{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T10:06:36Z","timestamp":1781777196921,"version":"3.54.5"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T00:00:00Z","timestamp":1620777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T00:00:00Z","timestamp":1620777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Henan Provincial Programs for Science and Technology Development","award":["182102310149"],"award-info":[{"award-number":["182102310149"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Human Cell"],"DOI":"10.1007\/s13577-021-00542-y","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T09:07:26Z","timestamp":1620810446000},"page":"1335-1345","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Down-regulation of long non-coding RNA XIST aggravates sepsis-induced lung injury by regulating miR-16-5p"],"prefix":"10.1007","volume":"34","author":[{"given":"Xiaofei","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaying","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4873-7162","authenticated-orcid":false,"given":"Yucheng","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,12]]},"reference":[{"issue":"5","key":"542_CR1","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1097\/01.CCM.0000261890.41311.E9","volume":"35","author":"VY Dombrovskiy","year":"2007","unstructured":"Dombrovskiy VY, Martin AA, Sunderram J, Paz HL. Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: a trend analysis from 1993 to 2003. Crit Care Med. 2007;35(5):1244\u201350.","journal-title":"Crit Care Med"},{"issue":"5","key":"542_CR2","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1097\/CCM.0b013e31827c09f8","volume":"41","author":"DF Gaieski","year":"2013","unstructured":"Gaieski DF, Edwards JM, Kallan MJ, Carr BG. Benchmarking the incidence and mortality of severe sepsis in the United States. Crit Care Med. 2013;41(5):1167\u201374.","journal-title":"Crit Care Med"},{"issue":"Database issue","key":"542_CR3","first-page":"D983","volume":"41","author":"G Chen","year":"2013","unstructured":"Chen G, Wang Z, Wang D, Qiu C, Liu M, Chen X, Zhang Q, Yan G, Cui Q. LncRNADisease: a database for long-non-coding RNA-associated diseases. Nucleic Acids Res. 2013;41(Database issue):D983\u20136.","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"542_CR4","doi-asserted-by":"crossref","first-page":"e00762","DOI":"10.7554\/eLife.00762","volume":"23","author":"NA Rapicavoli","year":"2013","unstructured":"Rapicavoli NA, Qu K, Zhang J, Mikhail M, Laberge RM, Chang HY. A mammalian pseudogene lncRNA at the interface of inflammation and anti-inflammatory therapeutics. Elife. 2013;23(2):e00762.","journal-title":"Elife"},{"key":"542_CR5","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.molimm.2018.05.030","volume":"101","author":"K Liao","year":"2018","unstructured":"Liao K, Xu J, Yang W, You X, Zhong Q, Wang X. The research progress of LncRNA involved in the regulation of inflammatory diseases. Mol Immunol. 2018;101:182\u20138.","journal-title":"Mol Immunol"},{"issue":"75","key":"542_CR6","doi-asserted-by":"crossref","first-page":"105731","DOI":"10.1016\/j.intimp.2019.105731","volume":"22","author":"CC Zhang","year":"2019","unstructured":"Zhang CC, Niu F. LncRNA NEAT1 promotes inflammatory response in sepsis-induced liver injury via the Let-7a\/TLR4 axis. Int Immunopharmacol. 2019;22(75):105731.","journal-title":"Int Immunopharmacol"},{"issue":"11","key":"542_CR7","first-page":"4898","volume":"23","author":"SM Wang","year":"2019","unstructured":"Wang SM, Liu GQ, Xian HB, Si JL, Qi SX, Yu YP. LncRNA NEAT1 alleviates sepsis-induced myocardial injury by regulating the TLR2\/NF-\u03baB signaling pathway. Eur Rev Med Pharmacol Sci. 2019;23(11):4898\u2013907.","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"14","key":"542_CR8","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1042\/CS20190519","volume":"133","author":"J Wang","year":"2019","unstructured":"Wang J, Cai H, Dai Z, Wang G. Down-regulation of lncRNA XIST inhibits cell proliferation via regulating miR-744\/RING1 axis in non-small cell lung cancer. Clin Sci (Lond). 2019;133(14):1567\u201379.","journal-title":"Clin Sci (Lond)"},{"key":"542_CR9","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.biocel.2019.05.021","volume":"113","author":"J Shen","year":"2019","unstructured":"Shen J, Hong L, Yu D, Cao T, Zhou Z, He S. LncRNA XIST promotes pancreatic cancer migration, invasion and EMT by sponging miR-429 to modulate ZEB1 expression. Int J Biochem Cell Biol. 2019;113:17\u201326.","journal-title":"Int J Biochem Cell Biol"},{"key":"542_CR10","doi-asserted-by":"crossref","first-page":"102600","DOI":"10.1016\/j.ebiom.2019.102600","volume":"52","author":"J Li","year":"2020","unstructured":"Li J, Wei L, Han Z, Chen Z, Zhang Q. Long non-coding RNA X-inactive specific transcript silencing ameliorates primary graft dysfunction following lung transplantation through microRNA-21-dependent mechanism. EBioMedicine. 2020;52:102600.","journal-title":"EBioMedicine"},{"issue":"2","key":"542_CR11","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","volume":"116","author":"DP Bartel","year":"2004","unstructured":"Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004;116(2):281\u201397.","journal-title":"Cell"},{"issue":"21","key":"542_CR12","doi-asserted-by":"crossref","first-page":"4653","DOI":"10.1242\/dev.02073","volume":"132","author":"I Alvarez-Garcia","year":"2005","unstructured":"Alvarez-Garcia I, Miska EA. MicroRNA functions in animal development and human disease. Development. 2005;132(21):4653\u201362.","journal-title":"Development"},{"issue":"1","key":"542_CR13","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/j.1582-4934.2008.00534.x","volume":"13","author":"E Sonkoly","year":"2009","unstructured":"Sonkoly E, Pivarcsi A. Advances in microRNAs: implications for immunity and inflammatory diseases. J Cell Mol Med. 2009;13(1):24\u201338.","journal-title":"J Cell Mol Med"},{"issue":"7","key":"542_CR14","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s00011-017-1031-9","volume":"66","author":"SMK Kingsley","year":"2017","unstructured":"Kingsley SMK, Bhat BV. Role of microRNAs in sepsis. Inflamm Res. 2017;66(7):553\u201369.","journal-title":"Inflamm Res"},{"issue":"1","key":"542_CR15","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s12890-019-0836-4","volume":"19","author":"W Zhang","year":"2019","unstructured":"Zhang W, Jia J, Liu Z, Si D, Ma L, Zhang G. Circulating microRNAs as biomarkers for sepsis secondary to pneumonia diagnosed via sepsis 3.0. BMC Pulm Med. 2019;19(1):93.","journal-title":"BMC Pulm Med"},{"issue":"7","key":"542_CR16","doi-asserted-by":"crossref","first-page":"733","DOI":"10.7150\/thno.10305","volume":"5","author":"J Zhang","year":"2015","unstructured":"Zhang J, Song Y, Zhang C, Zhi X, Hualin Fu, Ma Y, et al. Circulating miR-16-5p and miR-19b-3p as two novel potential biomarkers to indicate progression of gastric cancer. Theranostics. 2015;5(7):733\u201345.","journal-title":"Theranostics"},{"issue":"6","key":"542_CR17","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/s41419-018-0738-z","volume":"9","author":"H Zhang","year":"2018","unstructured":"Zhang H, Yang K, Ren T, Huang Y, Tang X, Guo W. miR-16-5p inhibits chordoma cell proliferation, invasion and metastasis by targeting Smad3. Cell Death Dis. 2018;9(6):680.","journal-title":"Cell Death Dis"},{"key":"542_CR18","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.mito.2018.11.008","volume":"49","author":"X Yang","year":"2019","unstructured":"Yang X, Lu GP, Cai XD, Lu ZJ, Kissoon N. Alterations of complex IV in the tissues of a septic mouse model. Mitochondrion. 2019;49:89\u201396.","journal-title":"Mitochondrion"},{"issue":"5 Suppl 1","key":"542_CR19","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1097\/PCC.0000000000000431","volume":"16","author":"A Sapru","year":"2015","unstructured":"Sapru A, Flori H, Quasney MW, Dahmer MK, et al. Pathobiology of acute respiratory distress syndrome. Pediatr Crit Care Med. 2015;16(5 Suppl 1):S6-22.","journal-title":"Pediatr Crit Care Med"},{"key":"542_CR20","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.intimp.2018.12.053","volume":"68","author":"X Wang","year":"2019","unstructured":"Wang X, An X, Wang X, Hu X, Bi J, Tong L, Yang D, Song Y, Bai C. Peroxiredoxin 6 knockout aggravates cecal ligation and puncture-induced acute lung injury. Int Immunopharmacol. 2019;68:252\u20138.","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"542_CR21","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s10787-019-00622-4","volume":"28","author":"YY Bai","year":"2020","unstructured":"Bai YY, Yan D, Zhou HY, Li WX, Lou YY, Zhou XR, Qian LB, Xiao C. Betulinic acid attenuates lipopolysaccharide-induced vascular hyporeactivity in the rat aorta by modulating Nrf2 antioxidative function. Inflammopharmacology. 2020;28(1):165\u201374.","journal-title":"Inflammopharmacology"},{"issue":"9","key":"542_CR22","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1016\/j.ajem.2018.06.008","volume":"36","author":"Q Huang","year":"2018","unstructured":"Huang Q, Huang C, Luo Y, He F, Zhang R. Circulating lncRNA NEAT1 correlates with increased risk, elevated severity and unfavorable prognosis in sepsis patients. Am J Emerg Med. 2018;36(9):1659\u201363.","journal-title":"Am J Emerg Med"},{"issue":"5","key":"542_CR23","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.3892\/ijmm.2017.2920","volume":"39","author":"Z Yu","year":"2017","unstructured":"Yu Z, Rayile A, Zhang X, Li Y, Zhao Q. Ulinastatin protects against lipopolysaccharide-induced cardiac microvascular endothelial cell dysfunction via downregulation of lncRNA MALAT1 and EZH2 in sepsis. Int J Mol Med. 2017;39(5):1269\u201376.","journal-title":"Int J Mol Med"},{"issue":"5","key":"542_CR24","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1002\/cbf.3392","volume":"37","author":"Y Zhang","year":"2019","unstructured":"Zhang Y, Zhu Y, Gao G, Zhou Z. Knockdown XIST alleviates LPS-induced WI-38 cell apoptosis and inflammation injury via targeting miR-370-3p\/TLR4 in acute pneumonia. Cell Biochem Funct. 2019;37(5):348\u201358.","journal-title":"Cell Biochem Funct"},{"issue":"1","key":"542_CR25","doi-asserted-by":"crossref","first-page":"e12525","DOI":"10.1111\/cpr.12525","volume":"52","author":"M Ma","year":"2019","unstructured":"Ma M, Pei Y, Wang X, Feng J, Zhang Y, Gao MQ. LncRNA XIST mediates bovine mammary epithelial cell inflammatory response via NF-\u03baB\/NLRP3 inflammasome pathway. Cell Prolif. 2019;52(1):e12525.","journal-title":"Cell Prolif"},{"issue":"8","key":"542_CR26","first-page":"3512","volume":"23","author":"ZJ Jiang","year":"2019","unstructured":"Jiang ZJ, Zhang MY, Fan ZW, Sun WL, Tang Y. Influence of lncRNA HOTAIR on acute kidney injury in sepsis rats through regulating miR-34a\/Bcl-2 pathway. Eur Rev Med Pharmacol Sci. 2019;23(8):3512\u20139.","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"542_CR27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000500484","volume":"44","author":"L Ling","year":"2019","unstructured":"Ling L, Lu HT, Wang HF, Shen MJ, Zhang HB. MicroRNA-203 acts as a potent suppressor in septic shock by alleviating lung injury via inhibition of VNN1. Kidney Blood Press Res. 2019;44:1\u201318.","journal-title":"Kidney Blood Press Res"},{"issue":"8","key":"542_CR28","doi-asserted-by":"crossref","first-page":"BSR20191611","DOI":"10.1042\/BSR20191611","volume":"39","author":"L Ruan","year":"2019","unstructured":"Ruan L, Qian X. MiR-16-5p inhibits breast cancer by reducing AKT3 to restrain NF-\u03baB pathway. Biosci Rep. 2019;39(8):BSR20191611.","journal-title":"Biosci Rep"},{"issue":"3","key":"542_CR29","doi-asserted-by":"crossref","first-page":"L585","DOI":"10.1152\/ajplung.00151.2001","volume":"282","author":"J Zhao","year":"2002","unstructured":"Zhao J, Shi W, Wang YL, Chen H, Bringas P Jr, Datto MB, Frederick JP, Wang XF, Warburton D. Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice. Am J Physiol Lung Cell Mol Physiol. 2002;282(3):L585\u201393.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"7","key":"542_CR30","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.injury.2010.07.242","volume":"42","author":"SJ Yang","year":"2011","unstructured":"Yang SJ, Chen HM, Hsieh CH, Hsu JT, Yeh CN, Yeh TS, Hwang TL, Jan YY, Chen MF. Akt pathway is required for oestrogen-mediated attenuation of lung injury in a rodent model of cerulein-induced acute pancreatitis. Injury. 2011;42(7):638\u201342.","journal-title":"Injury"},{"issue":"536","key":"542_CR31","doi-asserted-by":"crossref","first-page":"eaao2387","DOI":"10.1126\/scisignal.aao2387","volume":"11","author":"R Li","year":"2018","unstructured":"Li R, Fang L, Pu Q, Bu H, Zhu P, Chen Z, Yu M, Li X, Weiland T, Bansal A, Ye SQ, Wei Y, Jiang J, Wu M. MEG3-4 is a miRNA decoy that regulates IL-1\u03b2 abundance to initiate and then limit inflammation to prevent sepsis during lung infection. Sci Signal. 2018;11(536):eaao2387.","journal-title":"Sci Signal"}],"container-title":["Human Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13577-021-00542-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13577-021-00542-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13577-021-00542-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T22:45:19Z","timestamp":1744152319000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13577-021-00542-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,12]]},"references-count":31,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,9]]}},"alternative-id":["542"],"URL":"https:\/\/doi.org\/10.1007\/s13577-021-00542-y","relation":{},"ISSN":["1749-0774"],"issn-type":[{"value":"1749-0774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,12]]},"assertion":[{"value":"19 August 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 April 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that there are no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The animal study procedures were approved by the Animal Studies Committee of Henan Provincial People\u2019s Hospital (Approval No. 2014-A11) and it also followed the ARRIVE guidelines.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}