{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T15:20:46Z","timestamp":1781536846546,"version":"3.54.5"},"reference-count":104,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:00:00Z","timestamp":1739923200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:00:00Z","timestamp":1739923200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100009509","name":"Kementerian Riset Teknologi Dan Pendidikan Tinggi Republik Indonesia","doi-asserted-by":"publisher","award":["NKB-888\/UN2.RST\/HKP.05.00\/2024"],"award-info":[{"award-number":["NKB-888\/UN2.RST\/HKP.05.00\/2024"]}],"id":[{"id":"10.13039\/501100009509","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Human Cell"],"DOI":"10.1007\/s13577-025-01178-y","type":"journal-article","created":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T06:40:27Z","timestamp":1739947227000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Extrachromosomal circular DNA: a double-edged sword in cancer progression and age-related diseases"],"prefix":"10.1007","volume":"38","author":[{"given":"Shadira Anindieta","family":"Irdianto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astari","family":"Dwiranti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anom","family":"Bowolaksono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,19]]},"reference":[{"key":"1178_CR1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.792555","author":"S Zuo","year":"2022","unstructured":"Zuo S, Yi Y, Wang C, Li X, Zhou M, Peng Q, et al. Extrachromosomal circular DNA (eccDNA): from chaos to function. Front Cell Dev Biol. 2022.\u00a0https:\/\/doi.org\/10.3389\/fcell.2021.792555.","journal-title":"Front Cell Dev Biol."},{"key":"1178_CR2","unstructured":"Hotta Y, Bassel A. Biochemistry: Molecular Size and Circularity of DNA in Cells of Mammals and Higher Plants. Cell Biol. 1964."},{"issue":"6a","key":"1178_CR3","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1101\/gr.907603","volume":"13","author":"S Cohen","year":"2003","unstructured":"Cohen S, Yacobi K, Segal D. Extrachromosomal circular DNA of tandemly repeated genomic sequences in Drosophila. Genome Res. 2003;13(6a):1133\u201345. https:\/\/doi.org\/10.1101\/gr.907603.","journal-title":"Genome Res"},{"key":"1178_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2024.05.008","author":"B Mohan","year":"2024","unstructured":"Mohan B, Thingujam D, Pajerowska-Mukhtar KM, Mukhtar MS. EccDNA in plant-stress and biotechnological solutions in agriculture. Trends Biotechnol. 2024. https:\/\/doi.org\/10.1016\/j.tibtech.2024.05.008.","journal-title":"Trends Biotechnol"},{"key":"1178_CR5","doi-asserted-by":"publisher","DOI":"10.1126\/science.71759","author":"G Balaban-Malenbaum","year":"1977","unstructured":"Balaban-Malenbaum G, Gilbert F. Double minute chromosomes and the homogeneously staining regions in chromosomes of a human neuroblastoma cell line. Science. 1977. https:\/\/doi.org\/10.1126\/science.71759.","journal-title":"Science"},{"issue":"5931","key":"1178_CR6","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/305245a0","volume":"305","author":"M Schwab","year":"1983","unstructured":"Schwab M, et al. Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour. Nature. 1983;305(5931):245\u20138. https:\/\/doi.org\/10.1038\/305245a0.","journal-title":"Nature"},{"issue":"13","key":"1178_CR7","doi-asserted-by":"publisher","first-page":"4804","DOI":"10.1073\/pnas.85.13.4804","volume":"85","author":"DD Von Hoff","year":"1988","unstructured":"Von Hoff DD, Needham-VanDevanter DR, Yucel J, Windle BE, Wahl GM. Amplified human MYC oncogenes localized to replicating submicroscopic circular DNA molecules. Proc Natl Acad Sci. 1988;85(13):4804\u20138. https:\/\/doi.org\/10.1073\/pnas.85.13.4804.","journal-title":"Proc Natl Acad Sci"},{"issue":"1","key":"1178_CR8","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/0047-6374(85)90050-8","volume":"29","author":"T Kunisada","year":"1985","unstructured":"Kunisada T, Yamagishi H, Ogita Z, Kirakawa T, Mitsui Y. Appearance of extrachromosomal circular DNAs during in vivo and in vitro ageing of mammalian cells. Mech Ageing Dev. 1985;29(1):89\u201399. https:\/\/doi.org\/10.1016\/0047-6374(85)90050-8.","journal-title":"Mech Ageing Dev"},{"key":"1178_CR9","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.934159","author":"Y Zhu","year":"2022","unstructured":"Zhu Y, et al. Whole-genome sequencing of extrachromosomal circular DNA of cerebrospinal fluid of medulloblastoma. Front Oncol. 2022. https:\/\/doi.org\/10.3389\/fonc.2022.934159.","journal-title":"Front Oncol"},{"issue":"1","key":"1178_CR10","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1186\/s12943-021-01413-8","volume":"20","author":"X Ling","year":"2021","unstructured":"Ling X, et al. Small extrachromosomal circular DNA (eccDNA): major functions in evolution and cancer. Mol Cancer. 2021;20(1):113. https:\/\/doi.org\/10.1186\/s12943-021-01413-8.","journal-title":"Mol Cancer"},{"key":"1178_CR11","doi-asserted-by":"publisher","first-page":"6011","DOI":"10.1016\/j.csbj.2022.10.033","volume":"20","author":"M Wu","year":"2022","unstructured":"Wu M, Rai K. Demystifying extrachromosomal DNA circles: Categories, biogenesis, and cancer therapeutics. Comput Struct Biotechnol J. 2022;20:6011\u201322. https:\/\/doi.org\/10.1016\/j.csbj.2022.10.033.","journal-title":"Comput Struct Biotechnol J"},{"key":"1178_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2020.188392","author":"Z Liao","year":"2020","unstructured":"Liao Z, Jiang W, Ye L, Li T, Yu X, Liu L. Classification of extrachromosomal circular DNA with a focus on the role of extrachromosomal DNA (ecDNA) in tumor heterogeneity and progression. Biochimica et Biophysica Acta\u2013Rev Cancer. 2020. https:\/\/doi.org\/10.1016\/j.bbcan.2020.188392.","journal-title":"Biochimica et Biophysica Acta\u2013Rev Cancer"},{"issue":"1","key":"1178_CR13","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1471-2407-3-13","volume":"3","author":"M Nugoli","year":"2003","unstructured":"Nugoli M, et al. Genetic variability in MCF-7 sublines: evidence of rapid genomic and RNA expression profile modifications. BMC Cancer. 2003;3(1):13. https:\/\/doi.org\/10.1186\/1471-2407-3-13.","journal-title":"BMC Cancer"},{"issue":"4","key":"1178_CR14","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.tig.2017.12.010","volume":"34","author":"T Paulsen","year":"2018","unstructured":"Paulsen T, Kumar P, Koseoglu MM, Dutta A. Discoveries of extrachromosomal circles of DNA in normal and tumor cells. Trends Genet. 2018;34(4):270\u20138. https:\/\/doi.org\/10.1016\/j.tig.2017.12.010.","journal-title":"Trends Genet"},{"issue":"11","key":"1178_CR15","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1016\/j.celrep.2015.05.020","volume":"11","author":"LW Dillon","year":"2015","unstructured":"Dillon LW, et al. Production of extrachromosomal microDNAs is linked to mismatch repair pathways and transcriptional activity. Cell Rep. 2015;11(11):1749\u201359. https:\/\/doi.org\/10.1016\/j.celrep.2015.05.020.","journal-title":"Cell Rep"},{"key":"1178_CR16","doi-asserted-by":"publisher","DOI":"10.1126\/science.1213307","author":"Y Shibata","year":"2012","unstructured":"Shibata Y, et al. Extrachromosomal microDNAs and chromosomal microdeletions in normal tissues. Science. 2012. https:\/\/doi.org\/10.1126\/science.1213307.","journal-title":"Science"},{"issue":"4","key":"1178_CR17","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/j.cell.2012.03.030","volume":"149","author":"J-B Vannier","year":"2012","unstructured":"Vannier J-B, Pavicic-Kaltenbrunner V, Petalcorin MIR, Ding H, Boulton SJ. RTEL1 Dismantles T Loops and Counteracts Telomeric G4-DNA to Maintain Telomere Integrity. Cell. 2012;149(4):795\u2013806. https:\/\/doi.org\/10.1016\/j.cell.2012.03.030.","journal-title":"Cell"},{"issue":"10","key":"1178_CR18","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1038\/nsmb.1660","volume":"16","author":"L Tomaska","year":"2009","unstructured":"Tomaska L, Nosek J, Kramara J, Griffith JD. Telomeric circles: universal players in telomere maintenance? Nat Struct Mol Biol. 2009;16(10):1010\u20135. https:\/\/doi.org\/10.1038\/nsmb.1660.","journal-title":"Nat Struct Mol Biol"},{"issue":"4","key":"1178_CR19","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/S0092-8674(00)80760-6","volume":"97","author":"JD Griffith","year":"1999","unstructured":"Griffith JD, et al. Mammalian telomeres end in a large duplex loop. Cell. 1999;97(4):503\u201314. https:\/\/doi.org\/10.1016\/S0092-8674(00)80760-6.","journal-title":"Cell"},{"issue":"10","key":"1178_CR20","doi-asserted-by":"publisher","first-page":"2384","DOI":"10.3390\/cancers13102384","volume":"13","author":"D MacKenzie","year":"2021","unstructured":"MacKenzie D, et al. ALT positivity in human cancers: prevalence and clinical insights. Cancers (Basel). 2021;13(10):2384. https:\/\/doi.org\/10.3390\/cancers13102384.","journal-title":"Cancers (Basel)"},{"issue":"6","key":"1178_CR21","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1038\/nsmb.1660","volume":"66","author":"WKC Rossa","year":"2020","unstructured":"Rossa WKC, Anindya D, Henssen A, Lo YMD, Mischel P, Regenberg B. What is extrachromosomal circular DNA and what does it do? Clinical Chemistry. 2020;66(6):754\u2013759. https:\/\/doi.org\/10.1093\/clinchem\/hvaa096","journal-title":"Clinical Chemistry"},{"key":"1178_CR22","doi-asserted-by":"publisher","DOI":"10.3390\/genes12101533","author":"N Shimizu","year":"2021","unstructured":"Shimizu N. Gene amplification and the extrachromosomal circular dna. Genes (Basel). 2021. https:\/\/doi.org\/10.3390\/genes12101533.","journal-title":"Genes (Basel)."},{"issue":"6","key":"1178_CR23","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1016\/j.cell.2019.10.039","volume":"179","author":"AR Morton","year":"2019","unstructured":"Morton AR, et al. Functional enhancers shape extrachromosomal oncogene amplifications. Cell. 2019;179(6):1330-1341.e13. https:\/\/doi.org\/10.1016\/j.cell.2019.10.039.","journal-title":"Cell"},{"key":"1178_CR24","doi-asserted-by":"publisher","DOI":"10.1042\/BST20221045","author":"LT Pecorino","year":"2022","unstructured":"Pecorino LT, Verhaak RGW, Henssen A, Mischel PS. \u201cExtrachromosomal DNA (ecDNA): an origin of tumor heterogeneity, genomic remodeling, and drug resistance. Biochem Soc Trans. 2022. https:\/\/doi.org\/10.1042\/BST20221045.","journal-title":"Biochem Soc Trans"},{"key":"1178_CR25","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-00403-4","author":"X Zeng","year":"2020","unstructured":"Zeng X, Wan M, Wu J. \u201cecDNA within tumors: a new mechanism that drives tumor heterogeneity and drug resistance. Sig Transduct Target Ther. 2020. https:\/\/doi.org\/10.1038\/s41392-020-00403-4.","journal-title":"Sig Transduct Target Ther"},{"key":"1178_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2022.110000","author":"S Ashique","year":"2022","unstructured":"Ashique S, et al. Impact of ecDNA: A mechanism that directs tumorigenesis in cancer drug Resistance-A review. Chemico-Biol Interact. 2022. https:\/\/doi.org\/10.1016\/j.cbi.2022.110000.","journal-title":"Chemico-Biol Interact"},{"key":"1178_CR27","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1194405","author":"Y Dong","year":"2023","unstructured":"Dong Y, He Q, Chen X, Yang F, He L, Zheng Y. \u201cExtrachromosomal DNA (ecDNA) in cancer: mechanisms, functions, and clinical implications. Front Oncol. 2023. https:\/\/doi.org\/10.3389\/fonc.2023.1194405.","journal-title":"Front Oncol"},{"issue":"5","key":"1178_CR28","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.3390\/cells10051102","volume":"10","author":"M Shorokhova","year":"2021","unstructured":"Shorokhova M, Nikolsky N, Grinchuk T. Chromothripsis\u2014explosion in genetic science. Cells. 2021;10(5):1102. https:\/\/doi.org\/10.3390\/cells10051102.","journal-title":"Cells"},{"issue":"7848","key":"1178_CR29","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1038\/s41586-020-03064-z","volume":"591","author":"O Shoshani","year":"2021","unstructured":"Shoshani O, et al. Chromothripsis drives the evolution of gene amplification in cancer. Nature. 2021;591(7848):137\u201341. https:\/\/doi.org\/10.1038\/s41586-020-03064-z.","journal-title":"Nature"},{"key":"1178_CR30","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.73479","author":"Z Li","year":"2022","unstructured":"Li Z, Wang B, Liang H, Han L. \u201cPioneering insights of extrachromosomal DNA (ecDNA) generation, action and its implications for cancer therapy. Int J Biol Sci. 2022. https:\/\/doi.org\/10.7150\/ijbs.73479.","journal-title":"Int J Biol Sci."},{"issue":"4","key":"1178_CR31","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1038\/s41568-024-00669-8","volume":"24","author":"X Yan","year":"2024","unstructured":"Yan X, Mischel P, Chang H. Extrachromosomal DNA in cancer. Nat Rev Cancer. 2024;24(4):261\u201373. https:\/\/doi.org\/10.1038\/s41568-024-00669-8.","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"1178_CR32","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1038\/s41392-022-01176-8","volume":"7","author":"L Yang","year":"2022","unstructured":"Yang L, et al. Extrachromosomal circular DNA: biogenesis, structure, functions and diseases. Signal Transduct Target Ther. 2022;7(1):342. https:\/\/doi.org\/10.1038\/s41392-022-01176-8.","journal-title":"Signal Transduct Target Ther"},{"issue":"9","key":"1178_CR33","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1093\/carcin\/bgac072","volume":"43","author":"Y Tao","year":"2022","unstructured":"Tao Y, Ning Q, Wang Z, Tang N, Zhao X, Tang S. The formation mechanism and homeostasis of extrachromosomal DNA. Carcinogenesis. 2022;43(9):815\u201325. https:\/\/doi.org\/10.1093\/carcin\/bgac072.","journal-title":"Carcinogenesis"},{"key":"1178_CR34","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-020-01726-4","author":"X Gu","year":"2020","unstructured":"Gu X, Yu J, Chai P, Ge S, Fan X. Novel insights into extrachromosomal DNA: Redefining the onco-drivers of tumor progression. J Exp Clin Cancer Res. 2020. https:\/\/doi.org\/10.1186\/s13046-020-01726-4.","journal-title":"J Exp Clin Cancer Res"},{"issue":"12","key":"1178_CR35","doi-asserted-by":"publisher","first-page":"6744","DOI":"10.3390\/ijms25126744","volume":"25","author":"Y Li","year":"2024","unstructured":"Li Y, et al. Exploring the role of clustered mutations in carcinogenesis and their potential clinical implications in cancer. Int J Mol Sci. 2024;25(12):6744. https:\/\/doi.org\/10.3390\/ijms25126744.","journal-title":"Int J Mol Sci"},{"issue":"7897","key":"1178_CR36","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1038\/s41586-022-04398-6","volume":"602","author":"EN Bergstrom","year":"2022","unstructured":"Bergstrom EN, et al. Mapping clustered mutations in cancer reveals APOBEC3 mutagenesis of ecDNA. Nature. 2022;602(7897):510\u20137. https:\/\/doi.org\/10.1038\/s41586-022-04398-6.","journal-title":"Nature"},{"issue":"7784","key":"1178_CR37","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1038\/s41586-019-1763-5","volume":"575","author":"S Wu","year":"2019","unstructured":"Wu S, et al. Circular ecDNA promotes accessible chromatin and high oncogene expression. Nature. 2019;575(7784):699\u2013703. https:\/\/doi.org\/10.1038\/s41586-019-1763-5.","journal-title":"Nature"},{"key":"1178_CR38","doi-asserted-by":"publisher","DOI":"10.1101\/2021.10.18.464907","author":"OS Chapman","year":"2021","unstructured":"Chapman OS, et al. The landscape of extrachromosomal circular DNA in medulloblastoma. bioRxiv. 2021. https:\/\/doi.org\/10.1101\/2021.10.18.464907.","journal-title":"bioRxiv"},{"key":"1178_CR39","doi-asserted-by":"publisher","DOI":"10.1186\/s13072-021-00416-5","author":"W Chen","year":"2021","unstructured":"Chen W, et al. Sequencing of methylase-accessible regions in integral circular extrachromosomal DNA reveals differences in chromatin structure. Epigenetics Chromatin. 2021. https:\/\/doi.org\/10.1186\/s13072-021-00416-5.","journal-title":"Epigenetics Chromatin"},{"issue":"8","key":"1178_CR40","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1038\/s41594-022-00806-7","volume":"29","author":"KL Hung","year":"2022","unstructured":"Hung KL, Mischel PS, Chang HY. Gene regulation on extrachromosomal DNA. Nat Struct Mol Biol. 2022;29(8):736\u201344. https:\/\/doi.org\/10.1038\/s41594-022-00806-7.","journal-title":"Nat Struct Mol Biol"},{"issue":"7890","key":"1178_CR41","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1038\/s41586-021-04116-8","volume":"600","author":"KL Hung","year":"2021","unstructured":"Hung KL, et al. ecDNA hubs drive cooperative intermolecular oncogene expression. Nature. 2021;600(7890):731\u20136. https:\/\/doi.org\/10.1038\/s41586-021-04116-8.","journal-title":"Nature"},{"issue":"9","key":"1178_CR42","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/j.trecan.2022.04.011","volume":"8","author":"Y Zhu","year":"2022","unstructured":"Zhu Y, Gong L, Wei C-L. Guilt by association: EcDNA as a mobile transactivator in cancer. Trends Cancer. 2022;8(9):747\u201358. https:\/\/doi.org\/10.1016\/j.trecan.2022.04.011.","journal-title":"Trends Cancer"},{"key":"1178_CR43","doi-asserted-by":"publisher","DOI":"10.6084\/m9.figshare.9826115.v1","author":"S Wu","year":"2019","unstructured":"Wu S, et al. Circular ecDNA promotes accessible chromatin and high oncogene expression. 2019. Nature. https:\/\/doi.org\/10.6084\/m9.figshare.9826115.v1."},{"key":"1178_CR44","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.80207","author":"K Purshouse","year":"2022","unstructured":"Purshouse K, et al. \u201cOncogene expression from extrachromosomal DNA is driven by copy number amplification and does not require spatial clustering in glioblastoma stem cells. Elife. 2022. https:\/\/doi.org\/10.7554\/eLife.80207.","journal-title":"Elife."},{"issue":"11","key":"1178_CR45","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1038\/s41571-022-00679-1","volume":"19","author":"I Noorani","year":"2022","unstructured":"Noorani I, Mischel PS, Swanton C. Leveraging extrachromosomal DNA to fine-tune trials of targeted therapy for glioblastoma: opportunities and challenges. Nat Rev Clin Oncol. 2022;19(11):733\u201343. https:\/\/doi.org\/10.1038\/s41571-022-00679-1.","journal-title":"Nat Rev Clin Oncol"},{"key":"1178_CR46","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-022-02617-8","author":"M KaramiFath","year":"2022","unstructured":"KaramiFath M, et al. Revisiting characteristics of oncogenic extrachromosomal DNA as mobile enhancers on neuroblastoma and glioma cancers. Cancer Cell Int. 2022. https:\/\/doi.org\/10.1186\/s12935-022-02617-8.","journal-title":"Cancer Cell Int"},{"issue":"14","key":"1178_CR47","doi-asserted-by":"publisher","first-page":"9131","DOI":"10.1093\/nar\/gku590","volume":"42","author":"A L\u2019Abbate","year":"2014","unstructured":"L\u2019Abbate A, et al. Genomic organization and evolution of double minutes\/homogeneously staining regions with MYC amplification in human cancer. Nucleic Acids Res. 2014;42(14):9131\u201345. https:\/\/doi.org\/10.1093\/nar\/gku590.","journal-title":"Nucleic Acids Res"},{"key":"1178_CR48","doi-asserted-by":"crossref","unstructured":"Von Hoff DD et al., \u201cElimination of extrachromosomally amplified MYC genes from human tumor cells reduces their tumorigenicity (hydroxyurea\/gene ampllflcatlon\/oncogenes\/double-minute chromosomes),\u201d 1992.","DOI":"10.1073\/pnas.89.17.8165"},{"issue":"6","key":"1178_CR49","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1093\/hmg\/ddl010","volume":"15","author":"CT Storlazzi","year":"2006","unstructured":"Storlazzi CT, et al. MYC-containing double minutes in hematologic malignancies: Evidence in favor of the episome model and exclusion of MYC as the target gene. Hum Mol Genet. 2006;15(6):933\u201342. https:\/\/doi.org\/10.1093\/hmg\/ddl010.","journal-title":"Hum Mol Genet"},{"issue":"2","key":"1178_CR50","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1038\/s41588-021-01000-z","volume":"54","author":"E van Leen","year":"2022","unstructured":"van Leen E, Br\u00fcckner L, Henssen AG. The genomic and spatial mobility of extrachromosomal DNA and its implications for cancer therapy. Nat Genet. 2022;54(2):107\u201314. https:\/\/doi.org\/10.1038\/s41588-021-01000-z.","journal-title":"Nat Genet"},{"key":"1178_CR51","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.24425","author":"G Xu","year":"2022","unstructured":"Xu G, et al. Differential expression and analysis of extrachromosomal circular DNAs as serum biomarkers in lung adenocarcinoma. J Clin Lab Anal. 2022. https:\/\/doi.org\/10.1002\/jcla.24425.","journal-title":"J Clin Lab Anal"},{"key":"1178_CR52","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-05755-7","author":"Y Yang","year":"2023","unstructured":"Yang Y, et al. PLCG2 can exist in eccDNA and contribute to the metastasis of non-small cell lung cancer by regulating mitochondrial respiration. Cell Death Dis. 2023. https:\/\/doi.org\/10.1038\/s41419-023-05755-7.","journal-title":"Cell Death Dis"},{"key":"1178_CR53","doi-asserted-by":"publisher","DOI":"10.1002\/tbio.201900028","author":"L Shi","year":"2020","unstructured":"Shi L, et al. Application of 5-aminolevulinic acid-photodynamic therapy in common skin diseases. Transl Biophotonics. 2020. https:\/\/doi.org\/10.1002\/tbio.201900028.","journal-title":"Transl Biophotonics"},{"issue":"4","key":"1178_CR54","doi-asserted-by":"publisher","first-page":"66","DOI":"10.3390\/medsci12040066","volume":"12","author":"A Pustimbara","year":"2024","unstructured":"Pustimbara A, et al. Hemin promotes higher effectiveness of aminolevulinic-photodynamic therapy (ALA-PDT) in A549 lung cancer cell line by interrupting ABCG2 expression. Med Sci. 2024;12(4):66. https:\/\/doi.org\/10.3390\/medsci12040066.","journal-title":"Med Sci"},{"issue":"1","key":"1178_CR55","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1038\/s41572-019-0086-z","volume":"5","author":"Y Peters","year":"2019","unstructured":"Peters Y, et al. Barrett oesophagus. Nat Rev Dis Primers. 2019;5(1):35. https:\/\/doi.org\/10.1038\/s41572-019-0086-z.","journal-title":"Nat Rev Dis Primers"},{"issue":"7958","key":"1178_CR56","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1038\/s41586-023-05937-5","volume":"616","author":"J Luebeck","year":"2023","unstructured":"Luebeck J, et al. Extrachromosomal DNA in the cancerous transformation of Barrett\u2019s oesophagus. Nature. 2023;616(7958):798\u2013805. https:\/\/doi.org\/10.1038\/s41586-023-05937-5.","journal-title":"Nature"},{"issue":"5","key":"1178_CR57","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1093\/carcin\/bgg034","volume":"24","author":"PL Opresko","year":"2003","unstructured":"Opresko PL. Werner syndrome and the function of the Werner protein; what they can teach us about the molecular aging process. Carcinogenesis. 2003;24(5):791\u2013802. https:\/\/doi.org\/10.1093\/carcin\/bgg034.","journal-title":"Carcinogenesis"},{"key":"1178_CR58","doi-asserted-by":"publisher","DOI":"10.1126\/science.272.5259.258","author":"C-E Yu","year":"1996","unstructured":"Yu C-E, et al. Positional cloning of the werner\u2019s syndrome gene. Science. 1996. https:\/\/doi.org\/10.1126\/science.272.5259.258.","journal-title":"Science"},{"issue":"12","key":"1178_CR59","doi-asserted-by":"publisher","first-page":"7748","DOI":"10.1093\/nar\/gku454","volume":"42","author":"DN Edwards","year":"2014","unstructured":"Edwards DN, Orren DK, Machwe A. Strand exchange of telomeric DNA catalyzed by the Werner syndrome protein (WRN) is specifically stimulated by TRF2. Nucleic Acids Res. 2014;42(12):7748\u201361. https:\/\/doi.org\/10.1093\/nar\/gku454.","journal-title":"Nucleic Acids Res"},{"issue":"20","key":"1178_CR60","doi-asserted-by":"publisher","first-page":"15379","DOI":"10.3390\/ijms242015379","volume":"24","author":"J van der Linden","year":"2023","unstructured":"van der Linden J, et al. Model systems to study the mechanism of vascular aging. Int J Mol Sci. 2023;24(20):15379. https:\/\/doi.org\/10.3390\/ijms242015379.","journal-title":"Int J Mol Sci"},{"key":"1178_CR61","doi-asserted-by":"publisher","first-page":"101835","DOI":"10.1016\/j.toxrep.2024.101835","volume":"13","author":"NM Prakoso","year":"2024","unstructured":"Prakoso NM, et al. Methylglyoxal impairs human dermal fibroblast survival and migration by altering RAGE-hTERT mRNA expression in vitro. Toxicol Rep. 2024;13:101835. https:\/\/doi.org\/10.1016\/j.toxrep.2024.101835.","journal-title":"Toxicol Rep"},{"issue":"9","key":"1178_CR62","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1038\/s41580-020-0244-x","volume":"21","author":"K-P Hopfner","year":"2020","unstructured":"Hopfner K-P, Hornung V. Molecular mechanisms and cellular functions of cGAS\u2013STING signalling. Nat Rev Mol Cell Biol. 2020;21(9):501\u201321. https:\/\/doi.org\/10.1038\/s41580-020-0244-x.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"1178_CR63","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.cyto.2019.01.013","volume":"117","author":"S Lopes-Paciencia","year":"2019","unstructured":"Lopes-Paciencia S, Saint-Germain E, Rowell M-C, Ruiz AF, Kalegari P, Ferbeyre G. The senescence-associated secretory phenotype and its regulation. Cytokine. 2019;117:15\u201322. https:\/\/doi.org\/10.1016\/j.cyto.2019.01.013.","journal-title":"Cytokine"},{"issue":"7","key":"1178_CR64","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1016\/S0092-8674(00)80493-6","volume":"91","author":"DA Sinclair","year":"1997","unstructured":"Sinclair DA, Guarente L. Extrachromosomal rDNA Circles\u2014a Cause of Aging in Yeast. Cell. 1997;91(7):1033\u201342. https:\/\/doi.org\/10.1016\/S0092-8674(00)80493-6.","journal-title":"Cell"},{"key":"1178_CR65","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14393","author":"P Masrori","year":"2020","unstructured":"Masrori P, Van Damme P. \u201cAmyotrophic lateral sclerosis: a clinical review. Euro J Neurol. 2020. https:\/\/doi.org\/10.1111\/ene.14393.","journal-title":"Euro J Neurol"},{"key":"1178_CR66","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-023-01116-1","author":"D Gerovska","year":"2023","unstructured":"Gerovska D, et al. A distinct circular DNA profile intersects with proteome changes in the genotoxic stress-related hSOD1G93A model of ALS. Cell Biosci. 2023. https:\/\/doi.org\/10.1186\/s13578-023-01116-1.","journal-title":"Cell Biosci"},{"key":"1178_CR67","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.226377","author":"D Penndorf","year":"2018","unstructured":"Penndorf D, Witte OW, Kretz A. DNA plasticity and damage in amyotrophic lateral sclerosis. Neural Regen Res. 2018. https:\/\/doi.org\/10.4103\/1673-5374.226377.","journal-title":"Neural Regen Res"},{"key":"1178_CR68","doi-asserted-by":"publisher","DOI":"10.1186\/s11658-023-00530-0","author":"X Kong","year":"2024","unstructured":"Kong X, et al. Increased serum extrachromosomal circular DNA SORBS1circle level is associated with insulin resistance in patients with newly diagnosed type 2 diabetes mellitus. Cell Mol Biol Lett. 2024. https:\/\/doi.org\/10.1186\/s11658-023-00530-0.","journal-title":"Cell Mol Biol Lett"},{"issue":"1","key":"1178_CR69","doi-asserted-by":"publisher","first-page":"10574","DOI":"10.1038\/s41598-018-28891-z","volume":"8","author":"T-J Chang","year":"2018","unstructured":"Chang T-J, et al. Genetic variation of SORBS1 gene is associated with glucose homeostasis and age at onset of diabetes: a SAPPHIRe Cohort Study. Sci Rep. 2018;8(1):10574. https:\/\/doi.org\/10.1038\/s41598-018-28891-z.","journal-title":"Sci Rep"},{"issue":"6801","key":"1178_CR70","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1038\/35025089","volume":"407","author":"CA Baumann","year":"2000","unstructured":"Baumann CA, et al. CAP defines a second signalling pathway required for insulin-stimulated glucose transport. Nature. 2000;407(6801):202\u20137. https:\/\/doi.org\/10.1038\/35025089.","journal-title":"Nature"},{"issue":"10","key":"1178_CR71","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1038\/s41580-018-0044-8","volume":"19","author":"Q Yang","year":"2018","unstructured":"Yang Q, Vijayakumar A, Kahn BB. Metabolites as regulators of insulin sensitivity and metabolism. Nat Rev Mol Cell Biol. 2018;19(10):654\u201372. https:\/\/doi.org\/10.1038\/s41580-018-0044-8.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"24","key":"1178_CR72","doi-asserted-by":"publisher","first-page":"15489","DOI":"10.18632\/aging.205388","volume":"15","author":"Q Zhu","year":"2023","unstructured":"Zhu Q, Chen R, Kuang M, Zhang W, Wang D, Han S. Identification and characterization of extrachromosomal circular DNA in age-related osteoporosis. Aging. 2023;15(24):15489\u2013503. https:\/\/doi.org\/10.18632\/aging.205388.","journal-title":"Aging"},{"key":"1178_CR73","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.573455","author":"W Xie","year":"2020","unstructured":"Xie W, Xiao W, Tang K, Zhang L, Li Y. Yes-associated protein 1: role and treatment prospects in orthopedic degenerative diseases. Front Cell Dev Biol. 2020. https:\/\/doi.org\/10.3389\/fcell.2020.573455.","journal-title":"Front Cell Dev Biol"},{"issue":"1\u20133","key":"1178_CR74","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1159\/000204105","volume":"23","author":"S Peng","year":"2009","unstructured":"Peng S, et al. Strontium promotes osteogenic differentiation of mesenchymal stem cells through the Ras\/MAPK signaling pathway. Cell Physiol Biochem. 2009;23(1\u20133):165\u201374. https:\/\/doi.org\/10.1159\/000204105.","journal-title":"Cell Physiol Biochem"},{"issue":"6","key":"1178_CR75","doi-asserted-by":"publisher","first-page":"640","DOI":"10.3109\/10799893.2015.1041647","volume":"35","author":"J-C Xi","year":"2015","unstructured":"Xi J-C, et al. The PI3K\/AKT cell signaling pathway is involved in regulation of osteoporosis. J Recept Signal Transduct. 2015;35(6):640\u20135. https:\/\/doi.org\/10.3109\/10799893.2015.1041647.","journal-title":"J Recept Signal Transduct"},{"key":"1178_CR76","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/978-94-017-0433-5_2","volume-title":"Atlas of Human Chromosome Heteromorphisms","author":"GVN Velagaleti","year":"2004","unstructured":"Velagaleti GVN, Tonk VS. Methods of Studying Human Chromosomes and Nomenclature The Normal Human Karyotype. In: Atlas of Human Chromosome Heteromorphisms. Dordrecht: Springer Netherlands; 2004. p. 11\u201331."},{"issue":"3","key":"1178_CR77","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1017\/S1431927619000266","volume":"25","author":"A Dwiranti","year":"2019","unstructured":"Dwiranti A, Takata H, Fukui K. Reversible changes of chromosome structure upon different concentrations of divalent cations. Microsc Microanal. 2019;25(3):817\u2013821. https:\/\/doi.org\/10.1017\/S1431927619000266.","journal-title":"Microsc Microanal"},{"issue":"3","key":"1178_CR78","doi-asserted-by":"publisher","first-page":"215","DOI":"10.31185\/wjps.181","volume":"2","author":"MA Al-Ammar","year":"2023","unstructured":"Al-Ammar MA, Abdulameer SJ. The ideal time to add Colcemid to obtain a division of the lymphocyte cells. Wasit J Pure Sci. 2023;2(3):215\u201323.","journal-title":"Wasit J Pure Sci"},{"key":"1178_CR79","doi-asserted-by":"publisher","DOI":"10.1101\/2020.08.13.249664","author":"AM Rozario","year":"2020","unstructured":"Rozario AM, et al. Ultra-low colcemid doses induce microtubule dysfunction as revealed by super-resolution microscopy. bioRxiv. 2020. https:\/\/doi.org\/10.1101\/2020.08.13.249664.","journal-title":"bioRxiv"},{"key":"1178_CR80","unstructured":"Cooper GM. The Cell: A Molecular Approach. 2nd ed. Sinauer Associates; 2000. ISBN: 0-87893-106-6."},{"key":"1178_CR81","doi-asserted-by":"publisher","DOI":"10.3791\/50203","author":"B Howe","year":"2014","unstructured":"Howe B, Umrigar A, Tsien F. chromosome preparation from cultured cells. J Vis Exp. 2014. https:\/\/doi.org\/10.3791\/50203.","journal-title":"J Vis Exp"},{"key":"1178_CR82","doi-asserted-by":"crossref","unstructured":"Schmidt N, Weber B, Klekar J, Liedtke S, Breitenbach S, and Heitkam T, \u201cPreparation of Mitotic Chromosomes with the Dropping Technique,\u201d 2023, pp 151\u2013162.","DOI":"10.1007\/978-1-0716-3226-0_8"},{"issue":"1","key":"1178_CR83","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1002\/cyto.a.10004","volume":"51A","author":"W Deng","year":"2003","unstructured":"Deng W, Tsao SW, Lucas JN, Leung CS, Cheung ALM. A new method for improving metaphase chromosome spreading. Cytometry A. 2003;51A(1):46\u201351. https:\/\/doi.org\/10.1002\/cyto.a.10004.","journal-title":"Cytometry A"},{"key":"1178_CR84","doi-asserted-by":"publisher","DOI":"10.1002\/9780471729259.mc02b02s25","author":"ER Fischer","year":"2012","unstructured":"Fischer ER, Hansen BT, Nair V, Hoyt FH, Dorward DW. Scanning electron microscopy. Curr Protoc Microbiol. 2012. https:\/\/doi.org\/10.1002\/9780471729259.mc02b02s25.","journal-title":"Curr Protoc Microbiol"},{"issue":"1\u20134","key":"1178_CR85","first-page":"19","volume":"19","author":"A Dwiranti","year":"2016","unstructured":"Dwiranti A, Takata H, Uchiyama S, Fukui K. The effect of magnesium ions on chromosome structure as observed by scanning electron microscopy (SEM) and scanning transmission electron microscope (STEM) tomography. Chromosome Sci. 2016;19(1\u20134):19\u201323.","journal-title":"Chromosome Sci"},{"key":"1178_CR86","unstructured":"Sumner AL, Ross AR, and Graham E, \u201cPreparation of Chromosomes for Scanning Electron Microscopy.\u201d"},{"key":"1178_CR87","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/978-0-387-39620-0_4","volume-title":"Scanning Microscopy for Nanotechnology","author":"MD Frey","year":"2006","unstructured":"Frey MD. Low kV Scanning Electron Microscopy. In: Scanning Microscopy for Nanotechnology. New York: Springer; 2006. p. 101\u201319."},{"key":"1178_CR88","doi-asserted-by":"publisher","unstructured":"Irdianto SA, Fadhillah, Lestari R, Fadilah, Bowolaksono A, Dwiranti A. Extrachromosomal DNA in breast cancer cell lines: detection and characterization. Microsc Res Tech. 2024;1\u20139. https:\/\/doi.org\/10.1002\/jemt.24780","DOI":"10.1002\/jemt.24780"},{"key":"1178_CR89","doi-asserted-by":"publisher","unstructured":"de Jong H, van de Belt J, Fransz P. Critical steps in DAPI and FISH imaging of chromosome spread preparations. In: Heitkam T, Garcia S, editors. Plant Cytogenetics and Cytogenomics. Methods in Molecular Biology. New York, NY: Humana; 2023. vol 2672. https:\/\/doi.org\/10.1007\/978-1-0716-3226-0_15","DOI":"10.1007\/978-1-0716-3226-0_15"},{"issue":"1","key":"1178_CR90","doi-asserted-by":"publisher","first-page":"251","DOI":"10.3390\/CIMB43010021","volume":"43","author":"E \u0160imoli\u016bnas","year":"2021","unstructured":"\u0160imoli\u016bnas E, Kantakevi\u010dius P, Kalvaityt\u0117 M, Bagdzevi\u010di\u016bt\u0117 L, Alksn\u0117 M, Baltriukien\u0117 D. Dna-dapi interaction-based method for cell proliferation rate evaluation in 3d structures. Curr Issues Mol Biol. 2021;43(1):251\u201363. https:\/\/doi.org\/10.3390\/CIMB43010021.","journal-title":"Curr Issues Mol Biol"},{"key":"1178_CR91","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2023.107680","author":"X Zhao","year":"2023","unstructured":"Zhao X, Zhao H, Liu Y, Guo Z. \u201cMethods, bioinformatics tools and databases in ecDNA research: an overview. Comput Biol Med. 2023. https:\/\/doi.org\/10.1016\/j.compbiomed.2023.107680.","journal-title":"Comput Biol Med"},{"key":"1178_CR92","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-024-02280-2","author":"K Purshouse","year":"2024","unstructured":"Purshouse K, Pollard SM, Bickmore WA. \u201cImaging extrachromosomal DNA (ecDNA) in cancer. Histochem Cell Biol. 2024. https:\/\/doi.org\/10.1007\/s00418-024-02280-2.","journal-title":"Histochem Cell Biol"},{"key":"1178_CR93","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-019-0128-6","author":"RGW Verhaak","year":"2019","unstructured":"Verhaak RGW, Bafna V, Mischel PS. \u201cExtrachromosomal oncogene amplification in tumour pathogenesis and evolution. Nat Rev Cancer. 2019. https:\/\/doi.org\/10.1038\/s41568-019-0128-6.","journal-title":"Nat Rev Cancer"},{"key":"1178_CR94","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2019.10.035","author":"U Rajkumar","year":"2019","unstructured":"Rajkumar U, et al. EcSeg: semantic segmentation of metaphase images containing extrachromosomal DNA. iScience. 2019. https:\/\/doi.org\/10.1016\/j.isci.2019.10.035.","journal-title":"iScience"},{"key":"1178_CR95","doi-asserted-by":"publisher","first-page":"100916","DOI":"10.1016\/j.bbrep.2021.100916","volume":"25","author":"MH Shihan","year":"2021","unstructured":"Shihan MH, Novo SG, Le Marchand SJ, Wang Y, Duncan MK. A simple method for quantitating confocal fluorescent images. Biochem Biophys Rep. 2021;25:100916. https:\/\/doi.org\/10.1016\/j.bbrep.2021.100916.","journal-title":"Biochem Biophys Rep"},{"key":"1178_CR96","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbad388","author":"F Li","year":"2023","unstructured":"Li F, et al. FLED: a full-length eccDNA detector for long-reads sequencing data. Brief Bioinform. 2023. https:\/\/doi.org\/10.1093\/bib\/bbad388.","journal-title":"Brief Bioinform"},{"key":"1178_CR97","doi-asserted-by":"publisher","unstructured":"M\u00f8ller, H.D. Circle-seq: isolation and sequencing of chromosome-derived circular DNA elements in cells. In: Hanada, K, editor. DNA Electrophoresis. Methods in Molecular Biology. New York, NY: Humana; 2020. p. 2119. https:\/\/doi.org\/10.1007\/978-1-0716-0323-9_15","DOI":"10.1007\/978-1-0716-0323-9_15"},{"key":"1178_CR98","doi-asserted-by":"publisher","DOI":"10.1038\/protex.2019.006","author":"A Henssen","year":"2019","unstructured":"Henssen A, MacArthur I, Koche R, Dorado-Garc\u00eda H, Henssen A. Purification and sequencing of large circular DNA from human cells. Protoc Exch. 2019. https:\/\/doi.org\/10.1038\/protex.2019.006.","journal-title":"Protoc Exch"},{"key":"1178_CR99","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-023-01386-y","author":"R Chamorro Gonz\u00e1lez","year":"2023","unstructured":"Chamorro Gonz\u00e1lez R, et al. Parallel sequencing of extrachromosomal circular DNAs and transcriptomes in single cancer cells. Nat Genet. 2023. https:\/\/doi.org\/10.1038\/s41588-023-01386-y.","journal-title":"Nat Genet"},{"issue":"7884","key":"1178_CR100","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1038\/s41586-021-04009-w","volume":"599","author":"Y Wang","year":"2021","unstructured":"Wang Y, et al. eccDNAs are apoptotic products with high innate immunostimulatory activity. Nature. 2021;599(7884):308\u201314. https:\/\/doi.org\/10.1038\/s41586-021-04009-w.","journal-title":"Nature"},{"key":"1178_CR101","doi-asserted-by":"publisher","unstructured":"Hino S, Sato T, and Nakao M. Chromatin immunoprecipitation sequencing (ChIP-seq) for detecting histone modifications and modifiers. In: Hatada, I., Horii, T,  editors. Epigenomics. Methods in Molecular Biology. New York, NY: Humana; 2023. vol 2577. https:\/\/doi.org\/10.1007\/978-1-0716-2724-2_4","DOI":"10.1007\/978-1-0716-2724-2_4"},{"issue":"1","key":"1178_CR102","doi-asserted-by":"publisher","first-page":"3016","DOI":"10.1038\/s41467-022-30787-6","volume":"13","author":"JK Barrows","year":"2022","unstructured":"Barrows JK, Lin B, Quaas CE, Fullbright G, Wallace EN, Long DT. BRD4 promotes resection and homology-directed repair of DNA double-strand breaks. Nat Commun. 2022;13(1):3016. https:\/\/doi.org\/10.1038\/s41467-022-30787-6.","journal-title":"Nat Commun"},{"issue":"2","key":"1178_CR103","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1158\/2159-8290.CD-21-1376","volume":"12","author":"E Yi","year":"2022","unstructured":"Yi E, et al. Live-cell imaging shows uneven segregation of extrachromosomal DNA elements and transcriptionally active extrachromosomal DNA hubs in cancer. Cancer Discov. 2022;12(2):468\u201383. https:\/\/doi.org\/10.1158\/2159-8290.CD-21-1376.","journal-title":"Cancer Discov"},{"issue":"19","key":"1178_CR104","doi-asserted-by":"publisher","first-page":"3085","DOI":"10.1093\/bioinformatics\/btv335","volume":"31","author":"FA Klein","year":"2015","unstructured":"Klein FA, Pakozdi T, Anders S, Ghavi-Helm Y, Furlong EEM, Huber W. FourCSeq: analysis of 4C sequencing data. Bioinformatics. 2015;31(19):3085\u201391. https:\/\/doi.org\/10.1093\/bioinformatics\/btv335.","journal-title":"Bioinformatics"}],"container-title":["Human Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13577-025-01178-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13577-025-01178-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13577-025-01178-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T01:41:24Z","timestamp":1741311684000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13577-025-01178-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,19]]},"references-count":104,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,3]]}},"alternative-id":["1178"],"URL":"https:\/\/doi.org\/10.1007\/s13577-025-01178-y","relation":{"references":[{"id-type":"uri","id":"","asserted-by":"subject"}]},"ISSN":["1749-0774"],"issn-type":[{"value":"1749-0774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,19]]},"assertion":[{"value":"27 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"58"}}