{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T20:11:32Z","timestamp":1793218292960,"version":"4.5.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T00:00:00Z","timestamp":1633305600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T00:00:00Z","timestamp":1633305600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974566"],"award-info":[{"award-number":["81974566"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81804006"],"award-info":[{"award-number":["81804006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2018ZC1157"],"award-info":[{"award-number":["ZR2018ZC1157"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012620","name":"Taishan Scholar Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ts201712042"],"award-info":[{"award-number":["ts201712042"]}],"id":[{"id":"10.13039\/100012620","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019446","name":"Medical and Health Science and Technology Development Project of Shandong Province","doi-asserted-by":"crossref","award":["2019WS556"],"award-info":[{"award-number":["2019WS556"]}],"id":[{"id":"10.13039\/501100019446","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100019446","name":"Medical and Health Science and Technology Development Project of Shandong Province","doi-asserted-by":"crossref","award":["2019WS553"],"award-info":[{"award-number":["2019WS553"]}],"id":[{"id":"10.13039\/501100019446","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100010031","name":"Postdoctoral Research Foundation of China","doi-asserted-by":"publisher","award":["2020M672125"],"award-info":[{"award-number":["2020M672125"]}],"id":[{"id":"10.13039\/501100010031","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Human Cell"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1007\/s13577-021-00600-5","type":"journal-article","created":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T04:33:57Z","timestamp":1633408437000},"page":"51-62","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":82,"title":["Piezo1 mediates endothelial atherogenic inflammatory responses via regulation of YAP\/TAZ activation"],"prefix":"10.1007","volume":"35","author":[{"given":"Ying","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danyang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zichen","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2129-1447","authenticated-orcid":false,"given":"Yunlun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,4]]},"reference":[{"issue":"1","key":"600_CR1","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/s41572-019-0106-z","volume":"5","author":"P Libby","year":"2019","unstructured":"Libby P, Buring JE, Badimon L, Hansson GK, Deanfield J, Bittencourt MS, et al. Atherosclerosis. Nat Rev Dis Primers. 2019;5(1):56. https:\/\/doi.org\/10.1038\/s41572-019-0106-z.","journal-title":"Nat Rev Dis Primers"},{"issue":"10","key":"600_CR2","doi-asserted-by":"publisher","first-page":"e56","DOI":"10.1161\/cir.0000000000000659","volume":"139","author":"EJ Benjamin","year":"2019","unstructured":"Benjamin EJ, Muntner P, Alonso A, Bittencourt MS, Callaway CW, Carson AP, et al. Heart disease and stroke statistics-2019 update: a report from the American heart association. Circulation. 2019;139(10):e56\u2013528. https:\/\/doi.org\/10.1161\/cir.0000000000000659.","journal-title":"Circulation"},{"issue":"2","key":"600_CR3","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1159\/000330939","volume":"119","author":"A Indermuehle","year":"2011","unstructured":"Indermuehle A, Crake T, Meier P. Oxidized low-density lipoprotein cholesterol and coronary artery disease. Cardiology. 2011;119(2):106\u20137. https:\/\/doi.org\/10.1159\/000330939.","journal-title":"Cardiology"},{"issue":"2","key":"600_CR4","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1161\/circresaha.118.313591","volume":"124","author":"D Wolf","year":"2019","unstructured":"Wolf D, Ley K. Immunity and inflammation in atherosclerosis. Circ Res. 2019;124(2):315\u201327. https:\/\/doi.org\/10.1161\/circresaha.118.313591.","journal-title":"Circ Res"},{"issue":"4","key":"600_CR5","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1161\/circresaha.115.306301","volume":"118","author":"MA Gimbrone Jr","year":"2016","unstructured":"Gimbrone MA Jr, Garc\u00eda-Carde\u00f1a G. Endothelial cell dysfunction and the pathobiology of atherosclerosis. Circ Res. 2016;118(4):620\u201336. https:\/\/doi.org\/10.1161\/circresaha.115.306301.","journal-title":"Circ Res"},{"key":"600_CR6","doi-asserted-by":"publisher","DOI":"10.3390\/biom8030080","author":"Y Zhu","year":"2018","unstructured":"Zhu Y, Xian X, Wang Z, Bi Y, Chen Q, Han X, et al. Research progress on the relationship between atherosclerosis and inflammation. Biomolecules. 2018. https:\/\/doi.org\/10.3390\/biom8030080.","journal-title":"Biomolecules"},{"issue":"10","key":"600_CR7","doi-asserted-by":"publisher","first-page":"2655","DOI":"10.1084\/jem.20180483","volume":"215","author":"J Albarran-Juarez","year":"2018","unstructured":"Albarran-Juarez J, Iring A, Wang S, Joseph S, Grimm M, Strilic B, et al. Piezo1 and Gq\/G11 promote endothelial inflammation depending on flow pattern and integrin activation. J Exp Med. 2018;215(10):2655\u201372. https:\/\/doi.org\/10.1084\/jem.20180483.","journal-title":"J Exp Med"},{"issue":"12","key":"600_CR8","doi-asserted-by":"publisher","first-page":"4527","DOI":"10.1172\/jci87343","volume":"126","author":"S Wang","year":"2016","unstructured":"Wang S, Chennupati R, Kaur H, Iring A, Wettschureck N, Offermanns S. Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release. J Clin Investig. 2016;126(12):4527\u201336. https:\/\/doi.org\/10.1172\/jci87343.","journal-title":"J Clin Investig"},{"issue":"7526","key":"600_CR9","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1038\/nature13701","volume":"515","author":"J Li","year":"2014","unstructured":"Li J, Hou B, Tumova S, Muraki K, Bruns A, Ludlow MJ, et al. Piezo1 integration of vascular architecture with physiological force. Nature. 2014;515(7526):279\u201382. https:\/\/doi.org\/10.1038\/nature13701.","journal-title":"Nature"},{"issue":"4","key":"600_CR10","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1016\/j.neuron.2018.09.046","volume":"100","author":"X Chen","year":"2018","unstructured":"Chen X, Wanggou S, Bodalia A, Zhu M, Dong W, Fan JJ, et al. A feedforward mechanism mediated by mechanosensitive ion channel Piezo1 and tissue mechanics promotes glioma aggression. Neuron. 2018;100(4):799-815.e7. https:\/\/doi.org\/10.1016\/j.neuron.2018.09.046.","journal-title":"Neuron"},{"issue":"1","key":"600_CR11","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1002\/glia.23709","volume":"68","author":"M Velasco-Estevez","year":"2020","unstructured":"Velasco-Estevez M, Rolle SO, Mampay M, Dev KK. Piezo1 regulates calcium oscillations and cytokine release from astrocytes. Glia. 2020;68(1):145\u201360. https:\/\/doi.org\/10.1002\/glia.23709.","journal-title":"Glia"},{"issue":"7772","key":"600_CR12","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/s41586-019-1485-8","volume":"573","author":"AG Solis","year":"2019","unstructured":"Solis AG, Bielecki P, Steach HR, Sharma L, Harman CCD, Yun S, et al. Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity. Nature. 2019;573(7772):69\u201374. https:\/\/doi.org\/10.1038\/s41586-019-1485-8.","journal-title":"Nature"},{"issue":"10","key":"600_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2020.158779","volume":"1865","author":"Y Yang","year":"2020","unstructured":"Yang Y, Pei K, Zhang Q, Wang D, Feng H, Du Z, et al. Salvianolic acid B ameliorates atherosclerosis via inhibiting YAP\/TAZ\/JNK signaling pathway in endothelial cells and pericytes. Biochim Biophys Acta. 2020;1865(10): 158779. https:\/\/doi.org\/10.1016\/j.bbalip.2020.158779.","journal-title":"Biochim Biophys Acta"},{"issue":"4","key":"600_CR14","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1161\/circresaha.117.311950","volume":"122","author":"J He","year":"2018","unstructured":"He J, Bao Q, Zhang Y, Liu M, Lv H, Liu Y, et al. Yes-associated protein promotes angiogenesis via signal transducer and activator of transcription 3 in endothelial cells. Circ Res. 2018;122(4):591\u2013605. https:\/\/doi.org\/10.1161\/circresaha.117.311950.","journal-title":"Circ Res"},{"issue":"41","key":"600_CR15","doi-asserted-by":"publisher","first-page":"11525","DOI":"10.1073\/pnas.1613121113","volume":"113","author":"KC Wang","year":"2016","unstructured":"Wang KC, Yeh YT, Nguyen P, Limqueco E, Lopez J, Thorossian S, et al. Flow-dependent YAP\/TAZ activities regulate endothelial phenotypes and atherosclerosis. Proc Natl Acad Sci USA. 2016;113(41):11525\u201330. https:\/\/doi.org\/10.1073\/pnas.1613121113.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"12","key":"600_CR16","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1038\/nrm.2017.87","volume":"18","author":"T Panciera","year":"2017","unstructured":"Panciera T, Azzolin L, Cordenonsi M, Piccolo S. Mechanobiology of YAP and TAZ in physiology and disease. Nat Rev Mol Cell Biol. 2017;18(12):758\u201370. https:\/\/doi.org\/10.1038\/nrm.2017.87.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"7634","key":"600_CR17","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1038\/nature20602","volume":"540","author":"L Wang","year":"2016","unstructured":"Wang L, Luo JY, Li B, Tian XY, Chen LJ, Huang Y, et al. Integrin-YAP\/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow. Nature. 2016;540(7634):579\u201382. https:\/\/doi.org\/10.1038\/nature20602.","journal-title":"Nature"},{"issue":"45","key":"600_CR18","doi-asserted-by":"publisher","first-page":"16148","DOI":"10.1073\/pnas.1409802111","volume":"111","author":"MM Pathak","year":"2014","unstructured":"Pathak MM, Nourse JL, Tran T, Hwe J, Arulmoli J, Le DT, et al. Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells. Proc Natl Acad Sci USA. 2014;111(45):16148\u201353. https:\/\/doi.org\/10.1073\/pnas.1409802111.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"600_CR19","doi-asserted-by":"publisher","first-page":"H1019","DOI":"10.1152\/ajpheart.00103.2018","volume":"315","author":"L John","year":"2018","unstructured":"John L, Ko NL, Gokin A, Gokina N, Mandal\u00e0 M, Osol G. The Piezo1 cation channel mediates uterine artery shear stress mechanotransduction and vasodilation during rat pregnancy. Am J Physiol Heart Circ Physiol. 2018;315(4):H1019\u201326. https:\/\/doi.org\/10.1152\/ajpheart.00103.2018.","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"1","key":"600_CR20","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1007\/s12035-016-0311-7","volume":"55","author":"JR Lopez","year":"2018","unstructured":"Lopez JR, Kolster J, Uryash A, Est\u00e8ve E, Altamirano F, Adams JA. Dysregulation of intracellular Ca (2+) in dystrophic cortical and hippocampal neurons. Mol Neurobiol. 2018;55(1):603\u201318. https:\/\/doi.org\/10.1007\/s12035-016-0311-7.","journal-title":"Mol Neurobiol"},{"key":"600_CR21","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.yjmcc.2016.07.005","volume":"98","author":"J Wang","year":"2016","unstructured":"Wang J, Ma Y, Sachs F, Li J, Suchyna TM. GsMTx4-D is a cardioprotectant against myocardial infarction during ischemia and reperfusion. J Mol Cell Cardiol. 2016;98:83\u201394. https:\/\/doi.org\/10.1016\/j.yjmcc.2016.07.005.","journal-title":"J Mol Cell Cardiol"},{"issue":"11","key":"600_CR22","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.3324\/haematol.2016.142463","volume":"101","author":"I Andolfo","year":"2016","unstructured":"Andolfo I, Russo R, Gambale A, Iolascon A. New insights on hereditary erythrocyte membrane defects. Haematologica. 2016;101(11):1284\u201394. https:\/\/doi.org\/10.3324\/haematol.2016.142463.","journal-title":"Haematologica"},{"key":"600_CR23","doi-asserted-by":"publisher","first-page":"8085","DOI":"10.1038\/ncomms9085","volume":"6","author":"E Fotiou","year":"2015","unstructured":"Fotiou E, Martin-Almedina S, Simpson MA, Lin S, Gordon K, Brice G, et al. Novel mutations in PIEZO1 cause an autosomal recessive generalized lymphatic dysplasia with non-immune hydrops fetalis. Nat Commun. 2015;6:8085. https:\/\/doi.org\/10.1038\/ncomms9085.","journal-title":"Nat Commun"},{"key":"600_CR24","doi-asserted-by":"publisher","first-page":"8329","DOI":"10.1038\/ncomms9329","volume":"6","author":"V Lukacs","year":"2015","unstructured":"Lukacs V, Mathur J, Mao R, Bayrak-Toydemir P, Procter M, Cahalan SM, et al. Impaired PIEZO1 function in patients with a novel autosomal recessive congenital lymphatic dysplasia. Nat Commun. 2015;6:8329. https:\/\/doi.org\/10.1038\/ncomms9329.","journal-title":"Nat Commun"},{"issue":"5","key":"600_CR25","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1007\/s12551-019-00584-5","volume":"11","author":"P Ridone","year":"2019","unstructured":"Ridone P, Vassalli M, Martinac B. Piezo1 mechanosensitive channels: what are they and why are they important. Biophys Rev. 2019;11(5):795\u2013805. https:\/\/doi.org\/10.1007\/s12551-019-00584-5.","journal-title":"Biophys Rev"},{"issue":"11","key":"600_CR26","doi-asserted-by":"publisher","first-page":"2228","DOI":"10.1161\/atvbaha.119.313348","volume":"39","author":"DJ Beech","year":"2019","unstructured":"Beech DJ, Kalli AC. Force sensing by piezo channels in cardiovascular health and disease. Arterioscler Thromb Vasc Biol. 2019;39(11):2228\u201339. https:\/\/doi.org\/10.1161\/atvbaha.119.313348.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1","key":"600_CR27","doi-asserted-by":"publisher","first-page":"1715","DOI":"10.1038\/s41467-018-04194-9","volume":"9","author":"JM Romac","year":"2018","unstructured":"Romac JM, Shahid RA, Swain SM, Vigna SR, Liddle RA. Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis. Nat Commun. 2018;9(1):1715. https:\/\/doi.org\/10.1038\/s41467-018-04194-9.","journal-title":"Nat Commun"},{"issue":"1","key":"600_CR28","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1038\/s41467-017-00429-3","volume":"8","author":"B Rode","year":"2017","unstructured":"Rode B, Shi J, Endesh N, Drinkhill MJ, Webster PJ, Lotteau SJ, et al. Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance. Nat Commun. 2017;8(1):350. https:\/\/doi.org\/10.1038\/s41467-017-00429-3.","journal-title":"Nat Commun"},{"key":"600_CR29","doi-asserted-by":"publisher","first-page":"373","DOI":"10.3389\/fendo.2019.00373","volume":"10","author":"C Zhao","year":"2019","unstructured":"Zhao C, Sun Q, Tang L, Cao Y, Nourse JL, Pathak MM, et al. Mechanosensitive ion channel piezo1 regulates diet-induced adipose inflammation and systemic insulin resistance. Front Endocrinol. 2019;10:373. https:\/\/doi.org\/10.3389\/fendo.2019.00373.","journal-title":"Front Endocrinol"},{"key":"600_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106681","volume":"85","author":"Y Sun","year":"2020","unstructured":"Sun Y, Leng P, Song M, Li D, Guo P, Xu X, et al. Piezo1 activates the NLRP3 inflammasome in nucleus pulposus cell-mediated by Ca (2+)\/NF-\u03baB pathway. Int Immunopharmacol. 2020;85: 106681. https:\/\/doi.org\/10.1016\/j.intimp.2020.106681.","journal-title":"Int Immunopharmacol"},{"issue":"3\u20134","key":"600_CR31","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1159\/000486374","volume":"101","author":"H Okuyama","year":"2018","unstructured":"Okuyama H, Hamazaki T, Hama R, Ogushi Y, Kobayashi T, Ohara N, et al. A critical review of the consensus statement from the European atherosclerosis society consensus panel 2017. Pharmacology. 2018;101(3\u20134):184\u2013218. https:\/\/doi.org\/10.1159\/000486374.","journal-title":"Pharmacology"},{"issue":"2","key":"600_CR32","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.jbspin.2017.12.009","volume":"85","author":"P Henrot","year":"2018","unstructured":"Henrot P, Foret J, Barnetche T, Lazaro E, Duffau P, Seneschal J, et al. Assessment of subclinical atherosclerosis in systemic lupus erythematosus: a systematic review and meta-analysis. Joint Bone Spine. 2018;85(2):155\u201363. https:\/\/doi.org\/10.1016\/j.jbspin.2017.12.009.","journal-title":"Joint Bone Spine"},{"issue":"8","key":"600_CR33","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.17219\/acem\/71080","volume":"27","author":"E Etem","year":"2018","unstructured":"Etem E, Ceylan GG, \u00d6zayd\u0131n S, Ceylan C, \u00d6zercan I, Kulo\u011flu T. The increased expression of Piezo1 and Piezo2 ion channels in human and mouse bladder carcinoma. Adv Clin Exp Med. 2018;27(8):1025\u201331. https:\/\/doi.org\/10.17219\/acem\/71080.","journal-title":"Adv Clin Exp Med"},{"issue":"3","key":"600_CR34","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.smim.2015.03.013","volume":"27","author":"J Viola","year":"2015","unstructured":"Viola J, Soehnlein O. Atherosclerosis\u2014a matter of unresolved inflammation. Semin Immunol. 2015;27(3):184\u201393. https:\/\/doi.org\/10.1016\/j.smim.2015.03.013.","journal-title":"Semin Immunol"},{"issue":"6","key":"600_CR35","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1093\/eurheartj\/ehl445","volume":"28","author":"TN Patel","year":"2007","unstructured":"Patel TN, Shishehbor MH, Bhatt DL. A review of high-dose statin therapy: targeting cholesterol and inflammation in atherosclerosis. Eur Heart J. 2007;28(6):664\u201372. https:\/\/doi.org\/10.1093\/eurheartj\/ehl445.","journal-title":"Eur Heart J"},{"issue":"12","key":"600_CR36","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1038\/nrm3896","volume":"15","author":"JD Humphrey","year":"2014","unstructured":"Humphrey JD, Dufresne ER, Schwartz MA. Mechanotransduction and extracellular matrix homeostasis. Nat Rev Mol Cell Biol. 2014;15(12):802\u201312. https:\/\/doi.org\/10.1038\/nrm3896.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"600_CR37","doi-asserted-by":"publisher","unstructured":"Hope JM, Lopez-Cavestany M, Wang W. Activation of Piezo1 sensitizes cells to TRAIL-mediated apoptosis through mitochondrial outer membrane permeability. 2019;10 (11):837. doi:https:\/\/doi.org\/10.1038\/s41419-019-2063-6.","DOI":"10.1038\/s41419-019-2063-6"}],"container-title":["Human Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13577-021-00600-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13577-021-00600-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13577-021-00600-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T18:16:05Z","timestamp":1641406565000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13577-021-00600-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,4]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["600"],"URL":"https:\/\/doi.org\/10.1007\/s13577-021-00600-5","relation":{},"ISSN":["1749-0774"],"issn-type":[{"value":"1749-0774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,4]]},"assertion":[{"value":"9 May 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 August 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 October 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have declared that no conflict of interest exists.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Human participants are not included in this research. The procedures for care and use of animals were approved by the Ethics Committee of the Shandong University of Traditional Chinese Medicine (SDUTCM20180928001).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}