{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T02:49:38Z","timestamp":1785293378642,"version":"3.55.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T00:00:00Z","timestamp":1659657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T00:00:00Z","timestamp":1659657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2019BH021"],"award-info":[{"award-number":["ZR2019BH021"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2019A1515110116"],"award-info":[{"award-number":["2019A1515110116"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2019A1515110221"],"award-info":[{"award-number":["2019A1515110221"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20200224"],"award-info":[{"award-number":["BK20200224"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Chinese Foundation for Hepatitis Prevention and Control-TianQing Liver Disease Research Fund Subject","award":["TQGB20200043"],"award-info":[{"award-number":["TQGB20200043"]}]},{"DOI":"10.13039\/501100014764","name":"China International Medical Foundation","doi-asserted-by":"crossref","award":["Z-2014-06-2102"],"award-info":[{"award-number":["Z-2014-06-2102"]}],"id":[{"id":"10.13039\/501100014764","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Human Cell"],"DOI":"10.1007\/s13577-022-00760-y","type":"journal-article","created":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T05:02:32Z","timestamp":1659675752000},"page":"1752-1765","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["FOSL2 deficiency delays nonalcoholic steatohepatitis progression by regulating LY6D-mediated NLRP3 activation"],"prefix":"10.1007","volume":"35","author":[{"given":"Pei-Xin","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Yan","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Ping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Qing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,8,5]]},"reference":[{"issue":"21","key":"760_CR1","doi-asserted-by":"publisher","first-page":"2063","DOI":"10.1056\/NEJMra1503519","volume":"377","author":"AM Diehl","year":"2017","unstructured":"Diehl AM, Day C. Cause, pathogenesis, and treatment of nonalcoholic steatohepatitis. N Engl J Med. 2017;377(21):2063\u201372. https:\/\/doi.org\/10.1056\/NEJMra1503519.","journal-title":"N Engl J Med"},{"issue":"2","key":"760_CR2","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1055\/s-0037-1601350","volume":"37","author":"F Alegre","year":"2017","unstructured":"Alegre F, Pelegrin P, Feldstein AE. Inflammasomes in liver fibrosis. Semin Liver Dis. 2017;37(2):119\u201327. https:\/\/doi.org\/10.1055\/s-0037-1601350.","journal-title":"Semin Liver Dis"},{"issue":"1","key":"760_CR3","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1055\/s-0035-1571272","volume":"36","author":"A Wree","year":"2016","unstructured":"Wree A, Mehal WZ, Feldstein AE. Targeting cell death and sterile inflammation loop for the treatment of nonalcoholic steatohepatitis. Semin Liver Dis. 2016;36(1):27\u201336. https:\/\/doi.org\/10.1055\/s-0035-1571272.","journal-title":"Semin Liver Dis"},{"key":"760_CR4","doi-asserted-by":"publisher","first-page":"6489012","DOI":"10.1155\/2016\/6489012","volume":"2016","author":"X Wan","year":"2016","unstructured":"Wan X, Xu C, Yu C, Li Y. Role of NLRP3 inflammasome in the progression of NAFLD to NASH. Can J Gastroenterol Hepatol. 2016;2016:6489012. https:\/\/doi.org\/10.1155\/2016\/6489012.","journal-title":"Can J Gastroenterol Hepatol"},{"issue":"5","key":"760_CR5","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1016\/j.jhep.2013.12.026","volume":"60","author":"A Eguchi","year":"2014","unstructured":"Eguchi A, Wree A, Feldstein AE. Biomarkers of liver cell death. J Hepatol. 2014;60(5):1063\u201374. https:\/\/doi.org\/10.1016\/j.jhep.2013.12.026.","journal-title":"J Hepatol"},{"issue":"1","key":"760_CR6","first-page":"667","volume":"9","author":"IF McKenzie","year":"1977","unstructured":"McKenzie IF, Gardiner J, Cherry M, Snell GD. Lymphocyte antigens: Ly-4, Ly-6, and Ly-7. Transpl Proc. 1977;9(1):667\u20139.","journal-title":"Transpl Proc"},{"issue":"4","key":"760_CR7","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1136\/jcp.45.4.303","volume":"45","author":"R Torenbeek","year":"1992","unstructured":"Torenbeek R, Blomjous CE, Quak JJ, Ybema S, Meijer CJ. Use of monoclonal antibody E48 in diagnosing transitional cell carcinoma of urinary bladder. J Clin Pathol. 1992;45(4):303\u20137. https:\/\/doi.org\/10.1136\/jcp.45.4.303.","journal-title":"J Clin Pathol"},{"key":"760_CR8","doi-asserted-by":"publisher","unstructured":"Nagano T, Yamao S, Terachi A, Yarimizu H, Itoh H, Katasho R, Kawai K, Nakashima A, Iwasaki T, Kikkawa U, Kamada S (2019) d-amino acid oxidase promotes cellular senescence via the production of reactive oxygen species. Life Sci Alliance 2 (1). doi:https:\/\/doi.org\/10.26508\/lsa.201800045","DOI":"10.26508\/lsa.201800045"},{"issue":"30","key":"760_CR9","doi-asserted-by":"publisher","first-page":"10525","DOI":"10.1073\/pnas.0801414105","volume":"105","author":"R Eferl","year":"2008","unstructured":"Eferl R, Hasselblatt P, Rath M, Popper H, Zenz R, Komnenovic V, Idarraga MH, Kenner L, Wagner EF. Development of pulmonary fibrosis through a pathway involving the transcription factor Fra-2\/AP-1. Proc Natl Acad Sci USA. 2008;105(30):10525\u201330. https:\/\/doi.org\/10.1073\/pnas.0801414105.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"760_CR10","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1515\/med-2021-0286","volume":"16","author":"S Liao","year":"2021","unstructured":"Liao S, He H, Zeng Y, Yang L, Liu Z, An Z, Zhang M. A nomogram for predicting metabolic steatohepatitis: the combination of NAMPT, RALGDS, GADD45B, FOSL2, RTP3, and RASD1. Open Med (Wars). 2021;16(1):773\u201385. https:\/\/doi.org\/10.1515\/med-2021-0286.","journal-title":"Open Med (Wars)."},{"key":"760_CR11","doi-asserted-by":"publisher","unstructured":"Ramos MJ, Bandiera L, Menolascina F, Fallowfield JA (2022) In vitro models for non-alcoholic fatty liver disease: Emerging platforms and their applications. iScience 25 (1):103549. https:\/\/doi.org\/10.1016\/j.isci.2021.103549","DOI":"10.1016\/j.isci.2021.103549"},{"key":"760_CR12","doi-asserted-by":"publisher","first-page":"2313641","DOI":"10.1155\/2020\/2313641","volume":"2020","author":"T Zhai","year":"2020","unstructured":"Zhai T, Xu W, Liu Y, Qian K, Xiong Y, Chen Y. Honokiol alleviates methionine-choline deficient diet-induced hepatic steatosis and oxidative stress in C57BL\/6 mice by regulating CFLAR-JNK pathway. Oxid Med Cell Longev. 2020;2020:2313641. https:\/\/doi.org\/10.1155\/2020\/2313641.","journal-title":"Oxid Med Cell Longev"},{"issue":"11","key":"760_CR13","doi-asserted-by":"publisher","first-page":"3219","DOI":"10.1084\/jem.20171419","volume":"214","author":"H Jiang","year":"2017","unstructured":"Jiang H, He H, Chen Y, Huang W, Cheng J, Ye J, Wang A, Tao J, Wang C, Liu Q, Jin T, Jiang W, Deng X, Zhou R. Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders. J Exp Med. 2017;214(11):3219\u201338. https:\/\/doi.org\/10.1084\/jem.20171419.","journal-title":"J Exp Med"},{"issue":"2","key":"760_CR14","doi-asserted-by":"publisher","first-page":"2000","DOI":"10.1096\/fj.201800828RR","volume":"33","author":"S Tan","year":"2019","unstructured":"Tan S, Lu Y, Xu M, Huang X, Liu H, Jiang J, Wu B. beta-Arrestin1 enhances liver fibrosis through autophagy-mediated Snail signaling. FASEB J. 2019;33(2):2000\u201316. https:\/\/doi.org\/10.1096\/fj.201800828RR.","journal-title":"FASEB J"},{"issue":"24","key":"760_CR15","doi-asserted-by":"publisher","first-page":"7427","DOI":"10.3748\/wjg.v21.i24.7427","volume":"21","author":"H Enomoto","year":"2015","unstructured":"Enomoto H, Bando Y, Nakamura H, Nishiguchi S, Koga M. Liver fibrosis markers of nonalcoholic steatohepatitis. World J Gastroenterol. 2015;21(24):7427\u201335. https:\/\/doi.org\/10.3748\/wjg.v21.i24.7427.","journal-title":"World J Gastroenterol"},{"key":"760_CR16","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s40364-020-00232-1","volume":"8","author":"N Andersson","year":"2020","unstructured":"Andersson N, Ohlsson J, Wahlin S, Nodin B, Boman K, Lundgren S, Jirstrom K. Lymphocyte antigen 6 superfamily member D is a marker of urothelial and squamous differentiation: implications for risk stratification of bladder cancer. Biomark Res. 2020;8:51. https:\/\/doi.org\/10.1186\/s40364-020-00232-1.","journal-title":"Biomark Res."},{"key":"760_CR17","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA120.013500","volume":"296","author":"T Nagano","year":"2021","unstructured":"Nagano T, Iwasaki T, Onishi K, Awai Y, Terachi A, Kuwaba S, Asano S, Katasho R, Nagai K, Nakashima A, Kikkawa U, Kamada S. LY6D-induced macropinocytosis as a survival mechanism of senescent cells. J Biol Chem. 2021;296: 100049. https:\/\/doi.org\/10.1074\/jbc.RA120.013500.","journal-title":"J Biol Chem"},{"issue":"5","key":"760_CR18","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1016\/j.jhep.2017.01.022","volume":"66","author":"AR Mridha","year":"2017","unstructured":"Mridha AR, Wree A, Robertson AAB, Yeh MM, Johnson CD, Van Rooyen DM, Haczeyni F, Teoh NC, Savard C, Ioannou GN, Masters SL, Schroder K, Cooper MA, Feldstein AE, Farrell GC. NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice. J Hepatol. 2017;66(5):1037\u201346. https:\/\/doi.org\/10.1016\/j.jhep.2017.01.022.","journal-title":"J Hepatol"},{"key":"760_CR19","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.668708","volume":"12","author":"J Chu","year":"2021","unstructured":"Chu J, Yan R, Wang S, Li G, Kang X, Hu Y, Lin M, Shan W, Zhao Y, Wang Z, Sun R, Yao J, Zhang N. Sinapic acid reduces oxidative stress and pyroptosis via inhibition of BRD4 in alcoholic liver disease. Front Pharmacol. 2021;12: 668708. https:\/\/doi.org\/10.3389\/fphar.2021.668708.","journal-title":"Front Pharmacol"},{"issue":"10","key":"760_CR20","doi-asserted-by":"publisher","first-page":"873","DOI":"10.21037\/atm-21-2158","volume":"9","author":"T Zhang","year":"2021","unstructured":"Zhang T, Li J, Liu CP, Guo M, Gao CL, Zhou LP, Long Y, Xu Y. Butyrate ameliorates alcoholic fatty liver disease via reducing endotoxemia and inhibiting liver gasdermin D-mediated pyroptosis. Ann Transl Med. 2021;9(10):873. https:\/\/doi.org\/10.21037\/atm-21-2158.","journal-title":"Ann Transl Med."},{"issue":"2","key":"760_CR21","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1016\/j.jcmgh.2021.04.009","volume":"12","author":"Y Zhu","year":"2021","unstructured":"Zhu Y, Zhao H, Lu J, Lin K, Ni J, Wu G, Tang H. Caspase-11-mediated hepatocytic pyroptosis promotes the progression of nonalcoholic steatohepatitis. Cell Mol Gastroenterol Hepatol. 2021;12(2):653\u201364. https:\/\/doi.org\/10.1016\/j.jcmgh.2021.04.009.","journal-title":"Cell Mol Gastroenterol Hepatol"},{"issue":"5","key":"760_CR22","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.14336\/AD.2019.0116","volume":"10","author":"J Wu","year":"2019","unstructured":"Wu J, Lin S, Wan B, Velani B, Zhu Y. Pyroptosis in liver disease: new insights into disease mechanisms. Aging Dis. 2019;10(5):1094\u2013108. https:\/\/doi.org\/10.14336\/AD.2019.0116.","journal-title":"Aging Dis"},{"issue":"7575","key":"760_CR23","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1038\/nature15514","volume":"526","author":"J Shi","year":"2015","unstructured":"Shi J, Zhao Y, Wang K, Shi X, Wang Y, Huang H, Zhuang Y, Cai T, Wang F, Shao F. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature. 2015;526(7575):660\u20135. https:\/\/doi.org\/10.1038\/nature15514.","journal-title":"Nature"},{"issue":"10","key":"760_CR24","doi-asserted-by":"publisher","first-page":"2757","DOI":"10.1111\/jcmm.17277","volume":"26","author":"H Yang","year":"2022","unstructured":"Yang H, Wang J, Liu ZG. Multi-faceted role of pyroptosis mediated by inflammasome in liver fibrosis. J Cell Mol Med. 2022;26(10):2757\u201365. https:\/\/doi.org\/10.1111\/jcmm.17277.","journal-title":"J Cell Mol Med"},{"issue":"4","key":"760_CR25","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1016\/j.jhep.2017.11.040","volume":"68","author":"B Xu","year":"2018","unstructured":"Xu B, Jiang M, Chu Y, Wang W, Chen D, Li X, Zhang Z, Zhang D, Fan D, Nie Y, Shao F, Wu K, Liang J. Gasdermin D plays a key role as a pyroptosis executor of non-alcoholic steatohepatitis in humans and mice. J Hepatol. 2018;68(4):773\u201382. https:\/\/doi.org\/10.1016\/j.jhep.2017.11.040.","journal-title":"J Hepatol"},{"key":"760_CR26","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.jnutbio.2017.04.009","volume":"47","author":"M Maguire","year":"2017","unstructured":"Maguire M, Bushkofsky JR, Larsen MC, Foong YH, Tanumihardjo SA, Jefcoate CR. Diet-dependent retinoid effects on liver gene expression include stellate and inflammation markers and parallel effects of the nuclear repressor Shp. J Nutr Biochem. 2017;47:63\u201374. https:\/\/doi.org\/10.1016\/j.jnutbio.2017.04.009.","journal-title":"J Nutr Biochem"},{"key":"760_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2019.109408","volume":"64","author":"A Birnhuber","year":"2019","unstructured":"Birnhuber A, Biasin V, Schnoegl D, Marsh LM, Kwapiszewska G. Transcription factor Fra-2 and its emerging role in matrix deposition, proliferation and inflammation in chronic lung diseases. Cell Signal. 2019;64: 109408. https:\/\/doi.org\/10.1016\/j.cellsig.2019.109408.","journal-title":"Cell Signal"},{"issue":"8","key":"760_CR28","doi-asserted-by":"publisher","first-page":"3293","DOI":"10.1172\/JCI125366","volume":"129","author":"AC Ucero","year":"2019","unstructured":"Ucero AC, Bakiri L, Roediger B, Suzuki M, Jimenez M, Mandal P, Braghetta P, Bonaldo P, Paz-Ares L, Fustero-Torre C, Ximenez-Embun P, Hernandez AI, Megias D, Wagner EF. Fra-2-expressing macrophages promote lung fibrosis in mice. J Clin Invest. 2019;129(8):3293\u2013309. https:\/\/doi.org\/10.1172\/JCI125366.","journal-title":"J Clin Invest"},{"issue":"4","key":"760_CR29","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1093\/cvr\/cvq123","volume":"87","author":"S Roy","year":"2010","unstructured":"Roy S, Khanna S, Azad A, Schnitt R, He G, Weigert C, Ichijo H, Sen CK. Fra-2 mediates oxygen-sensitive induction of transforming growth factor beta in cardiac fibroblasts. Cardiovasc Res. 2010;87(4):647\u201355. https:\/\/doi.org\/10.1093\/cvr\/cvq123.","journal-title":"Cardiovasc Res"},{"issue":"7","key":"760_CR30","doi-asserted-by":"publisher","first-page":"2669","DOI":"10.1172\/JCI96832","volume":"129","author":"N Hannemann","year":"2019","unstructured":"Hannemann N, Cao S, Eriksson D, Schnelzer A, Jordan J, Eberhardt M, Schleicher U, Rech J, Ramming A, Uebe S, Ekici A, Canete JD, Chen X, Bauerle T, Vera J, Bogdan C, Schett G, Bozec A. Transcription factor Fra-1 targets arginase-1 to enhance macrophage-mediated inflammation in arthritis. J Clin Invest. 2019;129(7):2669\u201384. https:\/\/doi.org\/10.1172\/JCI96832.","journal-title":"J Clin Invest"},{"issue":"3","key":"760_CR31","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1002\/hep.26592","volume":"59","author":"A Wree","year":"2014","unstructured":"Wree A, Eguchi A, McGeough MD, Pena CA, Johnson CD, Canbay A, Hoffman HM, Feldstein AE. NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice. Hepatology. 2014;59(3):898\u2013910. https:\/\/doi.org\/10.1002\/hep.26592.","journal-title":"Hepatology"},{"key":"760_CR32","doi-asserted-by":"publisher","unstructured":"Ramos-Tovar E, Muriel P (2020) Molecular Mechanisms That Link Oxidative Stress, Inflammation, and Fibrosis in the Liver. Antioxidants (Basel) 9 (12). https:\/\/doi.org\/10.3390\/antiox9121279","DOI":"10.3390\/antiox9121279"},{"key":"760_CR33","doi-asserted-by":"publisher","first-page":"8868361","DOI":"10.1155\/2021\/8868361","volume":"2021","author":"Z Li","year":"2021","unstructured":"Li Z, Huang Z, Zhang H, Lu J, Tian Y, Wei Y, Yang Y, Bai L. P2X7 receptor induces pyroptotic inflammation and cartilage degradation in osteoarthritis via NF-kappaB\/NLRP3 crosstalk. Oxid Med Cell Longev. 2021;2021:8868361. https:\/\/doi.org\/10.1155\/2021\/8868361.","journal-title":"Oxid Med Cell Longev"},{"key":"760_CR34","doi-asserted-by":"publisher","unstructured":"Oh S, Son M, Byun KA, Jang JT, Choi CH, Son KH, Byun K (2021) Attenuating Effects of Dieckol on High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease by Decreasing the NLRP3 Inflammasome and Pyroptosis. Mar Drugs 19 (6). https:\/\/doi.org\/10.3390\/md19060318","DOI":"10.3390\/md19060318"},{"key":"760_CR35","doi-asserted-by":"publisher","unstructured":"Wang P, Ni M, Tian Y, Wang H, Qiu J, You W, Wei S, Shi Y, Zhou J, Cheng F, Rao J, Lu L (2021) Myeloid Nrf2 deficiency aggravates non-alcoholic steatohepatitis progression by regulating YAP-mediated NLRP3 inflammasome signaling. iScience 24 (5):102427. https:\/\/doi.org\/10.1016\/j.isci.2021.102427","DOI":"10.1016\/j.isci.2021.102427"},{"issue":"4","key":"760_CR36","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1007\/s12565-017-0395-9","volume":"92","author":"H Senoo","year":"2017","unstructured":"Senoo H, Mezaki Y, Fujiwara M. The stellate cell system (vitamin A-storing cell system). Anat Sci Int. 2017;92(4):387\u2013455. https:\/\/doi.org\/10.1007\/s12565-017-0395-9.","journal-title":"Anat Sci Int"}],"container-title":["Human Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13577-022-00760-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13577-022-00760-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13577-022-00760-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T20:02:22Z","timestamp":1664308942000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13577-022-00760-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,5]]},"references-count":36,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,11]]}},"alternative-id":["760"],"URL":"https:\/\/doi.org\/10.1007\/s13577-022-00760-y","relation":{},"ISSN":["1749-0774"],"issn-type":[{"value":"1749-0774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,5]]},"assertion":[{"value":"31 March 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 August 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All animal procedures were performed in accordance with the Guidelines for the Care and Use of Laboratory Animals and were approved by the Institutional Ethics Committee of Jinan Central Hospital (Approval number: 2021\u201308-07\u201301).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All authors have given their consent.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}