{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T06:27:35Z","timestamp":1771914455298,"version":"3.50.1"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T00:00:00Z","timestamp":1635897600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T00:00:00Z","timestamp":1635897600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"natural science foundation of xinjiang uygur autonomous region","award":["2017D01C112"],"award-info":[{"award-number":["2017D01C112"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Human Cell"],"DOI":"10.1007\/s13577-021-00641-w","type":"journal-article","created":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T05:02:58Z","timestamp":1635915778000},"page":"179-188","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Identification of diagnostic signatures in ulcerative colitis patients via bioinformatic analysis integrated with machine learning"],"prefix":"10.1007","volume":"35","author":[{"given":"Jiajie","family":"Lu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Munila","family":"Maimaiti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjia","family":"Hui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adilai","family":"Abudourexiti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0319-2250","authenticated-orcid":false,"given":"Feng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,11,3]]},"reference":[{"issue":"9853","key":"641_CR1","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1016\/S0140-6736(12)60150-0","volume":"380","author":"I Ordas","year":"2012","unstructured":"Ordas I, Eckmann L, Talamini M, Baumgart DC, Sandborn WJ. Ulcerative colitis. Lancet. 2012;380(9853):1606\u201319.","journal-title":"Lancet"},{"key":"641_CR2","doi-asserted-by":"publisher","first-page":"106645","DOI":"10.1016\/j.intimp.2020.106645","volume":"85","author":"M Tian","year":"2020","unstructured":"Tian M, Ma P, Zhang Y, Mi Y, Fan D. Ginsenoside Rk3 alleviated DSS-induced ulcerative colitis by protecting colon barrier and inhibiting NLRP3 inflammasome pathway. Int Immunopharmacol. 2020;85:106645.","journal-title":"Int Immunopharmacol"},{"key":"641_CR3","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.biopha.2018.11.133","volume":"110","author":"AE Khodir","year":"2019","unstructured":"Khodir AE, Said E, Atif H, ElKashef HA, Salem HA. Targeting Nrf2\/HO-1 signaling by crocin: role in attenuation of AA-induced ulcerative colitis in rats. Biomed Pharmacother. 2019;110:389\u201399.","journal-title":"Biomed Pharmacother"},{"key":"641_CR4","doi-asserted-by":"publisher","first-page":"944","DOI":"10.3389\/fphar.2018.00944","volume":"9","author":"X Ma","year":"2018","unstructured":"Ma X, Hu Y, Li X, et al. Periplaneta americana ameliorates dextran sulfate sodium-induced ulcerative colitis in rats by keap1\/Nrf-2 activation, intestinal barrier function, and gut microbiota regulation. Front Pharmacol. 2018;9:944.","journal-title":"Front Pharmacol"},{"key":"641_CR5","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20181521","author":"L Tian","year":"2018","unstructured":"Tian L, Li Y, Zhang J, Chang R, Li J, Huo L. IL-9 promotes the pathogenesis of ulcerative colitis through STAT3\/SOCS3 signaling. 2018. Biosci Rep. https:\/\/doi.org\/10.1042\/BSR20181521."},{"issue":"18","key":"641_CR6","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1056\/NEJMra1102942","volume":"365","author":"S Danese","year":"2011","unstructured":"Danese S, Fiocchi C. Ulcerative colitis. N Engl J Med. 2011;365(18):1713\u201325.","journal-title":"N Engl J Med"},{"key":"641_CR7","doi-asserted-by":"publisher","first-page":"103433","DOI":"10.1016\/j.etap.2020.103433","volume":"79","author":"YM El-Far","year":"2020","unstructured":"El-Far YM, Elsherbiny NM, El-Shafey M, Said E. The interplay of the inhibitory effect of nifuroxazide on NF-kappaB\/STAT3 signaling attenuates acetic acid-induced ulcerative colitis in rats. Environ Toxicol Pharmacol. 2020;79:103433.","journal-title":"Environ Toxicol Pharmacol"},{"issue":"28","key":"641_CR8","doi-asserted-by":"publisher","first-page":"9458","DOI":"10.3748\/wjg.v20.i28.9458","volume":"20","author":"BC da Silva","year":"2014","unstructured":"da Silva BC, Lyra AC, Rocha R, Santana GO. Epidemiology, demographic characteristics and prognostic predictors of ulcerative colitis. World J Gastroenterol. 2014;20(28):9458\u201367.","journal-title":"World J Gastroenterol"},{"issue":"1","key":"641_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v033.i01","volume":"33","author":"J Friedman","year":"2010","unstructured":"Friedman J, Hastie T, Tibshirani R. Regularization paths for generalized linear models via coordinate descent. J Stat Softw. 2010;33(1):1\u201322.","journal-title":"J Stat Softw"},{"issue":"9","key":"641_CR10","first-page":"1323","volume":"76","author":"RC Langan","year":"2007","unstructured":"Langan RC, Gotsch PB, Krafczyk MA, Skillinge DD. Ulcerative colitis: diagnosis and treatment. Am Fam Physician. 2007;76(9):1323\u201330.","journal-title":"Am Fam Physician"},{"issue":"4\u20135","key":"641_CR11","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.autrev.2014.01.028","volume":"13","author":"K Conrad","year":"2014","unstructured":"Conrad K, Roggenbuck D, Laass MW. Diagnosis and classification of ulcerative colitis. Autoimmun Rev. 2014;13(4\u20135):463\u20136.","journal-title":"Autoimmun Rev"},{"issue":"5","key":"641_CR12","doi-asserted-by":"publisher","first-page":"444","DOI":"10.5152\/tjg.2016.16215","volume":"27","author":"DQ Zhan","year":"2016","unstructured":"Zhan DQ, Chen X, Wang R, et al. Diagnostic evaluation of appendiceal orifice inflammation in ulcerative colitis. Turk J Gastroenterol. 2016;27(5):444\u20139.","journal-title":"Turk J Gastroenterol"},{"issue":"9","key":"641_CR13","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1038\/s41591-018-0178-4","volume":"24","author":"CJ Lynch","year":"2018","unstructured":"Lynch CJ, Liston C. New machine-learning technologies for computer-aided diagnosis. Nat Med. 2018;24(9):1304\u20135.","journal-title":"Nat Med"},{"issue":"17","key":"641_CR14","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.3748\/wjg.v27.i17.1920","volume":"27","author":"J Gubatan","year":"2021","unstructured":"Gubatan J, Levitte S, Patel A, Balabanis T, Wei MT, Sinha SR. Artificial intelligence applications in inflammatory bowel disease: emerging technologies and future directions. World J Gastroenterol. 2021;27(17):1920\u201335.","journal-title":"World J Gastroenterol"},{"issue":"20","key":"641_CR15","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.1161\/CIRCULATIONAHA.115.001593","volume":"132","author":"RC Deo","year":"2015","unstructured":"Deo RC. Machine Learning in Medicine. Circulation. 2015;132(20):1920\u201330.","journal-title":"Circulation"},{"issue":"10","key":"641_CR16","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1001\/jama.2016.20441","volume":"317","author":"WJ Meurer","year":"2017","unstructured":"Meurer WJ, Tolles J. Logistic regression diagnostics: understanding how well a model predicts outcomes. JAMA. 2017;317(10):1068\u20139.","journal-title":"JAMA"},{"issue":"5","key":"641_CR17","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1097\/DCR.0000000000001276","volume":"62","author":"IL Leeds","year":"2019","unstructured":"Leeds IL, Sundel MH, Gabre-Kidan A, et al. Outcomes for ulcerative colitis with delayed emergency colectomy are worse when controlling for preoperative risk factors. Dis Colon Rectum. 2019;62(5):600\u20137.","journal-title":"Dis Colon Rectum"},{"issue":"1","key":"641_CR18","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1097\/MPG.0000000000001898","volume":"67","author":"K Li","year":"2018","unstructured":"Li K, Strauss R, Ouahed J, et al. Molecular comparison of adult and pediatric ulcerative colitis indicates broad similarity of molecular pathways in disease tissue. J Pediatr Gastroenterol Nutr. 2018;67(1):45\u201352.","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"10","key":"641_CR19","doi-asserted-by":"publisher","first-page":"1802","DOI":"10.1097\/MIB.0000000000000169","volume":"20","author":"PJ Smith","year":"2014","unstructured":"Smith PJ, Levine AP, Dunne J, et al. Mucosal transcriptomics implicates under expression of BRINP3 in the pathogenesis of ulcerative colitis. Inflamm Bowel Dis. 2014;20(10):1802\u201312.","journal-title":"Inflamm Bowel Dis"},{"issue":"6","key":"641_CR20","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1111\/fcp.12478","volume":"33","author":"L Guo","year":"2019","unstructured":"Guo L, Wan Z, Xu B, et al. Blockade of angiogenin by thalidomide inhibits the tumorigenesis of murine hemangioendothelioma. Fundam Clin Pharmacol. 2019;33(6):659\u201369.","journal-title":"Fundam Clin Pharmacol"},{"issue":"5","key":"641_CR21","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1038\/nmeth.3337","volume":"12","author":"AM Newman","year":"2015","unstructured":"Newman AM, Liu CL, Green MR, et al. Robust enumeration of cell subsets from tissue expression profiles. Nat Methods. 2015;12(5):453\u20137.","journal-title":"Nat Methods"},{"issue":"5","key":"641_CR22","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","volume":"16","author":"G Yu","year":"2012","unstructured":"Yu G, Wang LG, Han Y, He QY. clusterProfiler: an R package for comparing biological themes among gene clusters. OMICS. 2012;16(5):284\u20137.","journal-title":"OMICS"},{"issue":"D1","key":"641_CR23","doi-asserted-by":"publisher","first-page":"D607","DOI":"10.1093\/nar\/gky1131","volume":"47","author":"D Szklarczyk","year":"2019","unstructured":"Szklarczyk D, Gable AL, Lyon D, et al. STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Res. 2019;47(D1):D607\u201313.","journal-title":"Nucleic Acids Res"},{"issue":"11","key":"641_CR24","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"P Shannon","year":"2003","unstructured":"Shannon P, Markiel A, Ozier O, et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 2003;13(11):2498\u2013504.","journal-title":"Genome Res"},{"issue":"1","key":"641_CR25","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1038\/nrgastro.2015.186","volume":"13","author":"HS de Souza","year":"2016","unstructured":"de Souza HS, Fiocchi C. Immunopathogenesis of IBD: current state of the art. Nat Rev Gastroenterol Hepatol. 2016;13(1):13\u201327.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"1","key":"641_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00423-011-0789-4","volume":"397","author":"J Maul","year":"2012","unstructured":"Maul J, Zeitz M. Ulcerative colitis: immune function, tissue fibrosis and current therapeutic considerations. Langenbecks Arch Surg. 2012;397(1):1\u201310.","journal-title":"Langenbecks Arch Surg"},{"issue":"8","key":"641_CR27","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1038\/s41590-019-0415-0","volume":"20","author":"MF Neurath","year":"2019","unstructured":"Neurath MF. Targeting immune cell circuits and trafficking in inflammatory bowel disease. Nat Immunol. 2019;20(8):970\u20139.","journal-title":"Nat Immunol"},{"issue":"4","key":"641_CR28","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1093\/labmed\/lmz003","volume":"50","author":"K Okada","year":"2019","unstructured":"Okada K, Okabe M, Kimura Y, Itoh H, Ikemoto M. Serum S100A8\/A9 as a potentially sensitive biomarker for inflammatory bowel disease. Lab Med. 2019;50(4):370\u201380.","journal-title":"Lab Med"},{"issue":"10080","key":"641_CR29","doi-asserted-by":"publisher","first-page":"1756","DOI":"10.1016\/S0140-6736(16)32126-2","volume":"389","author":"R Ungaro","year":"2017","unstructured":"Ungaro R, Mehandru S, Allen PB, Peyrin-Biroulet L, Colombel JF. Ulcerative colitis. Lancet. 2017;389(10080):1756\u201370.","journal-title":"Lancet"},{"issue":"3","key":"641_CR30","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.cgh.2017.06.016","volume":"16","author":"M Fumery","year":"2018","unstructured":"Fumery M, Singh S, Dulai PS, Gower-Rousseau C, Peyrin-Biroulet L, Sandborn WJ. Natural history of adult ulcerative colitis in population-based cohorts: a systematic review. Clin Gastroenterol Hepatol. 2018;16(3):343-356 e3.","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"3","key":"641_CR31","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1053\/j.gastro.2018.12.008","volume":"156","author":"S Singh","year":"2019","unstructured":"Singh S, Feuerstein JD, Binion DG, Tremaine WJ. AGA technical review on the management of mild-to-moderate ulcerative colitis. Gastroenterology. 2019;156(3):769-808 e29.","journal-title":"Gastroenterology"},{"issue":"11","key":"641_CR32","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1038\/nrgastro.2016.116","volume":"13","author":"P Hindryckx","year":"2016","unstructured":"Hindryckx P, Jairath V, D\u2019Haens G. Acute severe ulcerative colitis: from pathophysiology to clinical management. Nat Rev Gastroenterol Hepatol. 2016;13(11):654\u201364.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"11","key":"641_CR33","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1093\/ecco-jcc\/jjx091","volume":"11","author":"N Planell","year":"2017","unstructured":"Planell N, Masamunt MC, Leal RF, et al. Usefulness of transcriptional blood biomarkers as a non-invasive surrogate marker of mucosal healing and endoscopic response in ulcerative colitis. J Crohns Colitis. 2017;11(11):1335\u201346.","journal-title":"J Crohns Colitis"},{"issue":"6","key":"641_CR34","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1111\/apt.15141","volume":"49","author":"AH Keshteli","year":"2019","unstructured":"Keshteli AH, Madsen KL, Mandal R, et al. Comparison of the metabolomic profiles of irritable bowel syndrome patients with ulcerative colitis patients and healthy controls: new insights into pathophysiology and potential biomarkers. Aliment Pharmacol Ther. 2019;49(6):723\u201332.","journal-title":"Aliment Pharmacol Ther"},{"issue":"7563","key":"641_CR35","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1136\/bmj.333.7563.340","volume":"333","author":"P Collins","year":"2006","unstructured":"Collins P, Rhodes J. Ulcerative colitis: diagnosis and management. BMJ. 2006;333(7563):340\u20133.","journal-title":"BMJ"},{"issue":"7789","key":"641_CR36","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1038\/s41586-019-1844-5","volume":"577","author":"K Nanki","year":"2020","unstructured":"Nanki K, Fujii M, Shimokawa M, et al. Somatic inflammatory gene mutations in human ulcerative colitis epithelium. Nature. 2020;577(7789):254\u20139.","journal-title":"Nature"},{"issue":"19","key":"641_CR37","doi-asserted-by":"publisher","first-page":"5823","DOI":"10.3748\/wjg.v21.i19.5823","volume":"21","author":"CS Catana","year":"2015","unstructured":"Catana CS, Berindan Neagoe I, Cozma V, Magdas C, Tabaran F, Dumitrascu DL. Contribution of the IL-17\/IL-23 axis to the pathogenesis of inflammatory bowel disease. World J Gastroenterol. 2015;21(19):5823\u201330.","journal-title":"World J Gastroenterol"},{"key":"641_CR38","doi-asserted-by":"publisher","first-page":"2211","DOI":"10.3389\/fimmu.2018.02211","volume":"9","author":"HP Sham","year":"2018","unstructured":"Sham HP, Bazett M, Bosiljcic M, et al. Immune stimulation using a gut microbe-based immunotherapy reduces disease pathology and improves barrier function in ulcerative colitis. Front Immunol. 2018;9:2211.","journal-title":"Front Immunol"},{"issue":"15","key":"641_CR39","first-page":"4941","volume":"22","author":"ZL Wang","year":"2018","unstructured":"Wang ZL, Wang YD, Wang K, Li JA, Li L. KFL2 participates in the development of ulcerative colitis through inhibiting inflammation via regulating cytokines. Eur Rev Med Pharmacol Sci. 2018;22(15):4941\u20138.","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"4","key":"641_CR40","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1007\/s00428-005-0136-7","volume":"448","author":"Y Jinno","year":"2006","unstructured":"Jinno Y, Ohtani H, Nakamura S, et al. Infiltration of CD19+ plasma cells with frequent labeling of Ki-67 in corticosteroid-resistant active ulcerative colitis. Virchows Arch. 2006;448(4):412\u201321.","journal-title":"Virchows Arch"},{"key":"641_CR41","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2016.215","volume":"7","author":"F Souza-Fonseca-Guimaraes","year":"2016","unstructured":"Souza-Fonseca-Guimaraes F, Krasnova Y, Putoczki T, et al. Granzyme M has a critical role in providing innate immune protection in ulcerative colitis. Cell Death Dis. 2016;7: e2302.","journal-title":"Cell Death Dis"},{"issue":"3","key":"641_CR42","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.apsb.2019.08.006","volume":"10","author":"H Li","year":"2020","unstructured":"Li H, Fan C, Lu H, et al. Protective role of berberine on ulcerative colitis through modulating enteric glial cells-intestinal epithelial cells-immune cells interactions. Acta Pharm Sin B. 2020;10(3):447\u201361.","journal-title":"Acta Pharm Sin B"},{"issue":"1","key":"641_CR43","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1111\/cei.13294","volume":"197","author":"H Rabe","year":"2019","unstructured":"Rabe H, Malmquist M, Barkman C, et al. Distinct patterns of naive, activated and memory T and B cells in blood of patients with ulcerative colitis or Crohn\u2019s disease. Clin Exp Immunol. 2019;197(1):111\u201329.","journal-title":"Clin Exp Immunol"},{"key":"641_CR44","doi-asserted-by":"publisher","first-page":"175628481879355","DOI":"10.1177\/1756284818793558","volume":"11","author":"A Acovic","year":"2018","unstructured":"Acovic A, Simovic Markovic B, Gazdic M, et al. Indoleamine 2,3-dioxygenase-dependent expansion of T-regulatory cells maintains mucosal healing in ulcerative colitis. Therap Adv Gastroenterol. 2018;11:1756284818793558.","journal-title":"Therap Adv Gastroenterol"},{"issue":"8","key":"641_CR45","doi-asserted-by":"publisher","first-page":"1992","DOI":"10.1097\/MIB.0000000000000824","volume":"22","author":"ST Gren","year":"2016","unstructured":"Gren ST, Grip O. Role of monocytes and intestinal macrophages in Crohn\u2019s disease and ulcerative colitis. Inflamm Bowel Dis. 2016;22(8):1992\u20138.","journal-title":"Inflamm Bowel Dis"},{"issue":"2","key":"641_CR46","doi-asserted-by":"publisher","first-page":"230","DOI":"10.2478\/v10039-012-0029-3","volume":"57","author":"O Stasikowska-Kanicka","year":"2012","unstructured":"Stasikowska-Kanicka O, Danilewicz M, Glowacka A, Wagrowska-Danilewicz M. Mast cells and eosinophils are involved in activation of ulcerative colitis. Adv Med Sci. 2012;57(2):230\u20136.","journal-title":"Adv Med Sci"},{"issue":"2","key":"641_CR47","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1080\/00365521.2016.1235224","volume":"52","author":"D Muthas","year":"2017","unstructured":"Muthas D, Reznichenko A, Balendran CA, et al. Neutrophils in ulcerative colitis: a review of selected biomarkers and their potential therapeutic implications. Scand J Gastroenterol. 2017;52(2):125\u201335.","journal-title":"Scand J Gastroenterol"},{"issue":"10","key":"641_CR48","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000014757","volume":"98","author":"G Xue","year":"2019","unstructured":"Xue G, Zhong Y, Hua L, et al. Aberrant alteration of follicular T helper cells in ulcerative colitis patients and its correlations with interleukin-21 and B cell subsets. Medicine (Baltimore). 2019;98(10): e14757.","journal-title":"Medicine (Baltimore)"},{"issue":"8","key":"641_CR49","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.17219\/acem\/94160","volume":"28","author":"XH Lin","year":"2019","unstructured":"Lin XH, Wang HC, Li YY, et al. IgG plasma cells initiate changes in the protein C system in mouse ulcerative colitis through CD14+CD64+ macrophage activation. Adv Clin Exp Med. 2019;28(8):1101\u201310.","journal-title":"Adv Clin Exp Med"},{"issue":"24","key":"641_CR50","doi-asserted-by":"publisher","first-page":"2285","DOI":"10.1056\/NEJMp1907407","volume":"381","author":"AS Adamson","year":"2019","unstructured":"Adamson AS, Welch HG. Machine learning and the cancer-diagnosis problem\u2014no gold standard. N Engl J Med. 2019;381(24):2285\u20137.","journal-title":"N Engl J Med"},{"issue":"9","key":"641_CR51","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1038\/s41591-019-0548-6","volume":"25","author":"J Wiens","year":"2019","unstructured":"Wiens J, Saria S, Sendak M, et al. Do no harm: a roadmap for responsible machine learning for health care. Nat Med. 2019;25(9):1337\u201340.","journal-title":"Nat Med"},{"issue":"7697","key":"641_CR52","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1038\/d41586-018-02881-7","volume":"555","author":"D Wong","year":"2018","unstructured":"Wong D, Yip S. Machine learning classifies cancer. Nature. 2018;555(7697):446\u20137.","journal-title":"Nature"},{"issue":"2","key":"641_CR53","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1148\/rg.2017160130","volume":"37","author":"BJ Erickson","year":"2017","unstructured":"Erickson BJ, Korfiatis P, Akkus Z, Kline TL. Machine learning for medical imaging. Radiographics. 2017;37(2):505\u201315.","journal-title":"Radiographics"},{"issue":"8","key":"641_CR54","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1136\/gutjnl-2019-318343","volume":"68","author":"D Biasci","year":"2019","unstructured":"Biasci D, Lee JC, Noor NM, et al. A blood-based prognostic biomarker in IBD. Gut. 2019;68(8):1386\u201395.","journal-title":"Gut"},{"issue":"1","key":"641_CR55","doi-asserted-by":"publisher","first-page":"2427","DOI":"10.1038\/s41598-017-02606-2","volume":"7","author":"E Mossotto","year":"2017","unstructured":"Mossotto E, Ashton JJ, Coelho T, Beattie RM, MacArthur BD, Ennis S. Classification of paediatric inflammatory bowel disease using machine learning. Sci Rep. 2017;7(1):2427.","journal-title":"Sci Rep"},{"issue":"2","key":"641_CR56","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031241","volume":"7","author":"R Duttagupta","year":"2012","unstructured":"Duttagupta R, DiRienzo S, Jiang R, et al. Genome-wide maps of circulating miRNA biomarkers for ulcerative colitis. PLoS ONE. 2012;7(2): e31241.","journal-title":"PLoS ONE"},{"issue":"12","key":"641_CR57","doi-asserted-by":"publisher","first-page":"2635","DOI":"10.3748\/wjg.v9.i12.2635","volume":"9","author":"YW Zhang","year":"2003","unstructured":"Zhang YW, Ding LS, Lai MD. Reg gene family and human diseases. World J Gastroenterol. 2003;9(12):2635\u201341.","journal-title":"World J Gastroenterol"},{"issue":"11","key":"641_CR58","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.3109\/00365521.2011.605463","volume":"46","author":"A Granlund","year":"2011","unstructured":"Granlund A, Beisvag V, Torp SH, et al. Activation of REG family proteins in colitis. Scand J Gastroenterol. 2011;46(11):1316\u201323.","journal-title":"Scand J Gastroenterol"},{"key":"641_CR59","first-page":"198","volume":"12","author":"C Tsuchida","year":"2017","unstructured":"Tsuchida C, Sakuramoto-Tsuchida S, Taked M, et al. Expression of REG family genes in human inflammatory bowel diseases and its regulation. Biochem Biophys Rep. 2017;12:198\u2013205.","journal-title":"Biochem Biophys Rep"},{"issue":"1","key":"641_CR60","doi-asserted-by":"publisher","first-page":"16241","DOI":"10.1038\/s41598-018-34263-4","volume":"8","author":"PK Shukla","year":"2018","unstructured":"Shukla PK, Meena AS, Rao V, Rao RG, Balazs L, Rao R. Human defensin-5 blocks ethanol and colitis-induced dysbiosis, tight junction disruption and inflammation in mouse intestine. Sci Rep. 2018;8(1):16241.","journal-title":"Sci Rep"},{"issue":"3","key":"641_CR61","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1093\/ecco-jcc\/jjx139","volume":"12","author":"H Taman","year":"2018","unstructured":"Taman H, Fenton CG, Hensel IV, Anderssen E, Florholmen J, Paulssen RH. Transcriptomic landscape of treatment-naive ulcerative colitis. J Crohns Colitis. 2018;12(3):327\u201336.","journal-title":"J Crohns Colitis"},{"issue":"4","key":"641_CR62","first-page":"1301","volume":"58","author":"CG Tieranu","year":"2017","unstructured":"Tieranu CG, Dobre M, Manuc TE, et al. Gene expression profile of endoscopically active and inactive ulcerative colitis: preliminary data. Rom J Morphol Embryol. 2017;58(4):1301\u20137.","journal-title":"Rom J Morphol Embryol"},{"issue":"5","key":"641_CR63","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1093\/hmg\/10.5.445","volume":"10","author":"IC Lawrance","year":"2001","unstructured":"Lawrance IC, Fiocchi C, Chakravarti S. Ulcerative colitis and Crohn\u2019s disease: distinctive gene expression profiles and novel susceptibility candidate genes. Hum Mol Genet. 2001;10(5):445\u201356.","journal-title":"Hum Mol Genet"},{"issue":"10","key":"641_CR64","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1136\/gut.2004.053587","volume":"54","author":"A Sekikawa","year":"2005","unstructured":"Sekikawa A, Fukui H, Fujii S, et al. Possible role of REG Ialpha protein in ulcerative colitis and colitic cancer. Gut. 2005;54(10):1437\u201344.","journal-title":"Gut"},{"issue":"11","key":"641_CR65","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1093\/ecco-jcc\/jjy117","volume":"12","author":"H Taman","year":"2018","unstructured":"Taman H, Fenton CG, Hensel IV, Anderssen E, Florholmen J, Paulssen RH. Genome-wide DNA methylation in treatment-naive ulcerative colitis. J Crohns Colitis. 2018;12(11):1338\u201347.","journal-title":"J Crohns Colitis"}],"container-title":["Human Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13577-021-00641-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13577-021-00641-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13577-021-00641-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T11:33:45Z","timestamp":1675856025000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13577-021-00641-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,3]]},"references-count":65,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,1]]}},"alternative-id":["641"],"URL":"https:\/\/doi.org\/10.1007\/s13577-021-00641-w","relation":{"references":[{"id-type":"uri","id":"","asserted-by":"subject"}]},"ISSN":["1749-0774"],"issn-type":[{"value":"1749-0774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,3]]},"assertion":[{"value":"27 July 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 October 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 November 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}