{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T03:50:41Z","timestamp":1790567441982,"version":"4.1.0"},"reference-count":172,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Human Cell"],"DOI":"10.1007\/s13577-025-01226-7","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T09:53:05Z","timestamp":1747734785000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The role of microglia in the development of diabetic retinopathy and its potential clinical application"],"prefix":"10.1007","volume":"38","author":[{"given":"Tingting","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiameng","family":"shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengdan","family":"Pu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyuan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,20]]},"reference":[{"issue":"5","key":"1226_CR1","doi-asserted-by":"publisher","first-page":"321","DOI":"10.7555\/JBR.36.20220017","volume":"36","author":"H Jia","year":"2022","unstructured":"Jia H, Xie T. Tracers progress for positron emission tomography imaging of glial-related disease. J Biomed Res. 2022;36(5):321.","journal-title":"J Biomed Res"},{"issue":"3","key":"1226_CR2","doi-asserted-by":"publisher","first-page":"607","DOI":"10.3390\/molecules23030607","volume":"23","author":"B Janssen","year":"2018","unstructured":"Janssen B, Vugts D, Windhorst A, et al. PET imaging of microglial activation-beyond targeting TSPO. Molecules. 2018;23(3):607.","journal-title":"Molecules"},{"issue":"21","key":"1226_CR3","doi-asserted-by":"publisher","first-page":"eabq2923","DOI":"10.1126\/sciadv.abq2923","volume":"8","author":"R Garcia-Hernandez","year":"2022","unstructured":"Garcia-Hernandez R, Cerd\u00e1n Cerd\u00e1 A, Trouve Carpena A, et al. Mapping microglia and astrocyte activation in vivo using diffusion MRI. Sci Adv. 2022;8(21):eabq2923.","journal-title":"Sci Adv"},{"issue":"4","key":"1226_CR4","doi-asserted-by":"publisher","first-page":"762","DOI":"10.2337\/db21-0551","volume":"71","author":"Z Hu","year":"2022","unstructured":"Hu Z, Mao X, Chen M, et al. Single-cell transcriptomics reveals novel role of microglia in fibrovascular membrane of proliferative diabetic retinopathy. Diabetes. 2022;71(4):762\u201373.","journal-title":"Diabetes"},{"issue":"8","key":"1226_CR5","doi-asserted-by":"publisher","first-page":"654","DOI":"10.3390\/antiox9080654","volume":"9","author":"S Vishwakarma","year":"2020","unstructured":"Vishwakarma S, Gupta RK, Jakati S, et al. Molecular assessment of epiretinal membrane: activated microglia, oxidative stress and inflammation. Antioxidants. 2020;9(8):654.","journal-title":"Antioxidants"},{"issue":"2","key":"1226_CR6","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1001\/archophthalmol.2007.65","volume":"126","author":"HY Zeng","year":"2008","unstructured":"Zeng HY, Green WR, Tso MOM. Microglial activation in human diabetic retinopathy. Arch Ophthalmol. 2008;126(2):227\u201332.","journal-title":"Arch Ophthalmol."},{"issue":"9","key":"1226_CR7","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1016\/j.bbadis.2016.05.024","volume":"1862","author":"A Ai","year":"2016","unstructured":"Ai A, et al. Modulation of microglia polarization dynamics during diabetic retinopathy in db\/db mice. Biochim et Biophys Acta. 2016;1862(9):1663\u201374.","journal-title":"Biochim et Biophys Acta"},{"issue":"12","key":"1226_CR8","doi-asserted-by":"publisher","first-page":"5043","DOI":"10.1167\/iovs.17-21654","volume":"58","author":"P Hu","year":"2017","unstructured":"Hu P, Hunt NH, Arfuso F, et al. Increased indoleamine 2,3-dioxygenase and quinolinic acid expression in microglia and M\u00fcller cells of diabetic human and rodent retina. Investig Opthalmol Vis Sci. 2017;58(12):5043.","journal-title":"Investig Opthalmol Vis Sci"},{"issue":"1","key":"1226_CR9","doi-asserted-by":"publisher","first-page":"110","DOI":"10.3390\/ijms19010110","volume":"19","author":"C Altmann","year":"2018","unstructured":"Altmann C, Schmidt MHH. The role of microglia in diabetic retinopathy: inflammation, microvasculature defects and neurodegeneration. Int J Mol Sci. 2018;19(1):110.","journal-title":"Int J Mol Sci"},{"key":"1226_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2014\/705783","volume":"2014","author":"JG Grigsby","year":"2014","unstructured":"Grigsby JG, Cardona SM, Pouw CE, et al. The role of microglia in diabetic retinopathy. J Ophthalmol. 2014;2014:1\u201315.","journal-title":"J Ophthalmol"},{"issue":"1","key":"1226_CR11","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.ophtha.2008.09.037","volume":"116","author":"H Funatsu","year":"2009","unstructured":"Funatsu H, Noma H, Mimura T, et al. Association of vitreous inflammatory factors with diabetic Macular Edema. Ophthalmology. 2009;116(1):73\u20139.","journal-title":"Ophthalmology"},{"issue":"5","key":"1226_CR12","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.3390\/cells9051217","volume":"9","author":"CH Alves","year":"2020","unstructured":"Alves CH, Fernandes R, Santiago AR, et al. Microglia contribution to the regulation of the retinal and choroidal vasculature in age-related macular degeneration. Cells. 2020;9(5):1217.","journal-title":"Cells"},{"issue":"4","key":"1226_CR13","doi-asserted-by":"publisher","first-page":"625","DOI":"10.4103\/1673-5374.266910","volume":"15","author":"HR Mendonca","year":"2020","unstructured":"Mendonca HR, Carpi-Santos R, da Costa CK, et al. Neuroinflammation and oxidative stress act in concert to promote neurodegeneration in the diabetic retina and optic nerve: galectin-3 participation. Neural Regen Res. 2020;15(4):625\u201335.","journal-title":"Neural Regen Res"},{"issue":"12","key":"1226_CR14","doi-asserted-by":"publisher","first-page":"e137317","DOI":"10.1172\/jci.insight.137317","volume":"5","author":"A Usui-Ouchi","year":"2020","unstructured":"Usui-Ouchi A, Usui Y, Kurihara T, et al. Retinal microglia are critical for subretinal neovascular formation. JCI Insight. 2020;5(12):e137317.","journal-title":"JCI Insight"},{"key":"1226_CR15","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.bcp.2018.11.011","volume":"159","author":"X Mei","year":"2019","unstructured":"Mei X, Zhang T, Ouyang H, et al. Scutellarin alleviates blood-retina-barrier oxidative stress injury initiated by activated microglia cells during the development of diabetic retinopathy. Biochem Pharmacol. 2019;159:82\u201395.","journal-title":"Biochem Pharmacol"},{"issue":"6005","key":"1226_CR16","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1126\/science.1194637","volume":"330","author":"F Ginhoux","year":"2010","unstructured":"Ginhoux F, Greter M, Leboeuf M, et al. Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science. 2010;330(6005):841\u20135.","journal-title":"Science"},{"issue":"1","key":"1226_CR17","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1146\/annurev-immunol-093019-110159","volume":"39","author":"M Prinz","year":"2021","unstructured":"Prinz M, Masuda T, Wheeler MA, et al. Microglia and central nervous system-associated macrophages-from origin to disease modulation. Annu Rev Immunol. 2021;39(1):251\u201377.","journal-title":"Annu Rev Immunol"},{"issue":"12","key":"1226_CR18","doi-asserted-by":"publisher","first-page":"1538","DOI":"10.1038\/nn2014","volume":"10","author":"B Ajami","year":"2007","unstructured":"Ajami B, Bennett JL, Krieger C, et al. Local self-renewal can sustain CNS microglia maintenance and function throughout adult life. Nat Neurosci. 2007;10(12):1538\u201343.","journal-title":"Nat Neurosci"},{"issue":"6","key":"1226_CR19","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1038\/nn.4547","volume":"20","author":"TL Tay","year":"2017","unstructured":"Tay TL, Mai D, Dautzenberg J, et al. A new fate mapping system reveals context-dependent random or clonal expansion of microglia. Nat Neurosci. 2017;20(6):793\u2013803.","journal-title":"Nat Neurosci"},{"issue":"2","key":"1226_CR20","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1002\/cne.21538","volume":"506","author":"AM Santos","year":"2008","unstructured":"Santos AM, Calvente R, Tassi M, et al. Embryonic and postnatal development of microglial cells in the mouse retina. J Compar Neurol. 2008;506(2):224\u201339.","journal-title":"J Compar Neurol"},{"issue":"9","key":"1226_CR21","doi-asserted-by":"publisher","first-page":"4169","DOI":"10.1167\/iovs.08-2076","volume":"49","author":"JE Lee","year":"2008","unstructured":"Lee JE, Liang KJ, Fariss RN, et al. Ex vivo dynamic imaging of retinal microglia using time-lapse confocal microscopy. Invest Ophthalmol Vis Sci. 2008;49(9):4169\u201376.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5726","key":"1226_CR22","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.1126\/science.1110647","volume":"308","author":"A Nimmerjahn","year":"2005","unstructured":"Nimmerjahn A, Kirchhoff F, Helmchen F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science. 2005;308(5726):1314\u20138.","journal-title":"Science"},{"issue":"9","key":"1226_CR23","doi-asserted-by":"publisher","first-page":"4444","DOI":"10.1167\/iovs.08-3357","volume":"50","author":"KJ Liang","year":"2009","unstructured":"Liang KJ, Lee JE, Wang YD, et al. Regulation of dynamic behavior of retinal microglia by CX3CR1 signaling. Investig Opthalmol Vis Sci. 2009;50(9):4444.","journal-title":"Investig Opthalmol Vis Sci"},{"issue":"1","key":"1226_CR24","doi-asserted-by":"publisher","first-page":"6233","DOI":"10.1038\/s41467-022-33932-3","volume":"13","author":"T Zhou","year":"2022","unstructured":"Zhou T, Li Y, Li X, et al. Microglial debris is cleared by astrocytes via C4b-facilitated phagocytosis and degraded via RUBICON-dependent noncanonical autophagy in mice. Nat Commun. 2022;13(1):6233.","journal-title":"Nat Commun"},{"issue":"2","key":"1226_CR25","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1093\/brain\/awn109","volume":"132","author":"H Neumann","year":"2008","unstructured":"Neumann H, Kotter MR, Franklin RJM. Debris clearance by microglia: an essential link between degeneration and regeneration. Brain. 2008;132(2):288\u201395.","journal-title":"Brain"},{"issue":"13","key":"1226_CR26","doi-asserted-by":"publisher","first-page":"3974","DOI":"10.1523\/JNEUROSCI.4363-08.2009","volume":"29","author":"H Wake","year":"2009","unstructured":"Wake H, Moorhouse AJ, Jinno S, et al. Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals. J Neurosci. 2009;29(13):3974\u201380.","journal-title":"J Neurosci"},{"issue":"4","key":"1226_CR27","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1002\/glia.20462","volume":"55","author":"BD Trapp","year":"2007","unstructured":"Trapp BD, Wujek JR, Criste GA, et al. Evidence for synaptic stripping by cortical microglia. Glia. 2007;55(4):360\u20138.","journal-title":"Glia"},{"issue":"21","key":"1226_CR28","doi-asserted-by":"publisher","first-page":"9228","DOI":"10.1523\/JNEUROSCI.22-21-09228.2002","volume":"22","author":"T Harada","year":"2002","unstructured":"Harada T, Harada C, Kohsaka S, et al. Microglia-M\u00fcller glia cell interactions control neurotrophic factor production during light-induced retinal degeneration. J Neurosci. 2002;22(21):9228\u201336.","journal-title":"J Neurosci"},{"issue":"8","key":"1226_CR29","doi-asserted-by":"publisher","first-page":"2508","DOI":"10.1523\/JNEUROSCI.16-08-02508.1996","volume":"16","author":"S Elkabes","year":"1996","unstructured":"Elkabes S, DiCicco-Bloom E, Black I. Brain microglia\/macrophages express neurotrophins that selectively regulate microglial proliferation and function. J Neurosci. 1996;16(8):2508\u201321.","journal-title":"J Neurosci"},{"issue":"7","key":"1226_CR30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002595","volume":"3","author":"A Roumier","year":"2008","unstructured":"Roumier A, Pascual O, B\u00e9chade C, et al. Prenatal activation of microglia induces delayed impairment of glutamatergic synaptic function. PLoS ONE. 2008;3(7): e2595.","journal-title":"PLoS ONE"},{"issue":"3","key":"1226_CR31","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1002\/glia.20459","volume":"55","author":"A Bessis","year":"2007","unstructured":"Bessis A, B\u00e9chade C, Bernard D, et al. Microglial control of neuronal death and synaptic properties. Glia. 2007;55(3):233\u20138.","journal-title":"Glia"},{"issue":"6","key":"1226_CR32","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1016\/j.devcel.2012.10.027","volume":"23","author":"Y Li","year":"2012","unstructured":"Li Y, Du XF, Liu CS, et al. Reciprocal regulation between resting microglial dynamics and neuronal activity in vivo. Dev Cell. 2012;23(6):1189\u2013202.","journal-title":"Dev Cell"},{"issue":"5","key":"1226_CR33","doi-asserted-by":"publisher","first-page":"976","DOI":"10.4103\/1673-5374.355743","volume":"18","author":"L Tang","year":"2023","unstructured":"Tang L, Xu GT, Zhang JF. Inflammation in diabetic retinopathy: possible roles in pathogenesis and potential implications for therapy. Neural Regen Res. 2023;18(5):976\u201382.","journal-title":"Neural Regen Res"},{"issue":"1","key":"1226_CR34","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1093\/stmcls\/sxad078","volume":"42","author":"Y Chen","year":"2024","unstructured":"Chen Y, Yao G, Tong J, et al. MSC-derived small extracellular vesicles alleviate diabetic retinopathy by delivering miR-22-3p to inhibit NLRP3 inflammasome activation. Stem Cells (Dayton, Ohio). 2024;42(1):64\u201375.","journal-title":"Stem Cells (Dayton, Ohio)"},{"issue":"11","key":"1226_CR35","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1016\/j.tins.2020.08.008","volume":"43","author":"LP Bernier","year":"2020","unstructured":"Bernier LP, York EM, MacVicar BA. Immunometabolism in the brain: how metabolism shapes microglial function. Trends Neurosci. 2020;43(11):854\u201369.","journal-title":"Trends Neurosci"},{"issue":"4","key":"1226_CR36","first-page":"423","volume":"13","author":"L Cai","year":"2024","unstructured":"Cai L, Xia M, Zhang F. Redox regulation of immunometabolism in microglia underpinning diabetic retinopathy. Antioxidants (Basel, Switzerland). 2024;13(4):423.","journal-title":"Antioxidants (Basel, Switzerland)"},{"issue":"4","key":"1226_CR37","doi-asserted-by":"publisher","first-page":"1563","DOI":"10.1167\/iovs.15-18395","volume":"57","author":"AB Simmons","year":"2016","unstructured":"Simmons AB, Merrill MM, Reed JC, et al. Defective angiogenesis and intraretinal bleeding in mouse models with disrupted inner retinal lamination. Invest Ophthalmol Vis Sci. 2016;57(4):1563\u201377.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"1226_CR38","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/s10456-024-09911-1","volume":"27","author":"A Hu","year":"2024","unstructured":"Hu A, Schmidt MH, Heinig N. Microglia in retinal angiogenesis and diabetic retinopathy. Angiogenesis. 2024;27(3):311\u201331.","journal-title":"Angiogenesis"},{"issue":"12","key":"1226_CR39","doi-asserted-by":"publisher","first-page":"3467","DOI":"10.1111\/jcmm.13256","volume":"21","author":"J Yin","year":"2017","unstructured":"Yin J, Xu WQ, Ye MX, et al. Up-regulated basigin-2 in microglia induced by hypoxia promotes retinal angiogenesis. J Cell Mol Med. 2017;21(12):3467\u201380.","journal-title":"J Cell Mol Med"},{"key":"1226_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2019.107902","volume":"191","author":"I Rana","year":"2020","unstructured":"Rana I, Suphapimol V, Jerome JR, et al. Angiotensin II and aldosterone activate retinal microglia. Exp Eye Res. 2020;191: 107902.","journal-title":"Exp Eye Res"},{"issue":"2","key":"1226_CR41","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1038\/s44321-024-00025-1","volume":"16","author":"X Chen","year":"2024","unstructured":"Chen X, Wang Y, Wang JN, et al. Lactylation-driven FTO targets CDK2 to aggravate microvascular anomalies in diabetic retinopathy. EMBO Mol Med. 2024;16(2):294\u2013318.","journal-title":"EMBO Mol Med"},{"issue":"8","key":"1226_CR42","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0030310","volume":"3","author":"RS Apte","year":"2006","unstructured":"Apte RS, Richter J, Herndon J, et al. macrophages inhibit neovascularization in a murine model of age-related macular degeneration. PLoS Med. 2006;3(8): e310.","journal-title":"PLoS Med"},{"issue":"1","key":"1226_CR43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015846","volume":"6","author":"SF Rymo","year":"2011","unstructured":"Rymo SF, Gerhardt H, Wolfhagen Sand F, et al. A two-way communication between microglial cells and angiogenic sprouts regulates angiogenesis in aortic ring cultures. PLoS ONE. 2011;6(1): e15846.","journal-title":"PLoS ONE"},{"issue":"10","key":"1226_CR44","first-page":"106","volume":"19","author":"MH Berrocal","year":"2019","unstructured":"Berrocal MH, Acaba LA, Chenworth ML. Surgical innovations in the treatment of diabetic Macular Edema and diabetic retinopathy. Curr DiabRep. 2019;19(10):106.","journal-title":"Curr DiabRep"},{"issue":"9735","key":"1226_CR45","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/S0140-6736(09)62124-3","volume":"376","author":"N Cheung","year":"2010","unstructured":"Cheung N, Mitchell P, Wong TY. Diabetic retinopathy. Lancet (London, England). 2010;376(9735):124\u201336.","journal-title":"Lancet (London, England)"},{"key":"1226_CR46","doi-asserted-by":"publisher","first-page":"1276225","DOI":"10.3389\/fendo.2023.1276225","volume":"14","author":"Y Yao","year":"2023","unstructured":"Yao Y, Li J, Zhou Y, et al. Macrophage\/microglia polarization for the treatment of diabetic retinopathy. Front Endocrinol. 2023;14:1276225.","journal-title":"Front Endocrinol"},{"issue":"3","key":"1226_CR47","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1097\/ICU.0000000000000760","volume":"32","author":"MH Berrocal","year":"2021","unstructured":"Berrocal MH, Acaba-Berrocal L. Early pars plana vitrectomy for proliferative diabetic retinopathy: update and review of current literature. Curr Opin Ophthalmol. 2021;32(3):203\u20138.","journal-title":"Curr Opin Ophthalmol"},{"issue":"9","key":"1226_CR48","first-page":"35","volume":"21","author":"LA Everett","year":"2021","unstructured":"Everett LA, Paulus YM. Laser therapy in the treatment of diabetic retinopathy and diabetic Macular Edema. Curr DiabRep. 2021;21(9):35.","journal-title":"Curr DiabRep"},{"issue":"3\u20134","key":"1226_CR49","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1007\/s00424-017-1947-5","volume":"469","author":"HR Chinnery","year":"2017","unstructured":"Chinnery HR, McMenamin PG, Dando SJ. Macrophage physiology in the eye. Pflugers Arch. 2017;469(3\u20134):501\u201315.","journal-title":"Pflugers Arch"},{"issue":"5","key":"1226_CR50","doi-asserted-by":"publisher","first-page":"45","DOI":"10.3892\/ijmm.2024.5369","volume":"53","author":"H Li","year":"2024","unstructured":"Li H, Li B, Zheng Y. Role of microglia\/macrophage polarisation in intraocular diseases (Review). Int J Mol Med. 2024;53(5):45.","journal-title":"Int J Mol Med"},{"issue":"11","key":"1226_CR51","doi-asserted-by":"publisher","first-page":"2644","DOI":"10.1002\/glia.24063","volume":"69","author":"T Zhou","year":"2021","unstructured":"Zhou T, Liu Y, Yang Z, et al. IL-17 signaling induces iNOS+ microglia activation in retinal vascular diseases. Glia. 2021;69(11):2644\u201357.","journal-title":"Glia"},{"key":"1226_CR52","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.3389\/fphar.2020.01126","volume":"11","author":"L Zhou","year":"2020","unstructured":"Zhou L, Wang D, Qiu X, et al. DHZCP modulates microglial M1\/M2 polarization via the p38 and TLR4\/NF-\u03baB signaling pathways in LPS-stimulated microglial cells. Front Pharmacol. 2020;11:1126.","journal-title":"Front Pharmacol"},{"issue":"9","key":"1226_CR53","doi-asserted-by":"publisher","first-page":"6425","DOI":"10.1002\/jcp.26429","volume":"233","author":"A Shapouri-Moghaddam","year":"2018","unstructured":"Shapouri-Moghaddam A, Mohammadian S, Vazini H, et al. Macrophage plasticity, polarization, and function in health and disease. J Cell Physiol. 2018;233(9):6425\u201340.","journal-title":"J Cell Physiol"},{"key":"1226_CR54","doi-asserted-by":"publisher","first-page":"01298","DOI":"10.3389\/fphar.2020.01298","volume":"11","author":"P Geng","year":"2020","unstructured":"Geng P, Zhu H, Zhou W, et al. baicalin inhibits influenza A virus infection via promotion of M1 macrophage polarization. Front Pharmacol. 2020;11:01298.","journal-title":"Front Pharmacol"},{"issue":"7","key":"1226_CR55","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1111\/imcb.12455","volume":"99","author":"X Wang","year":"2021","unstructured":"Wang X, Li H, Chen S, et al. P300\/CBP-associated factor (PCAF) attenuated M1 macrophage inflammatory responses possibly through KLF2 and KLF4. Immunol Cell Biol. 2021;99(7):724\u201336.","journal-title":"Immunol Cell Biol"},{"issue":"1","key":"1226_CR56","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s40425-017-0264-z","volume":"5","author":"MC Topf","year":"2017","unstructured":"Topf MC, Tuluc M, Harshyne LA, et al. Macrophage type 2 differentiation in a patient with laryngeal squamous cell carcinoma and metastatic prostate adenocarcinoma to the cervical lymph nodes. J Immunother Cancer. 2017;5(1):60.","journal-title":"J Immunother Cancer"},{"issue":"6","key":"1226_CR57","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1007\/s00592-017-0984-z","volume":"54","author":"AI Arroba","year":"2017","unstructured":"Arroba AI, Valverde \u00c1M. Modulation of microglia in the retina: new insights into diabetic retinopathy. Acta Diabetol. 2017;54(6):527\u201333.","journal-title":"Acta Diabetol"},{"issue":"6","key":"1226_CR58","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1007\/s13577-021-00580-6","volume":"34","author":"H Wu","year":"2021","unstructured":"Wu H, Wang M, Li X, et al. The metaflammatory and immunometabolic role of macrophages and microglia in diabetic retinopathy. Hum Cell. 2021;34(6):1617\u201328.","journal-title":"Hum Cell"},{"issue":"3","key":"1226_CR59","first-page":"i109145","volume":"27","author":"S Ben","year":"2024","unstructured":"Ben S, Ma Y, Bai Y, et al. Microglia-endothelial cross-talk regulates diabetes-induced retinal vascular dysfunction through remodeling inflammatory microenvironment. Science. 2024;27(3):i109145.","journal-title":"Science"},{"issue":"18","key":"1226_CR60","doi-asserted-by":"publisher","first-page":"10896","DOI":"10.1073\/pnas.95.18.10896","volume":"95","author":"JK Harrison","year":"1998","unstructured":"Harrison JK, Jiang Y, Chen S, et al. Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia. Proc Natl Acad Sci USA. 1998;95(18):10896\u2013901.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"1226_CR61","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s12974-023-02983-8","volume":"21","author":"D Rodriguez","year":"2024","unstructured":"Rodriguez D, Church KA, Pietramale AN, et al. Fractalkine isoforms differentially regulate microglia-mediated inflammation and enhance visual function in the diabetic retina. J Neuroinflammation. 2024;21(1):42.","journal-title":"J Neuroinflammation"},{"issue":"11","key":"1226_CR62","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1007\/s00109-016-1433-0","volume":"94","author":"E Beli","year":"2016","unstructured":"Beli E, Dominguez JM, Hu P, et al. CX3CR1 deficiency accelerates the development of retinopathy in a rodent model of type 1 diabetes. J Mol Med (Berl). 2016;94(11):1255\u201365.","journal-title":"J Mol Med (Berl)"},{"issue":"4","key":"1226_CR63","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1111\/jcmm.17179","volume":"26","author":"M Jiang","year":"2022","unstructured":"Jiang M, Xie H, Zhang C, et al. Enhancing fractalkine\/CX3CR1 signalling pathway can reduce neuroinflammation by attenuating microglia activation in experimental diabetic retinopathy. J Cell Mol Med. 2022;26(4):1229\u201344.","journal-title":"J Cell Mol Med"},{"issue":"4","key":"1226_CR64","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.1007\/s10753-024-01991-x","volume":"47","author":"Q Hu","year":"2024","unstructured":"Hu Q, Zhang X, Peng H, et al. A new modulator of neuroinflammation in diabetic retinopathy: USP25. Inflammation. 2024;47(4):1520\u201335.","journal-title":"Inflammation"},{"issue":"1","key":"1226_CR65","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1093\/brain\/awt323","volume":"137","author":"I Lastres-Becker","year":"2014","unstructured":"Lastres-Becker I, Innamorato NG, Jaworski T, et al. Fractalkine activates NRF2\/NFE2L2 and heme oxygenase 1 to restrain tauopathy-induced microgliosis. Brain. 2014;137(1):78\u201391.","journal-title":"Brain."},{"issue":"6","key":"1226_CR66","doi-asserted-by":"publisher","first-page":"904","DOI":"10.3390\/biom10060904","volume":"10","author":"\u00c1 Cores","year":"2020","unstructured":"Cores \u00c1, Piquero M, Villacampa M, et al. NRF2 regulation processes as a source of potential drug targets against neurodegenerative diseases. Biomolecules. 2020;10(6):904.","journal-title":"Biomolecules"},{"key":"1226_CR67","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2018.11.017","volume":"21","author":"F Sivandzade","year":"2019","unstructured":"Sivandzade F, Prasad S, Bhalerao A, et al. NRF2 and NF-\u049bB interplay in cerebrovascular and neurodegenerative disorders: Molecular mechanisms and possible therapeutic approaches. Redox Biol. 2019;21: 101059.","journal-title":"Redox Biol"},{"key":"1226_CR68","doi-asserted-by":"publisher","first-page":"11624","DOI":"10.1038\/ncomms11624","volume":"7","author":"EH Kobayashi","year":"2016","unstructured":"Kobayashi EH, Suzuki T, Funayama R, et al. Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription. Nat Commun. 2016;7:11624.","journal-title":"Nat Commun"},{"key":"1226_CR69","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.pharmthera.2015.11.003","volume":"157","author":"I Buendia","year":"2016","unstructured":"Buendia I, Michalska P, Navarro E, et al. Nrf2-ARE pathway: an emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases. Pharmacol Ther. 2016;157:84\u2013104.","journal-title":"Pharmacol Ther"},{"key":"1226_CR70","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101118","volume":"22","author":"S Castro-S\u00e1nchez","year":"2019","unstructured":"Castro-S\u00e1nchez S, Garc\u00eda-Yag\u00fce \u00c1J, K\u00fcgler S, et al. CX3CR1-deficient microglia shows impaired signalling of the transcription factor NRF2: implications in tauopathies. Redox Biol. 2019;22: 101118.","journal-title":"Redox Biol"},{"issue":"1","key":"1226_CR71","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1186\/s12938-023-01194-9","volume":"22","author":"Z Lu","year":"2023","unstructured":"Lu Z, Fan B, Li Y, et al. RAGE plays key role in diabetic retinopathy: a review. Biomed Eng Online. 2023;22(1):128.","journal-title":"Biomed Eng Online"},{"issue":"3","key":"1226_CR72","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.cmet.2018.08.014","volume":"28","author":"J Chaudhuri","year":"2018","unstructured":"Chaudhuri J, Bains Y, Guha S, et al. The role of advanced glycation end products in aging and metabolic diseases: bridging association and causality. Cell Metab. 2018;28(3):337\u201352.","journal-title":"Cell Metab"},{"issue":"3","key":"1226_CR73","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1172\/JCI119180","volume":"99","author":"ED Schleicher","year":"1997","unstructured":"Schleicher ED, Wagner E, Nerlich AG. Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging. J Clin Investig. 1997;99(3):457\u201368.","journal-title":"J Clin Investig."},{"issue":"12","key":"1226_CR74","doi-asserted-by":"publisher","first-page":"3631","DOI":"10.1016\/j.bbadis.2018.08.036","volume":"1864","author":"S Rowan","year":"2018","unstructured":"Rowan S, Bejarano E, Taylor A. Mechanistic targeting of advanced glycation end-products in age-related diseases. Biochim et Biophys Acta Mol Basis Dis. 2018;1864(12):3631\u201343.","journal-title":"Biochim et Biophys Acta Mol Basis Dis."},{"issue":"7","key":"1226_CR75","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1016\/S0092-8674(00)80801-6","volume":"97","author":"MA Hofmann","year":"1999","unstructured":"Hofmann MA, Drury S, Fu C, et al. RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100\/calgranulin polypeptides. Cell. 1999;97(7):889\u2013901.","journal-title":"Cell"},{"issue":"1\u20133","key":"1226_CR76","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/S0014-5793(03)00846-9","volume":"550","author":"K Ishihara","year":"2003","unstructured":"Ishihara K, Tsutsumi K, Kawane S, et al. The receptor for advanced glycation end-products (RAGE) directly binds to ERK by a D-domain-like docking site. FEBS Lett. 2003;550(1\u20133):107\u201313.","journal-title":"FEBS Lett"},{"key":"1226_CR77","doi-asserted-by":"publisher","first-page":"1037186","DOI":"10.3389\/fnut.2022.1037186","volume":"9","author":"Q Kang","year":"2022","unstructured":"Kang Q, Dai H, Jiang S, et al. Advanced glycation end products in diabetic retinopathy and phytochemical therapy. Front Nutr. 2022;9:1037186.","journal-title":"Front Nutr"},{"issue":"1","key":"1226_CR78","doi-asserted-by":"publisher","first-page":"83","DOI":"10.2174\/157016306776637555","volume":"3","author":"SI Yamagishi","year":"2006","unstructured":"Yamagishi SI, Nakamura K, Matsui T. Advanced glycation end products (AGEs) and their receptor (RAGE) system in diabetic retinopathy. Curr Drug Dis Technol. 2006;3(1):83\u20138.","journal-title":"Curr Drug Dis Technol."},{"issue":"1","key":"1226_CR79","doi-asserted-by":"publisher","first-page":"9702820","DOI":"10.1155\/2017\/9702820","volume":"2017","author":"C Li","year":"2017","unstructured":"Li C, Miao X, Li F, et al. Oxidative stress-related mechanisms and antioxidant therapy in diabetic retinopathy. Oxid Med Cell Longev. 2017;2017(1):9702820.","journal-title":"Oxid Med Cell Longev"},{"key":"1226_CR80","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101799","volume":"37","author":"Q Kang","year":"2020","unstructured":"Kang Q, Yang C. Oxidative stress and diabetic retinopathy: Molecular mechanisms, pathogenetic role and therapeutic implications. Redox Biol. 2020;37: 101799.","journal-title":"Redox Biol"},{"key":"1226_CR81","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/3085756","author":"NT Moldogazieva","year":"2019","unstructured":"Moldogazieva NT, Mokhosoev IM, Melnikova TI, et al. Oxidative stress and advanced lipoxidation and glycation end products (ALEs and AGEs) in aging and age-related diseases. Oxid Med Cell Longev. 2019. https:\/\/doi.org\/10.1155\/2019\/3085756.","journal-title":"Oxid Med Cell Longev"},{"issue":"1","key":"1226_CR82","doi-asserted-by":"publisher","first-page":"249","DOI":"10.2337\/db09-0801","volume":"59","author":"D Yao","year":"2010","unstructured":"Yao D, Brownlee M. Hyperglycemia-induced reactive oxygen species increase expression of the Receptor for Advanced Glycation End Products (RAGE) and RAGE ligands. Diabetes. 2010;59(1):249\u201355.","journal-title":"Diabetes"},{"issue":"3","key":"1226_CR83","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1007\/s00401-015-1529-6","volume":"131","author":"S Brandenburg","year":"2016","unstructured":"Brandenburg S, M\u00fcller A, Turkowski K, et al. Resident microglia rather than peripheral macrophages promote vascularization in brain tumors and are source of alternative pro-angiogenic factors. Acta Neuropathol. 2016;131(3):365\u201378.","journal-title":"Acta Neuropathol"},{"issue":"11","key":"1226_CR84","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1038\/nn1997","volume":"10","author":"UK Hanisch","year":"2007","unstructured":"Hanisch UK, Kettenmann H. Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Nat Neurosci. 2007;10(11):1387\u201394.","journal-title":"Nat Neurosci"},{"issue":"6","key":"1226_CR85","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.7150\/ijbs.79784","volume":"19","author":"X Chen","year":"2023","unstructured":"Chen X, Wang X, Cui Z, et al. M1 microglia-derived exosomes promote activation of resting microglia and amplifies proangiogenic effects through Irf1\/miR-155-5p\/Socs1 axis in the retina. Int J Biol Sci. 2023;19(6):1791\u2013812.","journal-title":"Int J Biol Sci"},{"issue":"5","key":"1226_CR86","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2024.101522","volume":"5","author":"X Guan","year":"2024","unstructured":"Guan X, Zhu S, Song J, et al. Microglial CMPK2 promotes neuroinflammation and brain injury after ischemic stroke. Cell Rep Med. 2024;5(5): 101522.","journal-title":"Cell Rep Med"},{"issue":"1","key":"1226_CR87","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1111\/ceo.14190","volume":"51","author":"EL Fletcher","year":"2023","unstructured":"Fletcher EL, Dixon MA, Mills SA, et al. Anomalies in neurovascular coupling during early diabetes: a review. Clin Exper Ophthalmol. 2023;51(1):81\u201391.","journal-title":"Clin Exper Ophthalmol"},{"issue":"9647","key":"1226_CR88","doi-asserted-by":"publisher","first-page":"1394","DOI":"10.1016\/S0140-6736(08)61412-9","volume":"372","author":"N Chaturvedi","year":"2008","unstructured":"Chaturvedi N, Porta M, Klein R, et al. Effect of candesartan on prevention (DIRECT-Prevent 1) and progression (DIRECT-Protect 1) of retinopathy in type 1 diabetes: randomised, placebo-controlled trials. Lancet (London, England). 2008;372(9647):1394\u2013402.","journal-title":"Lancet (London, England)"},{"issue":"9647","key":"1226_CR89","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1016\/S0140-6736(08)61411-7","volume":"372","author":"AK Sj\u00f8lie","year":"2008","unstructured":"Sj\u00f8lie AK, Klein R, Porta M, et al. Effect of candesartan on progression and regression of retinopathy in type 2 diabetes (DIRECT-Protect 2): a randomised placebo-controlled trial. The Lancet. 2008;372(9647):1385\u201393.","journal-title":"The Lancet"},{"issue":"4","key":"1226_CR90","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.preteyeres.2010.03.003","volume":"29","author":"EL Fletcher","year":"2010","unstructured":"Fletcher EL, Phipps JA, Ward MM, et al. The renin-angiotensin system in retinal health and disease: Its influence on neurons, glia and the vasculature. Prog Retin Eye Res. 2010;29(4):284\u2013311.","journal-title":"Prog Retin Eye Res"},{"issue":"3","key":"1226_CR91","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.90905","volume":"2","author":"S Ogura","year":"2024","unstructured":"Ogura S, Kurata K, Hattori Y, et al. Sustained inflammation after pericyte depletion induces irreversible blood-retina barrier breakdown. JCI Insight. 2024;2(3): e90905.","journal-title":"JCI Insight"},{"key":"1226_CR92","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.674189","volume":"12","author":"CC Hsiao","year":"2021","unstructured":"Hsiao CC, Sankowski R, Prinz M, et al. GPCRomics of homeostatic and disease-associated human microglia. Front Immunol. 2021;12: 674189.","journal-title":"Front Immunol"},{"issue":"3","key":"1226_CR93","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.3390\/ijms25031727","volume":"25","author":"D Rodriguez","year":"2024","unstructured":"Rodriguez D, Church KA, Smith CT, et al. Therapeutic delivery of soluble fractalkine ameliorates vascular dysfunction in the diabetic retina. Int J Mol Sci. 2024;25(3):1727.","journal-title":"Int J Mol Sci"},{"issue":"12","key":"1226_CR94","doi-asserted-by":"publisher","first-page":"3436","DOI":"10.1182\/blood-2010-12-327015","volume":"118","author":"HH Outtz","year":"2011","unstructured":"Outtz HH, Tattersall IW, Kofler NM, et al. Notch1 controls macrophage recruitment and notch signaling is activated at sites of endothelial cell anastomosis during retinal angiogenesis in mice. Blood. 2011;118(12):3436\u20139.","journal-title":"Blood"},{"issue":"2","key":"1226_CR95","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1002\/glia.23543","volume":"67","author":"S Murinello","year":"2019","unstructured":"Murinello S, Usui Y, Sakimoto S, et al. miR-30a-5p inhibition promotes interaction of Fas+ endothelial cells and FasL+ microglia to decrease pathological neovascularization and promote physiological angiogenesis. Glia. 2019;67(2):332\u201344.","journal-title":"Glia"},{"issue":"Pt A","key":"1226_CR96","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.116843","volume":"318","author":"Y Cai","year":"2024","unstructured":"Cai Y, Tu H, Wu C, et al. Therapeutic potential of elema-1,3,7(11),8-tetraen-8,12-lactam from Curcuma wenyujin on diabetic retinopathy via anti-inflammatory and anti-angiogenic pathways. J Ethnopharmacol. 2024;318(Pt A): 116843.","journal-title":"J Ethnopharmacol"},{"issue":"5","key":"1226_CR97","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.preteyeres.2011.05.002","volume":"30","author":"J Tang","year":"2011","unstructured":"Tang J, Kern TS. Inflammation in diabetic retinopathy. Prog Retin Eye Res. 2011;30(5):343\u201358.","journal-title":"Prog Retin Eye Res"},{"issue":"5","key":"1226_CR98","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1007\/s00125-014-3194-z","volume":"57","author":"RA Kowluru","year":"2014","unstructured":"Kowluru RA, Kowluru A, Veluthakal R, et al. TIAM1-RAC1 signalling axis-mediated activation of NADPH oxidase-2 initiates mitochondrial damage in the development of diabetic retinopathy. Diabetologia. 2014;57(5):1047\u201356.","journal-title":"Diabetologia"},{"issue":"5","key":"1226_CR99","first-page":"783","volume":"10","author":"RA Kowluru","year":"2021","unstructured":"Kowluru RA. Diabetic retinopathy and NADPH oxidase-2: a sweet slippery road. Antioxidants (Basel, Switzerland). 2021;10(5):783.","journal-title":"Antioxidants (Basel, Switzerland)"},{"issue":"12","key":"1226_CR100","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1111\/bph.13425","volume":"174","author":"J Haslund-Vinding","year":"2017","unstructured":"Haslund-Vinding J, McBean G, Jaquet V, et al. NADPH oxidases in oxidant production by microglia: activating receptors, pharmacology and association with disease. Br J Pharmacol. 2017;174(12):1733\u201349.","journal-title":"Br J Pharmacol"},{"issue":"3","key":"1226_CR101","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1007\/s13105-015-0416-x","volume":"71","author":"G Mohammad","year":"2015","unstructured":"Mohammad G, Alam K, Nawaz MI, et al. Mutual enhancement between high-mobility group box-1 and NADPH oxidase-derived reactive oxygen species mediates diabetes-induced upregulation of retinal apoptotic markers. J Physiol Biochem. 2015;71(3):359\u201372.","journal-title":"J Physiol Biochem"},{"issue":"2","key":"1226_CR102","first-page":"43","volume":"6","author":"M Rojas","year":"2017","unstructured":"Rojas M, Lemtalsi T, Toque HA, et al. NOX2-induced activation of arginase and diabetes-induced retinal endothelial cell senescence. Antioxidants (Basel, Switzerland). 2017;6(2):43.","journal-title":"Antioxidants (Basel, Switzerland)"},{"issue":"12","key":"1226_CR103","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0084357","volume":"8","author":"M Rojas","year":"2013","unstructured":"Rojas M, Zhang W, Xu Z, et al. Requirement of NOX2 expression in both retina and bone marrow for diabetes-induced retinal vascular injury. PLoS ONE. 2013;8(12): e84357.","journal-title":"PLoS ONE"},{"key":"1226_CR104","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.freeradbiomed.2013.07.036","volume":"66","author":"J Lu","year":"2014","unstructured":"Lu J, Holmgren A. The thioredoxin antioxidant system. Free Radical Biol Med. 2014;66:75\u201387.","journal-title":"Free Radical Biol Med"},{"issue":"9","key":"1226_CR105","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1016\/j.tips.2017.06.001","volume":"38","author":"J Zhang","year":"2017","unstructured":"Zhang J, Li X, Han X, et al. Targeting the thioredoxin system for cancer therapy. Trends Pharmacol Sci. 2017;38(9):794\u2013808.","journal-title":"Trends Pharmacol Sci"},{"issue":"12","key":"1226_CR106","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1111\/bph.13426","volume":"174","author":"F Vilhardt","year":"2017","unstructured":"Vilhardt F, Haslund-Vinding J, Jaquet V, et al. Microglia antioxidant systems and redox signalling. Br J Pharmacol. 2017;174(12):1719\u201332.","journal-title":"Br J Pharmacol"},{"issue":"1","key":"1226_CR107","doi-asserted-by":"publisher","first-page":"89","DOI":"10.3390\/antiox10010089","volume":"10","author":"A \u00c1lvarez-Barrios","year":"2021","unstructured":"\u00c1lvarez-Barrios A, \u00c1lvarez L, Garc\u00eda M, et al. Antioxidant defenses in the human eye: a focus on metallothioneins. Antioxidants. 2021;10(1):89.","journal-title":"Antioxidants"},{"key":"1226_CR108","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102297","volume":"52","author":"G Wang","year":"2022","unstructured":"Wang G, Li X, Li N, et al. Icariin alleviates uveitis by targeting peroxiredoxin 3 to modulate retinal microglia M1\/M2 phenotypic polarization. Redox Biol. 2022;52: 102297.","journal-title":"Redox Biol"},{"issue":"5","key":"1226_CR109","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.1159\/000494787","volume":"50","author":"X Ren","year":"2018","unstructured":"Ren X, Wang NN, Qi H, et al. Up-regulation thioredoxin inhibits advanced glycation end products-induced neurodegeneration. Cell Physiol Biochem. 2018;50(5):1673\u201386.","journal-title":"Cell Physiol Biochem"},{"key":"1226_CR110","doi-asserted-by":"publisher","first-page":"1896041","DOI":"10.1155\/2019\/1896041","volume":"2019","author":"L Xu","year":"2019","unstructured":"Xu L, Lin X, Guan M, et al. Verapamil attenuated prediabetic neuropathy in high-fat diet-fed mice through inhibiting TXNIP-mediated apoptosis and inflammation. Oxid Med Cell Longev. 2019;2019:1896041.","journal-title":"Oxid Med Cell Longev"},{"key":"1226_CR111","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2022\/1497813","volume":"2022","author":"Q Yang","year":"2022","unstructured":"Yang Q, Cai W, Jin H, et al. Downregulation of inflammatory response via Nrf2\/Trx1\/TXNIP axis in oxidative stress-induced ARPE-19 cells and mouse model of AMD. Oxid Med Cell Longev. 2022;2022:1\u201319.","journal-title":"Oxid Med Cell Longev"},{"key":"1226_CR112","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2021.174061","volume":"901","author":"LD Eissa","year":"2021","unstructured":"Eissa LD, Ghobashy WA, El-Azab MF. Inhibition of thioredoxin-interacting protein and inflammasome assembly using verapamil mitigates diabetic retinopathy and pancreatic injury. Eur J Pharmacol. 2021;901: 174061.","journal-title":"Eur J Pharmacol"},{"issue":"6","key":"1226_CR113","doi-asserted-by":"publisher","first-page":"3997","DOI":"10.1074\/jbc.M109.034421","volume":"285","author":"G Saxena","year":"2010","unstructured":"Saxena G, Chen J, Shalev A. Intracellular shuttling and mitochondrial function of thioredoxin-interacting protein. J Biol Chem. 2010;285(6):3997\u20134005.","journal-title":"J Biol Chem"},{"key":"1226_CR114","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118988","volume":"267","author":"H Ao","year":"2021","unstructured":"Ao H, Li H, Zhao X, et al. TXNIP positively regulates the autophagy and apoptosis in the rat m\u00fcller cell of diabetic retinopathy. Life Sci. 2021;267: 118988.","journal-title":"Life Sci"},{"issue":"12","key":"1226_CR115","doi-asserted-by":"publisher","first-page":"2738","DOI":"10.3390\/nu15122738","volume":"15","author":"M Iwasa","year":"2023","unstructured":"Iwasa M, Kato H, Iwashita K, et al. Taxifolin suppresses inflammatory responses of high-glucose-stimulated mouse microglia by attenuating the TXNIP-NLRP3 axis. Nutrients. 2023;15(12):2738.","journal-title":"Nutrients"},{"issue":"6","key":"1226_CR116","doi-asserted-by":"publisher","first-page":"3941","DOI":"10.1167\/iovs.13-11598","volume":"54","author":"Q Zhong","year":"2013","unstructured":"Zhong Q, Mishra M, Kowluru RA. Transcription factor Nrf2-mediated antioxidant defense system in the development of diabetic retinopathy. Invest Ophthalmol Vis Sci. 2013;54(6):3941\u20138.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"1226_CR117","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1152\/physrev.00023.2017","volume":"98","author":"M Yamamoto","year":"2018","unstructured":"Yamamoto M, Kensler TW, Motohashi H. The KEAP1\u2013NRF2 system: a thiol-based sensor-effector apparatus for maintaining redox homeostasis. Physiol Rev. 2018;98(3):1169\u2013203.","journal-title":"Physiol Rev"},{"issue":"13","key":"1226_CR118","doi-asserted-by":"publisher","first-page":"e00099","DOI":"10.1128\/MCB.00099-20","volume":"40","author":"L Baird","year":"2020","unstructured":"Baird L, Yamamoto M. The molecular mechanisms regulating the KEAP1\u2013NRF2 pathway. Mol Cell Biol. 2020;40(13):e00099-e120.","journal-title":"Mol Cell Biol"},{"issue":"6","key":"1226_CR119","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1038\/ki.2012.439","volume":"83","author":"S Ruiz","year":"2013","unstructured":"Ruiz S, Pergola PE, Zager RA, et al. Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease. Kidney Int. 2013;83(6):1029\u201341.","journal-title":"Kidney Int"},{"issue":"45","key":"1226_CR120","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2308214120","volume":"120","author":"CW Pfeifer","year":"2024","unstructured":"Pfeifer CW, Walsh JT, Santeford A, et al. Dysregulated CD200-CD200R signaling in early diabetes modulates microglia-mediated retinopathy. Proc Natl Acad Sci USA. 2024;120(45): e2308214120.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1226_CR121","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2022.155293","volume":"136","author":"Y Wen","year":"2022","unstructured":"Wen Y, Chen X, Feng H, et al. Kdm6a deficiency in microglia\/macrophages epigenetically silences Lcn2 expression and reduces photoreceptor dysfunction in diabetic retinopathy. Metab Clin Exp. 2022;136: 155293.","journal-title":"Metab Clin Exp."},{"key":"1226_CR122","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106135","volume":"178","author":"YX Xu","year":"2022","unstructured":"Xu YX, Pu SD, Li X, et al. Exosomal ncRNAs: novel therapeutic target and biomarker for diabetic complications. Pharmacol Res. 2022;178: 106135.","journal-title":"Pharmacol Res"},{"issue":"7","key":"1226_CR123","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.4103\/1673-5374.361536","volume":"18","author":"DD Liu","year":"2023","unstructured":"Liu DD, Zhang CY, Zhang JT, et al. Epigenetic modifications and metabolic memory in diabetic retinopathy: beyond the surface. Neural Regen Res. 2023;18(7):1441\u20139.","journal-title":"Neural Regen Res"},{"issue":"1","key":"1226_CR124","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/s12951-024-02330-w","volume":"22","author":"X Wang","year":"2024","unstructured":"Wang X, Xu C, Bian C, et al. M2 microglia-derived exosomes promote vascular remodeling in diabetic retinopathy. J Nanobiotechnol. 2024;22(1):56.","journal-title":"J Nanobiotechnol"},{"issue":"2","key":"1226_CR125","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1002\/glia.1106","volume":"36","author":"F Aloisi","year":"2001","unstructured":"Aloisi F. Immune function of microglia. Glia. 2001;36(2):165\u201379.","journal-title":"Glia"},{"issue":"6048","key":"1226_CR126","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1126\/science.1202529","volume":"333","author":"RC Paolicelli","year":"2011","unstructured":"Paolicelli RC, Bolasco G, Pagani F, et al. Synaptic pruning by microglia is necessary for normal brain development. Science. 2011;333(6048):1456\u20138.","journal-title":"Science"},{"issue":"4","key":"1226_CR127","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.stem.2010.08.014","volume":"7","author":"A Sierra","year":"2010","unstructured":"Sierra A, Encinas JM, Deudero JJP, et al. Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosis. Cell Stem Cell. 2010;7(4):483\u201395.","journal-title":"Cell Stem Cell"},{"issue":"22","key":"1226_CR128","doi-asserted-by":"publisher","first-page":"3292","DOI":"10.15252\/embj.201696056","volume":"36","author":"A Wlodarczyk","year":"2017","unstructured":"Wlodarczyk A, Holtman IR, Krueger M, et al. A novel microglial subset plays a key role in myelinogenesis in developing brain. EMBO J. 2017;36(22):3292\u2013308.","journal-title":"EMBO J"},{"issue":"5","key":"1226_CR129","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.2337\/diabetes.54.5.1559","volume":"54","author":"JK Krady","year":"2005","unstructured":"Krady JK, Basu A, Allen CM, et al. Minocycline reduces proinflammatory cytokine expression, microglial activation, and caspase-3 activation in a rodent model of diabetic retinopathy. Diabetes. 2005;54(5):1559\u201365.","journal-title":"Diabetes"},{"issue":"4","key":"1226_CR130","doi-asserted-by":"publisher","first-page":"893","DOI":"10.2337\/dc13-2002","volume":"37","author":"R Sim\u00f3","year":"2014","unstructured":"Sim\u00f3 R, Sundstrom JM, Antonetti DA. Ocular Anti-VEGF therapy for diabetic retinopathy: the role of VEGF in the pathogenesis of diabetic retinopathy. Diabetes Care. 2014;37(4):893\u20139.","journal-title":"Diabetes Care"},{"key":"1226_CR131","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.preteyeres.2015.04.003","volume":"48","author":"R Sim\u00f3","year":"2015","unstructured":"Sim\u00f3 R, Hern\u00e1ndez C. Novel approaches for treating diabetic retinopathy based on recent pathogenic evidence. Prog Retin Eye Res. 2015;48:160\u201380.","journal-title":"Prog Retin Eye Res"},{"issue":"7","key":"1226_CR132","doi-asserted-by":"publisher","first-page":"560","DOI":"10.2174\/1381612827666211115154907","volume":"28","author":"FI Himasa","year":"2022","unstructured":"Himasa FI, Singhal M, Ojha A, et al. Prospective for diagnosis and treatment of diabetic retinopathy. Curr Pharm Des. 2022;28(7):560\u20139.","journal-title":"Curr Pharm Des"},{"issue":"4","key":"1226_CR133","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1139\/cjpp-2016-0322","volume":"95","author":"S Jeong","year":"2017","unstructured":"Jeong S, Ku SK, Bae JS. Anti-inflammatory effects of pelargonidin on TGFBIp-induced responses. Can J Physiol Pharmacol. 2017;95(4):372\u201381.","journal-title":"Can J Physiol Pharmacol"},{"key":"1226_CR134","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.831660","volume":"13","author":"L Tang","year":"2022","unstructured":"Tang L, Zhang C, Lu L, et al. Melatonin maintains inner blood-retinal barrier by regulating microglia via inhibition of PI3K\/Akt\/Stat3\/NF-\u03baB signaling pathways in experimental diabetic retinopathy. Front Immunol. 2022;13: 831660.","journal-title":"Front Immunol"},{"key":"1226_CR135","doi-asserted-by":"publisher","first-page":"175909142211314","DOI":"10.1177\/17590914221131446","volume":"14","author":"B Sarker","year":"2022","unstructured":"Sarker B, Cardona SM, Church KA, et al. Defibrinogenation ameliorates retinal microgliosis and inflammation in A CX3CR1-independent manner. ASN Neuro. 2022;14:17590914221131446.","journal-title":"ASN Neuro"},{"issue":"3","key":"1226_CR136","doi-asserted-by":"publisher","first-page":"2291","DOI":"10.3390\/ijms24032291","volume":"24","author":"Y Chen","year":"2023","unstructured":"Chen Y, Schlotterer A, Kurowski L, et al. miRNA-124 prevents rat diabetic retinopathy by inhibiting the microglial inflammatory response. Int J Mol Sci. 2023;24(3):2291.","journal-title":"Int J Mol Sci"},{"issue":"8","key":"1226_CR137","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2010.42","volume":"1","author":"L Perrone","year":"2010","unstructured":"Perrone L, Devi TS, Hosoya KI, et al. Inhibition of TXNIP expression in vivo blocks early pathologies of diabetic retinopathy. Cell Death Dis. 2010;1(8): e65.","journal-title":"Cell Death Dis"},{"issue":"1","key":"1226_CR138","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1007\/s00125-013-3093-8","volume":"57","author":"Z Xu","year":"2014","unstructured":"Xu Z, Wei Y, Gong J, et al. NRF2 plays a protective role in diabetic retinopathy in mice. Diabetologia. 2014;57(1):204\u201313.","journal-title":"Diabetologia"},{"key":"1226_CR139","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.bbrc.2022.05.004","volume":"613","author":"JH Yun","year":"2022","unstructured":"Yun JH, Lee DH, Jeong HS, et al. STAT3 activation in microglia increases pericyte apoptosis in diabetic retinas through TNF-\u0251\/AKT\/p70S6 kinase signaling. Biochem Biophys Res Commun. 2022;613:133\u20139.","journal-title":"Biochem Biophys Res Commun"},{"issue":"4","key":"1226_CR140","first-page":"3719","volume":"20","author":"D Tao","year":"2019","unstructured":"Tao D, Ni N, Zhang T, et al. Accumulation of advanced glycation end products potentiate human retinal capillary endothelial cells mediated diabetic retinopathy. Mol Med Rep. 2019;20(4):3719\u201327.","journal-title":"Mol Med Rep"},{"issue":"6","key":"1226_CR141","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1111\/ceo.13155","volume":"46","author":"B Appukuttan","year":"2018","unstructured":"Appukuttan B, Ma Y, Stempel A, et al. Effect of NADPH oxidase 1 and 4 blockade in activated human retinal endothelial cells. Clin Experiment Ophthalmol. 2018;46(6):652\u201360.","journal-title":"Clin Experiment Ophthalmol"},{"issue":"17","key":"1226_CR142","doi-asserted-by":"publisher","first-page":"2726","DOI":"10.1089\/ars.2013.5357","volume":"20","author":"JL Wilkinson-Berka","year":"2014","unstructured":"Wilkinson-Berka JL, Deliyanti D, Rana I, et al. NADPH oxidase, NOX1, mediates vascular injury in ischemic retinopathy. Antioxid Redox Signal. 2014;20(17):2726\u201340.","journal-title":"Antioxid Redox Signal"},{"key":"1226_CR143","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.1016\/j.biopha.2018.11.077","volume":"109","author":"SY Zeng","year":"2019","unstructured":"Zeng SY, Yang L, Yan QJ, et al. Nox1\/4 dual inhibitor GKT137831 attenuates hypertensive cardiac remodelling associating with the inhibition of ADAM17-dependent proinflammatory cytokines-induced signalling pathways in the rats with abdominal artery constriction. Biomed Pharmacother. 2019;109:1907\u201314.","journal-title":"Biomed Pharmacother."},{"key":"1226_CR144","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2019.105892","volume":"90","author":"AT Reutens","year":"2020","unstructured":"Reutens AT, Jandeleit-Dahm K, Thomas M, et al. A physician-initiated double-blind, randomised, placebo-controlled, phase 2 study evaluating the efficacy and safety of inhibition of NADPH oxidase with the first-in-class Nox-1\/4 inhibitor, GKT137831, in adults with type 1 diabetes and persistently elevated urinary albumin excretion: protocol and statistical considerations. Contemp Clin Trials. 2020;90: 105892.","journal-title":"Contemp Clin Trials"},{"issue":"9","key":"1226_CR145","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0204271","volume":"13","author":"X Wang","year":"2018","unstructured":"Wang X, Elksnis A, Wikstr\u00f6m P, et al. The novel NADPH oxidase 4 selective inhibitor GLX7013114 counteracts human islet cell death in vitro. PLoS ONE. 2018;13(9): e0204271.","journal-title":"PLoS ONE"},{"issue":"5","key":"1226_CR146","doi-asserted-by":"publisher","first-page":"638","DOI":"10.2337\/db22-0515","volume":"72","author":"S Dionysopoulou","year":"2023","unstructured":"Dionysopoulou S, Wikstrom P, Bucolo C, et al. Topically administered NOX4 Inhibitor, GLX7013114, is efficacious in treating the early pathological events of diabetic retinopathy. Diabetes. 2023;72(5):638\u201352.","journal-title":"Diabetes"},{"issue":"9","key":"1226_CR147","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1111\/j.1751-7176.2011.00513.x","volume":"13","author":"WJ Elliott","year":"2011","unstructured":"Elliott WJ, Ram CVS. Calcium channel blockers. J Clin Hyper. 2011;13(9):687\u20139.","journal-title":"J Clin Hyper."},{"issue":"3","key":"1226_CR148","first-page":"243","volume":"95","author":"AM Borowiec","year":"2022","unstructured":"Borowiec AM, W\u0142aszczuk A, Olakowska E, et al. TXNIP inhibition in the treatment of diabetes. Verapamil as a novel therapeutic modality in diabetic patients. Med Pharm Rep. 2022;95(3):243\u201350.","journal-title":"Med Pharm Rep."},{"issue":"22","key":"1226_CR149","doi-asserted-by":"publisher","first-page":"4097","DOI":"10.3390\/molecules24224097","volume":"24","author":"R Borella","year":"2019","unstructured":"Borella R, Forti L, Gibellini L, et al. Synthesis and anticancer activity of CDDO and CDDO-me, two derivatives of natural triterpenoids. Molecules (Basel, Switzerland). 2019;24(22):4097.","journal-title":"Molecules (Basel, Switzerland)"},{"key":"1226_CR150","first-page":"2075","volume":"8","author":"YY Wang","year":"2014","unstructured":"Wang YY, Yang YX, Zhe H, et al. Bardoxolone methyl (CDDO-Me) as a therapeutic agent: an update on its pharmacokinetic and pharmacodynamic properties. Drug Des Dev Ther. 2014;8:2075\u201388.","journal-title":"Drug Des Dev Ther"},{"issue":"3","key":"1226_CR151","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/j.bbrc.2019.02.095","volume":"511","author":"P Xue","year":"2019","unstructured":"Xue P, Hu X, Powers J, et al. CDDO-Me, sulforaphane and tBHQ attenuate the RANKL-induced osteoclast differentiation via activating the NRF2-mediated antioxidant response. Biochem Biophys Res Commun. 2019;511(3):637\u201343.","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"1226_CR152","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1021\/np100826q","volume":"74","author":"MB Sporn","year":"2011","unstructured":"Sporn MB, Liby KT, Yore MM, et al. New synthetic triterpenoids: potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stress. J Nat Prod. 2011;74(3):537\u201345.","journal-title":"J Nat Prod"},{"key":"1226_CR153","doi-asserted-by":"publisher","first-page":"670","DOI":"10.3389\/fphar.2018.00670","volume":"9","author":"CBM Platania","year":"2018","unstructured":"Platania CBM, Fidilio A, Lazzara F, et al. Retinal protection and distribution of curcumin in vitro and in vivo. Front Pharmacol. 2018;9:670.","journal-title":"Front Pharmacol"},{"issue":"10","key":"1226_CR154","doi-asserted-by":"publisher","first-page":"17295","DOI":"10.1002\/jcp.28347","volume":"234","author":"C Bucolo","year":"2019","unstructured":"Bucolo C, Drago F, Maisto R, et al. Curcumin prevents high glucose damage in retinal pigment epithelial cells through ERK1\/2-mediated activation of the Nrf2\/HO-1 pathway. J Cell Physiol. 2019;234(10):17295\u2013304.","journal-title":"J Cell Physiol"},{"key":"1226_CR155","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.796565","volume":"12","author":"T Xie","year":"2021","unstructured":"Xie T, Chen X, Chen W, et al. Curcumin is a potential adjuvant to alleviates diabetic retinal injury via reducing oxidative stress and maintaining Nrf2 pathway homeostasis. Front Pharmacol. 2021;12: 796565.","journal-title":"Front Pharmacol"},{"issue":"1","key":"1226_CR156","doi-asserted-by":"publisher","first-page":"167","DOI":"10.3390\/molecules27010167","volume":"27","author":"SH Shahcheraghi","year":"2021","unstructured":"Shahcheraghi SH, Salemi F, Peirovi N, et al. Nrf2 regulation by curcumin: molecular aspects for therapeutic prospects. Molecules (Basel, Switzerland). 2021;27(1):167.","journal-title":"Molecules (Basel, Switzerland)"},{"issue":"12","key":"1226_CR157","first-page":"1228","volume":"9","author":"M Rahban","year":"2020","unstructured":"Rahban M, Habibi-Rezaei M, Mazaheri M, et al. Anti-viral potential and modulation of Nrf2 by curcumin: pharmacological implications. Antioxidants (Basel, Switzerland). 2020;9(12):1228.","journal-title":"Antioxidants (Basel, Switzerland)"},{"issue":"4","key":"1226_CR158","first-page":"481","volume":"13","author":"M Williams","year":"2013","unstructured":"Williams M, Hogg RE, Chakravarthy U. Antioxidants and diabetic retinopathy. Curr DiabRep. 2013;13(4):481\u20137.","journal-title":"Curr DiabRep"},{"key":"1226_CR159","doi-asserted-by":"publisher","first-page":"8562408","DOI":"10.1155\/2019\/8562408","volume":"2019","author":"OM Cecilia","year":"2019","unstructured":"Cecilia OM, Jos\u00e9 Alberto CG, Jos\u00e9 NP, et al. Oxidative stress as the main target in diabetic retinopathy pathophysiology. J Diabetes Res. 2019;2019:8562408.","journal-title":"J Diabetes Res"},{"issue":"1","key":"1226_CR160","doi-asserted-by":"publisher","first-page":"2272386","DOI":"10.1080\/13510002.2023.2272386","volume":"28","author":"J Gao","year":"2023","unstructured":"Gao J, Tao L, Jiang Z. Alleviate oxidative stress in diabetic retinopathy: antioxidant therapeutic strategies. Redox Rep. 2023;28(1):2272386.","journal-title":"Redox Rep"},{"key":"1226_CR161","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1186\/s12974-023-02982-9","volume":"20","author":"Z Yang","year":"2023","unstructured":"Yang Z, Liu Y, Chen X, et al. Empagliflozin targets Mfn1 and Opa1 to attenuate microglia-mediated neuroinflammation in retinal ischemia and reperfusion injury. J Neuroinflammation. 2023;20:296.","journal-title":"J Neuroinflammation"},{"key":"1226_CR162","volume":"2024","author":"M Yamato","year":"2024","unstructured":"Yamato M, Kato N, Yamada KI, et al. The early pathogenesis of diabetic retinopathy and its attenuation by sodium-glucose transporter 2 inhibitors. Diabetes. 2024;2024: 220970.","journal-title":"Diabetes."},{"key":"1226_CR163","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.112021","volume":"133","author":"FE Albalawi","year":"2024","unstructured":"Albalawi FE, Alsharif I, Moawadh MS, et al. Immunomodulatory effects of Kaempferol on microglial and macrophage cells during the progression of diabetic retinopathy. Int Immunopharmacol. 2024;133: 112021.","journal-title":"Int Immunopharmacol"},{"issue":"10","key":"1226_CR164","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1111\/1753-0407.13439","volume":"15","author":"Z Huang","year":"2023","unstructured":"Huang Z, Chu WK, Ng TK, et al. Protective effects of nattokinase against microvasculopathy and neuroinflammation in diabetic retinopathy. J Diabetes. 2023;15(10):866\u201380.","journal-title":"J Diabetes"},{"issue":"3","key":"1226_CR165","doi-asserted-by":"publisher","first-page":"2334","DOI":"10.3390\/ijms24032334","volume":"24","author":"JR Jerome","year":"2023","unstructured":"Jerome JR, Deliyanti D, Suphapimol V, et al. Finerenone, a non-steroidal mineralocorticoid receptor antagonist, reduces vascular injury and increases regulatory T-cells: studies in rodents with diabetic and neovascular retinopathy. Int J Mol Sci. 2023;24(3):2334.","journal-title":"Int J Mol Sci"},{"issue":"11","key":"1226_CR166","doi-asserted-by":"publisher","first-page":"2807","DOI":"10.1007\/s13346-023-01350-7","volume":"13","author":"M Bohley","year":"2023","unstructured":"Bohley M, Dillinger AE, Braunger BM, et al. Intravenous injection of cyclosporin A loaded lipid nanocapsules fights inflammation and immune system activation in a mouse model of diabetic retinopathy. Drug Deliv Transl Res. 2023;13(11):2807\u201318.","journal-title":"Drug Deliv Transl Res"},{"issue":"18","key":"1226_CR167","doi-asserted-by":"publisher","first-page":"2890","DOI":"10.3390\/cells11182890","volume":"11","author":"AA Abdelrahman","year":"2022","unstructured":"Abdelrahman AA, Bunch KL, Sandow PV, et al. Systemic administration of pegylated arginase-1 attenuates the progression of diabetic retinopathy. Cells. 2022;11(18):2890.","journal-title":"Cells"},{"issue":"2","key":"1226_CR168","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1159\/000491897","volume":"48","author":"J Xu","year":"2018","unstructured":"Xu J, Chen LJ, Yu J, et al. Involvement of advanced glycation end products in the pathogenesis of diabetic retinopathy. Cell Physiol Biochem. 2018;48(2):705\u201317.","journal-title":"Cell Physiol Biochem"},{"issue":"1","key":"1226_CR169","doi-asserted-by":"publisher","first-page":"23","DOI":"10.3164\/jcbn.22-71","volume":"72","author":"Y Ishihara","year":"2023","unstructured":"Ishihara Y, Itoh K. Microglial inflammatory reactions regulated by oxidative stress. J Clin Biochem Nutr. 2023;72(1):23\u20137.","journal-title":"J Clin Biochem Nutr"},{"key":"1226_CR170","doi-asserted-by":"publisher","first-page":"1034692","DOI":"10.3389\/fmed.2022.1034692","volume":"9","author":"AN Smith","year":"2022","unstructured":"Smith AN, Shaughness M, Collier S, et al. Therapeutic targeting of microglia mediated oxidative stress after neurotrauma. Front Med. 2022;9:1034692.","journal-title":"Front Med"},{"issue":"2","key":"1226_CR171","doi-asserted-by":"publisher","first-page":"187","DOI":"10.3390\/metabo13020187","volume":"13","author":"D Shu","year":"2023","unstructured":"Shu D, Chaudhary S, Cho KS, et al. Role of oxidative stress in ocular diseases: a balancing act. Metabolites. 2023;13(2):187.","journal-title":"Metabolites"},{"key":"1226_CR172","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2021.100954","volume":"84","author":"A Uemura","year":"2021","unstructured":"Uemura A, Fruttiger M, D\u2019Amore PA, et al. VEGFR1 signaling in retinal angiogenesis and microinflammation. Prog Retin Eye Res. 2021;84: 100954.","journal-title":"Prog Retin Eye Res"}],"container-title":["Human Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13577-025-01226-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13577-025-01226-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13577-025-01226-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T07:03:02Z","timestamp":1751698982000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13577-025-01226-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,20]]},"references-count":172,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,7]]}},"alternative-id":["1226"],"URL":"https:\/\/doi.org\/10.1007\/s13577-025-01226-7","relation":{},"ISSN":["1749-0774"],"issn-type":[{"value":"1749-0774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,20]]},"assertion":[{"value":"8 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All the authors declared no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"101"}}