{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T19:56:41Z","timestamp":1725911801359},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T00:00:00Z","timestamp":1651708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T00:00:00Z","timestamp":1651708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Human Cell"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1007\/s13577-022-00705-5","type":"journal-article","created":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T06:02:53Z","timestamp":1651730573000},"page":"1005-1015","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Factors influencing mesenchymal stromal cells in in vitro cellular models to study retinal pigment epithelial cell rescue"],"prefix":"10.1007","volume":"35","author":[{"given":"Girish K.","family":"Srivastava","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Rodriguez-Crespo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Fernandez-Bueno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Carlos","family":"Pastor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,5,5]]},"reference":[{"key":"705_CR1","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/S0039-6257(00)00140-5","volume":"45","author":"S Beatty","year":"2000","unstructured":"Beatty S, Koh H, Phil M, Henson D, Boulton M. The role of oxidative stress in the pathogenesis of age-related macular degeneration. Surv Ophthalmol. 2000;45:115\u201334.","journal-title":"Surv Ophthalmol"},{"key":"705_CR2","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/S1350-9462(99)00009-9","volume":"19","author":"J Cai","year":"2000","unstructured":"Cai J, Nelson KC, Wu M, Sternberg P, Jones DP. Oxidative damage and protection of the RPE. Prog Retin Eye Res. 2000;19:205\u201321.","journal-title":"Prog Retin Eye Res"},{"key":"705_CR3","first-page":"32","volume":"5","author":"BS Winkler","year":"1999","unstructured":"Winkler BS, Boulton ME, Gottsch JD, Sternberg P. Oxidative damage and age-related macular degeneration. Mol Vis. 1999;5:32.","journal-title":"Mol Vis"},{"key":"705_CR4","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1111\/jcmm.12070","volume":"17","author":"P Kay","year":"2013","unstructured":"Kay P, Yang YC, Paraoan L. Directional protein secretion by the retinal pigment epithelium: roles in retinal health and the development of age-related macular degeneration. J Cell Mol Med. 2013;17:833\u201343.","journal-title":"J Cell Mol Med"},{"key":"705_CR5","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.survophthal.2013.09.004","volume":"59","author":"AM Kolomeyer","year":"2014","unstructured":"Kolomeyer AM, Zarbin MA. Trophic factors in the pathogenesis and therapy for retinal degenerative diseases. Surv Ophthalmol. 2014;59:134\u201365.","journal-title":"Surv Ophthalmol"},{"key":"705_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2019.05.011","volume":"185","author":"S Labrador-Velandia","year":"2019","unstructured":"Labrador-Velandia S, Alonso-Alonso ML, Di Lauro S, Garc\u00eda-Gutierrez MT, Srivastava GK, Pastor JC, Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures. Exp Eye Res. 2019;185: 107671.","journal-title":"Exp Eye Res"},{"key":"705_CR7","first-page":"81","volume":"2","author":"S Di Lauro","year":"2019","unstructured":"Di Lauro S, Garcia-Gutierrez MT, Fernandez-Bueno I. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina. Allbiosolution. 2019;2:81\u20133.","journal-title":"Allbiosolution"},{"key":"705_CR8","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.stemcr.2015.01.001","volume":"4","author":"F Bortolotti","year":"2015","unstructured":"Bortolotti F, Ukovich L, Razban V, Martinelli V, Ruozi G, Pelos B, Dore F, Giacca M, Zacchigna S. In vivo therapeutic potential of mesenchymal stromal cells depends on the source and the isolation procedure. Stem Cell Rep. 2015;4:332\u20139.","journal-title":"Stem Cell Rep"},{"key":"705_CR9","doi-asserted-by":"publisher","first-page":"e8","DOI":"10.1017\/erm.2014.8","volume":"16","author":"MH Lim","year":"2014","unstructured":"Lim MH, Ong WK, Sugii S. The current landscape of adipose-derived stem cells in clinical applications. Expert Rev Mol Med. 2014;16:e8.","journal-title":"Expert Rev Mol Med"},{"key":"705_CR10","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1517\/14712598.2013.823153","volume":"13","author":"M Piku\u0142a","year":"2013","unstructured":"Piku\u0142a M, Marek-Trzonkowska N, Wardowska A, Renkielska A, Trzonkowski P. Adipose tissue-derived stem cells in clinical applications. Expert Opin Biol Ther. 2013;13:1357\u201370.","journal-title":"Expert Opin Biol Ther"},{"issue":"16","key":"705_CR11","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.stem.2015.02.019","volume":"2015","author":"Y Kfoury","year":"2015","unstructured":"Kfoury Y, Scadden DT. Mesenchymal cell contributions to the stem cell niche. Cell Stem Cell. 2015;2015(16):239\u201353.","journal-title":"Cell Stem Cell"},{"key":"705_CR12","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1038\/nrm3049","volume":"12","author":"C Nombela-Arrieta","year":"2011","unstructured":"Nombela-Arrieta C, Ritz J, Silberstein LE. The elusive nature and function of mesenchymal stem cells. Nat Rev Mol Cell Biol. 2011;12:126\u201331.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"705_CR13","doi-asserted-by":"publisher","first-page":"312","DOI":"10.4252\/wjsc.v6.i3.312","volume":"6","author":"W Tsuji","year":"2014","unstructured":"Tsuji W, Rubin JP, Marra KG. Adipose-derived stem cells: implications in tissue regeneration. World J Stem Cells. 2014;6:312\u20133214.","journal-title":"World J Stem Cells"},{"issue":"Suppl 1","key":"705_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000339839","volume":"48","author":"GA Moviglia","year":"2012","unstructured":"Moviglia GA, Blasetti N, Zarate JO, Pelayes DE. In vitro differentiation of adult adipose mesenchymal stem cells into retinal progenitor cells. Ophthalmic Res. 2012;48(Suppl 1):1\u20135.","journal-title":"Ophthalmic Res"},{"key":"705_CR15","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1007\/s00441-014-1987-5","volume":"358","author":"D Rodriguez-Crespo","year":"2014","unstructured":"Rodriguez-Crespo D, Di Lauro S, Singh AK, Garcia-Gutierrez MT, Garrosa M, Pastor JC, Fernandez-Bueno I, Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 2014;358:705\u201316.","journal-title":"Cell Tissue Res"},{"key":"705_CR16","first-page":"1577","volume":"28","author":"AK Singh","year":"2013","unstructured":"Singh AK, Srivastava GK, Garc\u00eda-Guti\u00e9rrez MT, Pastor JC. Adipose derived mesenchymal stem cells partially rescue mitomycin C treated ARPE19 cells from death in co-culture condition. Histol Histopathol. 2013;28:1577\u201383.","journal-title":"Histol Histopathol"},{"key":"705_CR17","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1080\/14653240802714819","volume":"11","author":"U Vossmerbaeumer","year":"2009","unstructured":"Vossmerbaeumer U, Ohnesorge S, Kuehl S, Haapalahti M, Kluter H, Jonas JB, Thierse H-J, Bieback K. Retinal pigment epithelial phenotype induced in human adipose tissue-derived mesenchymal stromal cells. Cytotherapy. 2009;11:177\u201388.","journal-title":"Cytotherapy"},{"key":"705_CR18","first-page":"2148","volume":"14","author":"I Fernandez-Bueno","year":"2006","unstructured":"Fernandez-Bueno I, Pastor JC, Gayoso MJ, Alcalde I, Garcia MT. M\u00fcller and macrophage-like cell interactions in an organotypic culture of porcine neuroretina. Mol Vis. 2006;14:2148\u201356.","journal-title":"Mol Vis"},{"key":"705_CR19","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.exer.2012.08.012","volume":"104","author":"I Fernandez-Bueno","year":"2012","unstructured":"Fernandez-Bueno I, Fern\u00e1ndez-S\u00e1nchez L, Gayoso MJ, Garc\u00eda-Gutierrez MT, Pastor JC, Cuenca N. Time course modifications in organotypic culture of human neuroretina. Exp Eye Res. 2012;104:26\u201338.","journal-title":"Exp Eye Res"},{"key":"705_CR20","first-page":"243","volume":"22","author":"S Di Lauro","year":"2016","unstructured":"Di Lauro S, Rodriguez-Crespo D, Gayoso MJ, Garcia-Gutierrez MT, Pastor JC, Srivastava GK, Fernandez-Bueno I. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Mol Vis. 2016;22:243\u201353.","journal-title":"Mol Vis"},{"key":"705_CR21","doi-asserted-by":"publisher","first-page":"933","DOI":"10.3109\/02713683.2013.802809","volume":"38","author":"T Nieto-Miguel","year":"2013","unstructured":"Nieto-Miguel T, Galindo S, Reinoso R, Corell A, Martino M, P\u00e9rez-Sim\u00f3n JA, Calonge M. In vitro simulation of corneal epithelium microenvironment induces a corneal epithelial-like cell phenotype from human adipose tissue mesenchymal stem cells. Curr Eye Res. 2013;38:933\u201344.","journal-title":"Curr Eye Res"},{"key":"705_CR22","doi-asserted-by":"publisher","first-page":"2160","DOI":"10.1002\/stem.2672","volume":"35","author":"S Galindo","year":"2017","unstructured":"Galindo S, Herreras JM, L\u00f3pez-Paniagua M, Rey E, Mata A, Plata-Cordero M, Calonge M, Teresa Nieto-Miguel T. Therapeutic effect of human adipose tissue-derived mesenchymal stem cells in experimental corneal failure due to limbal stem cell niche damage. Stem Cells. 2017;35:2160\u201374.","journal-title":"Stem Cells"},{"key":"705_CR23","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1002\/jbm.a.33050","volume":"97","author":"GK Srivastava","year":"2011","unstructured":"Srivastava GK, Mart\u00edn L, Singh AK, Fernandez-Bueno I, Gayoso MJ, Garcia- Gutierrez MT, Girotti A, Alonso M, Rodr\u00edguez-Cabello JC, Pastor JC. Elastin-like recombinamers as substrates for retinal pigment epithelial cell growth. J Biomed Mater Res A. 2011;97:243\u201350.","journal-title":"J Biomed Mater Res A"},{"key":"705_CR24","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.jim.2013.01.003","volume":"389","author":"GK Srivastava","year":"2013","unstructured":"Srivastava GK, Reinoso R, Singh AK, Fernandez-Bueno I, Martino M, Garcia- Gutierrez MT, Pastor JC, Corell A. Flow cytometry assessment of the purity of human retinal pigment epithelial primary cell cultures. J Immunol Methods. 2013;389:61\u20138.","journal-title":"J Immunol Methods"},{"key":"705_CR25","doi-asserted-by":"publisher","first-page":"5421","DOI":"10.1046\/j.1432-1327.2000.01606.x","volume":"267","author":"J O\u2019Brien","year":"2000","unstructured":"O\u2019Brien J, Wilson I, Orton T, Pognan F. Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity. Eur J Biochem. 2000;267:5421\u20136.","journal-title":"Eur J Biochem"},{"key":"705_CR26","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.2147\/CIA.S143508","volume":"12","author":"WM Al-Zamil","year":"2017","unstructured":"Al-Zamil WM, Yassin SA. Recent developments in age-related macular degeneration: a review. Clin Interv Aging. 2017;12:1313\u201330.","journal-title":"Clin Interv Aging"},{"key":"705_CR27","doi-asserted-by":"publisher","DOI":"10.3791\/56702","author":"S Petrus-Reurer","year":"2018","unstructured":"Petrus-Reurer S, Bartuma H, Aronsson M, Westman S, Lanner F, Kvanta A. Subretinal transplantation of human embryonic stem cell derived-retinal pigment epithelial cells into a large-eyed model of geographic atrophy. J Vis Exp. 2018. https:\/\/doi.org\/10.3791\/56702.","journal-title":"J Vis Exp"},{"key":"705_CR28","first-page":"1309","volume":"19","author":"M Flood","year":"1980","unstructured":"Flood M, Gouras P, Kjeldbye H. Growth characteristics and ultrastructure of human retinal pigment epithelium in vitro. Invest Ophthalmol Vis Sci. 1980;19:1309\u201320.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"705_CR29","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1002\/jbm.a.34726","volume":"102","author":"AK Singh","year":"2014","unstructured":"Singh AK, Srivastava GK, Mart\u00edn L, Alonso M, Pastor JC. Bioactive substrates for human retinal pigment epithelial cell growth from elastin-like recombinamers. J Biomed Mater Res A. 2014;102:639\u201346.","journal-title":"J Biomed Mater Res A"},{"key":"705_CR30","doi-asserted-by":"publisher","first-page":"3362","DOI":"10.3390\/ijms19113362","volume":"19","author":"LJ Rohowetz","year":"2018","unstructured":"Rohowetz LJ, Kraus JG, Koulen P. Reactive oxygen species-mediated damage of retinal neurons: drug development targets for therapies of chronic neurodegeneration of the retina. Int J Mol Sci. 2018;19:3362.","journal-title":"Int J Mol Sci"},{"key":"705_CR31","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1016\/j.freeradbiomed.2010.01.022","volume":"48","author":"P Kaczara","year":"2010","unstructured":"Kaczara P, Sarna T, Burke JM. Dynamics of H2O2 availability to ARPE-19 cultures in models of oxidative stress. Free Radic Biol Med. 2010;48:1064\u201370.","journal-title":"Free Radic Biol Med"},{"key":"705_CR32","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/S0921-8777(97)00047-5","volume":"385","author":"JJ Salazar","year":"1997","unstructured":"Salazar JJ, Van Houten B. Preferential mitochondrial DNA injury caused by glucose oxidase as a steady generator of hydrogen peroxide in human fibroblasts. Mutat Res. 1997;385:139\u201349.","journal-title":"Mutat Res"},{"key":"705_CR33","first-page":"3512","volume":"17","author":"X Wankun","year":"2011","unstructured":"Wankun X, Wenzhen Y, Min Z, Weiyan Z, Huan C, Wei D, Lvzhen H, Xu Y, Xiaoxin L. Protective effect of paeoniflorin against oxidative stress in human retinal pigment epithelium in vitro. Mol Vis. 2011;17:3512\u201322.","journal-title":"Mol Vis"},{"key":"705_CR34","first-page":"71","volume":"02","author":"GK Srivastava","year":"2020","unstructured":"Srivastava GK, Due\u00f1as-Laita A, Pastor JC. Dimethyl sulfoxide toxic and stimulation effects in retinal pigment epithelial cells. Allbiosolution. 2020;02:71\u20135.","journal-title":"Allbiosolution"}],"container-title":["Human Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13577-022-00705-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13577-022-00705-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13577-022-00705-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T17:16:37Z","timestamp":1656004597000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13577-022-00705-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,5]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["705"],"URL":"https:\/\/doi.org\/10.1007\/s13577-022-00705-5","relation":{},"ISSN":["1749-0774"],"issn-type":[{"value":"1749-0774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,5]]},"assertion":[{"value":"9 February 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 April 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 May 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no conflicts of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"The authors declare there is no participation of human and animal in this study. A local slaughterhouse (J. Gutierrez S.L. Valladolid, Spain) donated the porcine eyes under an institutional agreement for research purposes and the Ocular Surface Group (OSG) of our institution provided human AT-MSC; these cells were isolated, characterized, and used in the research studies of our research group [CitationRef removed, CitationRef removed], including publications by the OSG [CitationRef removed, CitationRef removed].","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research involving human participants and\/or animals"}}]}}