{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T16:32:01Z","timestamp":1724085121652},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T00:00:00Z","timestamp":1700697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T00:00:00Z","timestamp":1700697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Beijing Medical Award Foundation","award":["No. YXJL-2022-0080-0184"],"award-info":[{"award-number":["No. YXJL-2022-0080-0184"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Human Cell"],"DOI":"10.1007\/s13577-023-01005-2","type":"journal-article","created":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T01:01:50Z","timestamp":1700701310000},"page":"245-257","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Nucleoporin 93, a new substrate of the E3 ubiquitin protein ligase HECTD1, promotes esophageal squamous cell carcinoma progression"],"prefix":"10.1007","volume":"37","author":[{"given":"Jinfeng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanzhong","family":"Xin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodong","family":"Ling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luquan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengyuan","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianqun","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,11,23]]},"reference":[{"issue":"3","key":"1005_CR1","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1053\/j.gastro.2022.05.054","volume":"163","author":"E Morgan","year":"2022","unstructured":"Morgan E, Soerjomataram I, Rumgay H, Coleman HG, Thrift AP, Vignat J, et al. The global landscape of esophageal squamous cell carcinoma and esophageal adenocarcinoma incidence and mortality in 2020 and projections to 2040: new estimates from GLOBOCAN 2020. Gastroenterology. 2022;163(3):649-58.e2. https:\/\/doi.org\/10.1053\/j.gastro.2022.05.054.","journal-title":"Gastroenterology"},{"issue":"10125","key":"1005_CR2","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1016\/s0140-6736(17)33326-3","volume":"391","author":"C Allemani","year":"2018","unstructured":"Allemani C, Matsuda T, Di Carlo V, Harewood R, Matz M, Nik\u0161i\u0107 M, et al. Global surveillance of trends in cancer survival 2000\u201314 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries. Lancet (London, England). 2018;391(10125):1023\u201375. https:\/\/doi.org\/10.1016\/s0140-6736(17)33326-3.","journal-title":"Lancet (London, England)"},{"issue":"6283","key":"1005_CR3","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1126\/science.aaf0643","volume":"352","author":"J Kosinski","year":"2016","unstructured":"Kosinski J, Mosalaganti S, von Appen A, Teimer R, DiGuilio AL, Wan W, et al. Molecular architecture of the inner ring scaffold of the human nuclear pore complex. Science (New York, NY). 2016;352(6283):363\u20135. https:\/\/doi.org\/10.1126\/science.aaf0643.","journal-title":"Science (New York, NY)"},{"issue":"1","key":"1005_CR4","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1158\/2159-8290.Cd-20-0581","volume":"11","author":"S Sakuma","year":"2021","unstructured":"Sakuma S, Raices M, Borlido J, Guglielmi V, Zhu EYS, D\u2019Angelo MA. Inhibition of nuclear pore complex formation selectively induces cancer cell death. Cancer Discov. 2021;11(1):176\u201393. https:\/\/doi.org\/10.1158\/2159-8290.Cd-20-0581.","journal-title":"Cancer Discov"},{"key":"1005_CR5","doi-asserted-by":"publisher","DOI":"10.26508\/lsa.201900623","author":"S Bersini","year":"2020","unstructured":"Bersini S, Lytle NK, Schulte R, Huang L, Wahl GM, Hetzer MW. Nup93 regulates breast tumor growth by modulating cell proliferation and actin cytoskeleton remodeling. Life Sci Alliance. 2020. https:\/\/doi.org\/10.26508\/lsa.201900623.","journal-title":"Life Sci Alliance."},{"issue":"8","key":"1005_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.110418","volume":"38","author":"NB Nataraj","year":"2022","unstructured":"Nataraj NB, Noronha A, Lee JS, Ghosh S, Mohan Raju HR, Sekar A, et al. Nucleoporin-93 reveals a common feature of aggressive breast cancers: robust nucleocytoplasmic transport of transcription factors. Cell Rep. 2022;38(8): 110418. https:\/\/doi.org\/10.1016\/j.celrep.2022.110418.","journal-title":"Cell Rep"},{"issue":"12","key":"1005_CR7","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1093\/abbs\/gmz131","volume":"51","author":"X Ouyang","year":"2019","unstructured":"Ouyang X, Hao X, Liu S, Hu J, Hu L. Expression of Nup93 is associated with the proliferation, migration and invasion capacity of cervical cancer cells. Acta Biochim Biophys Sin. 2019;51(12):1276\u201385. https:\/\/doi.org\/10.1093\/abbs\/gmz131.","journal-title":"Acta Biochim Biophys Sin"},{"key":"1005_CR8","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.canlet.2021.11.001","volume":"526","author":"CS Lin","year":"2022","unstructured":"Lin CS, Liang Y, Su SG, Zheng YL, Yang X, Jiang N, et al. Nucleoporin 93 mediates \u03b2-catenin nuclear import to promote hepatocellular carcinoma progression and metastasis. Cancer Lett. 2022;526:236\u201347. https:\/\/doi.org\/10.1016\/j.canlet.2021.11.001.","journal-title":"Cancer Lett"},{"issue":"4","key":"1005_CR9","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1016\/j.bbrc.2019.11.035","volume":"521","author":"W Monwan","year":"2020","unstructured":"Monwan W, Kawasaki T, Hasan MZ, Ori D, Kawai T. Identification of nucleoporin 93 (Nup93) that mediates antiviral innate immune responses. Biochem Biophys Res Commun. 2020;521(4):1077\u201382. https:\/\/doi.org\/10.1016\/j.bbrc.2019.11.035.","journal-title":"Biochem Biophys Res Commun"},{"issue":"7","key":"1005_CR10","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1016\/j.stem.2021.02.008","volume":"28","author":"K Lv","year":"2021","unstructured":"Lv K, Gong C, Antony C, Han X, Ren JG, Donaghy R, et al. HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis. Cell Stem Cell. 2021;28(7):1275-90.e9. https:\/\/doi.org\/10.1016\/j.stem.2021.02.008.","journal-title":"Cell Stem Cell"},{"issue":"4","key":"1005_CR11","first-page":"1593","volume":"12","author":"Y Uemoto","year":"2022","unstructured":"Uemoto Y, Katsuta E, Kondo N, Wanifuchi-Endo Y, Fujita T, Asano T, et al. Low HECTD1 mRNA expression is associated with poor prognosis and may be correlated with increased mitochondrial respiratory function in breast cancer. Am J Cancer Res. 2022;12(4):1593\u2013605.","journal-title":"Am J Cancer Res"},{"issue":"4","key":"1005_CR12","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1016\/j.celrep.2017.12.096","volume":"22","author":"S Duhamel","year":"2018","unstructured":"Duhamel S, Goyette MA, Thibault MP, Filion D, Gaboury L, C\u00f4t\u00e9 JF. The E3 ubiquitin ligase HectD1 suppresses EMT and metastasis by targeting the +TIP ACF7 for degradation. Cell Rep. 2018;22(4):1016\u201330. https:\/\/doi.org\/10.1016\/j.celrep.2017.12.096.","journal-title":"Cell Rep"},{"issue":"5","key":"1005_CR13","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.3892\/ijo.2020.5002","volume":"56","author":"X Wang","year":"2020","unstructured":"Wang X, De Geyter C, Jia Z, Peng Y, Zhang H. HECTD1 regulates the expression of SNAIL: Implications for epithelial-mesenchymal transition. Int J Oncol. 2020;56(5):1186\u201398. https:\/\/doi.org\/10.3892\/ijo.2020.5002.","journal-title":"Int J Oncol"},{"issue":"2","key":"1005_CR14","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1002\/1097-0142(19920115)69:2<277::aid-cncr2820690202>3.0.co;2-c","volume":"69","author":"Y Shimada","year":"1992","unstructured":"Shimada Y, Imamura M, Wagata T, Yamaguchi N, Tobe T. Characterization of 21 newly established esophageal cancer cell lines. Cancer. 1992;69(2):277\u201384. https:\/\/doi.org\/10.1002\/1097-0142(19920115)69:2%3c277::aid-cncr2820690202%3e3.0.co;2-c.","journal-title":"Cancer"},{"issue":"23","key":"1005_CR15","doi-asserted-by":"publisher","first-page":"4474","DOI":"10.1111\/bph.14808","volume":"176","author":"S Twarock","year":"2019","unstructured":"Twarock S, Reichert C, Bach K, Reiners O, Kretschmer I, Gorski DJ, et al. Inhibition of the hyaluronan matrix enhances metabolic anticancer therapy by dichloroacetate in vitro and in vivo. Br J Pharmacol. 2019;176(23):4474\u201390. https:\/\/doi.org\/10.1111\/bph.14808.","journal-title":"Br J Pharmacol"},{"issue":"2","key":"1005_CR16","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1016\/j.dsx.2019.01.041","volume":"13","author":"MN Amin","year":"2019","unstructured":"Amin MN, Hussain MS, Sarwar MS, Rahman Moghal MM, Das A, Hossain MZ, et al. How the association between obesity and inflammation may lead to insulin resistance and cancer. Diabetes Metab Syndr. 2019;13(2):1213\u201324. https:\/\/doi.org\/10.1016\/j.dsx.2019.01.041.","journal-title":"Diabetes Metab Syndr"},{"issue":"1","key":"1005_CR17","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1186\/s12885-020-07307-0","volume":"20","author":"S Zargari","year":"2020","unstructured":"Zargari S, Negahban Khameneh S, Rad A, Forghanifard MM. MEIS1 promotes expression of stem cell markers in esophageal squamous cell carcinoma. BMC Cancer. 2020;20(1):789. https:\/\/doi.org\/10.1186\/s12885-020-07307-0.","journal-title":"BMC Cancer"},{"issue":"1","key":"1005_CR18","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1186\/s12885-022-10252-9","volume":"22","author":"SA Khales","year":"2022","unstructured":"Khales SA, Mozaffari-Jovin S, Geerts D, Abbaszadegan MR. TWIST1 activates cancer stem cell marker genes to promote epithelial-mesenchymal transition and tumorigenesis in esophageal squamous cell carcinoma. BMC Cancer. 2022;22(1):1272. https:\/\/doi.org\/10.1186\/s12885-022-10252-9.","journal-title":"BMC Cancer"},{"key":"1005_CR19","unstructured":"National Research Council Committee for the Update of the Guide for the C, Use of Laboratory A. The National Academies Collection: Reports funded by National Institutes of Health. Guide for the Care and Use of Laboratory Animals. Washington (DC): National Academies Press (US) Copyright \u00a9 2011, National Academy of Sciences. 2011."},{"issue":"W1","key":"1005_CR20","doi-asserted-by":"publisher","first-page":"W509","DOI":"10.1093\/nar\/gkaa407","volume":"48","author":"T Li","year":"2020","unstructured":"Li T, Fu J, Zeng Z, Cohen D, Li J, Chen Q, et al. TIMER2.0 for analysis of tumor-infiltrating immune cells. Nucleic Acids Res. 2020;48(W1):W509-w14. https:\/\/doi.org\/10.1093\/nar\/gkaa407.","journal-title":"Nucleic Acids Res."},{"issue":"7","key":"1005_CR21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000129","volume":"4","author":"K Yu","year":"2008","unstructured":"Yu K, Ganesan K, Tan LK, Laban M, Wu J, Zhao XD, et al. A precisely regulated gene expression cassette potently modulates metastasis and survival in multiple solid cancers. PLoS Genet. 2008;4(7): e1000129. https:\/\/doi.org\/10.1371\/journal.pgen.1000129.","journal-title":"PLoS Genet"},{"key":"1005_CR22","doi-asserted-by":"publisher","first-page":"30057","DOI":"10.1038\/srep30057","volume":"6","author":"YK Chen","year":"2016","unstructured":"Chen YK, Tung CW, Lee JY, Hung YC, Lee CH, Chou SH, et al. Plasma matrix metalloproteinase 1 improves the detection and survival prediction of esophageal squamous cell carcinoma. Sci Rep. 2016;6:30057. https:\/\/doi.org\/10.1038\/srep30057.","journal-title":"Sci Rep"},{"issue":"7757","key":"1005_CR23","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1038\/s41586-019-1186-3","volume":"569","author":"M Ghandi","year":"2019","unstructured":"Ghandi M, Huang FW, Jan\u00e9-Valbuena J, Kryukov GV, Lo CC, McDonald ER, et al. Next-generation characterization of the cancer cell line encyclopedia. Nature. 2019;569(7757):503\u20138. https:\/\/doi.org\/10.1038\/s41586-019-1186-3.","journal-title":"Nature"},{"key":"1005_CR24","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbac558","author":"C-J Liu","year":"2022","unstructured":"Liu C-J, Hu F-F, Xie G-Y, Miao Y-R, Li X-W, Zeng Y, et al. GSCA: an integrated platform for gene set cancer analysis at genomic, pharmacogenomic and immunogenomic levels. Brief Bioinform. 2022. https:\/\/doi.org\/10.1093\/bib\/bbac558.","journal-title":"Brief Bioinform."},{"issue":"2","key":"1005_CR25","doi-asserted-by":"publisher","first-page":"25","DOI":"10.7171\/jbt.18-2902-002","volume":"29","author":"A Bairoch","year":"2018","unstructured":"Bairoch A. The cellosaurus, a cell-line knowledge resource. J Biomol Tech JBT. 2018;29(2):25\u201338. https:\/\/doi.org\/10.7171\/jbt.18-2902-002.","journal-title":"J Biomol Tech JBT"},{"issue":"8","key":"1005_CR26","doi-asserted-by":"publisher","first-page":"1847","DOI":"10.1105\/tpc.002550%JThePlantCell","volume":"14","author":"H Nakagami","year":"2002","unstructured":"Nakagami H, Kawamura K, Sugisaka K, Sekine M, Shinmyo A. Phosphorylation of retinoblastoma-related protein by the cyclin D\/cyclin-dependent kinase complex is activated at the G1\/S-phase transition in tobacco. Plant Cell. 2002;14(8):1847\u201357. https:\/\/doi.org\/10.1105\/tpc.002550%JThePlantCell.","journal-title":"Plant Cell"},{"issue":"11","key":"1005_CR27","doi-asserted-by":"publisher","first-page":"7118","DOI":"10.1074\/jbc.M508162200","volume":"281","author":"M Qiao","year":"2006","unstructured":"Qiao M, Shapiro P, Fosbrink M, Rus H, Kumar R, Passaniti A. Cell cycle-dependent phosphorylation of the RUNX2 transcription factor by cdc2 regulates endothelial cell proliferation. J Biol Chem. 2006;281(11):7118\u201328. https:\/\/doi.org\/10.1074\/jbc.M508162200.","journal-title":"J Biol Chem"},{"issue":"4","key":"1005_CR28","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1158\/0008-5472.Can-20-0912","volume":"81","author":"D Dong","year":"2021","unstructured":"Dong D, Zhang W, Xiao W, Wu Q, Cao Y, Gao X, et al. A GRN autocrine-dependent FAM135B\/AKT\/mTOR feedforward loop promotes esophageal squamous cell carcinoma progression. Can Res. 2021;81(4):910\u201322. https:\/\/doi.org\/10.1158\/0008-5472.Can-20-0912.","journal-title":"Can Res"},{"issue":"1","key":"1005_CR29","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1042\/bj3310299","volume":"331","author":"KS Walker","year":"1998","unstructured":"Walker KS, Deak M, Paterson A, Hudson K, Cohen P, Alessi DR. Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha. Biochem J. 1998;331(1):299\u2013308. https:\/\/doi.org\/10.1042\/bj3310299.","journal-title":"Biochem J."},{"issue":"19","key":"1005_CR30","doi-asserted-by":"publisher","first-page":"11211","DOI":"10.1073\/pnas.95.19.11211","volume":"95","author":"M Delcommenne","year":"1998","unstructured":"Delcommenne M, Tan C, Gray V, Rue L, Woodgett J, Dedhar S. Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B\/AKT by the integrin-linked kinase. Proc Natl Acad Sci USA. 1998;95(19):11211\u20136. https:\/\/doi.org\/10.1073\/pnas.95.19.11211.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"1005_CR31","doi-asserted-by":"publisher","first-page":"318","DOI":"10.2337\/diabetes.55.02.06.db05-0757%JDiabetes","volume":"55","author":"S Fatrai","year":"2006","unstructured":"Fatrai S, Elghazi L, Balcazar N, Cras-M\u00e9neur C, Krits I, Kiyokawa H, et al. Akt induces \u03b2-cell proliferation by regulating cyclin D1, cyclin D2, and p21 levels and cyclin-dependent kinase-4 activity. Diabetes. 2006;55(2):318\u201325. https:\/\/doi.org\/10.2337\/diabetes.55.02.06.db05-0757%JDiabetes.","journal-title":"Diabetes"},{"issue":"3","key":"1005_CR32","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/s0014-5793(97)01235-0","volume":"416","author":"M Shaw","year":"1997","unstructured":"Shaw M, Cohen P, Alessi DR. Further evidence that the inhibition of glycogen synthase kinase-3beta by IGF-1 is mediated by PDK1\/PKB-induced phosphorylation of Ser-9 and not by dephosphorylation of Tyr-216. FEBS Lett. 1997;416(3):307\u201311. https:\/\/doi.org\/10.1016\/s0014-5793(97)01235-0.","journal-title":"FEBS Lett"},{"issue":"9","key":"1005_CR33","doi-asserted-by":"publisher","first-page":"2481","DOI":"10.1158\/0008-5472.Can-20-3580","volume":"81","author":"X Lu","year":"2021","unstructured":"Lu X, Pang Y, Cao H, Liu X, Tu L, Shen Y, et al. Integrated screens identify CDK1 as a therapeutic target in advanced gastrointestinal stromal tumors. Can Res. 2021;81(9):2481\u201394. https:\/\/doi.org\/10.1158\/0008-5472.Can-20-3580.","journal-title":"Can Res"},{"issue":"52","key":"1005_CR34","doi-asserted-by":"publisher","first-page":"20852","DOI":"10.1073\/pnas.0810958105","volume":"105","author":"M Marzec","year":"2008","unstructured":"Marzec M, Zhang Q, Goradia A, Raghunath PN, Liu X, Paessler M, et al. Oncogenic kinase NPM\/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7\u2013H1). Proc Natl Acad Sci USA. 2008;105(52):20852\u20137. https:\/\/doi.org\/10.1073\/pnas.0810958105.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"1005_CR35","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1186\/s13046-021-01972-0","volume":"40","author":"H Zhang","year":"2021","unstructured":"Zhang H, Qin G, Zhang C, Yang H, Liu J, Hu H, et al. TRAIL promotes epithelial-to-mesenchymal transition by inducing PD-L1 expression in esophageal squamous cell carcinomas. J Exp Clin Cancer Res. 2021;40(1):209. https:\/\/doi.org\/10.1186\/s13046-021-01972-0.","journal-title":"J Exp Clin Cancer Res"},{"issue":"6","key":"1005_CR36","doi-asserted-by":"publisher","first-page":"3753","DOI":"10.1074\/jbc.M112.415240","volume":"288","author":"H Tran","year":"2013","unstructured":"Tran H, Bustos D, Yeh R, Rubinfeld B, Lam C, Shriver S, et al. HectD1 E3 ligase modifies adenomatous polyposis coli (APC) with polyubiquitin to promote the APC-axin interaction. J Biol Chem. 2013;288(6):3753\u201367. https:\/\/doi.org\/10.1074\/jbc.M112.415240.","journal-title":"J Biol Chem"},{"issue":"66","key":"1005_CR37","doi-asserted-by":"publisher","first-page":"110490","DOI":"10.18632\/oncotarget.22798","volume":"8","author":"M Oikonomaki","year":"2017","unstructured":"Oikonomaki M, Bady P, Hegi ME. Ubiquitin specific peptidase 15 (USP15) suppresses glioblastoma cell growth via stabilization of HECTD1 E3 ligase attenuating WNT pathway activity. Oncotarget. 2017;8(66):110490\u2013502. https:\/\/doi.org\/10.18632\/oncotarget.22798.","journal-title":"Oncotarget"}],"container-title":["Human Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13577-023-01005-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13577-023-01005-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13577-023-01005-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T13:45:32Z","timestamp":1704289532000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13577-023-01005-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,23]]},"references-count":37,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1]]}},"alternative-id":["1005"],"URL":"https:\/\/doi.org\/10.1007\/s13577-023-01005-2","relation":{},"ISSN":["1749-0774"],"issn-type":[{"value":"1749-0774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,23]]},"assertion":[{"value":"30 July 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 October 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 November 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors declare no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Animal experiments were approved by the Ethics Committee of Harbin Medical University (Approval number 2020-50-IIT) and conducted according to the <i>Guide for the Care and Use of Laboratory Animals<\/i>.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}