{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T13:30:01Z","timestamp":1793194201489,"version":"4.5.0"},"reference-count":173,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T00:00:00Z","timestamp":1682640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T00:00:00Z","timestamp":1682640000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["BT\/PR32391\/MED\/30\/2235\/2020"],"award-info":[{"award-number":["BT\/PR32391\/MED\/30\/2235\/2020"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Manipal Academy of Higher Education, Manipal"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Human Cell"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Metabolic and inflammatory pathways are highly interdependent, and both systems are dysregulated in Type 2 diabetes (T2D). T2D is associated with pre-activated inflammatory signaling networks, aberrant cytokine production\u00a0and increased acute phase reactants which leads to a pro-inflammatory \u2018feed forward loop\u2019. Nutrient \u2018excess\u2019 conditions in T2D with hyperglycemia, elevated lipids and branched-chain amino acids significantly alter\u00a0the functions of immune cells including neutrophils. Neutrophils are metabolically active cells and utilizes energy from glycolysis, stored glycogen and\n                    <jats:italic>\u03b2<\/jats:italic>\n                    -oxidation while depending on the pentose phosphate pathway for NADPH for performing effector functions such as chemotaxis, phagocytosis and forming extracellular traps. Metabolic changes in T2D result in constitutive activation and impeded acquisition of effector or regulatory activities of neutrophils and render T2D subjects for recurrent infections. Increased flux through the polyol and hexosamine pathways, elevated production of advanced glycation end products (AGEs), and activation of protein kinase C isoforms lead to (a) an enhancement in superoxide generation; (b) the stimulation of inflammatory pathways and subsequently to (c) abnormal host responses. Neutrophil dysfunction diminishes the effectiveness of wound healing, successful tissue regeneration and immune surveillance against offending pathogens. Hence, Metabolic reprogramming in neutrophils determines frequency, severity and duration of infections in T2D. The present review discusses the influence of the altered immuno-metabolic axis on neutrophil dysfunction along with challenges and therapeutic opportunities for clinical management of T2D-associated infections.\n                  <\/jats:p>","DOI":"10.1007\/s13577-023-00905-7","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T08:02:59Z","timestamp":1682668979000},"page":"1265-1282","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":102,"title":["Neutrophil (dys)function due to altered immuno-metabolic axis in type 2 diabetes: implications in combating infections"],"prefix":"10.1007","volume":"36","author":[{"given":"Pooja Yedehalli","family":"Thimmappa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sampara","family":"Vasishta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailash","family":"Ganesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aswathy S","family":"Nair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjunath B","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,4,28]]},"reference":[{"key":"905_CR1","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1002\/JLB.5VMR0118-021RR","volume":"104","author":"LM Frydrych","year":"2018","unstructured":"Frydrych LM, Bian G, O\u2019Lone DE, Ward PA, Delano MJ. Obesity and type 2 diabetes mellitus drive immune dysfunction, infection development, and sepsis mortality. J Leukoc Biol. 2018;104:525\u201334.","journal-title":"J Leukoc Biol"},{"key":"905_CR2","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1038\/sj.cdd.4401320","volume":"11","author":"NA Maianski","year":"2004","unstructured":"Maianski NA, Geissler J, Srinivasula SM, Alnemri ES, Roos D, Kuijpers TW. Functional characterization of mitochondria in neutrophils: a role restricted to apoptosis. Cell Death Differ. 2004;11:143\u201353.","journal-title":"Cell Death Differ"},{"key":"905_CR3","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/1472-6890-3-3","volume":"3","author":"DC Doeing","year":"2003","unstructured":"Doeing DC, Borowicz JL, Crockett ET. Gender dimorphism in differential peripheral blood leukocyte counts in mice using cardiac, tail, foot, and saphenous vein puncture methods. BMC Clin Pathol. 2003;3:3.","journal-title":"BMC Clin Pathol"},{"key":"905_CR4","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/nri3399","volume":"13","author":"E Kolaczkowska","year":"2013","unstructured":"Kolaczkowska E, Kubes P. Neutrophil recruitment and function in health and inflammation. Nat Rev Immunol. 2013;13:159\u201375.","journal-title":"Nat Rev Immunol"},{"key":"905_CR5","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1038\/nri3660","volume":"14","author":"MG Manz","year":"2014","unstructured":"Manz MG, Boettcher S. Emergency granulopoiesis. Nat Rev Immunol. 2014;14:302\u201314.","journal-title":"Nat Rev Immunol"},{"key":"905_CR6","doi-asserted-by":"publisher","first-page":"19345","DOI":"10.1073\/pnas.0709747104","volume":"104","author":"RJ DeBerardinis","year":"2007","unstructured":"DeBerardinis RJ, Mancuso A, Daikhin E, Nissim I, Yudkoff M, Wehrli S, et al. Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc Natl. 2007;104:19345\u201350.","journal-title":"Proc Natl"},{"key":"905_CR7","doi-asserted-by":"publisher","first-page":"2241","DOI":"10.1016\/j.febslet.2013.05.053","volume":"587","author":"MB Joshi","year":"2013","unstructured":"Joshi MB, Lad A, Bharath Prasad AS, Balakrishnan A, Ramachandra L, Satyamoorthy K. High glucose modulates IL-6 mediated immune homeostasis through impeding neutrophil extracellular trap formation. FEBS Lett. 2013;587:2241\u20136.","journal-title":"FEBS Lett"},{"key":"905_CR8","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/0163-7258(92)90031-T","volume":"54","author":"DR Tomlinson","year":"1992","unstructured":"Tomlinson DR, Willars GB, Carrington AL. Aldose reductase inhibitors and diabetic complications. Pharmacol Ther. 1992;54:151\u201394.","journal-title":"Pharmacol Ther"},{"key":"905_CR9","doi-asserted-by":"publisher","first-page":"655","DOI":"10.3390\/metabo11100655","volume":"11","author":"M Singh","year":"2021","unstructured":"Singh M, Kapoor A, Bhatnagar A. Physiological and pathological roles of aldose reductase. Metabolites. 2021;11:655.","journal-title":"Metabolites"},{"key":"905_CR10","doi-asserted-by":"publisher","first-page":"818","DOI":"10.2337\/diabetes.54.3.818","volume":"54","author":"KV Ramana","year":"2005","unstructured":"Ramana KV, Friedrich B, Tammali R, West MB, Bhatnagar A, Srivastava SK. Requirement of aldose reductase for the hyperglycemic activation of protein kinase C and formation of diacylglycerol in vascular smooth muscle cells. Diabetes. 2005;54:818\u201329.","journal-title":"Diabetes"},{"key":"905_CR11","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/278963","volume":"2011","author":"B Lewko","year":"2011","unstructured":"Lewko B, Latawiec E, Maryn A, Barczy\u0144ska A, Piku\u0142a M, Zieli\u0144ski M, et al. Osmolarity and glucose differentially regulate aldose reductase activity in cultured mouse podocytes. Exp Diabetes Res. 2011;2011: 278963.","journal-title":"Exp Diabetes Res"},{"key":"905_CR12","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1038\/414813a","volume":"414","author":"M Brownlee","year":"2001","unstructured":"Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature. 2001;414:813\u201320.","journal-title":"Nature"},{"key":"905_CR13","doi-asserted-by":"publisher","first-page":"10912","DOI":"10.1016\/S0021-9258(19)38533-3","volume":"265","author":"DL Vander Jagt","year":"1990","unstructured":"Vander Jagt DL, Hunsaker LA, Robinson B, Stangebye LA, Deck LM. Aldehyde and aldose reductases from human placenta. Heterogeneous expression of multiple enzyme forms. J Biol Chem. 1990;265:10912\u20138.","journal-title":"J Biol Chem"},{"key":"905_CR14","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.2337\/diab.40.10.1233","volume":"40","author":"Y Hamada","year":"1991","unstructured":"Hamada Y, Kitoh R, Raskin P. Crucial role of aldose reductase activity and plasma glucose level in sorbitol accumulation in erythrocytes from diabetic patients. Diabetes. 1991;40:1233\u201340.","journal-title":"Diabetes"},{"key":"905_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2020.165940","volume":"1866","author":"MB Joshi","year":"2020","unstructured":"Joshi MB, Ahamed R, Hegde M, Nair AS, Ramachandra L, Satyamoorthy K. Glucose induces metabolic reprogramming in neutrophils during type 2 diabetes to form constitutive extracellular traps and decreased responsiveness to lipopolysaccharides. Biochim Biophys Acta Mol Basis Dis. 2020;1866: 165940.","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"905_CR16","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1161\/CIRCRESAHA.110.223545","volume":"107","author":"F Giacco","year":"2010","unstructured":"Giacco F, Brownlee M. Oxidative stress and diabetic complications. Circ Res. 2010;107:1058\u201370.","journal-title":"Circ Res"},{"key":"905_CR17","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.678771","volume":"12","author":"R Dowey","year":"2021","unstructured":"Dowey R, Iqbal A, Heller SR, Sabroe I, Prince LR. A bittersweet response to infection in diabetes; targeting neutrophils to modify inflammation and improve host immunity. Front Immunol. 2021;12: 678771.","journal-title":"Front Immunol"},{"key":"905_CR18","doi-asserted-by":"publisher","first-page":"5187","DOI":"10.2741\/3074","volume":"13","author":"CB Guest","year":"2008","unstructured":"Guest CB, Park MJ, Johnson DR, Freund GG. The implication of proinflammatory cytokines in type 2 diabetes. Front Biosci. 2008;13:5187\u201394.","journal-title":"Front Biosci"},{"key":"905_CR19","doi-asserted-by":"publisher","DOI":"10.4110\/in.2020.20.e46","volume":"20","author":"J-H Jeon","year":"2020","unstructured":"Jeon J-H, Hong C-W, Kim EY, Lee JM. Current understanding on the metabolism of neutrophils. Immune Netw. 2020;20:e46.","journal-title":"Immune Netw"},{"key":"905_CR20","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.826515","volume":"13","author":"Stoarko","year":"2022","unstructured":"Stoarko, Gigon L, Peng S, Lukowski R, Ruth P, Karaulov A, et al. Physiological and pathophysiological roles of metabolic pathways for NET formation and other neutrophil functions. Front Immunol. 2022;13:826515.","journal-title":"Front Immunol"},{"key":"905_CR21","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1111\/imm.12437","volume":"145","author":"O Rodr\u00edguez-Espinosa","year":"2015","unstructured":"Rodr\u00edguez-Espinosa O, Rojas-Espinosa O, Moreno-Altamirano MMB, L\u00f3pez-Villegas EO, S\u00e1nchez-Garc\u00eda FJ. Metabolic requirements for neutrophil extracellular traps formation. Immunology. 2015;145:213\u201324.","journal-title":"Immunology"},{"key":"905_CR22","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1016\/j.cmet.2021.03.018","volume":"33","author":"P Sadiku","year":"2021","unstructured":"Sadiku P, Willson JA, Ryan EM, Sammut D, Coelho P, Watts ER, et al. Neutrophils fuel effective immune responses through gluconeogenesis and glycogenesis. Cell Metab. 2021;33:1062\u20134.","journal-title":"Cell Metab"},{"key":"905_CR23","doi-asserted-by":"publisher","first-page":"2783","DOI":"10.1182\/blood-2009-12-258491","volume":"116","author":"HS Jun","year":"2010","unstructured":"Jun HS, Lee YM, Cheung YY, McDermott DH, Murphy PM, De Ravin SS, et al. Lack of glucose recycling between endoplasmic reticulum and cytoplasm underlies cellular dysfunction in glucose-6-phosphatase-beta-deficient neutrophils in a congenital neutropenia syndrome. Blood. 2010;116:2783\u201392.","journal-title":"Blood"},{"key":"905_CR24","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.826515","volume":"13","author":"D Stojkov","year":"2022","unstructured":"Stojkov D, Gigon L, Peng S, Lukowski R, Ruth P, Karaulov A, et al. Physiological and pathophysiological roles of metabolic pathways for NET formation and other neutrophil functions. Front Immunol. 2022;13: 826515.","journal-title":"Front Immunol"},{"key":"905_CR25","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1083\/jcb.95.3.933","volume":"95","author":"JM Robinson","year":"1982","unstructured":"Robinson JM, Karnovsky ML, Karnovsky MJ. Glycogen accumulation in polymorphonuclear leukocytes, and other intracellular alterations that occur during inflammation. J Cell Biol. 1982;95:933\u201342.","journal-title":"J Cell Biol"},{"key":"905_CR26","doi-asserted-by":"publisher","first-page":"22174","DOI":"10.1074\/jbc.M115.640094","volume":"290","author":"EP Azevedo","year":"2015","unstructured":"Azevedo EP, Rochael NC, Guimar\u00e3es-Costa AB, de Souza-Vieira TS, Ganilho J, Saraiva EM, et al. A metabolic shift toward pentose phosphate pathway is necessary for amyloid fibril- and phorbol 12-myristate 13-acetate-induced neutrophil extracellular trap (NET) formation. J Biol Chem. 2015;290:22174\u201383.","journal-title":"J Biol Chem"},{"key":"905_CR27","doi-asserted-by":"publisher","first-page":"5003","DOI":"10.4049\/jimmunol.1103430","volume":"188","author":"A Pizzolla","year":"2012","unstructured":"Pizzolla A, Hultqvist M, Nilson B, Grimm MJ, Eneljung T, Jonsson I-M, et al. Reactive oxygen species produced by the NADPH oxidase 2 complex in monocytes protect mice from bacterial infections. J Immunol. 2012;188:5003\u201311.","journal-title":"J Immunol"},{"key":"905_CR28","doi-asserted-by":"publisher","first-page":"2515S","DOI":"10.1093\/jn\/131.9.2515S","volume":"131","author":"P Newsholme","year":"2001","unstructured":"Newsholme P. Why is l-glutamine metabolism important to cells of the immune system in health, postinjury, surgery or infection? J Nutr. 2001;131:2515S-S2522.","journal-title":"J Nutr"},{"key":"905_CR29","doi-asserted-by":"publisher","first-page":"C1124","DOI":"10.1152\/ajpcell.1997.273.4.C1124","volume":"273","author":"TC Curi","year":"1997","unstructured":"Curi TC, De Melo MP, De Azevedo RB, Zorn TM, Curi R. Glutamine utilization by rat neutrophils: presence of phosphate-dependent glutaminase. Am J Physiol. 1997;273:C1124\u20139.","journal-title":"Am J Physiol"},{"key":"905_CR30","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1042\/cs0960549","volume":"96","author":"C Garcia","year":"1999","unstructured":"Garcia C, Pithon-Curi TC, de Lourdes Firmano M, Pires de Melo M, Newsholme P, Curi R. Effects of adrenaline on glucose and glutamine metabolism and superoxide production by rat neutrophils. Clin Sci (Lond). 1999;96:549\u201355.","journal-title":"Clin Sci (Lond)"},{"key":"905_CR31","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1016\/S0899-9007(97)00271-2","volume":"13","author":"S Furukawa","year":"1997","unstructured":"Furukawa S, Saito H, Fukatsu K, Hashiguchi Y, Inaba T, Lin MT, et al. Glutamine-enhanced bacterial killing by neutrophils from postoperative patients. Nutrition. 1997;13:863\u20139.","journal-title":"Nutrition"},{"key":"905_CR32","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/S0899-9007(00)00228-8","volume":"16","author":"S Furukawa","year":"2000","unstructured":"Furukawa S, Saito H, Inoue T, Matsuda T, Fukatsu K, Han I, et al. Supplemental glutamine augments phagocytosis and reactive oxygen intermediate production by neutrophils and monocytes from postoperative patients in vitro. Nutrition. 2000;16:323\u20139.","journal-title":"Nutrition"},{"key":"905_CR33","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1146\/annurev-immunol-020711-074942","volume":"30","author":"B Amulic","year":"2012","unstructured":"Amulic B, Cazalet C, Hayes GL, Metzler KD, Zychlinsky A. Neutrophil function: from mechanisms to disease. Annu Rev Immunol. 2012;30:459\u201389.","journal-title":"Annu Rev Immunol"},{"key":"905_CR34","doi-asserted-by":"publisher","first-page":"e115","DOI":"10.1097\/BCR.0000000000000171","volume":"37","author":"M Tian","year":"2016","unstructured":"Tian M, Qing C, Niu Y, Dong J, Cao X, Song F, et al. The relationship between inflammation and impaired wound healing in a diabetic rat burn model. J Burn Care Res. 2016;37:e115\u201324.","journal-title":"J Burn Care Res"},{"key":"905_CR35","doi-asserted-by":"publisher","first-page":"16","DOI":"10.31254\/jmr.2018.4105","volume":"4","author":"AK Tshikongo","year":"2018","unstructured":"Tshikongo AK, Songela RK, Koke JK, Mawazo SS, Kalala L, Otshudi AL. Polynuclear neutrophil variation and oxidative stress in type 2 diabetics. JMR. 2018;4:16\u20139.","journal-title":"JMR"},{"key":"905_CR36","doi-asserted-by":"publisher","first-page":"2384","DOI":"10.1016\/j.celrep.2017.11.010","volume":"21","author":"T Fainsod-Levi","year":"2017","unstructured":"Fainsod-Levi T, Gershkovitz M, V\u00f6ls S, Kumar S, Khawaled S, Sagiv JY, et al. Hyperglycemia impairs neutrophil mobilization leading to enhanced metastatic seeding. Cell Rep. 2017;21:2384\u201392.","journal-title":"Cell Rep"},{"key":"905_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-018-35809-2","volume":"8","author":"WMT Kuwabara","year":"2018","unstructured":"Kuwabara WMT, Yokota CNF, Curi R, Alba-Loureiro TC. Obesity and type 2 diabetes mellitus induce lipopolysaccharide tolerance in rat neutrophils. Sci Rep. 2018;8:1\u201313.","journal-title":"Sci Rep"},{"key":"905_CR38","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.arcmed.2013.10.003","volume":"45","author":"E Zurawska-p","year":"2014","unstructured":"Zurawska-p E, Piwowar A, Knapik-kordecka M, Warwas M. Activities of neutrophil membrane-bound proteases in type 2 diabetic patients. Arch Med Res. 2014;45:36\u201343.","journal-title":"Arch Med Res"},{"key":"905_CR39","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1172\/JCI92450","volume":"127","author":"MJ Kraakman","year":"2017","unstructured":"Kraakman MJ, Lee MKS, Al-sharea A, Dragoljevic D, Barrett TJ, Montenont E, et al. Neutrophil-derived S100 calcium-binding proteins A8\/A9 promote reticulated thrombocytosis and atherogenesis in diabetes. J Clin Invest. 2017;127:18\u201322.","journal-title":"J Clin Invest"},{"key":"905_CR40","doi-asserted-by":"publisher","first-page":"9","DOI":"10.15605\/jafes.030.01.02","volume":"30","author":"W Umsa-ard","year":"2015","unstructured":"Umsa-ard W, Thongboonkerd V, Soongsathitanon J. Activated status and altered functions of neutrophils in poorly controlled diabetes. J ASEAN Fed Endocr Soc. 2015;30:9.","journal-title":"J ASEAN Fed Endocr Soc"},{"key":"905_CR41","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s12865-021-00428-6","volume":"22","author":"SE Kleinstein","year":"2021","unstructured":"Kleinstein SE, McCorrison J, Ahmed A, Hasturk H, van Dyke TE, Freire M. Transcriptomics of type 2 diabetic and healthy human neutrophils. BMC Immunol. 2021;22:37.","journal-title":"BMC Immunol"},{"key":"905_CR42","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1016\/j.clinbiochem.2007.07.016","volume":"40","author":"H Wang","year":"2007","unstructured":"Wang H, Meng QH, Gordon JR, Khandwala H, Wu L. Proinflammatory and proapoptotic effects of methylglyoxal on neutrophils from patients with type 2 diabetes mellitus. Clin Biochem. 2007;40:1232\u20139.","journal-title":"Clin Biochem"},{"issue":"25","key":"905_CR43","first-page":"1563","volume":"2","author":"E Gokalp-Ozkorkmaz","year":"2018","unstructured":"Gokalp-Ozkorkmaz E, Kirman G, Pekkolay Z, Asir F, Deveci E. Expression of apoptotic proteins bax and bcl-2 in blood cells of type 2 diabetic patients. Proceedings. 2018;2(25):1563.","journal-title":"Proceedings."},{"key":"905_CR44","doi-asserted-by":"publisher","first-page":"617","DOI":"10.2337\/db18-0313","volume":"68","author":"T Umehara","year":"2019","unstructured":"Umehara T, Mori R, Mace KA, Murase T, Abe Y, Yamamoto T, et al. Identification of specific miRNAs in neutrophils of type 2 diabetic mice: overexpression of miRNA-129-2-3p accelerates diabetic wound healing. Diabetes. 2019;68:617\u201330.","journal-title":"Diabetes"},{"key":"905_CR45","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/j.immuni.2010.11.011","volume":"33","author":"N Borregaard","year":"2010","unstructured":"Borregaard N. Neutrophils, from marrow to microbes. Immunity. 2010;33:657\u201370.","journal-title":"Immunity"},{"key":"905_CR46","doi-asserted-by":"publisher","first-page":"15","DOI":"10.3390\/jcm6020015","volume":"6","author":"E Warren","year":"2017","unstructured":"Warren E, Teskey G, Venketaraman V. Effector mechanisms of neutrophils within the innate immune system in response to mycobacterium tuberculosis infection. J Clin Med. 2017;6:15.","journal-title":"J Clin Med"},{"key":"905_CR47","doi-asserted-by":"publisher","first-page":"3084","DOI":"10.1210\/jc.2005-2749","volume":"91","author":"J Lin","year":"2015","unstructured":"Lin J, Siu LK, Fung C, Tsou H, Wang J, Chen C, et al. Impaired phagocytosis of capsular serotypes K1 or K2 klebsiella pneumoniae in type 2 diabetes mellitus patients with poor glycemic control. J Clin Endocrinol Metab. 2015;91:3084\u20137.","journal-title":"J Clin Endocrinol Metab"},{"key":"905_CR48","doi-asserted-by":"publisher","first-page":"401","DOI":"10.3389\/fcimb.2017.00401","volume":"7","author":"IR Lee","year":"2017","unstructured":"Lee IR, Sng E, Lee K, Molton JS, Chan M, Kalimuddin S, et al. Comparison of diabetic and non-diabetic human leukocytic responses to different capsule types of klebsiella pneumoniae responsible for causing pyogenic liver abscess bacterial strains and culture conditions. Front Cell Infect Microbiol. 2017;7:401.","journal-title":"Front Cell Infect Microbiol"},{"key":"905_CR49","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1136\/jcp.37.7.783","volume":"37","author":"NJ Davidson","year":"1984","unstructured":"Davidson NJ, Sowden JM, Fletcher J. Defective phagocytosis in insulin controlled diabetics: evidence for a reaction between glucose and opsonising proteins. J Clin Pathol. 1984;37:783\u20136.","journal-title":"J Clin Pathol"},{"key":"905_CR50","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1080\/15438600490424244","volume":"5","author":"Z Osar","year":"2004","unstructured":"Osar Z, Demirel Y, Damci T, Ilkova H. Nicotinamide effects oxidative burst activity of neutrophils in patients with poorly controlled type 2 diabetes mellitus. Exp Diabesity Res. 2004;5:155\u201362.","journal-title":"Exp Diabesity Res"},{"key":"905_CR51","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1006\/mgme.2001.3185","volume":"73","author":"MA Mazade","year":"2001","unstructured":"Mazade MA, Edwards MS. Impairment of type III group B Streptococcus-stimulated superoxide production and opsonophagocytosis by neutrophils in diabetes. Mol Genet Metab. 2001;73:259\u201367.","journal-title":"Mol Genet Metab"},{"key":"905_CR52","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069108","volume":"8","author":"A Rossi","year":"2013","unstructured":"Rossi A, Lord J. Adiponectin inhibits neutrophil phagocytosis of Escherichia coli by inhibition of PKB and ERK 1\/2 MAPK signalling and Mac-1 activation. PLoS\u00a0One. 2013;8: e69108.","journal-title":"PLoS\u00a0One"},{"key":"905_CR53","doi-asserted-by":"publisher","first-page":"4409","DOI":"10.1128\/IAI.00787-12","volume":"80","author":"H Yano","year":"2012","unstructured":"Yano H, Kinoshita M, Fujino K, Nakashima M, Yamamoto Y, Miyazaki H, et al. Insulin treatment directly restores neutrophil phagocytosis and bactericidal activity in diabetic mice and thereby improves surgical site Staphylococcus aureus infection. Infect Immun. 2012;80:4409\u201316.","journal-title":"Infect Immun"},{"key":"905_CR54","first-page":"577","volume":"5","author":"V Brinkmann","year":"2007","unstructured":"Brinkmann V, Zychlinsky A. A beneficial suicide: why neutrophils die to make NETs. NatRevMicrobiol. 2007;5:577\u201382.","journal-title":"NatRevMicrobiol"},{"key":"905_CR55","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1007\/s00592-014-0676-x","volume":"52","author":"L Menegazzo","year":"2015","unstructured":"Menegazzo L, Ciciliot S, Poncina N, Mazzucato M, Persano M, Bonora B, et al. NETosis is induced by high glucose and associated with type 2 diabetes. Acta Diabetol. 2015;52:497\u2013503.","journal-title":"Acta Diabetol"},{"key":"905_CR56","doi-asserted-by":"publisher","first-page":"36362","DOI":"10.1038\/srep36362","volume":"6","author":"MB Joshi","year":"2016","unstructured":"Joshi MB, Baipadithaya G, Balakrishnan A, Hegde M, Vohra M, Ahamed R, et al. Elevated homocysteine levels in type 2 diabetes induce constitutive neutrophil extracellular traps. Sci Rep. 2016;6:36362.","journal-title":"Sci Rep"},{"key":"905_CR57","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1038\/nm.3887","volume":"21","author":"S Wong","year":"2015","unstructured":"Wong S, Demers M, Martinod K, Gallant M. medicine YW-N, 2015 undefined. Diabetes primes neutrophils to undergo NETosis, which impairs wound healing. Nat Med. 2015;21:815\u20139.","journal-title":"Nat Med"},{"key":"905_CR58","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0168647","volume":"11","author":"A Carestia","year":"2016","unstructured":"Carestia A, Frechtel G, Cerrone G, Linari MA, Gonzalez CD, Casais P, et al. NETosis before and after hyperglycemic control in type 2 diabetes mellitus patients. PLoS ONE. 2016;11: e0168647.","journal-title":"PLoS ONE"},{"key":"905_CR59","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1159\/000444881","volume":"83","author":"A Miyoshi","year":"2016","unstructured":"Miyoshi A, Yamada M, Shida H, Nakazawa D, Kusunoki Y, Nakamura A, et al. Circulating neutrophil extracellular trap levels in well-controlled type 2 diabetes and pathway involved in their formation induced by high-dose glucose. Pathobiology. 2016;83:243\u201351.","journal-title":"Pathobiology"},{"key":"905_CR60","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/817038","volume":"2015","author":"I Naegelen","year":"2015","unstructured":"Naegelen I, Beaume N, Plan\u00e7on S, Schenten V, Tschirhart EJ, Br\u00e9chard S. Regulation of neutrophil degranulation and cytokine secretion: a novel model approach based on linear fitting. J Immunol Res. 2015;2015: 817038.","journal-title":"J Immunol Res"},{"key":"905_CR61","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1189\/jlb.0505248","volume":"79","author":"S Pellm\u00e9","year":"2006","unstructured":"Pellm\u00e9 S, M\u00f6rgelin M, Tapper H, Mellqvist U-H, Dahlgren C, Karlsson A. Localization of human neutrophil interleukin-8 (CXCL-8) to organelle(s) distinct from the classical granules and secretory vesicles. J Leukoc Biol. 2006;79:564\u201373.","journal-title":"J Leukoc Biol"},{"key":"905_CR62","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/s42003-018-0081-z","volume":"1","author":"L Willetts","year":"2018","unstructured":"Willetts L, Felix LC, Jacobsen EA, Puttagunta L, Condjella RM, Zellner KR, et al. Vesicle-associated membrane protein 7-mediated eosinophil degranulation promotes allergic airway inflammation in mice. Commun Biol. 2018;1:83.","journal-title":"Commun Biol"},{"key":"905_CR63","doi-asserted-by":"publisher","first-page":"2925","DOI":"10.1128\/AAC.44.11.2925-2931.2000","volume":"44","author":"O Levy","year":"2000","unstructured":"Levy O. A neutrophil-derived anti-infective molecule: bactericidal\/permeability-increasing protein. Antimicrob Agents Chemother. 2000;44:2925\u201331.","journal-title":"Antimicrob Agents Chemother"},{"key":"905_CR64","first-page":"1","volume":"2019","author":"D Insuela","year":"2019","unstructured":"Insuela D, Coutinho D, Martins M, Ferrero M, Carvalho V. Neutrophil function impairment is a host susceptibility factor to bacterial infection in diabetes. Cells Immune Syst. 2019;2019:1\u201322.","journal-title":"Cells Immune Syst."},{"key":"905_CR65","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1182\/blood-2007-11-121723","volume":"112","author":"ME Stegenga","year":"2008","unstructured":"Stegenga ME, van der Crabben SN, Regje M, Bl\u00fcmer E, Levi M, Meijers JCM, Serlie MJ, et al. Hyperglycemia enhances coagulation and reduces neutrophil degranulation, whereas hyperinsulinemia inhibits fibrinolysis during human endotoxemia. Blood. 2008;112:82\u20139.","journal-title":"Blood"},{"key":"905_CR66","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.ppat.1003794","volume":"9","author":"YH Gan","year":"2013","unstructured":"Gan YH. Host Susceptibility Factors to Bacterial Infections in Type 2 Diabetes. PLoS Pathog. 2013;9:1\u20133.","journal-title":"PLoS Pathog"},{"key":"905_CR67","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1111\/jdi.12469","volume":"7","author":"J Huang","year":"2016","unstructured":"Huang J, Xiao Y, Xu A, Zhou Z. Neutrophils in type 1 diabetes. J Diabetes Investig. 2016;7:652\u201363.","journal-title":"J Diabetes Investig"},{"key":"905_CR68","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1177\/003693309203700205","volume":"37","author":"MH Jackson","year":"1992","unstructured":"Jackson MH, Collier A, Nicoll JJ, Muir AL, Dawes J, Clarke BF, et al. Neutrophil count and activation in vascular disease. Scott Med J. 1992;37:41\u20133.","journal-title":"Scott Med J"},{"key":"905_CR69","first-page":"135","volume":"10","author":"A Collier","year":"1989","unstructured":"Collier A, Jackson M, Bell D, Patrick AW, Matthews DM, Young RJ, et al. Neutrophil activation detected by increased neutrophil elastase activity in type 1 (insulin-dependent) diabetes mellitus. Diabetes Res. 1989;10:135\u20138.","journal-title":"Diabetes Res"},{"key":"905_CR70","doi-asserted-by":"publisher","first-page":"271","DOI":"10.4239\/wjd.v7.i13.271","volume":"7","author":"N Ridzuan","year":"2016","unstructured":"Ridzuan N, John CM, Sandrasaigaran P, Maqbool M, Liew LC, Lim J, et al. Preliminary study on overproduction of reactive oxygen species by neutrophils in diabetes mellitus. World J Diabetes. 2016;7:271\u20138.","journal-title":"World J Diabetes"},{"key":"905_CR71","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1007\/s00281-008-0118-3","volume":"30","author":"J El-Benna","year":"2008","unstructured":"El-Benna J, Dang PM-C, Gougerot-Pocidalo M-A. Priming of the neutrophil NADPH oxidase activation: role of p47phox phosphorylation and NOX2 mobilization to the plasma membrane. Semin Immunopathol. 2008;30:279\u201389.","journal-title":"Semin Immunopathol"},{"key":"905_CR72","doi-asserted-by":"publisher","first-page":"19910","DOI":"10.1016\/S0021-9258(17)45459-7","volume":"265","author":"D Rotrosen","year":"1990","unstructured":"Rotrosen D, Leto TL. Phosphorylation of neutrophil 47-kDa cytosolic oxidase factor. Translocation to membrane is associated with distinct phosphorylation events. J Biol Chem. 1990;265:19910\u20135.","journal-title":"J Biol Chem"},{"key":"905_CR73","doi-asserted-by":"publisher","first-page":"6777","DOI":"10.1016\/S0021-9258(18)68710-1","volume":"263","author":"N Okamura","year":"1988","unstructured":"Okamura N, Curnutte JT, Roberts RL, Babior BM. Relationship of protein phosphorylation to the activation of the respiratory burst in human neutrophils. Defects in the phosphorylation of a group of closely related 48-kDa proteins in two forms of chronic granulomatous disease. J Biol Chem. 1988;263:6777\u201382.","journal-title":"J Biol Chem"},{"key":"905_CR74","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1189\/jlb.1207832","volume":"84","author":"K Omori","year":"2008","unstructured":"Omori K, Ohira T, Uchida Y, Ayilavarapu S, Batista ELJ, Yagi M, et al. Priming of neutrophil oxidative burst in diabetes requires preassembly of the NADPH oxidase. J Leukoc Biol. 2008;84:292\u2013301.","journal-title":"J Leukoc Biol"},{"key":"905_CR75","doi-asserted-by":"publisher","first-page":"2846","DOI":"10.2337\/diabetes.51.9.2846","volume":"51","author":"RKM Wong","year":"2002","unstructured":"Wong RKM, Pettit AI, Davies JE, Ng LL. Augmentation of the neutrophil respiratory burst through the action of advanced glycation end products: a potential contributor to vascular oxidant stress. Diabetes. 2002;51:2846\u201353.","journal-title":"Diabetes"},{"key":"905_CR76","first-page":"1","volume":"13","author":"A Garg","year":"2018","unstructured":"Garg A, Gupta A, Mishra A, Singh M, Yadav S, Nityanand S. Role of granulocyte transfusions in combating life-threatening infections in patients with severe neutropenia: experience from a tertiary care centre in North India. PLoS\u00a0One. 2018;13:1\u201314.","journal-title":"PLoS\u00a0One"},{"key":"905_CR77","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1111\/j.1600-065X.2011.01082.x","volume":"245","author":"RI Lehrer","year":"2012","unstructured":"Lehrer RI, Lu W. \u03b1-Defensins in human innate immunity. Immunol Rev. 2012;245:84\u2013112.","journal-title":"Immunol Rev"},{"key":"905_CR78","doi-asserted-by":"publisher","first-page":"4350","DOI":"10.1073\/pnas.1601831113","volume":"113","author":"M Brook","year":"2016","unstructured":"Brook M, Tomlinson GH, Miles K, Smith RWP, Rossi AG, Hiemstra PS, et al. Neutrophil-derived alpha defensins control inflammation by inhibiting macrophage mRNA translation. Proc Natl Acad Sci USA. 2016;113:4350\u20135.","journal-title":"Proc Natl Acad Sci USA"},{"key":"905_CR79","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1513\/AnnalsATS.201305-112OC","volume":"10","author":"NP Kumar","year":"2013","unstructured":"Kumar NP, Sridhar R, Banurekha VV, Jawahar MS, Fay MP, Nutman TB, et al. Type 2 diabetes mellitus coincident with pulmonary tuberculosis is associated with heightened systemic type 1, type 17, and other proinflammatory cytokines. Ann Am Thorac Soc. 2013;10:441\u20139.","journal-title":"Ann Am Thorac Soc"},{"key":"905_CR80","doi-asserted-by":"publisher","first-page":"H1817","DOI":"10.1152\/ajpheart.00472.2008","volume":"295","author":"K Quinn","year":"2008","unstructured":"Quinn K, Henriques M, Parker T, Slutsky AS, Zhang H. Human neutrophil peptides: a novel potential mediator of inflammatory cardiovascular diseases. Am J Physiol Heart Circ Physiol. 2008;295:H1817\u201324.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"905_CR81","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1210\/jc.2007-1910","volume":"93","author":"G Joseph","year":"2008","unstructured":"Joseph G, Tarnow L, Astrup AS, Hansen TK, Parving H-H, Flyvbjerg A, et al. Plasma alpha-defensin is associated with cardiovascular morbidity and mortality in type 1 diabetic patients. J Clin Endocrinol Metab. 2008;93:1470\u20135.","journal-title":"J Clin Endocrinol Metab"},{"key":"905_CR82","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1038\/s41573-019-0054-z","volume":"19","author":"T N\u00e9meth","year":"2020","unstructured":"N\u00e9meth T, Sperandio M, M\u00f3csai A. Neutrophils as emerging therapeutic targets. Nat Rev Drug Discov. 2020;19:253\u201375.","journal-title":"Nat Rev Drug Discov"},{"key":"905_CR83","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1086\/497143","volume":"41","author":"DL Stevens","year":"2005","unstructured":"Stevens DL, Bisno AL, Chambers HF, Everett ED, Dellinger P, Goldstein EJC, et al. Practice guidelines for the diagnosis and management of skin and soft-tissue infections. Clin Infect Dis. 2005;41:1373\u2013406.","journal-title":"Clin Infect Dis"},{"key":"905_CR84","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1086\/380488","volume":"37","author":"LA Mandell","year":"2003","unstructured":"Mandell LA, Bartlett JG, Dowell SF, File TMJ, Musher DM, Whitney C. Update of practice guidelines for the management of community-acquired pneumonia in immunocompetent adults. Clin Infect Dis. 2003;37:1405\u201333.","journal-title":"Clin Infect Dis"},{"key":"905_CR85","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1086\/427507","volume":"40","author":"LE Nicolle","year":"2005","unstructured":"Nicolle LE, Bradley S, Colgan R, Rice JC, Schaeffer A, Hooton TM. Infectious Diseases Society of America guidelines for the diagnosis and treatment of asymptomatic bacteriuria in adults. Clin Infect Dis. 2005;40:643\u201354.","journal-title":"Clin Infect Dis"},{"key":"905_CR86","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1086\/520427","volume":"29","author":"JW Warren","year":"1999","unstructured":"Warren JW, Abrutyn E, Hebel JR, Johnson JR, Schaeffer AJ, Stamm WE. Guidelines for antimicrobial treatment of uncomplicated acute bacterial cystitis and acute pyelonephritis in women. Infectious Diseases Society of America (IDSA). Clin Infect Dis. 1999;29:745\u201358.","journal-title":"Clin Infect Dis"},{"key":"905_CR87","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1002\/dmrr.682","volume":"23","author":"AY Peleg","year":"2007","unstructured":"Peleg AY, Weerarathna T, McCarthy JS, Davis TME. Common infections in diabetes: pathogenesis, management and relationship to glycaemic control. Diabetes Metab Res Rev. 2007;23:3\u201313.","journal-title":"Diabetes Metab Res Rev"},{"key":"905_CR88","doi-asserted-by":"publisher","first-page":"271","DOI":"10.2337\/diab.39.3.271","volume":"39","author":"MK Hostetter","year":"1990","unstructured":"Hostetter MK. Handicaps to host defense. Effects of hyperglycemia on C3 and Candida albicans. Diabetes. 1990;39:271\u20135.","journal-title":"Diabetes"},{"key":"905_CR89","first-page":"818","volume":"12","author":"WS Beck","year":"1952","unstructured":"Beck WS, Valentine WN. The aerobic carbohydrate metabolism of leukocytes in health and leukemia. I. Glycolysis and respiration. Cancer Res. 1952;12:818\u201322.","journal-title":"Cancer Res"},{"key":"905_CR90","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1590\/S0100-879X1999000100002","volume":"32","author":"R Curi","year":"1999","unstructured":"Curi R, Newsholme P, Pithon-Curi TC, Pires-de-Melo M, Garcia C, Homem-de-Bittencourt J\u00fanior PI, et al. Metabolic fate of glutamine in lymphocytes, macrophages and neutrophils. Braz J Med Biol Res. 1999;32:15\u201321.","journal-title":"Braz J Med Biol Res"},{"key":"905_CR91","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.2337\/diab.36.11.1307","volume":"36","author":"MA Pereira","year":"1987","unstructured":"Pereira MA, Sannomiya P, Leme JG. Inhibition of leukocyte chemotaxis by factor in alloxan-induced diabetic rat plasma. Diabetes. 1987;36:1307\u201314.","journal-title":"Diabetes"},{"key":"905_CR92","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1056\/NEJM197103252841201","volume":"284","author":"A Mowat","year":"1971","unstructured":"Mowat A, Baum J. Chemotaxis of polymorphonuclear leukocytes from patients with diabetes mellitus. N Engl J Med. 1971;284:621\u20137.","journal-title":"N Engl J Med"},{"key":"905_CR93","doi-asserted-by":"publisher","first-page":"889","DOI":"10.2337\/diab.27.9.889","volume":"27","author":"CM Nolan","year":"1978","unstructured":"Nolan CM, Beaty HN, Bagdade JD. Further characterization of the impaired bactericidal function of granulocytes in patients with poorly controlled diabetes. Diabetes. 1978;27:889\u201394.","journal-title":"Diabetes"},{"key":"905_CR94","first-page":"26","volume":"85","author":"JS Tan","year":"1975","unstructured":"Tan JS, Anderson JL, Watanakunakorn C, Phair JP. Neutrophil dysfunction in diabetes mellitus. J Lab Clin Med. 1975;85:26\u201333.","journal-title":"J Lab Clin Med"},{"key":"905_CR95","first-page":"97","volume":"101","author":"ALJ Sagone","year":"1983","unstructured":"Sagone ALJ, Greenwald J, Kraut EH, Bianchine J, Singh D. Glucose: a role as a free radical scavenger in biological systems. J Lab Clin Med. 1983;101:97\u2013104.","journal-title":"J Lab Clin Med"},{"key":"905_CR96","first-page":"478","volume":"63","author":"RM Wilson","year":"1986","unstructured":"Wilson RM, Reeves WG. Neutrophil phagocytosis and killing in insulin-dependent diabetes. Clin Exp Immunol. 1986;63:478\u201384.","journal-title":"Clin Exp Immunol"},{"key":"905_CR97","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1136\/thoraxjnl-2012-203178","volume":"68","author":"JP Garnett","year":"2013","unstructured":"Garnett JP, Baker EH, Naik S, Lindsay JA, Knight GM, Gill S, et al. Metformin reduces airway glucose permeability and hyperglycaemia-induced Staphylococcus aureus load independently of effects on blood glucose. Thorax. 2013;68:835\u201345.","journal-title":"Thorax"},{"key":"905_CR98","doi-asserted-by":"publisher","first-page":"2289","DOI":"10.1172\/JCI57817","volume":"122","author":"KS Tan","year":"2012","unstructured":"Tan KS, Lee KO, Low KC, Gamage AM, Liu Y, Tan G-YG, et al. Glutathione deficiency in type 2 diabetes impairs cytokine responses and control of intracellular bacteria. J Clin Invest. 2012;122:2289\u2013300.","journal-title":"J Clin Invest"},{"key":"905_CR99","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1515\/BC.2009.033","volume":"390","author":"N Ballatori","year":"2009","unstructured":"Ballatori N, Krance SM, Notenboom S, Shi S, Tieu K, Hammond CL. Glutathione dysregulation and the etiology and progression of human diseases. Biol Chem. 2009;390:191\u2013214.","journal-title":"Biol Chem"},{"key":"905_CR100","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/S0304-3940(01)02174-7","volume":"312","author":"W Deuther-Conrad","year":"2001","unstructured":"Deuther-Conrad W, Loske C, Schinzel R, Dringen R, Riederer P, M\u00fcnch G. Advanced glycation endproducts change glutathione redox status in SH-SY5Y human neuroblastoma cells by a hydrogen peroxide dependent mechanism. Neurosci Lett. 2001;312:29\u201332.","journal-title":"Neurosci Lett"},{"key":"905_CR101","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1007\/s007020050108","volume":"105","author":"C Loske","year":"1998","unstructured":"Loske C, Neumann A, Cunningham AM, Nichol K, Schinzel R, Riederer P, et al. Cytotoxicity of advanced glycation endproducts is mediated by oxidative stress. J Neural Transm (Vienna). 1998;105:1005\u201315.","journal-title":"J Neural Transm (Vienna)"},{"key":"905_CR102","doi-asserted-by":"publisher","first-page":"15146","DOI":"10.1074\/jbc.271.25.15146","volume":"271","author":"Y Urata","year":"1996","unstructured":"Urata Y, Yamamoto H, Goto S, Tsushima H, Akazawa S, Yamashita S, et al. Long exposure to high glucose concentration impairs the responsive expression of \u03b3-glutamylcysteine synthetase by interleukin-1beta and tumor necrosis factor-alpha in mouse endothelial cells. J Biol Chem. 1996;271:15146\u201352.","journal-title":"J Biol Chem"},{"key":"905_CR103","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1007\/s10534-011-9492-8","volume":"25","author":"TJ Zwang","year":"2012","unstructured":"Zwang TJ, Gormally MV, Johal MS, Sazinsky MH. Enhanced iron availability by protein glycation may explain higher infection rates in diabetics. Biometals. 2012;25:237\u201345.","journal-title":"Biometals"},{"key":"905_CR104","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.00170-22","volume":"10","author":"TI Bui","year":"2022","unstructured":"Bui TI, Gill AL, Mooney RA, Gill SR. Modulation of gut microbiota metabolism in obesity-related type 2 diabetes reduces osteomyelitis severity. Microbiol Spectr. 2022;10: e0017022.","journal-title":"Microbiol Spectr"},{"key":"905_CR105","first-page":"561","volume":"21","author":"V Esmann","year":"1983","unstructured":"Esmann V. The polymorphonuclear leukocyte in diabetes mellitus. J Clin Chem Clin Biochem. 1983;21:561\u20137.","journal-title":"J Clin Chem Clin Biochem"},{"key":"905_CR106","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1677\/joe.1.06438","volume":"188","author":"TC Alba-Loureiro","year":"2006","unstructured":"Alba-Loureiro TC, Hirabara SM, Mendon\u00e7a JR, Curi R, Pithon-Curi TC. Diabetes causes marked changes in function and metabolism of rat neutrophils. J Endocrinol. 2006;188:295\u2013303.","journal-title":"J Endocrinol"},{"key":"905_CR107","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2019.165542","volume":"1865","author":"D Awasthi","year":"2019","unstructured":"Awasthi D, Nagarkoti S, Sadaf S, Chandra T, Kumar S, Dikshit M. Glycolysis dependent lactate formation in neutrophils: a metabolic link between NOX-dependent and independent NETosis. Biochim Biophys Acta Mol Basis Dis. 2019;1865: 165542.","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"905_CR108","doi-asserted-by":"publisher","first-page":"C255","DOI":"10.1152\/ajpcell.00618.2006","volume":"293","author":"JW Zmijewski","year":"2007","unstructured":"Zmijewski JW, Zhao X, Xu Z, Abraham E. Exposure to hydrogen peroxide diminishes NF-\u03baB activation, I\u03baB-\u03b1 degradation, and proteasome activity in neutrophils. Am J Physiol Cell Physiol. 2007;293:C255\u201366.","journal-title":"Am J Physiol Cell Physiol"},{"key":"905_CR109","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1677\/joe.0.1600389","volume":"160","author":"G Papaccio","year":"1999","unstructured":"Papaccio G, Ammendola E, Pisanti FA. Nicotinamide decreases MHC class II but not MHC class I expression and increases intercellular adhesion molecule-1 structures in non-obese diabetic mouse pancreas. J Endocrinol. 1999;160:389\u2013400.","journal-title":"J Endocrinol"},{"key":"905_CR110","doi-asserted-by":"publisher","first-page":"2768","DOI":"10.1182\/blood-2013-10-463646","volume":"123","author":"K Martinod","year":"2014","unstructured":"Martinod K, Wagner DD. Thrombosis: tangled up in NETs. Blood. 2014;123:2768\u201376.","journal-title":"Blood"},{"key":"905_CR111","doi-asserted-by":"publisher","first-page":"2784","DOI":"10.1182\/blood-2013-04-457671","volume":"122","author":"BG Yipp","year":"2013","unstructured":"Yipp BG, Kubes P. NETosis: how vital is it? Blood. 2013;122:2784\u201394.","journal-title":"Blood"},{"key":"905_CR112","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/nrendo.2014.29","volume":"10","author":"M Laakso","year":"2014","unstructured":"Laakso M, Kuusisto J. Insulin resistance and hyperglycaemia in cardiovascular disease development. Nat Rev Endocrinol. 2014;10:293\u2013302.","journal-title":"Nat Rev Endocrinol"},{"key":"905_CR113","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1046\/j.1524-475X.2003.11308.x","volume":"11","author":"HP Shi","year":"2003","unstructured":"Shi HP, Most D, Efron DT, Witte MB, Barbul A. Supplemental l-arginine enhances wound healing in diabetic rats. Wound Repair Regen. 2003;11:198\u2013203.","journal-title":"Wound Repair Regen"},{"key":"905_CR114","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1007\/s00134-002-1628-4","volume":"29","author":"A Perner","year":"2003","unstructured":"Perner A, Nielsen SE, Rask-Madsen J. High glucose impairs superoxide production from isolated blood neutrophils. Intensive Care Med. 2003;29:642\u20135.","journal-title":"Intensive Care Med"},{"key":"905_CR115","doi-asserted-by":"publisher","first-page":"e34","DOI":"10.1016\/S2666-7568(20)30033-7","volume":"2","author":"CT Bramante","year":"2021","unstructured":"Bramante CT, Ingraham NE, Murray TA, Marmor S, Hovertsen S, Gronski J, et al. Metformin and risk of mortality in patients hospitalised with COVID-19: a retrospective cohort analysis. Lancet Healthy Longev. 2021;2:e34\u201341.","journal-title":"Lancet Healthy Longev"},{"key":"905_CR116","doi-asserted-by":"publisher","first-page":"3229","DOI":"10.1038\/s41598-020-60213-0","volume":"10","author":"W Saenwongsa","year":"2020","unstructured":"Saenwongsa W, Nithichanon A, Chittaganpitch M, Buayai K, Kewcharoenwong C, Thumrongwilainet B, et al. Metformin-induced suppression of IFN-\u03b1 via mTORC1 signalling following seasonal vaccination is associated with impaired antibody responses in type 2 diabetes. Sci Rep. 2020;10:3229.","journal-title":"Sci Rep"},{"key":"905_CR117","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.cell.2013.02.035","volume":"153","author":"F Cabreiro","year":"2013","unstructured":"Cabreiro F, Au C, Leung K-Y, Vergara-Irigaray N, Cochem\u00e9 HM, Noori T, et al. Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell. 2013;153:228\u201339.","journal-title":"Cell"},{"key":"905_CR118","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.cmet.2014.07.013","volume":"20","author":"JA Baur","year":"2014","unstructured":"Baur JA, Birnbaum MJ. Control of gluconeogenesis by metformin: does redox trump energy charge? Cell Metab. 2014;20:197\u20139.","journal-title":"Cell Metab"},{"key":"905_CR119","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1164\/rccm.200710-1602OC","volume":"178","author":"JW Zmijewski","year":"2008","unstructured":"Zmijewski JW, Lorne E, Zhao X, Tsuruta Y, Sha Y, Liu G, et al. Mitochondrial respiratory complex I regulates neutrophil activation and severity of lung injury. Am J Respir Crit Care Med. 2008;178:168\u201379.","journal-title":"Am J Respir Crit Care Med"},{"key":"905_CR120","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/ni.2833","volume":"15","author":"B Everts","year":"2014","unstructured":"Everts B, Amiel E, Huang SC-C, Smith AM, Chang C-H, Lam WY, et al. TLR-driven early glycolytic reprogramming via the kinases TBK1-IKK\u025b supports the anabolic demands of dendritic cell activation. Nat Immunol. 2014;15:323\u201332.","journal-title":"Nat Immunol"},{"key":"905_CR121","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1016\/j.molcel.2022.02.028","volume":"82","author":"A De Jesus","year":"2022","unstructured":"De Jesus A, Keyhani-Nejad F, Pusec CM, Goodman L, Geier JA, Stoolman JS, et al. Hexokinase 1 cellular localization regulates the metabolic fate of glucose. Mol Cell. 2022;82:1261\u201377 (e9).","journal-title":"Mol Cell"},{"key":"905_CR122","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1007\/s00018-022-04267-5","volume":"79","author":"SW Sim","year":"2022","unstructured":"Sim SW, Jang Y, Park TS, Park B-C, Lee YM, Jun HS. Molecular mechanisms of aberrant neutrophil differentiation in glycogen storage disease type Ib. Cell Mol Life Sci. 2022;79:246.","journal-title":"Cell Mol Life Sci"},{"key":"905_CR123","doi-asserted-by":"publisher","first-page":"17807","DOI":"10.1073\/pnas.0803090105","volume":"105","author":"M Ralser","year":"2008","unstructured":"Ralser M, Wamelink MM, Struys EA, Joppich C, Krobitsch S, Jakobs C, et al. A catabolic block does not sufficiently explain how 2-deoxy-d-glucose inhibits cell growth. Proc Natl Acad Sci USA. 2008;105:17807\u201311.","journal-title":"Proc Natl Acad Sci USA"},{"key":"905_CR124","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.593103","volume":"11","author":"S Iwata","year":"2020","unstructured":"Iwata S, Zhang M, Hao H, Trimova G, Hajime M, Miyazaki Y, et al. Enhanced fatty acid synthesis leads to subset imbalance and IFN-\u03b3 overproduction in T helper 1 cells. Front Immunol. 2020;11: 593103.","journal-title":"Front Immunol"},{"key":"905_CR125","doi-asserted-by":"publisher","first-page":"957","DOI":"10.4049\/jimmunol.2000137","volume":"205","author":"SY Tan","year":"2020","unstructured":"Tan SY, Kelkar Y, Hadjipanayis A, Shipstone A, Wynn TA, Hall JP. Metformin and 2-deoxyglucose collaboratively suppress human CD4(+) T cell effector functions and activation-induced metabolic reprogramming. J Immunol. 2020;205:957\u201367.","journal-title":"J Immunol"},{"key":"905_CR126","doi-asserted-by":"publisher","first-page":"3099","DOI":"10.1074\/jbc.RA119.010589","volume":"295","author":"NE Murugina","year":"2020","unstructured":"Murugina NE, Budikhina AS, Dagil YA, Maximchik PV, Balyasova LS, Murugin VV, et al. Glycolytic reprogramming of macrophages activated by NOD1 and TLR4 agonists: No association with proinflammatory cytokine production in normoxia. J Biol Chem. 2020;295:3099\u2013114.","journal-title":"J Biol Chem"},{"key":"905_CR127","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2020.108079","volume":"197","author":"R Francis","year":"2020","unstructured":"Francis R, Singh PK, Singh S, Giri S, Kumar A. Glycolytic inhibitor 2-deoxyglucose suppresses inflammatory response in innate immune cells and experimental staphylococcal endophthalmitis. Exp Eye Res. 2020;197: 108079.","journal-title":"Exp Eye Res"},{"key":"905_CR128","doi-asserted-by":"publisher","first-page":"3177","DOI":"10.1038\/s41598-019-39722-0","volume":"9","author":"A Castellv\u00ed","year":"2019","unstructured":"Castellv\u00ed A, Crespo I, Crosas E, C\u00e1mara-Artigas A, Gavira JA, Aranda MAG, et al. Efficacy of aldose reductase inhibitors is affected by oxidative stress induced under X-ray irradiation. Sci Rep. 2019;9:3177.","journal-title":"Sci Rep"},{"key":"905_CR129","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.2174\/0929867033457359","volume":"10","author":"AG Demaine","year":"2003","unstructured":"Demaine AG. Polymorphisms of the aldose reductase gene and susceptibility to diabetic microvascular complications. Curr Med Chem. 2003;10:1389\u201398.","journal-title":"Curr Med Chem"},{"key":"905_CR130","doi-asserted-by":"publisher","first-page":"2","DOI":"10.4103\/jrms.JRMS_250_20","volume":"26","author":"DW Abu-Hassan","year":"2021","unstructured":"Abu-Hassan DW, Al-Bdour MD, Saleh I, Freihat M, El-Khateeb M. The relationship between aldose reductase gene C106T polymorphism and the severity of retinopathy in Type 2 diabetic patients: a case-control study. J Res Med Sci. 2021;26:2.","journal-title":"J Res Med Sci"},{"key":"905_CR131","doi-asserted-by":"publisher","first-page":"727","DOI":"10.2337\/diabetes.44.7.727","volume":"44","author":"BC Ko","year":"1995","unstructured":"Ko BC, Lam KS, Wat NM, Chung SS. An (A-C)n dinucleotide repeat polymorphic marker at the 5\u2019 end of the aldose reductase gene is associated with early-onset diabetic retinopathy in NIDDM patients. Diabetes. 1995;44:727\u201332.","journal-title":"Diabetes"},{"key":"905_CR132","doi-asserted-by":"publisher","first-page":"281","DOI":"10.2174\/1874364101812010281","volume":"12","author":"DM Wihandani","year":"2018","unstructured":"Wihandani DM, Suastika K, Agus Bagiada IN, Malik SG. Polymorphisms of aldose reductase (ALR2) regulatory gene are risk factors for diabetic retinopathy in type-2 diabetes mellitus patients in Bali. Indonesia Open Ophthalmol J. 2018;12:281\u20138.","journal-title":"Indonesia Open Ophthalmol J"},{"key":"905_CR133","first-page":"237","volume":"18","author":"SD Varma","year":"1979","unstructured":"Varma SD, Schocket SS, Richards RD. Implications of aldose reductase in cataracts in human diabetes. Invest Ophthalmol Vis Sci. 1979;18:237\u201341.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"905_CR134","first-page":"640","volume":"24","author":"TS Hu","year":"1983","unstructured":"Hu TS, Datiles M, Kinoshita JH. Reversal of galactose cataract with Sorbinil in rats. Invest Ophthalmol Vis Sci. 1983;24:640\u20134.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"905_CR135","doi-asserted-by":"publisher","first-page":"120","DOI":"10.2174\/1389557515666150909143737","volume":"16","author":"AS Grewal","year":"2016","unstructured":"Grewal AS, Bhardwaj S, Pandita D, Lather V, Sekhon BS. Updates on aldose reductase inhibitors for management of diabetic complications and non-diabetic diseases. Mini Rev Med Chem. 2016;16:120\u201362.","journal-title":"Mini Rev Med Chem"},{"key":"905_CR136","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/175901","volume":"2013","author":"A Ota","year":"2013","unstructured":"Ota A, Kakehashi A, Toyoda F, Kinoshita N, Shinmura M, Takano H, et al. Effects of long-term treatment with ranirestat, a potent aldose reductase inhibitor, on diabetic cataract and neuropathy in spontaneously diabetic torii rats. J Diabetes Res. 2013;2013: 175901.","journal-title":"J Diabetes Res"},{"key":"905_CR137","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1254\/jphs.08071FP","volume":"107","author":"T Matsumoto","year":"2008","unstructured":"Matsumoto T, Ono Y, Kuromiya A, Toyosawa K, Ueda Y, Bril V. Long-term treatment with ranirestat (AS-3201), a potent aldose reductase inhibitor, suppresses diabetic neuropathy and cataract formation in rats. J Pharmacol Sci Japan. 2008;107:340\u20138.","journal-title":"J Pharmacol Sci Japan"},{"key":"905_CR138","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1177\/1479164116640220","volume":"13","author":"Y Ishibashi","year":"2016","unstructured":"Ishibashi Y, Matsui T, Matsumoto T, Kato H, Yamagishi S-I. Ranirestat has a stronger inhibitory activity on aldose reductase and suppresses inflammatory reactions in high glucose-exposed endothelial cells. Diab Vasc Dis Res. 2016;13:312\u20135.","journal-title":"Diab Vasc Dis Res"},{"key":"905_CR139","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1038\/cr.2010.150","volume":"21","author":"Q Remijsen","year":"2011","unstructured":"Remijsen Q, van den Berghe T, Wirawan E, Asselbergh B, Parthoens E, de Rycke R, et al. Neutrophil extracellular trap cell death requires both autophagy and superoxide generation. Cell Res. 2011;21:290\u2013304.","journal-title":"Cell Res"},{"key":"905_CR140","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/s00441-022-03636-7","volume":"389","author":"PY Thimmappa","year":"2022","unstructured":"Thimmappa PY, Nair AS, Najar Mohd A, Mohanty V, Shastry S, Prasad TSK, et al. Quantitative phosphoproteomics reveals diverse stimuli activate distinct signaling pathways during neutrophil activation. Cell Tissue Res. 2022;389:241\u201357.","journal-title":"Cell Tissue Res"},{"key":"905_CR141","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.864638","volume":"13","author":"G Burczyk","year":"2022","unstructured":"Burczyk G, Cichon I, Kolaczkowska E. Itaconate suppresses formation of neutrophil extracellular traps (NETs): involvement of hypoxia-inducible factor 1\u03b1 (Hif-1\u03b1) and heme oxygenase (HO-1). Front Immunol. 2022;13: 864638.","journal-title":"Front Immunol"},{"key":"905_CR142","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1182\/blood-2007-11-121723","volume":"112","author":"ME Stegenga","year":"2008","unstructured":"Stegenga ME, van der Crabben SN, Bl\u00fcmer RME, Levi M, Meijers JCM, Serlie MJ, et al. Hyperglycemia enhances coagulation and reduces neutrophil degranulation, whereas hyperinsulinemia inhibits fibrinolysis during human endotoxemia. Blood. 2008;112:82\u20139.","journal-title":"Blood"},{"key":"905_CR143","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1002\/cbf.2840","volume":"30","author":"FC de Souza","year":"2012","unstructured":"de Souza FC, Ara\u00fajo TH, \u00c2ngelo ML, Pennacchi PC, Okada SS, de Ara\u00fajo Paula FB, et al. Neutrophil dysfunction induced by hyperglycemia: modulation of myeloperoxidase activity. Cell Biochem Funct. 2012;30:604\u201310.","journal-title":"Cell Biochem Funct"},{"key":"905_CR144","doi-asserted-by":"publisher","first-page":"323","DOI":"10.3389\/fphar.2019.00323","volume":"10","author":"A Meier","year":"2019","unstructured":"Meier A, Chien J, Hobohm L, Patras KA, Nizet V, Corriden R. Inhibition of human neutrophil extracellular trap (NET) production by propofol and lipid emulsion. Front Pharmacol. 2019;10:323.","journal-title":"Front Pharmacol"},{"key":"905_CR145","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.119836","volume":"238","author":"EB Okeke","year":"2020","unstructured":"Okeke EB, Louttit C, Fry C, Najafabadi AH, Han K, Nemzek J, et al. Inhibition of neutrophil elastase prevents neutrophil extracellular trap formation and rescues mice from endotoxic shock. Biomaterials. 2020;238: 119836.","journal-title":"Biomaterials"},{"key":"905_CR146","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.biomaterials.2018.04.052","volume":"172","author":"Y Liu","year":"2018","unstructured":"Liu Y, Cao Z-T, Xu C-F, Lu Z-D, Luo Y-L, Wang J. Optimization of lipid-assisted nanoparticle for disturbing neutrophils-related inflammation. Biomaterials. 2018;172:92\u2013104.","journal-title":"Biomaterials"},{"key":"905_CR147","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1111\/bph.13373","volume":"173","author":"K Shishikura","year":"2016","unstructured":"Shishikura K, Horiuchi T, Sakata N, Trinh D-A, Shirakawa R, Kimura T, et al. Prostaglandin E2 inhibits neutrophil extracellular trap formation through production of cyclic AMP. Br J Pharmacol. 2016;173:319\u201331.","journal-title":"Br J Pharmacol"},{"key":"905_CR148","doi-asserted-by":"crossref","unstructured":"Poddar SK, Sifat AE, Haque S, Nahid NA, Chowdhury S, Mehedi I. Nicotinamide mononucleotide: exploration of diverse therapeutic applications of a potential molecule. Biomolecules. 2019;9(1):34.","DOI":"10.3390\/biom9010034"},{"key":"905_CR149","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1016\/j.cmet.2011.08.014","volume":"14","author":"J Yoshino","year":"2011","unstructured":"Yoshino J, Mills KF, Yoon MJ, Imai S. Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell Metab. 2011;14:528\u201336.","journal-title":"Cell Metab"},{"key":"905_CR150","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.1126\/science.abe9985","volume":"372","author":"M Yoshino","year":"2021","unstructured":"Yoshino M, Yoshino J, Kayser BD, Patti GJ, Franczyk MP, Mills KF, et al. Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science. 2021;372:1224\u20139.","journal-title":"Science"},{"key":"905_CR151","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.112659","volume":"147","author":"Q Pu","year":"2022","unstructured":"Pu Q, Guo X-X, Hu J-J, Li A-L, Li G-G, Li X-Y. Nicotinamide mononucleotide increases cell viability and restores tight junctions in high-glucose-treated human corneal epithelial cells via the SIRT1\/Nrf2\/HO-1 pathway. Biomed Pharmacother. 2022;147:112659.","journal-title":"Biomed Pharmacother"},{"key":"905_CR152","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1172\/JCI29069","volume":"116","author":"SE Shoelson","year":"2006","unstructured":"Shoelson SE, Lee J, Goldfine AB. Inflammation and insulin resistance. J Clin Invest. 2006;116:1793\u2013801.","journal-title":"J Clin Invest"},{"key":"905_CR153","doi-asserted-by":"publisher","first-page":"2369","DOI":"10.1038\/sj.emboj.7600244","volume":"23","author":"F Yeung","year":"2004","unstructured":"Yeung F, Hoberg JE, Ramsey CS, Keller MD, Jones DR, Frye RA, et al. Modulation of NF-\u03baB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J. 2004;23:2369\u201380.","journal-title":"EMBO J"},{"key":"905_CR154","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1126\/science.1104343","volume":"307","author":"BB Lowell","year":"2005","unstructured":"Lowell BB, Shulman GI. Mitochondrial dysfunction and type 2 diabetes. Science. 2005;307:384\u20137.","journal-title":"Science"},{"key":"905_CR155","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1111\/tmi.12206","volume":"18","author":"SP Fisher-Hoch","year":"2013","unstructured":"Fisher-Hoch SP, Mathews CE, McCormick JB. Obesity, diabetes and pneumonia: the menacing interface of non-communicable and infectious diseases. Trop Med Int Health. 2013;18:1510\u20139.","journal-title":"Trop Med Int Health"},{"issue":"1","key":"905_CR156","first-page":"S27","volume":"16","author":"J Casqueiro","year":"2012","unstructured":"Casqueiro J, Casqueiro J, Alves C. Infections in patients with diabetes mellitus: a review of pathogenesis. Indian J Endocrinol Metab. 2012;16(1):S27\u201336.","journal-title":"Indian J Endocrinol Metab."},{"issue":"1","key":"905_CR157","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1002\/dmrr.682","volume":"23","author":"AY Peleg","year":"2007","unstructured":"Peleg AY, Weerarathna T, McCarthy JS, Davis TME. Common infections in diabetes: pathogenesis, management and relationship to glycaemic control. Diabetes Metab Res Rev. 2007;23(1):3\u201313.","journal-title":"Diabetes Metab Res Rev."},{"issue":"5","key":"905_CR158","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.4161\/hv.28252","volume":"10","author":"Y Egawa","year":"2014","unstructured":"Egawa Y, Ohfuji S, Fukushima W, Yamazaki Y, Morioka T, Emoto M, et al. Immunogenicity of influenza A(H1N1)pdm09 vaccine in patients with diabetes mellitus: with special reference to age, body mass index, and HbA1c. Hum Vaccin Immunother. 2014;10(5):1187\u201394.","journal-title":"Hum Vaccin Immunother."},{"issue":"6","key":"905_CR159","first-page":"S51","volume":"182","author":"SL Chen","year":"2009","unstructured":"Chen SL, Jackson SL, Boyko EJ. Diabetes mellitus and urinary tract infection: epidemiology, pathogenesis and proposed studies in animal models. J Urol. 2009;182(6):S51\u20136.","journal-title":"Journal of Urology."},{"issue":"9","key":"905_CR160","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1038\/nrgastro.2013.101","volume":"10","author":"WL Neumann","year":"2013","unstructured":"Neumann WL, Coss E, Rugge M, Genta RM. Autoimmune atrophic gastritis\u2013pathogenesis, pathology and management. Nat Rev Gastroenterol Hepatol. 2013;10(9):529\u201341.","journal-title":"Nat Rev Gastroenterol Hepatol."},{"issue":"4","key":"905_CR161","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1053\/jhep.2002.32486","volume":"35","author":"MB Streiff","year":"2002","unstructured":"Streiff MB, Mehta S, Thomas DL. Peripheral blood count abnormalities among patients with hepatitis C in the United States. Hepatology. 2002;35(4):947\u201352.","journal-title":"Hepatology"},{"issue":"26","key":"905_CR162","first-page":"254","volume":"26","author":"RO Darouiche","year":"1998","unstructured":"Darouiche RO. Oropharyngeal and esophageal candidiasis in immunocompromised patients: treatment issues. Clin Infect Dis. 1998;26(26):254\u20139.","journal-title":"Clin Infect Dis."},{"issue":"13","key":"905_CR163","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.3748\/wjg.15.1537","volume":"15","author":"F Negro","year":"2009","unstructured":"Negro F, Alaei M. Hepatitis C virus and type 2 diabetes. World J Gastroenterol. 2009;15(13):1537\u201347.","journal-title":"World J Gastroenterol."},{"issue":"4","key":"905_CR164","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1111\/j.1600-0714.1993.tb01051.x","volume":"22","author":"E Ueta","year":"1993","unstructured":"Ueta E, Osaki T, Yoneda K, Yamamoto T. Prevalence of diabetes mellitus in odontogenic infections and oral candidiasis: an analysis of neutrophil suppression. J Oral Pathol Med. 1993;22(4):168\u201374.","journal-title":"J Oral Pathol Med."},{"issue":"4","key":"905_CR165","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.jinf.2007.06.003","volume":"55","author":"C Top","year":"2007","unstructured":"Top C, Yildiz S, Onc\u00fcl O, Qydedi T, Cevikba\u015f A, Soyogul UG, et al. Phagocytic activity of neutrophils improves over the course of therapy of diabetic foot infections. J Infect. 2007;55(4):369\u201373.","journal-title":"J Infect."},{"issue":"12","key":"905_CR166","doi-asserted-by":"publisher","first-page":"2714","DOI":"10.1172\/JCI119096","volume":"98","author":"DL Pitrak","year":"1996","unstructured":"Pitrak DL, Tsai HC, Mullane KM, Sutton SH, Stevens P. Accelerated neutrophil apoptosis in the acquired immunodeficiency syndrome. J Clin Invest. 1996;98(12):2714\u20139.","journal-title":"J Clin Invest."},{"issue":"3","key":"905_CR167","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1007\/s11892-013-0369-9","volume":"13","author":"S Kalra","year":"2013","unstructured":"Kalra S, Agrawal N. Diabetes and HIV: current understanding and future perspectives. Curr Diab Rep. 2013;13(3):419\u201327.","journal-title":"Curr Diab Rep."},{"key":"905_CR168","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.lfs.2019.02.030","volume":"221","author":"M-S Chen","year":"2019","unstructured":"Chen M-S, Lin W-C, Yeh H-T, Hu C-L, Sheu S-M. Propofol specifically reduces PMA-induced neutrophil extracellular trap formation through inhibition of p-ERK and HOCl. Life Sci. 2019;221:178\u201386.","journal-title":"Life Sci."},{"issue":"12","key":"905_CR169","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1111\/tmi.12206","volume":"18","author":"SP Fisher-Hoch","year":"2013","unstructured":"Fisher-Hoch SP, Mathews CE, McCormick JB. Obesity, diabetes and pneumonia: the menacing interface of non-communicable and infectious diseases. Trop Med Int Health. 2013;18(12):1510\u20139.","journal-title":"Trop Med Int Health"},{"issue":"4","key":"905_CR170","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1042\/cs1030403","volume":"103","author":"TC Pithon-Curi","year":"2002","unstructured":"Pithon-Curi TC, Levada AC, Lopes LR, Doi SQ, Curi R. Glutamine plays a role in superoxide production and the expression of p47phox, p22phox and gp91phox in rat neutrophils. Clin Sci (Lond). 2002;103(4):403\u20138.","journal-title":"Clin Sci (Lond)."},{"issue":"5","key":"905_CR171","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/S0899-9007(00)00228-8","volume":"16","author":"S Furukawa","year":"2000","unstructured":"Furukawa S, Saito H, Inoue T, et al. Supplemental glutamine augments phagocytosis and reactive oxygen intermediate production by neutrophils and monocytes from postoperative patients in vitro. Nutrition. 2000;16(5):323\u20139.","journal-title":"Nutrition."},{"key":"905_CR172","doi-asserted-by":"publisher","first-page":"17","DOI":"10.3389\/fimmu.2015.00017","volume":"6","author":"ZA Kopp","year":"2015","unstructured":"Kopp ZA, Jain U, van Limbergen Stadnyl AW. Do antimicrobial peptides and complete collaborate in the intestinal mucosa? Front Immunol. 2015;6:17.","journal-title":"Front Immunol."},{"issue":"5","key":"905_CR173","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1111\/j.1600-0625.2012.01459.x","volume":"21","author":"Y Dombrowski","year":"2012","unstructured":"Dombrowski Y, Schauber J. Cathelicidin LL-37: a defense molecule with a potential role in psoriasis pathogenesis. Exp Dermatol. 2012;21(5):327\u201330.","journal-title":"Exp Dermatol."}],"container-title":["Human Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13577-023-00905-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13577-023-00905-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13577-023-00905-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T10:27:19Z","timestamp":1687343239000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13577-023-00905-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,28]]},"references-count":173,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,7]]}},"alternative-id":["905"],"URL":"https:\/\/doi.org\/10.1007\/s13577-023-00905-7","relation":{},"ISSN":["1749-0774"],"issn-type":[{"value":"1749-0774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,28]]},"assertion":[{"value":"12 December 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 March 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 April 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no potential conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}