{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T14:28:04Z","timestamp":1787668084860,"version":"build-2736575974"},"reference-count":99,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T00:00:00Z","timestamp":1671408000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T00:00:00Z","timestamp":1671408000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Human Cell"],"DOI":"10.1007\/s13577-022-00846-7","type":"journal-article","created":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T05:02:40Z","timestamp":1671426160000},"page":"515-527","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Recent topics and advanced therapies in chronic granulomatous disease"],"prefix":"10.1007","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3067-0809","authenticated-orcid":false,"given":"Hiroyuki","family":"Nunoi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toyoki","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Matsukura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,12,19]]},"reference":[{"key":"846_CR1","doi-asserted-by":"publisher","first-page":"11444","DOI":"10.1016\/S0021-9258(18)67262-X","volume":"261","author":"R Makino","year":"1986","unstructured":"Makino R, Tanaka T, Iizuka T, Ishimura Y, Kanegasaki S. Stoichiometric conversion of oxygen to superoxide anion during the respiratory burst in neutrophils. J Biol Chem. 1986;261:11444\u20137. https:\/\/doi.org\/10.1016\/S0021-9258(18)67262-X.","journal-title":"J Biol Chem"},{"key":"846_CR2","first-page":"388","volume":"88","author":"CA Janeway","year":"1954","unstructured":"Janeway CA, Craig J, Davidson M, Downey W, Gitlin D, Sullivan JC. Hypergammaglobulinemia associated with severe, recurrent, and chronic non-specific infection. Am J Dis Child. 1954;88:388\u201392.","journal-title":"Am J Dis Child"},{"key":"846_CR3","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1016\/s0140-6736(66)90238-8","volume":"1","author":"B Holmes","year":"1966","unstructured":"Holmes B, Quie PG, Windhorst DB, Good RA. Fatal granulomatous disease of childhood. An inborn abnormality of phagocytic function. Lancet. 1966;1:1225\u20138. https:\/\/doi.org\/10.1016\/s0140-6736(66)90238-8.","journal-title":"Lancet"},{"key":"846_CR4","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1001\/archpedi.1959.02070010389004","volume":"97","author":"RA Bridges","year":"1959","unstructured":"Bridges RA, Berendes H, Good RA. A fatal granulomatous disease of childhood: clinical, pathological, and laboratory features of a new syndrome. AMA J Dis Child. 1959;97:387\u2013408. https:\/\/doi.org\/10.1001\/archpedi.1959.02070010389004.","journal-title":"AMA J Dis Child"},{"key":"846_CR5","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1111\/j.1365-2249.2008.03644.x","volume":"152","author":"LBKR Jones","year":"2008","unstructured":"Jones LBKR, McGrogan P, Flood TJ, Gennery AR, Morton L, Thrasher A, et al. Special article: chronic granulomatous disease in the United Kingdom and Ireland: a comprehensive national patient-based registry. Clin Exp Immunol. 2008;152:211\u20138. https:\/\/doi.org\/10.1111\/j.1365-2249.2008.03644.x.","journal-title":"Clin Exp Immunol"},{"key":"846_CR6","doi-asserted-by":"publisher","first-page":"2600","DOI":"10.1056\/NEJMoa1007097","volume":"363","author":"DB Kuhns","year":"2010","unstructured":"Kuhns DB, Alvord WG, Heller T, Feld JJ, Pike KMBE, et al. Residual NADPH oxidase activity and survival in chronic granulomatous diseases. New Engl J Med. 2010;363:2600\u201310. https:\/\/doi.org\/10.1056\/NEJMoa1007097.","journal-title":"New Engl J Med"},{"key":"846_CR7","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1038\/327717a0","volume":"327","author":"MC Dinauer","year":"1987","unstructured":"Dinauer MC, Orkin SH, Brown R, Jesaitis AJ, Parkos CA. Glycoprotein encoded by the X-linked chronic granulomatous disease locus is a component of the neutrophil cytochrome b complex. Nature. 1987;327:717\u201320. https:\/\/doi.org\/10.1038\/327717a0.","journal-title":"Nature"},{"key":"846_CR8","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.1126\/science.2848319","volume":"242","author":"H Nunoi","year":"1988","unstructured":"Nunoi H, Rotrosen D, Gallin JI, Malech HL. The two forms of autosomal chronic granulomatous disease lack distinct neutrophil cytosolic factors. Science. 1988;242:1298\u2013301. https:\/\/doi.org\/10.1126\/science.2848319.","journal-title":"Science"},{"key":"846_CR9","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1172\/JCI114898","volume":"86","author":"MC Dinauer","year":"1990","unstructured":"Dinauer MC, Pierce EA, Bruns GA, Curnutte JT, Orkin SH. Human neutrophil cytochrome b light chain (p22-phox). Gene structure, chromosomal location, and mutations in cytochrome-negative autosomal recessive chronic granulomatous disease. J Clin Invest. 1990;86:1729\u201337. https:\/\/doi.org\/10.1172\/JCI114898.","journal-title":"J Clin Invest"},{"key":"846_CR10","doi-asserted-by":"publisher","first-page":"3309","DOI":"10.1182\/blood-2009-07-231498","volume":"114","author":"JD Matute","year":"2009","unstructured":"Matute JD, Arias AA, Wright NA, Wrobel I, Waterhouse CC, Li XJ, et al. A new genetic subgroup of chronic granulomatous disease with autosomal recessive mutations in p40phox and selective defects in neutrophil NADPH oxidase activity. Blood. 2009;114:3309\u201315. https:\/\/doi.org\/10.1182\/blood-2009-07-231498.","journal-title":"Blood"},{"key":"846_CR11","doi-asserted-by":"publisher","first-page":"16767","DOI":"10.1016\/S0021-9258(18)41846-7","volume":"267","author":"A Abo","year":"1992","unstructured":"Abo A, Boyhan A, West I, Thrasher AJ, Segal AW. Reconstitution of neutrophil NADPH oxidase activity in the cell-free system with four components: p67-phox, p47-phox, p21rac1, and cytochrome b-245. J Biol Chem. 1992;267:16767\u201370. https:\/\/doi.org\/10.1016\/S0021-9258(18)41846-7.","journal-title":"J Biol Chem"},{"key":"846_CR12","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1042\/BJ20041835","volume":"386","author":"Y Groemping","year":"2005","unstructured":"Groemping Y, Rittinger K. Activation and assembly of the NADPH oxidase: a structural perspective. Biochem J. 2005;386:401\u201316. https:\/\/doi.org\/10.1042\/BJ20041835.","journal-title":"Biochem J"},{"key":"846_CR13","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/85259","volume":"2","author":"BA Diebold","year":"2001","unstructured":"Diebold BA, Bokoch GM. Molecular basis for Rac2 regulation of phagocyte NADPH oxidase. Nat Immunol. 2001;2:211\u20135. https:\/\/doi.org\/10.1038\/85259.","journal-title":"Nat Immunol"},{"issue":"Suppl 2","key":"846_CR14","doi-asserted-by":"publisher","first-page":"e12951","DOI":"10.1111\/eci.12951","volume":"48","author":"SA Belambri","year":"2018","unstructured":"Belambri SA, Rolas L, Raad H, Hurtado-Nedelec M, Dang PM-C. NADPH oxidase activation in neutrophils: role of the phosphorylation of its subunits. Eur J Clin Invest. 2018;48(Suppl 2):e12951. https:\/\/doi.org\/10.1111\/eci.12951.","journal-title":"Eur J Clin Invest"},{"key":"846_CR15","doi-asserted-by":"publisher","first-page":"2669","DOI":"10.1084\/jem.20180371","volume":"216","author":"D Ohayon","year":"2019","unstructured":"Ohayon D, De Chiara A, Dang PM-C, et al. Cytosolic PCNA interacts with p47phox and controls NOX2 activation in neutrophils. J Exp Med. 2019;216:2669\u201387. https:\/\/doi.org\/10.1084\/jem.20180371.","journal-title":"J Exp Med"},{"key":"846_CR16","unstructured":"Leiding JW, Holland SM, Chronic granulomatous disease, GeneReviews\u00ae [Internet], 2016. Update"},{"key":"846_CR17","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1093\/cid\/ciu1154","volume":"60","author":"BE Marciano","year":"2015","unstructured":"Marciano BE, Spalding C, Fitzgerald A, Mann D, Brown T, Osgood S, et al. Common severe infections in chronic granulomatous disease. Clin Infect Dis. 2015;60:1176\u201383. https:\/\/doi.org\/10.1093\/cid\/ciu1154.","journal-title":"Clin Infect Dis"},{"key":"846_CR18","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1007\/s10875-013-9940-z","volume":"33","author":"M Raptaki","year":"2013","unstructured":"Raptaki M, Varela I, Spanou K, Tzanoudaki M, Tantou S, Liatsis M, et al. Chronic granulomatous disease: a 25-year patient registry based on a multistep diagnostic procedure from the referral center for primary immunodeficiencies in Greece. J Clin Immunol. 2013;33:1302\u20139. https:\/\/doi.org\/10.1007\/s10875-013-9940-z.","journal-title":"J Clin Immunol"},{"key":"846_CR19","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.clim.2008.06.012","volume":"129","author":"B Wolach","year":"2008","unstructured":"Wolach B, Gavrieli R, De Boer M, Gottesman G, Ben-Ari J, Rottem M, et al. Chronic granulomatous disease in Israel: clinical, functional, and molecular studies of 38 patients. Clin Immunol. 2008;129:103\u201314. https:\/\/doi.org\/10.1016\/j.clim.2008.06.012.","journal-title":"Clin Immunol"},{"key":"846_CR20","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1097\/00005792-200005000-00003","volume":"79","author":"JA Winkelstein","year":"2000","unstructured":"Winkelstein JA, Marino MC, Johnston RB, Boyle J, Curnutte J, Gallin JI, et al. Chronic granulomatous disease. Report on a national registry of 368 patients. Medicine (Baltim). 2000;79:155\u201369. https:\/\/doi.org\/10.1097\/00005792-200005000-00003.","journal-title":"Medicine (Baltim)"},{"key":"846_CR21","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1007\/s004390000288","volume":"106","author":"F Ishibashi","year":"2000","unstructured":"Ishibashi F, Nunoi H, Endo F, Matsuda I, Kanegasaki S. Statistical and mutational analysis of chronic granulomatous disease in Japan with special reference to gp91-phox and p22-phox deficiencies. Hum Genet. 2000;106:473\u201381. https:\/\/doi.org\/10.1007\/s004390000288.","journal-title":"Hum Genet"},{"key":"846_CR22","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1111\/j.1651-2227.1995.tb13575.x","volume":"84","author":"A Ahlin","year":"1995","unstructured":"Ahlin A, de Boer M, Roos D, Leusen J, Smith CI, Sundin U, et al. Prevalence, genetics, and clinical presentation of chronic granulomatous disease in Sweden. Acta Paediatr. 1995;84:1386\u201394. https:\/\/doi.org\/10.1111\/j.1651-2227.1995.tb13575.x.","journal-title":"Acta Paediatr"},{"key":"846_CR23","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.clim.2007.09.008","volume":"126","author":"B Martire","year":"2008","unstructured":"Martire B, Rondelli R, Soresina A, Pignata C, Broccoletti T, Finocchi A, et al. Clinical features, long-term follow-up, and outcomes of a large cohort of patients with chronic granulomatous disease: an Italian multicenter study. Clin Immunol. 2008;126:155\u201364. https:\/\/doi.org\/10.1016\/j.clim.2007.09.008.","journal-title":"Clin Immunol"},{"key":"846_CR24","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8745254","author":"J Wu","year":"2017","unstructured":"Wu J, Wang W-F, Zhang YD, Chen TX. Clinical features and genetic analysis of 48 patients with chronic granulomatous disease in a single-center study from Shanghai, China (2005\u20132015): new studies and literature review. J Immunol Res. 2017. https:\/\/doi.org\/10.1155\/2017\/8745254.","journal-title":"J Immunol Res"},{"key":"846_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5734\/JGM.2013.10.1.1","volume":"10","author":"M Cho","year":"2013","unstructured":"Cho M, Shin K-S. Chronic granulomatous disease on Jeju Island. Korea J Genet Med. 2013;10:1\u20136. https:\/\/doi.org\/10.5734\/JGM.2013.10.1.1.","journal-title":"Korea J Genet Med"},{"key":"846_CR26","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1007\/s10875-011-9567-x","volume":"31","author":"F Fattahi","year":"2011","unstructured":"Fattahi F, Badalzadeh M, Sedighipour L, Movahedi M, Fazlollahi MR, Mansouri SD, et al. Inheritance patterns and clinical aspects of 93 Iranian patients with chronic granulomatous disease. J Clin Immunol. 2011;31:792\u2013801. https:\/\/doi.org\/10.1007\/s10875-011-9567-x.","journal-title":"J Clin Immunol"},{"key":"846_CR27","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.639226","author":"FG Bakri","year":"2021","unstructured":"Bakri FG, Mollin M, Beaumel S, Vigne B, Roux-Buisson N, Wahadneh AM, et al. A second report of chronic granulomatous disease in Jordan: Clinical and genetic description of 31 patients from 21 different families, including families from Lybia and Iraq. Front Immunol. 2021. https:\/\/doi.org\/10.3389\/fimmu.2021.639226.","journal-title":"Front Immunol"},{"key":"846_CR28","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1159\/000496181","volume":"179","author":"E Mortaz","year":"2019","unstructured":"Mortaz E, Azempour E, Mansouri D, Tabarsi P, Ghazi M, Koenderman L, et al. Common infections and target organs associated with chronic granulomatous disease in Iran. Int Arch Allergy Immunol. 2019;179:62\u201373. https:\/\/doi.org\/10.1159\/000496181.","journal-title":"Int Arch Allergy Immunol"},{"key":"846_CR29","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.625320","volume":"12","author":"A Rawat","year":"2021","unstructured":"Rawat A, Vignesh P, Sudhakar M, Sharma M, Suri D, Jindal A, et al. Clinical, immunological, and molecular profiles of chronic granulomatous disease: a multi-centric study of 236 patients from India. Front Immunol. 2021;12: 625320. https:\/\/doi.org\/10.3389\/fimmu.2021.625320.","journal-title":"Front Immunol"},{"key":"846_CR30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005234","volume":"4","author":"JM van den Berg","year":"2009","unstructured":"van den Berg JM, van Koppen E, Ahlin A, Belohradsky BH, Bernatowska E, Corbeel L, et al. Chronic granulomatous disease: European experience. PLoS ONE. 2009;4: e5234. https:\/\/doi.org\/10.1371\/journal.pone.0005234.","journal-title":"PLoS ONE"},{"key":"846_CR31","doi-asserted-by":"publisher","first-page":"2157","DOI":"10.1093\/molbev\/mst119","volume":"30","author":"E Tarazona-Santos","year":"2013","unstructured":"Tarazona-Santos E, Machado M, Magalh\u00e3es WC, Chen R, Lyon F, Burdett L, et al. The evolutionary dynamics of the human NADPH oxidase genes CYBB, CYBA, NCF2, and NCF4 have functional implications. Mol Biol Evol. 2013;30:2157\u201367. https:\/\/doi.org\/10.1093\/molbev\/mst119.","journal-title":"Mol Biol Evol"},{"issue":"9","key":"846_CR32","doi-asserted-by":"publisher","first-page":"4654","DOI":"10.1073\/pnas.080074897","volume":"97","author":"DR Ambruso","year":"2000","unstructured":"Ambruso DR, Knall C, Abell AN, et al. Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation. PNAS. 2000;97(9):4654\u20139. https:\/\/doi.org\/10.1073\/pnas.080074897.","journal-title":"PNAS"},{"key":"846_CR33","doi-asserted-by":"publisher","first-page":"1646","DOI":"10.1182\/blood.V96.5.1646","volume":"96","author":"DA Williams","year":"2000","unstructured":"Williams DA, Tao W, Yang F, et al. Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency. Blood. 2000;96:1646\u201354. https:\/\/doi.org\/10.1182\/blood.V96.5.1646.","journal-title":"Blood"},{"key":"846_CR34","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.jaci.2010.10.013","volume":"127","author":"D Accetta","year":"2011","unstructured":"Accetta D, Syverson G, Bonacci B, Reddy S, Bengtson C, Surfus J, et al. Human phagocyte defect caused by a Rac2 mutation detected by means of neonatal screening for T-cell lymphopenia. (Letter) J Allergy Clin Immun. 2011;127:535\u20138. https:\/\/doi.org\/10.1016\/j.jaci.2010.10.013.","journal-title":"(Letter) J Allergy Clin Immun"},{"key":"846_CR35","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.3389\/fimmu.2017.01264","volume":"8","author":"G Natalija","year":"2017","unstructured":"Natalija G, Minghui H, Carin IM, et al. The Small Rho GTPases Rac1 and Rac2 Are Important for T-Cell Independent Antigen Responses and for Suppressing Switching to IgG2b in Mice. Front Immunol. 2017;8:1264. https:\/\/doi.org\/10.3389\/fimmu.2017.01264.","journal-title":"Front Immunol"},{"issue":"9","key":"846_CR36","doi-asserted-by":"publisher","first-page":"3957","DOI":"10.1172\/JCI97116","volume":"128","author":"AV de Geer","year":"2018","unstructured":"de Geer AV, Nieto-Patl\u00e1n A, Kuhns DS, Tool ATJ, Arias AA, Bouaziz M, et al. Inherited p40phox deficiency differs from classic chronic granulomatous disease. Clin Invest. 2018;128(9):3957\u201375. https:\/\/doi.org\/10.1172\/JCI97116.","journal-title":"Clin Invest"},{"key":"846_CR37","doi-asserted-by":"publisher","first-page":"4447","DOI":"10.1038\/s41467-018-06964-x","volume":"9","author":"GA Arnadottir","year":"2018","unstructured":"Arnadottir GA, Norddahl GL, Gudmundsdottir S, Agustsdottir AB, Sigurdsson S, Jensson BO, et al. A homozygous loss-of-function mutation that leads to CYBC1 deficiency causes chronic granulomatous disease. Nat Commun. 2018;9:4447. https:\/\/doi.org\/10.1038\/s41467-018-06964-x.","journal-title":"Nat Commun"},{"key":"846_CR38","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1007\/s10875-020-00750-5","volume":"40","author":"L Blancas-Galicia","year":"2020","unstructured":"Blancas-Galicia L, Santos-Ch\u00e1vez E, Deswarte C, Mignac Q, Medina-Vera I, Le\u00f3n-Lara X, et al. Genetic, immunological, and clinical features of the first Mexican cohort of patients with chronic granulomatous disease. J Clin Immunol. 2020;40:475\u201393. https:\/\/doi.org\/10.1007\/s10875-020-00750-5.","journal-title":"J Clin Immunol"},{"key":"846_CR39","doi-asserted-by":"publisher","first-page":"2101","DOI":"10.1002\/pbc.25674","volume":"62","author":"EB de Oliveira-Junior","year":"2015","unstructured":"de Oliveira-Junior EB, Zurro NB, Prando C, Cabral-Marques O, Pereira PV, Schimke LF, et al. Clinical and genotypic spectrum of chronic granulomatous disease in 71 Latin American patients: the first report from the LASID registry. Pediatr Blood Cancer. 2015;62:2101\u20137. https:\/\/doi.org\/10.1002\/pbc.25674.","journal-title":"Pediatr Blood Cancer"},{"key":"846_CR40","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1007\/s10875-021-01002-w","volume":"41","author":"HT Akar","year":"2021","unstructured":"Akar HT, Esenboga S, Cagdas D, Halacli SO, Ozbek B, van Leeuwen K, et al. Clinical and immunological characteristics of 63 patients with chronic granulomatous disease: hacettepe\u2019s experience. J Clin Immunol. 2021;41:992\u20131003. https:\/\/doi.org\/10.1007\/s10875-021-01002-w.","journal-title":"J Clin Immunol"},{"key":"846_CR41","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1007\/s10038-006-0039-8","volume":"51","author":"R El Kares","year":"2006","unstructured":"El Kares R, Barbouche MR, Elloumi-Zghal H, Bejaoui M, Chemli J, Mellouli F, et al. Genetic and mutational heterogeneity of autosomal recessive chronic granulomatous disease in Tunisia. J Hum Genet. 2006;51:887\u201395. https:\/\/doi.org\/10.1007\/s10038-006-0039-8.","journal-title":"J Hum Genet"},{"key":"846_CR42","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.aller.2014.11.003","volume":"43","author":"S Meshaal","year":"2015","unstructured":"Meshaal S, El Hawary R, Abd Elaziz D, Alkady R, Galal N, Boutros J, et al. Chronic granulomatous disease: review of a cohort of Egyptian patients. Allergol Immunopathol (Madr). 2015;43:279\u201385. https:\/\/doi.org\/10.1016\/j.aller.2014.11.003.","journal-title":"Allergol Immunopathol (Madr)"},{"issue":"1","key":"846_CR43","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1002\/ajh.24573","volume":"92","author":"B Wolach","year":"2017","unstructured":"Wolach B, Gavrieli R, de Boer M, Leeuwen KV, Berger-Achituv S, Stauber T, et al. Chronic granulomatous disease: clinical, functional, molecular, and genetic studies. The Israeli experience with 84 patients. Am J Hematol. 2017;92(1):28\u201336. https:\/\/doi.org\/10.1002\/ajh.24573.","journal-title":"Am J Hematol"},{"key":"846_CR44","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1007\/s10875-019-00680-x","volume":"39","author":"S Wang","year":"2019","unstructured":"Wang S, Wang T, Xiang Q, Xiao M, Cao Y, et al. Clinical and molecular features of chronic granulomatous disease in mainland China and an XL-CGD female infant after prenatal diagnosis. J Clin Immunol. 2019;39:762\u201375. https:\/\/doi.org\/10.1007\/s10875-019-00680-x.","journal-title":"J Clin Immunol"},{"key":"846_CR45","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.803763","volume":"12","author":"TL Chiu","year":"2022","unstructured":"Chiu TL, Leung D, Chan KW, Yeung HM, Wong CY, Mao H, et al. Phenomic analysis of chronic granulomatous disease reveals more severe integumentary infections in X-linked compared to autosomal recessive chronic granulomatous disease. Front Immuno. 2022;12: 803763. https:\/\/doi.org\/10.3389\/fimmu.2021.803763.","journal-title":"Front Immuno"},{"key":"846_CR46","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9912436","author":"GE Villalpando-Rodriguez","year":"2021","unstructured":"Villalpando-Rodriguez GE, Gibson SB. Reactive oxygen species (ROS) regulate different types of cell death by acting as rheostats. Oxid Med Cell Longev. 2021. https:\/\/doi.org\/10.1155\/2021\/9912436.","journal-title":"Oxid Med Cell Longev"},{"key":"846_CR47","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1111\/j.1365-2443.2005.00907.x","volume":"10","author":"J Kuroda","year":"2005","unstructured":"Kuroda J, Nakagawa K, Yamasaki T, Nakamura K, Takeya R, Kuribayashi F, et al. Superoxide-producing NAD(P)H oxidase Nox 4 in the nucleus of human vascular endothelial cells. Genes Cells. 2005;10:1139\u201351. https:\/\/doi.org\/10.1111\/j.1365-2443.2005.00907.x.","journal-title":"Genes Cells"},{"key":"846_CR48","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1159\/00013635","volume":"15","author":"B Rada","year":"2008","unstructured":"Rada B, Leto TL. Oxidative innate immune defenses are mediated by the Nox\/Duox family NADPH oxidase. Contrib Microbiol. 2008;15:164\u201387. https:\/\/doi.org\/10.1159\/00013635.","journal-title":"Contrib Microbiol"},{"key":"846_CR49","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1056\/NEJM197007302830501","volume":"283","author":"B Holmes","year":"1970","unstructured":"Holmes B, Park BH, Malawista SE, Quie PG, Nelson DL, Good RA. Chronic granulomatous disease in females. New Engl J Med. 1970;283:217\u201321. https:\/\/doi.org\/10.1056\/NEJM197007302830501.","journal-title":"New Engl J Med"},{"key":"846_CR50","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/s0022-3476(76)80010-8","volume":"88","author":"I Matsuda","year":"1976","unstructured":"Matsuda I, Oka Y, Taniguchi N, Furuyama M, Kodama S, Arashima S, et al. Leukocyte glutathione peroxidase deficiency in a male patient with chronic granulomatous disease. J Pediatr. 1976;88:581\u20133. https:\/\/doi.org\/10.1016\/s0022-3476(76)80010-8.","journal-title":"J Pediatr"},{"key":"846_CR51","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/1750-1172-2-16","volume":"2","author":"E Ristoff","year":"2007","unstructured":"Ristoff E, Larsson A. Inborn errors in the metabolism of glutathione. Orphanet J Rare Dis. 2007;2:16. https:\/\/doi.org\/10.1186\/1750-1172-2-16.","journal-title":"Orphanet J Rare Dis"},{"key":"846_CR52","doi-asserted-by":"publisher","first-page":"4480","DOI":"10.1016\/j.cell.2021.07.004","volume":"184","author":"N Amara","year":"2021","unstructured":"Amara N, Cooper MP, Voronkova MA, Webb BA, Lynch EM, Kollman JM, et al. Selective activation of PFKL suppresses the phagocytic oxidative burst. Cell. 2021;184:4480-94.e15. https:\/\/doi.org\/10.1016\/j.cell.2021.07.004.","journal-title":"Cell"},{"key":"846_CR53","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.freeradbiomed.2018.06.011","volume":"125","author":"DC Thomas","year":"2018","unstructured":"Thomas DC. How the phagocyte NADPH oxidase regulates innate immunity. Free Radic Biol Med. 2018;125:44\u201352. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2018.06.011.","journal-title":"Free Radic Biol Med"},{"key":"846_CR54","doi-asserted-by":"publisher","first-page":"8477","DOI":"10.1128\/MCB.24.19.8477-8486.2004","volume":"24","author":"SB Cullinan","year":"2004","unstructured":"Cullinan SB, Gordan JD, Jin J, Harper JW, Diehl JA. The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase, and oxidative stress sensing by a Cul3-Keap1 ligase. Mol Cell Biol. 2004;24:8477\u201386. https:\/\/doi.org\/10.1128\/MCB.24.19.8477-8486.2004.","journal-title":"Mol Cell Biol"},{"key":"846_CR55","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.jaci.2007.10.037","volume":"121","author":"D Hartl","year":"2008","unstructured":"Hartl D, Lehmann N, Hoffmann F, Jasson A, Hector A, Notheis G, et al. Dysregulation of innate immune receptors on neutrophils in chronic granulomatous disease. J Allergy Clin Immunol. 2008;121:375\u201382. https:\/\/doi.org\/10.1016\/j.jaci.2007.10.037.","journal-title":"J Allergy Clin Immunol"},{"issue":"4","key":"846_CR56","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1111\/imm.12530","volume":"146","author":"SM McLetchie","year":"2015","unstructured":"McLetchie SM, Volpp BD, Dinauer MC, Blum JS. Hyper-responsive Toll-like receptor 7 and 9 activation in NADPH oxidase-deficient B lymphoblasts. Immunology. 2015;146(4):595\u2013606. https:\/\/doi.org\/10.1111\/imm.12530.","journal-title":"Immunology"},{"key":"846_CR57","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1038\/s41418-017-0012-4","volume":"25","author":"L Galluzzi","year":"2018","unstructured":"Galluzzi L, Vitale I, Aaronson SA, Abrams J, Adam D, Agostinis P, et al. Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. Cell Death Differ. 2018;25:486\u2013541. https:\/\/doi.org\/10.1038\/s41418-017-0012-4.","journal-title":"Cell Death Differ"},{"key":"846_CR58","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/252460","author":"N Rieber","year":"2012","unstructured":"Rieber N, Hector A, Kuijpers T, Roos D, Hartl D. Current concepts of hyperinflammation in chronic granulomatous disease. Clin Dev Immunol. 2012. https:\/\/doi.org\/10.1155\/2012\/252460.","journal-title":"Clin Dev Immunol"},{"key":"846_CR59","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1016\/j.jaci.2015.07.034","volume":"136","author":"RF Fernandez-Boyanapalli","year":"2015","unstructured":"Fernandez-Boyanapalli RF, Falcone EL, Zerbe CS, Marciano BE, Frasch SC, Henson PM, et al. Impaired efferocytosis in human chronic granulomatous disease is reversed by pioglitazone treatment. J Allergy Clin Immunol. 2015;136:1399-401.E3. https:\/\/doi.org\/10.1016\/j.jaci.2015.07.034.","journal-title":"J Allergy Clin Immunol"},{"key":"846_CR60","doi-asserted-by":"publisher","first-page":"3562","DOI":"10.4049\/jimmunol.174.6.3562","volume":"174","author":"J Bylund","year":"2005","unstructured":"Bylund J, Campsall PA, Ma RC, Conway BAD, Barbara-Ann D. Speert CDP, Burkholderia cenocepacia induces neutrophil necrosis in chronic granulomatous diseases. J Immunol. 2005;174:3562\u20139. https:\/\/doi.org\/10.4049\/jimmunol.174.6.3562.","journal-title":"J Immunol"},{"key":"846_CR61","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/nrmicro2070","volume":"7","author":"T Bergsbaken","year":"2009","unstructured":"Bergsbaken T, Fink SL, Cookson BT. Pyroptosis: host cell death and inflammation. Nat Rev Microbiol. 2009;7:99\u2013109. https:\/\/doi.org\/10.1038\/nrmicro2070.","journal-title":"Nat Rev Microbiol"},{"key":"846_CR62","doi-asserted-by":"publisher","first-page":"1570","DOI":"10.1182\/blood-2010-01-264218","volume":"116","author":"F Meissner","year":"2010","unstructured":"Meissner F, Seger RA, Moshous D, Fischer A, Reichenbach J, Zychlisky A. Inflammasome activation in NADPH oxidase defective mononuclear phagocytes from patients with chronic granulomatous disease. Blood. 2010;116:1570\u20133. https:\/\/doi.org\/10.1182\/blood-2010-01-264218.","journal-title":"Blood"},{"key":"846_CR63","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1038\/mi.2016.73","volume":"10","author":"JC Ryu","year":"2017","unstructured":"Ryu JC, Kim MJ, Kwon Y, Oh JH, Yoon SS, Shin SJ, et al. Neutrophil pyroptosis mediates the pathology of P. aeruginosa lung infection in the absence of the NADPH oxidase NOX2. Mucosal Immunol. 2017;10:757\u201374. https:\/\/doi.org\/10.1038\/mi.2016.73.","journal-title":"Mucosal Immunol"},{"key":"846_CR64","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-017-0058-8","author":"X Wang","year":"2018","unstructured":"Wang X, Shida Y, Simon H-U. Necroptosis and neutrophil-associated disorders. Cell Death Dis. 2018. https:\/\/doi.org\/10.1038\/s41419-017-0058-8.","journal-title":"Cell Death Dis"},{"issue":"17","key":"846_CR65","doi-asserted-by":"publisher","first-page":"3214","DOI":"10.1016\/j.cell.2022.06.038","volume":"185","author":"CG Weindel","year":"2022","unstructured":"Weindel CG, Martinez LE, Zhao X, Mabry CJ, Bell SL, Vail KJ, et al. Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis. Cell. 2022;185(17):3214-3231.e23. https:\/\/doi.org\/10.1016\/j.cell.2022.06.038.","journal-title":"Cell"},{"key":"846_CR66","doi-asserted-by":"publisher","first-page":"4090","DOI":"10.4049\/jimmunol.1600051","volume":"197","author":"X Wang","year":"2016","unstructured":"Wang X, He Z, Liu H, Shida Y, Simon H-U. Neutrophil necroptosis is triggered by ligation of adhesion molecules following GM-CSF priming. J Immunol. 2016;197:4090\u2013100. https:\/\/doi.org\/10.4049\/jimmunol.1600051.","journal-title":"J Immunol"},{"issue":"11","key":"846_CR67","doi-asserted-by":"publisher","first-page":"6532","DOI":"10.4049\/jimmunol.1004055","volume":"186","author":"CC Mihalache","year":"2011","unstructured":"Mihalache CC, Yousefi S, Conus S, Villiger PM, Schneider EM, Simon HU. Inflammation-associated autophagy-related programmed necrotic death of human neutrophils characterized by organelle fusion events. J Immunol. 2011;186(11):6532\u201342. https:\/\/doi.org\/10.4049\/jimmunol.1004055.","journal-title":"J Immunol"},{"key":"846_CR68","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.24437","volume":"6","author":"EF Kenny","year":"2017","unstructured":"Kenny EF, Herzig A, Kr\u00fcger R, Muth A, Mondal S, Thompson PR, et al. Diverse stimuli are engaged in different neutrophil extracellular trap pathways. Cell Biol Immunol Inflamm. 2017;6: e24437. https:\/\/doi.org\/10.7554\/eLife.24437.","journal-title":"Cell Biol Immunol Inflamm"},{"key":"846_CR69","doi-asserted-by":"publisher","first-page":"360","DOI":"10.3389\/fimmu.2012.00360","volume":"3","author":"AS Rohrbach","year":"2012","unstructured":"Rohrbach AS, Slade DJ, Thompson PR, Mowen KA. Activation of PAD4 during NET formation. Front Immunol. 2012;3:360. https:\/\/doi.org\/10.3389\/fimmu.2012.00360.","journal-title":"Front Immunol"},{"key":"846_CR70","doi-asserted-by":"publisher","first-page":"2619","DOI":"10.1182\/blood-2009-05-221606","volume":"114","author":"M Bianchi","year":"2009","unstructured":"Bianchi M, Hakkim A, Brinkmann V, Siler U, Seger RA, Zychlinsky A, et al. Restoration of NET formation by gene therapy in CGD controls aspergillosis. Blood. 2009;114:2619\u201322. https:\/\/doi.org\/10.1182\/blood-2009-05-221606.","journal-title":"Blood"},{"key":"846_CR71","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.3389\/fimmu.2019.01739","volume":"10","author":"P Hule Gouri","year":"2019","unstructured":"Hule Gouri P, Bargir UA, Kulkarni M, Kambli P, Taur P, Desai M, et al. Does pioglitazone lead to neutrophil extracellular trap formation in chronic granulomatous disease patients? Front Immunol. 2019;10:1739. https:\/\/doi.org\/10.3389\/fimmu.2019.01739.","journal-title":"Front Immunol"},{"key":"846_CR72","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.coi.2013.10.012","volume":"26","author":"P Mehta","year":"2014","unstructured":"Mehta P, Henault J, Kolbeck R, Sanjuan MA. Noncanonical autophagy: one small step for LC3, a giant leap for immunity. Curr Opin Immunol. 2014;26:69\u201375. https:\/\/doi.org\/10.1016\/j.coi.2013.10.012.","journal-title":"Curr Opin Immunol"},{"key":"846_CR73","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.chom.2015.12.002","volume":"19","author":"T Akoumianaki","year":"2016","unstructured":"Akoumianaki T, Kyrmizi I, Valsecchi I, Gresnigt MS, Samonis G, Drakos E, et al. Aspergillus cell wall melanin blocks LC3-associated phagocytosis to promote pathogenicity. Cell Host Microb. 2016;19:79\u201390. https:\/\/doi.org\/10.1016\/j.chom.2015.12.002.","journal-title":"Cell Host Microb"},{"key":"846_CR74","doi-asserted-by":"publisher","first-page":"8658","DOI":"10.1074\/jbc.M112.412841","volume":"288","author":"K Buffen","year":"2013","unstructured":"Buffen K, Oosting M, Mennens S, Anand PK, Plantinga TS, Sturm P, et al. Autophagy modulates Borrelia burgdorferi-induced production of interleukin-1\u03b2 (IL-1\u03b2). J Biol Chem. 2013;288:8658\u201366. https:\/\/doi.org\/10.1074\/jbc.M112.412841.","journal-title":"J Biol Chem"},{"key":"846_CR75","doi-asserted-by":"publisher","first-page":"3526","DOI":"10.1073\/pnas.1322831111","volume":"9","author":"A De Luca","year":"2014","unstructured":"De Luca A, Smeekens PS, Casagrande A, Anand PK, Plantinga TS, Sturm P, et al. IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans. Proc Natl Acad Sci USA. 2014;9:3526\u201331. https:\/\/doi.org\/10.1073\/pnas.1322831111.","journal-title":"Proc Natl Acad Sci USA"},{"key":"846_CR76","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1016\/j.chom.2016.10.012","volume":"20","author":"V Oikonomou","year":"2016","unstructured":"Oikonomou V, Moretti S, Renga G, Galosi C, Borghi M, Pariano M, et al. Non-canonical fungal autophagy inhibits inflammation in response to IFN-\u03b3 via DAPK1. Cell Host Microb. 2016;20:744\u201357. https:\/\/doi.org\/10.1016\/j.chom.2016.10.012.","journal-title":"Cell Host Microb"},{"key":"846_CR77","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/S0140-6736(13)62069-3","volume":"383","author":"T G\u00fcng\u00f6r","year":"2014","unstructured":"G\u00fcng\u00f6r T, Teira P, Slatter M, Stussi G, Stepensky P, Moshous D, et al. Reduced-intensity conditioning and HLA-matched hematopoietic stem cell transplantation in patients with chronic granulomatous disease: a prospective multicenter study. Lancet. 2014;383:436\u201348. https:\/\/doi.org\/10.1016\/S0140-6736(13)62069-3.","journal-title":"Lancet"},{"key":"846_CR78","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.3389\/fimmu.2020.01617","volume":"11","author":"M Yanagimachi","year":"2020","unstructured":"Yanagimachi M, Kato K, Iguchi A, Sasaki K, Kiyotani C, Koh K, et al. Hematopoietic cell transplantation for chronic granulomatous disease in Japan. Front Immunol. 2020;11:1617. https:\/\/doi.org\/10.3389\/fimmu.2020.01617.","journal-title":"Front Immunol"},{"key":"846_CR79","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1007\/s10875-019-00635-2","volume":"39","author":"JR Yonkof","year":"2019","unstructured":"Yonkof JR, Gupta A, Pingfu F, Garabedian E, Dalal J, The United States immunodeficiency network Consortium. Role of allogeneic hematopoietic stem cell transplant for chronic granulomatous disease (CGD): a report of the United States immunodeficiency network. J Clin Immunol. 2019;39:448\u201358. https:\/\/doi.org\/10.1007\/s10875-019-00635-2.","journal-title":"J Clin Immunol"},{"key":"846_CR80","doi-asserted-by":"publisher","first-page":"2052","DOI":"10.1038\/s41409-021-01378-8","volume":"56","author":"AC Lankester","year":"2021","unstructured":"Lankester AC, Albert MH, Booth C, Gennery AR, G\u00fcng\u00f6r T, H\u00f6nig M, et al. EBMT\/ESID inborn errors working party guidelines for hematopoietic stem cell transplantation for inborn errors of immunity. Bone Marrow Transplant. 2021;56:2052\u201362. https:\/\/doi.org\/10.1038\/s41409-021-01378-8.","journal-title":"Bone Marrow Transplant"},{"key":"846_CR81","doi-asserted-by":"publisher","first-page":"12133","DOI":"10.1073\/pnas.94.22.12133","volume":"94","author":"HL Malech","year":"1997","unstructured":"Malech HL, Maples PB, Whiting-Theobald N, Linton GF, Sekhsaria S, Vowells SJ, et al. Prolonged production of NADPH oxidase-corrected granulocytes after gene therapy in chronic granulomatous disease. Proc Natl Acad Sci USA. 1997;94:12133\u20138. https:\/\/doi.org\/10.1073\/pnas.94.22.12133.","journal-title":"Proc Natl Acad Sci USA"},{"key":"846_CR82","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1038\/gt.2010.177","volume":"18","author":"AD Miller","year":"2011","unstructured":"Miller AD, Metzger MJ. APOBEC3-mediated hypermutation of retroviral vectors produced from some retrovirus packaging cell lines. Gene Ther. 2011;18:528\u201330. https:\/\/doi.org\/10.1038\/gt.2010.177.","journal-title":"Gene Ther"},{"key":"846_CR83","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1038\/mt.2010.226","volume":"19","author":"G Santilli","year":"2011","unstructured":"Santilli G, Almarza E, Brendel C, Choi U, Beilin C, Blundell MP, et al. Biochemical correction of X-CGD using a novel chimeric promoter that regulates high levels of transgene expression in myeloid cells. Mol Ther. 2011;19:122\u201332. https:\/\/doi.org\/10.1038\/mt.2010.226.","journal-title":"Mol Ther"},{"key":"846_CR84","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.1038\/mt.2014.87","volume":"22","author":"M Chiriaco","year":"2014","unstructured":"Chiriaco M, Farinelli G, Capo V, Zonari E, Scaramuzza S, Di Matteo G, et al. Dual-regulated lentiviral vectors for gene therapy of X-linked chronic granulomatosis. Mol Ther. 2014;22:1472\u201383. https:\/\/doi.org\/10.1038\/mt.2014.87.","journal-title":"Mol Ther"},{"key":"846_CR85","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1038\/s41591-019-0735-5","volume":"26","author":"DB Kohn","year":"2020","unstructured":"Kohn DB, Booth C, Kang EM, Pai SY, Shaw KL, Santilli G, et al. Lentiviral gene therapy for X-linked chronic granulomatous disease. Nat Med [epub]. 2020;26:200\u20136. https:\/\/doi.org\/10.1038\/s41591-019-0735-5.","journal-title":"Nat Med [epub]"},{"key":"846_CR86","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1038\/s41434-021-00251-z","volume":"28","author":"CL Sweeney","year":"2021","unstructured":"Sweeney CL, Pavel-Dinu M, Choi U, Brault J, Liu T, Koontz S, et al. Correction of X-CGD patient HSPCs by targeted CYBB cDNA insertion using CRISPR\/Cas9 with 53BP1 inhibition for enhanced homology-directed repair. Gene Ther. 2021;28:373\u201390. https:\/\/doi.org\/10.1038\/s41434-021-00251-z.","journal-title":"Gene Ther"},{"key":"846_CR87","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1007\/s10545-017-0032-8","volume":"40","author":"M Ries","year":"2017","unstructured":"Ries M. Enzyme replacement therapy and beyond-in memoriam Roscoe O. Brady, M.D. (1923\u20132016). J Inherit Metab Dis. 2017;40:343\u201356. https:\/\/doi.org\/10.1007\/s10545-017-0032-8.","journal-title":"J Inherit Metab Dis"},{"key":"846_CR88","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/j.bbamcr.2008.10.016","volume":"1793","author":"T Braulke","year":"2009","unstructured":"Braulke T, Bonifacino JS. Sorting of lysosomal proteins. Biochim Biophys Acta. 2009;1793:605\u201314. https:\/\/doi.org\/10.1016\/j.bbamcr.2008.10.016.","journal-title":"Biochim Biophys Acta"},{"key":"846_CR89","doi-asserted-by":"publisher","first-page":"3578","DOI":"10.1016\/S0021-9258(17)40291-2","volume":"252","author":"A Abuchowski","year":"1977","unstructured":"Abuchowski A, van Es T, Palczuk NC, Davis FF. Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol. J Biol Chem. 1977;252:3578\u201381. https:\/\/doi.org\/10.1016\/S0021-9258(17)40291-2.","journal-title":"J Biol Chem"},{"key":"846_CR90","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1016\/j.ymthe.2017.12.022","volume":"26","author":"MP Cicalese","year":"2018","unstructured":"Cicalese MP, Ferrua F, Castagnaro L, Rolfe K, De Boever E, Reinhardt RR, et al. Gene therapy for adenosine deaminase deficiency: a comprehensive evaluation of short- and medium-term safety. Mol Ther. 2018;26:917\u201331. https:\/\/doi.org\/10.1016\/j.ymthe.2017.12.022.","journal-title":"Mol Ther"},{"key":"846_CR91","doi-asserted-by":"publisher","first-page":"2161","DOI":"10.2147\/IJN.S128611","volume":"12","author":"J Brault","year":"2017","unstructured":"Brault J, Vaganay G, Le Roy A, Lenormand J-L, Cortes S, Stasia MJ. Therapeutic effects of proteoliposomes on X-linked chronic granulomatous disease: proof of concept using macrophages differentiated from patient-specific induced pluripotent stem cells. J Nanomed. 2017;12:2161\u201377. https:\/\/doi.org\/10.2147\/IJN.S128611.","journal-title":"J Nanomed"},{"key":"846_CR92","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1084\/jem.154.5.1539","volume":"154","author":"CF Nathan","year":"1981","unstructured":"Nathan CF, Cohn ZA. Antitumor effects of hydrogen peroxide in vivo. J Exp Med. 1981;154:1539\u201353. https:\/\/doi.org\/10.1084\/jem.154.5.1539.","journal-title":"J Exp Med"},{"key":"846_CR93","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1038\/bjc.1994.460","volume":"70","author":"O Ben-Yoseph","year":"1994","unstructured":"Ben-Yoseph O, Ross BD. Oxidation therapy: the use of a reactive oxygen species-generating enzyme system for tumour treatment. Br J Cancer. 1994;70:1131\u20135. https:\/\/doi.org\/10.1038\/bjc.1994.460.","journal-title":"Br J Cancer"},{"key":"846_CR94","first-page":"666","volume":"60","author":"T Sawa","year":"2000","unstructured":"Sawa T, Wu J, Akaike T, Maeda H. Tumor-targeting chemotherapy by a xanthine oxidase-polymer conjugate that generates oxygen-free radicals in tumor tissue. Cancer Res. 2000;60:666\u201371.","journal-title":"Cancer Res"},{"key":"846_CR95","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1111\/cas.12152","volume":"104","author":"H Maeda","year":"2013","unstructured":"Maeda H. The link between infection and cancer: tumor vasculature, free radicals, and drug delivery to tumors via the EPR effect. Cancer Sci. 2013;104:779\u201389. https:\/\/doi.org\/10.1111\/cas.12152.","journal-title":"Cancer Sci"},{"key":"846_CR96","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1258\/ebm","volume":"237","author":"H Nakamura","year":"2012","unstructured":"Nakamura H, Fang J, Mizukami T, Nunoi H, Maeda H. Pegylated D-amino acid oxidase restores bactericidal activity of neutrophils in chronic granulomatous disease via hypochlorite. EBM. 2012;237:703\u20138. https:\/\/doi.org\/10.1258\/ebm.","journal-title":"EBM"},{"key":"846_CR97","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.addr.2015.01.002","volume":"91","author":"H Maeda","year":"2015","unstructured":"Maeda H. Toward a full understanding of the EPR effect in primary and metastatic tumors as well as issues related to its heterogeneity. Adv Drug Deliv Rev. 2015;91:3\u20136. https:\/\/doi.org\/10.1016\/j.addr.2015.01.002.","journal-title":"Adv Drug Deliv Rev"},{"key":"846_CR98","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/s10753-016-0461-9","volume":"40","author":"D Endo","year":"2017","unstructured":"Endo D, Fujimoto K, Hirose R, Yamanaka H, Homme M, Ishibashi KI, et al. Genetic phagocyte NADPH oxidase deficiency enhances nonviable Candida albicans-induced inflammation in mouse lungs. Inflammation. 2017;40:123\u201335. https:\/\/doi.org\/10.1007\/s10753-016-0461-9.","journal-title":"Inflammation"},{"key":"846_CR99","doi-asserted-by":"publisher","first-page":"1668","DOI":"10.1007\/s10753-022-01650-z","volume":"45","author":"H Nunoi","year":"2022","unstructured":"Nunoi H, Xie P, Nakamura H, Aratani Y, Fang J, Nishimura T, et al. Treatment with polyethylene glycol\u2013conjugated fungal D-amino acid oxidase reduces lung inflammation in a mouse model of chronic granulomatous disease. Inflammation. 2022;45:1668\u201379. https:\/\/doi.org\/10.1007\/s10753-022-01650-z.","journal-title":"Inflammation"}],"container-title":["Human Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13577-022-00846-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13577-022-00846-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13577-022-00846-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T22:09:33Z","timestamp":1677103773000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13577-022-00846-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,19]]},"references-count":99,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["846"],"URL":"https:\/\/doi.org\/10.1007\/s13577-022-00846-7","relation":{},"ISSN":["1749-0774"],"issn-type":[{"value":"1749-0774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,19]]},"assertion":[{"value":"9 November 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 December 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 December 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}