":"Ferguson R, Vogelsang M, Ucisik-Akkaya E, et al. Genetic markers of pigmentation are novel risk loci for uveal melanoma. Sci Rep. 2016;6:31191.","journal-title":"Sci Rep"},{"key":"397_CR17","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1001\/jamaophthalmol.2014.5395","volume":"133","author":"ER Simpson","year":"2015","unstructured":"Simpson ER, Gallie BL, Saakyan S, et al. International validation of the American Joint Committee on Cancer\u2019s 7th edition classification of uveal melanoma. JAMA Ophthalmol. 2015;133:376\u201383.","journal-title":"JAMA Ophthalmol."},{"key":"397_CR18","first-page":"2603","volume":"34","author":"JC Whelchel","year":"1993","unstructured":"Whelchel JC, Farah SE, McLean IW, Burnier M. Immunohistochemistry of infiltrating lymphocytes in uveal malignant melanoma. Investig Ophthalmol Vis Sci. 1993;34:2603\u20136.","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"397_CR19","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1001\/jamadermatol.2014.1348","volume":"150","author":"NE Thomas","year":"2014","unstructured":"Thomas NE, Kricker A, Waxweiler WT, et al. Comparison of clinicopathologic features and survival of histopathologically amelanotic and pigmented melanomas. JAMA Dermatol. 2014;150:1306\u201314.","journal-title":"JAMA Dermatol"},{"key":"397_CR20","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2019-315490","author":"L Singh","year":"2020","unstructured":"Singh L, Singh MK, Rizvi MA, et al. Prognostic significance of immune checkpoints in the tumour-stromal microenvironment of sebaceous gland carcinoma. Br J Ophthalmol. 2020. https:\/\/doi.org\/10.1136\/bjophthalmol-2019-315490.","journal-title":"Br J Ophthalmol"},{"key":"397_CR21","doi-asserted-by":"publisher","first-page":"1874","DOI":"10.1038\/bjc.2011.458","volume":"105","author":"Z Janjetovic","year":"2010","unstructured":"Janjetovic Z, Brozyna AA, Tuckey RC, et al. High basal NF-kappaB activity in nonpigmented melanoma cells is associated with an enhanced sensitivity to vitamin D3 derivatives. Br J Cancer. 2010;105:1874\u201384.","journal-title":"Br J Cancer"},{"key":"397_CR22","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.abb.2014.06.030","volume":"563","author":"A Slominski","year":"2014","unstructured":"Slominski A, Kim TK, Brozyna AA, et al. The role of melanogenesis in regulation of melanoma behavior: melanogenesis leads to stimulation of HIF-1alpha expression and HIF-dependent attendant pathways. Arch Biochem Biophys. 2014;563:79\u201393.","journal-title":"Arch Biochem Biophys"},{"key":"397_CR23","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1016\/j.ophtha.2015.01.026","volume":"122","author":"CL Shields","year":"2015","unstructured":"Shields CL, Kaliki S, Furuta M, Fulco E, Alarcon C, Shields JA. American joint committee on cancer classification of uveal melanoma (anatomic stage) predicts prognosis in 7731 patients. Ophthalmology. 2015;122:1180\u20136.","journal-title":"Ophthalmology"},{"issue":"9","key":"397_CR24","doi-asserted-by":"publisher","first-page":"2237","DOI":"10.1158\/1078-0432.CCR-15-2294","volume":"22","author":"LD Rothermel","year":"2016","unstructured":"Rothermel LD, Sabesan AC, Stephens DJ, Chandran SS, Paria BC, Srivastava AK, Somerville R, Wunderlich JR, Lee CC, Xi L, Pham TH. Identification of an immunogenic subset of metastatic uveal melanoma. Clin Cancer Res. 2016;22(9):2237\u201349.","journal-title":"Clin Cancer Res"},{"key":"397_CR25","doi-asserted-by":"publisher","first-page":"1778","DOI":"10.1016\/j.ophtha.2008.04.025","volume":"115","author":"SE Coupland","year":"2008","unstructured":"Coupland SE, Campbell I, Damato B. Routes of extraocular extension of uveal melanoma risk factors and influence on survival probability. Ophthalmology. 2008;115:1778\u2013855.","journal-title":"Ophthalmology"},{"key":"397_CR26","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1097\/00006324-200101010-00005","volume":"78","author":"DS Lee","year":"2001","unstructured":"Lee DS, Anderson SF, Perez EM, Townsend JC. Amelanotic choroidal nevus and melanoma: cytology, tumor size, and pigmentation as prognostic indicators. Optom Vis Sci. 2001;78:7.","journal-title":"Optom Vis Sci"},{"key":"397_CR27","doi-asserted-by":"publisher","first-page":"1894","DOI":"10.1001\/archopht.1983.01040020896012","volume":"101","author":"JM Seddon","year":"1983","unstructured":"Seddon JM, Albert DM, Lavin PT, Robinson N. A prognostic factor study of disease-free interval and survival following enucleation for uveal melanoma. Arch Ophthalmol. 1983;101:1894\u20139.","journal-title":"Arch Ophthalmol"},{"key":"397_CR28","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1111\/j.1600-0625.2010.01115.x","volume":"19","author":"M Ibarrola-Villava","year":"2010","unstructured":"Ibarrola-Villava M, Fernandez LP, Pita G, et al. Genetic analysis of three important genes in pigmentation and melanoma susceptibility: CDKN2A, MC1R and HERC2\/OCA2. Exp Dermatol. 2010;19:836\u201344.","journal-title":"Exp Dermatol"},{"key":"397_CR29","doi-asserted-by":"publisher","first-page":"93","DOI":"10.4103\/0301-4738.154367","volume":"63","author":"S Kaliki","year":"2015","unstructured":"Kaliki S, Shields CL, Shields JA. Uveal melanoma: estimating prognosis. Indian J Ophthalmol. 2015;63:93\u2013102.","journal-title":"Indian J Ophthalmol"},{"key":"397_CR30","doi-asserted-by":"publisher","first-page":"2071","DOI":"10.1016\/j.humpath.2013.02.022","volume":"44","author":"AA Brozyna","year":"2013","unstructured":"Brozyna AA, Jozwicki W, Carlson JA, Slominski AT. Melanogenesis affects overall and disease-free survival in patients with stage III and IV melanoma. Hum Pathol. 2013;44:2071\u20134.","journal-title":"Hum Pathol"}],"container-title":["Human Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13577-020-00397-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13577-020-00397-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13577-020-00397-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,18]],"date-time":"2021-07-18T23:06:25Z","timestamp":1626649585000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13577-020-00397-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,19]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["397"],"URL":"https:\/\/doi.org\/10.1007\/s13577-020-00397-9","relation":{},"ISSN":["1749-0774"],"issn-type":[{"value":"1749-0774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,19]]},"assertion":[{"value":"9 May 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 July 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 July 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The author(s) have no proprietary or commercial interest in any materials discussed in this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This research involved the human participants. All procedures were approved by the institutional ethics committee, All India Institute of Medical Sciences (AIIMS), New Delhi, India (IEC-472\/07.09.2018).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Written informed consent was obtained from all patients before participation in this study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}