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We successfully employed steroidogenic factor- 1 (SF1), androgen receptor (AR), and class III \u03b2-tubulin as markers. SF1 and AR specifically highlighted the intraneural cell precursors of Leydig cells, which were previously identified in a published case of mature cystic teratoma of the ovary, and the adult ovarian Leydig cells. Furthermore, the transient expression of class III \u03b2-tubulin could be associated with the intraneural displacement of these precursors, cooperating in their migration to colonize the ovaries of adult women.<\/jats:p>","DOI":"10.1007\/s13577-025-01210-1","type":"journal-article","created":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T01:05:31Z","timestamp":1744419931000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ovarian Leydig cells and neural crests"],"prefix":"10.1007","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9140-2053","authenticated-orcid":false,"given":"Jos\u00e9-Luis","family":"Carrasco\u2011Juan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"Tapia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Gonz\u00e1lez\u2011G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abian","family":"Vega-Falc\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Garc\u00eda\u2011Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexis","family":"Rufino-G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"M\u00e9ndez-Medina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo","family":"\u00c1lvarez-Arguelles Cabrera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,4,12]]},"reference":[{"key":"1210_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-3-319-31973-5","volume-title":"Molecular mechanisms of cell differentiation in gonad development, results and problems in cell differentiation, 58","author":"RP Piprek","year":"2016","unstructured":"Piprek RP, Kloc M, Kubiak JZ. Early development of the gonads: origin and differentiation of the somatic cells of the genital ridges. In: Piprek RP, editor. Molecular mechanisms of cell differentiation in gonad development, results and problems in cell differentiation, 58. Switzerland: Springer International Publishing; 2016. p. 1\u201322."},{"key":"1210_CR2","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1210\/mend.8.5.8058073","volume":"8","author":"Y Ikeda","year":"1994","unstructured":"Ikeda Y, Shen WH, Ingraham HA, Parker KL. Developmental expression of mouse steroidogenic factor-1, an essential regulator of the steroid hydroxylases. Mol Endocrinol. 1994;8:654\u201362. https:\/\/doi.org\/10.1210\/mend.8.5.8058073.","journal-title":"Mol Endocrinol"},{"issue":"3","key":"1210_CR3","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1210\/endo.143.3.8683","volume":"143","author":"P Koskimies","year":"2002","unstructured":"Koskimies P, Levallet J, Sipil\u00e4 P, Huhtaniemi I, Poutanen M. 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Ethical approval for this study was obtained from the Ethics Committee of La Laguna University (Comit\u00e9 de \u00c9tica de la Investigaci\u00f3n y de Bienestar Animal, CEIBA 2018 -\u20090289), including the dissociation of the samples from any information that could identify the patient. The authors, therefore, had no access to identifiable patient information.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"85"}}