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The five-year survival rate is poor due to late diagnosis. Oral tongue squamous cell carcinoma (OTSCC) is the second-most common OSCC. An in vitro cell line model is a valuable tool to get a deeper understanding of the molecular mechanisms involved in therapy resistance and disease progression. We report establishment of three OTSCC cell lines from advanced\u00a0stage treatment\u00a0na\u00efve Indian patient samples, such as ACOTSC120, ACOSTC132, and ACOTSC140. All three OTSCC cell lines showed epithelial morphology, which was confirmed by Keratin-14 staining. The cell lines showed in vitro spheroid-forming and in vivo tumorigenic potential. The STR of the cell lines ensured their human origin and novelty when compared to DSMZ cell line database. The karyotype of the cell lines showed aneuploidy and further confirmed their human origin. These cell lines showed the presence of cancer stem cell (CSCs) population, i.e., the ALDH<jats:sup>br<\/jats:sup>\/CD44<jats:sup>+<\/jats:sup> population. These cell lines thus provide a model to help understand the biology of disease and its progression.<\/jats:p>","DOI":"10.1007\/s13577-025-01231-w","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T17:09:31Z","timestamp":1747760971000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Establishment and characterization of patient-derived tongue squamous cell carcinoma cell lines"],"prefix":"10.1007","volume":"38","author":[{"given":"Priyanka","family":"Joshi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Bane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj","family":"Chaturvedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poonam","family":"Gera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3693-5620","authenticated-orcid":false,"given":"Sanjeev K.","family":"Waghmare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,20]]},"reference":[{"issue":"January","key":"1231_CR1","first-page":"1","volume":"2020","author":"V Borse","year":"2020","unstructured":"Borse V, Konwar AN, Buragohain P. 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This study was performed as per the principles of Helsinki. The animal protocol was approved by the Institutional Ethics Committee (IEC-III Project no. 900188).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All the protocols were approved by Institutional Animal Ethics committee (IAEC). We have adhered to the CPSEA criteria set by the Indian Ministry of Environment and Forests for conducting all animal research. In addition, we adhered to the Arrive criteria and the requirements for care and animal welfare set by the National Research Council in Washington, DC. The animal protocol was approved by the Institutional Animal Ethics Committee (IAEC Project no. 33\/2020).","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and animal rights"}},{"value":"Informed consent was obtained from all the individual participants included in the study. This study was approved by the Institutional Human Ethics Committee (IEC-III Project no. 900188).","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors affirm that human research participants provided informed consent for the publication of the images in this manuscript (IEC-III Project no. 900188).","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}],"article-number":"102"}}