{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T16:54:10Z","timestamp":1793120050537,"version":"4.5.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T00:00:00Z","timestamp":1678752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T00:00:00Z","timestamp":1678752000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81970528"],"award-info":[{"award-number":["81970528"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Shanghai Municipal Science and Technology Commission Research Project","award":["22ZR1449700"],"award-info":[{"award-number":["22ZR1449700"]}]},{"name":"Shanghai General Hospital Start-up Fund","award":["02.06.01.20.01"],"award-info":[{"award-number":["02.06.01.20.01"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Human Cell"],"DOI":"10.1007\/s13577-023-00889-4","type":"journal-article","created":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T12:02:27Z","timestamp":1678795347000},"page":"1054-1067","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Identification of LBH and SPP1 involved in hepatic stellate cell activation during liver fibrogenesis"],"prefix":"10.1007","volume":"36","author":[{"given":"Weiming","family":"Dai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuecheng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyang","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lungen","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7697-5873","authenticated-orcid":false,"given":"Xiaobo","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,3,14]]},"reference":[{"key":"889_CR1","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.mam.2018.09.002","volume":"65","author":"M Parola","year":"2019","unstructured":"Parola M, Pinzani M. Liver fibrosis: pathophysiology, pathogenetic targets and clinical issues. Mol Aspects Med. 2019;65:37\u201355. https:\/\/doi.org\/10.1016\/j.mam.2018.09.002.","journal-title":"Mol Aspects Med"},{"issue":"2","key":"889_CR2","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1177\/1535370219898141","volume":"245","author":"D Dhar","year":"2020","unstructured":"Dhar D, et al. Mechanisms of liver fibrosis and its role in liver cancer. Exp Biol Med (Maywood). 2020;245(2):96\u2013108. https:\/\/doi.org\/10.1177\/1535370219898141.","journal-title":"Exp Biol Med (Maywood)"},{"issue":"1","key":"889_CR3","doi-asserted-by":"publisher","first-page":"19396","DOI":"10.1038\/s41598-021-98806-y","volume":"11","author":"ZY Wang","year":"2021","unstructured":"Wang ZY, et al. Single-cell and bulk transcriptomics of the liver reveals potential targets of NASH with fibrosis. Sci Rep. 2021;11(1):19396. https:\/\/doi.org\/10.1038\/s41598-021-98806-y.","journal-title":"Sci Rep"},{"issue":"3","key":"889_CR4","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1038\/s41575-020-00372-7","volume":"18","author":"T Kisseleva","year":"2021","unstructured":"Kisseleva T, Brenner D. Molecular and cellular mechanisms of liver fibrosis and its regression. Nat Rev Gastroenterol Hepatol. 2021;18(3):151\u201366. https:\/\/doi.org\/10.1038\/s41575-020-00372-7.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"7","key":"889_CR5","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/nrgastro.2017.38","volume":"14","author":"T Tsuchida","year":"2017","unstructured":"Tsuchida T, Friedman SL. Mechanisms of hepatic stellate cell activation. Nat Rev Gastroenterol Hepatol. 2017;14(7):397\u2013411. https:\/\/doi.org\/10.1038\/nrgastro.2017.38.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"1","key":"889_CR6","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.jhep.2015.01.036","volume":"63","author":"P Kocabayoglu","year":"2015","unstructured":"Kocabayoglu P, et al. \u03b2-PDGF receptor expressed by hepatic stellate cells regulates fibrosis in murine liver injury, but not carcinogenesis. J Hepatol. 2015;63(1):141\u20137. https:\/\/doi.org\/10.1016\/j.jhep.2015.01.036.","journal-title":"J Hepatol"},{"issue":"5","key":"889_CR7","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1053\/j.gastro.2014.01.061","volume":"146","author":"L Yang","year":"2014","unstructured":"Yang L, et al. Vascular endothelial growth factor promotes fibrosis resolution and repair in mice. Gastroenterology. 2014;146(5):1339-50.e1. https:\/\/doi.org\/10.1053\/j.gastro.2014.01.061.","journal-title":"Gastroenterology"},{"issue":"7","key":"889_CR8","doi-asserted-by":"publisher","first-page":"2495","DOI":"10.2741\/4067","volume":"17","author":"H Guangcun","year":"2012","unstructured":"Guangcun H, et al. Regulation of hepatic stellate cells by connective tissue growth factor. Front Biosci. 2012;17(7):2495\u2013507.","journal-title":"Front Biosci"},{"issue":"11","key":"889_CR9","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1038\/nm1663","volume":"13","author":"E Seki","year":"2007","unstructured":"Seki E, et al. TLR4 enhances TGF-\u03b2 signaling and hepatic fibrosis. Nat Med. 2007;13(11):1324\u201332. https:\/\/doi.org\/10.1038\/nm1663.","journal-title":"Nat Med"},{"issue":"3","key":"889_CR10","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1053\/j.gastro.2012.05.049","volume":"143","author":"F Meng","year":"2012","unstructured":"Meng F, et al. Interleukin-17 signaling in inflammatory, Kupffer Cells, and hepatic stellate cells exacerbates liver fibrosis in mice. Gastroenterology. 2012;143(3):765-776.e3. https:\/\/doi.org\/10.1053\/j.gastro.2012.05.049.","journal-title":"Gastroenterology"},{"key":"889_CR11","doi-asserted-by":"publisher","first-page":"e11910","DOI":"10.7717\/peerj.11910","volume":"9","author":"Y Tai","year":"2021","unstructured":"Tai Y, et al. Identification of miRNA-target gene regulatory networks in liver fibrosis based on bioinformatics analysis. PeerJ. 2021;9:e11910. https:\/\/doi.org\/10.7717\/peerj.11910.","journal-title":"PeerJ"},{"issue":"1","key":"889_CR12","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1038\/s41598-019-57322-w","volume":"10","author":"JY Kim","year":"2020","unstructured":"Kim JY, et al. Induction of E6AP by microRNA-302c dysregulation inhibits TGF-beta-dependent fibrogenesis in hepatic stellate cells. Sci Rep. 2020;10(1):444. https:\/\/doi.org\/10.1038\/s41598-019-57322-w.","journal-title":"Sci Rep"},{"issue":"10","key":"889_CR13","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1016\/j.bbamcr.2019.06.011","volume":"1866","author":"L Chen","year":"2019","unstructured":"Chen L, et al. Delta-like ligand 4\/DLL4 regulates the capillarization of liver sinusoidal endothelial cell and liver fibrogenesis. Biochim Biophys Acta Mol Cell Res. 2019;1866(10):1663\u201375. https:\/\/doi.org\/10.1016\/j.bbamcr.2019.06.011.","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"issue":"1","key":"889_CR14","doi-asserted-by":"publisher","first-page":"166290","DOI":"10.1016\/j.bbadis.2021.166290","volume":"1868","author":"Y Guo","year":"2022","unstructured":"Guo Y, et al. TGF-beta\/YB-1\/Atg7 axis promotes the proliferation of hepatic progenitor cells and liver fibrogenesis. Biochim Biophys Acta Mol Basis Dis. 2022;1868(1):166290. https:\/\/doi.org\/10.1016\/j.bbadis.2021.166290.","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"889_CR15","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.ejphar.2018.05.030","volume":"833","author":"P Xia","year":"2018","unstructured":"Xia P, et al. Therapeutic effects of recombinant human S100A6 and soluble receptor for advanced glycation end products(sRAGE) on CCl(4)-induced liver fibrosis in mice. Eur J Pharmacol. 2018;833:86\u201393. https:\/\/doi.org\/10.1016\/j.ejphar.2018.05.030.","journal-title":"Eur J Pharmacol"},{"issue":"2","key":"889_CR16","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1016\/j.bbrc.2018.11.155","volume":"508","author":"K Ashad-Bishop","year":"2019","unstructured":"Ashad-Bishop K, et al. Loss of Limb-Bud-and-Heart (LBH) attenuates mammary hyperplasia and tumor development in MMTV-Wnt1 transgenic mice. Biochem Biophys Res Commun. 2019;508(2):536\u201342. https:\/\/doi.org\/10.1016\/j.bbrc.2018.11.155.","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"889_CR17","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1159\/000489801","volume":"47","author":"M Deng","year":"2018","unstructured":"Deng M, et al. Limb-bud and heart attenuates growth and invasion of human lung adenocarcinoma cells and predicts survival outcome. Cell Physiol Biochem. 2018;47(1):223\u201334. https:\/\/doi.org\/10.1159\/000489801.","journal-title":"Cell Physiol Biochem"},{"issue":"5","key":"889_CR18","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1002\/art.39060","volume":"67","author":"AK Ekwall","year":"2015","unstructured":"Ekwall AK, et al. The rheumatoid arthritis risk gene LBH regulates growth in fibroblast-like synoviocytes. Arthritis Rheumatol. 2015;67(5):1193\u2013202. https:\/\/doi.org\/10.1002\/art.39060.","journal-title":"Arthritis Rheumatol"},{"issue":"5","key":"889_CR19","doi-asserted-by":"publisher","first-page":"503","DOI":"10.3390\/cells8050503","volume":"8","author":"O Krenkel","year":"2019","unstructured":"Krenkel O, et al. Single cell RNA sequencing identifies subsets of hepatic stellate cells and myofibroblasts in liver fibrosis. Cells. 2019;8(5):503. https:\/\/doi.org\/10.3390\/cells8050503.","journal-title":"Cells"},{"issue":"17","key":"889_CR20","doi-asserted-by":"publisher","first-page":"1973","DOI":"10.3748\/wjg.v27.i17.1973","volume":"27","author":"XH Dong","year":"2021","unstructured":"Dong XH, et al. S100 calcium binding protein A6 and associated long noncoding ribonucleic acids as biomarkers in the diagnosis and staging of primary biliary cholangitis. World J Gastroenterol. 2021;27(17):1973\u201392. https:\/\/doi.org\/10.3748\/wjg.v27.i17.1973.","journal-title":"World J Gastroenterol"},{"issue":"4 Pt A","key":"889_CR21","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1016\/j.bbadis.2018.01.019","volume":"1864","author":"W Zhao","year":"2018","unstructured":"Zhao W, et al. Inhibition of lysyl oxidase-like 1 (LOXL1) expression arrests liver fibrosis progression in cirrhosis by reducing elastin crosslinking. Biochim Biophys Acta Mol Basis Dis. 2018;1864(4 Pt A):1129\u201337. https:\/\/doi.org\/10.1016\/j.bbadis.2018.01.019.","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"issue":"5","key":"889_CR22","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1007\/s12072-021-10210-w","volume":"15","author":"A Yang","year":"2021","unstructured":"Yang A, et al. Hepatic stellate cells-specific LOXL1 deficiency abrogates hepatic inflammation, fibrosis, and corrects lipid metabolic abnormalities in non-obese NASH mice. Hepatol Int. 2021;15(5):1122\u201335. https:\/\/doi.org\/10.1007\/s12072-021-10210-w.","journal-title":"Hepatol Int"},{"issue":"4","key":"889_CR23","doi-asserted-by":"publisher","first-page":"1594","DOI":"10.1002\/hep.31582","volume":"73","author":"Z Song","year":"2021","unstructured":"Song Z, et al. Osteopontin takes center stage in chronic liver disease. Hepatology. 2021;73(4):1594\u2013608. https:\/\/doi.org\/10.1002\/hep.31582.","journal-title":"Hepatology"},{"issue":"7","key":"889_CR24","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.1111\/liv.14464","volume":"40","author":"AD Nardo","year":"2020","unstructured":"Nardo AD, et al. Impact of osteopontin on the development of non-alcoholic liver disease and related hepatocellular carcinoma. Liver Int. 2020;40(7):1620\u201333. https:\/\/doi.org\/10.1111\/liv.14464.","journal-title":"Liver Int"},{"key":"889_CR25","doi-asserted-by":"publisher","first-page":"609900","DOI":"10.3389\/fimmu.2020.609900","volume":"11","author":"F Zeng","year":"2020","unstructured":"Zeng F, et al. Predicting non-alcoholic fatty liver disease progression and immune deregulations by specific gene expression patterns. Front Immunol. 2020;11:609900. https:\/\/doi.org\/10.3389\/fimmu.2020.609900.","journal-title":"Front Immunol"},{"issue":"6","key":"889_CR26","doi-asserted-by":"publisher","first-page":"8988","DOI":"10.1002\/jcp.27571","volume":"234","author":"G Cui","year":"2019","unstructured":"Cui G, et al. Thrombin cleavage of osteopontin controls activation of hepatic stellate cells and is essential for liver fibrogenesis. J Cell Physiol. 2019;234(6):8988\u201397. https:\/\/doi.org\/10.1002\/jcp.27571.","journal-title":"J Cell Physiol"},{"issue":"12","key":"889_CR27","doi-asserted-by":"publisher","first-page":"4202","DOI":"10.1096\/fj.201600392RR","volume":"30","author":"J Tian","year":"2016","unstructured":"Tian J, et al. Galectin-3 regulates inflammasome activation in cholestatic liver injury. FASEB J. 2016;30(12):4202\u201313. https:\/\/doi.org\/10.1096\/fj.201600392RR.","journal-title":"FASEB J"},{"issue":"4","key":"889_CR28","doi-asserted-by":"publisher","first-page":"G439","DOI":"10.1152\/ajpgi.00257.2011","volume":"302","author":"JX Jiang","year":"2012","unstructured":"Jiang JX, et al. Galectin-3 modulates phagocytosis-induced stellate cell activation and liver fibrosis in vivo. Am J Physiol Gastrointest Liver Physiol. 2012;302(4):G439\u201346. https:\/\/doi.org\/10.1152\/ajpgi.00257.2011.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"10","key":"889_CR29","doi-asserted-by":"publisher","first-page":"e75361","DOI":"10.1371\/journal.pone.0075361","volume":"8","author":"PG Traber","year":"2013","unstructured":"Traber PG, et al. Regression of fibrosis and reversal of cirrhosis in rats by galectin inhibitors in thioacetamide-induced liver disease. PLoS ONE. 2013;8(10):e75361. https:\/\/doi.org\/10.1371\/journal.pone.0075361.","journal-title":"PLoS ONE"},{"issue":"2","key":"889_CR30","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1111\/j.1600-0463.2011.02816.x","volume":"120","author":"Y Zhang","year":"2012","unstructured":"Zhang Y, Yao X. Role of c-Jun N-terminal kinase and p38\/activation protein-1 in interleukin-1\u03b2-mediated type I collagen synthesis in rat hepatic stellate cells. APMIS. 2012;120(2):101\u20137. https:\/\/doi.org\/10.1111\/j.1600-0463.2011.02816.x.","journal-title":"APMIS"},{"issue":"9","key":"889_CR31","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1038\/s41418-018-0239-8","volume":"26","author":"I Schulien","year":"2019","unstructured":"Schulien I, et al. The transcription factor c-Jun\/AP-1 promotes liver fibrosis during non-alcoholic steatohepatitis by regulating Osteopontin expression. Cell Death Differ. 2019;26(9):1688\u201399. https:\/\/doi.org\/10.1038\/s41418-018-0239-8.","journal-title":"Cell Death Differ"},{"issue":"8","key":"889_CR32","doi-asserted-by":"publisher","first-page":"4494","DOI":"10.1096\/fj.201701137R","volume":"32","author":"S Zhuang","year":"2018","unstructured":"Zhuang S, et al. Inhibition of GSK-3\u03b2 induces AP-1-mediated osteopontin expression to promote cholestatic liver fibrosis. FASEB J. 2018;32(8):4494\u2013503. https:\/\/doi.org\/10.1096\/fj.201701137R.","journal-title":"FASEB J"},{"issue":"6","key":"889_CR33","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1016\/j.jhep.2019.07.019","volume":"71","author":"Q Guo","year":"2019","unstructured":"Guo Q, et al. Integrin \u03b2(1)-enriched extracellular vesicles mediate monocyte adhesion and promote liver inflammation in murine NASH. J Hepatol. 2019;71(6):1193\u2013205. https:\/\/doi.org\/10.1016\/j.jhep.2019.07.019.","journal-title":"J Hepatol"},{"issue":"5","key":"889_CR34","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1021\/acs.jafc.8b05943","volume":"67","author":"XJ Mi","year":"2019","unstructured":"Mi XJ, et al. Maltol mitigates thioacetamide-induced liver fibrosis through TGF-\u03b21-mediated activation of PI3K\/Akt signaling pathway. J Agric Food Chem. 2019;67(5):1392\u2013401. https:\/\/doi.org\/10.1021\/acs.jafc.8b05943.","journal-title":"J Agric Food Chem"},{"issue":"1","key":"889_CR35","doi-asserted-by":"publisher","first-page":"4032","DOI":"10.1038\/s41598-017-04317-0","volume":"7","author":"XK Zhao","year":"2017","unstructured":"Zhao XK, et al. Focal adhesion kinase regulates hepatic stellate cell activation and liver fibrosis. Sci Rep. 2017;7(1):4032. https:\/\/doi.org\/10.1038\/s41598-017-04317-0.","journal-title":"Sci Rep"}],"container-title":["Human Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13577-023-00889-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13577-023-00889-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13577-023-00889-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T10:29:21Z","timestamp":1681727361000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13577-023-00889-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,14]]},"references-count":35,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,5]]}},"alternative-id":["889"],"URL":"https:\/\/doi.org\/10.1007\/s13577-023-00889-4","relation":{},"ISSN":["1749-0774"],"issn-type":[{"value":"1749-0774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,14]]},"assertion":[{"value":"1 November 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 March 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 March 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that no conflicts of interest exist.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All experimental protocols were approved by the Institutional Animal Care and Use Committee of the Shanghai General Hospital (2020AW075). All methods were executed out in compliance with relevant guidelines and regulations and reported in consistent with the ARRIVE guidelines for reporting animal experiments.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}