{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T01:35:04Z","timestamp":1780450504068,"version":"3.54.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["Grant No. 81272872"],"award-info":[{"award-number":["Grant No. 81272872"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Human Cell"],"DOI":"10.1007\/s13577-025-01249-0","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T09:20:16Z","timestamp":1750670416000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Identification of autophagy-related biomarkers in prostate cancer prognosis"],"prefix":"10.1007","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4432-0191","authenticated-orcid":false,"given":"Yancheng","family":"Di","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,23]]},"reference":[{"issue":"2","key":"1249_CR1","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.eururo.2023.04.021","volume":"84","author":"O Bergengren","year":"2023","unstructured":"Bergengren O, Pekala KR, Matsoukas K, et al. 2022 update on prostate cancer epidemiology and risk factors\u2014a systematic review. Eur Urol. 2023;84(2):191\u2013206.","journal-title":"Eur Urol"},{"issue":"3","key":"1249_CR2","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","volume":"74","author":"F Bray","year":"2024","unstructured":"Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74(3):229\u201363.","journal-title":"CA Cancer J Clin"},{"key":"1249_CR3","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/978-3-319-99286-0_7","volume":"1096","author":"A Mansinho","year":"2018","unstructured":"Mansinho A, Macedo D, Fernandes I, Costa L. Castration-resistant prostate cancer: mechanisms, targets and treatment. Adv Exp Med Biol. 2018;1096:117\u201333.","journal-title":"Adv Exp Med Biol"},{"key":"1249_CR4","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.862995","volume":"12","author":"PH Patel","year":"2022","unstructured":"Patel PH, Tunariu N, Levine DS, et al. Oligoprogression in metastatic, castrate-resistant prostate cancer-prevalence and current clinical practice. Front Oncol. 2022;12: 862995.","journal-title":"Front Oncol"},{"issue":"11","key":"1249_CR5","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1002\/1873-3468.14087","volume":"595","author":"J Verhoeven","year":"2021","unstructured":"Verhoeven J, Baelen J, Agrawal M, Agostinis P. Endothelial cell autophagy in homeostasis and cancer. FEBS Lett. 2021;595(11):1497\u2013511.","journal-title":"FEBS Lett"},{"key":"1249_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2023.216494","volume":"581","author":"R Chen","year":"2024","unstructured":"Chen R, Zou J, Zhong X, Li J, Kang R, Tang D. HMGB1 in the interplay between autophagy and apoptosis in cancer. Cancer Lett. 2024;581: 216494.","journal-title":"Cancer Lett"},{"key":"1249_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155512","volume":"128","author":"XH Wang","year":"2024","unstructured":"Wang XH, Shen CP, Wang TT, et al. Shikonin suppresses rheumatoid arthritis by inducing apoptosis and autophagy via modulation of the AMPK\/mTOR\/ULK-1 signaling pathway. Phytomedicine. 2024;128: 155512.","journal-title":"Phytomedicine"},{"issue":"2","key":"1249_CR8","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.18047","volume":"28","author":"S Wang","year":"2024","unstructured":"Wang S, Ding Q, Xiu A, Xia Y, Wang G, Zhang C. Upregulation of ATG9b by propranolol promotes autophagic cell death of hepatic stellate cells to improve liver fibrosis. J Cell Mol Med. 2024;28(2): e18047.","journal-title":"J Cell Mol Med"},{"issue":"10","key":"1249_CR9","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.1002\/mc.23590","volume":"62","author":"Y Zhou","year":"2023","unstructured":"Zhou Y, Liu T, Wu Q, Wang H, Sun Y. Baohuoside I inhibits resistance to cisplatin in ovarian cancer cells by suppressing autophagy via downregulating HIF-1alpha\/ATG5 axis. Mol Carcinog. 2023;62(10):1474\u201386.","journal-title":"Mol Carcinog"},{"key":"1249_CR10","doi-asserted-by":"publisher","first-page":"1489171","DOI":"10.3389\/fimmu.2024.1489171","volume":"15","author":"C Zhu","year":"2024","unstructured":"Zhu C, Feng X, Tong L, et al. Prediction of acute myeloid leukemia prognosis based on autophagy features and characterization of its immune microenvironment. Front Immunol. 2024;15:1489171.","journal-title":"Front Immunol"},{"key":"1249_CR11","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.695865","volume":"12","author":"D Fu","year":"2021","unstructured":"Fu D, Zhang B, Wu S, et al. Prognosis and characterization of immune microenvironment in acute myeloid leukemia through identification of an autophagy-related signature. Front Immunol. 2021;12: 695865.","journal-title":"Front Immunol"},{"key":"1249_CR12","doi-asserted-by":"publisher","first-page":"6609195","DOI":"10.1155\/2022\/6609195","volume":"2022","author":"J Zhang","year":"2022","unstructured":"Zhang J, Yan H, Fu Y. Effects of autophagy-related genes on the prognosis and immune micro-environment of ovarian cancer. Biomed Res Int. 2022;2022:6609195.","journal-title":"Biomed Res Int"},{"issue":"1","key":"1249_CR13","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1186\/s12894-023-01345-z","volume":"23","author":"R Semba","year":"2023","unstructured":"Semba R, Uchida K, Hirokawa Y, et al. Short-term prognosis of low-risk prostate cancer patients is favorable despite the presence of pathological prognostic factors: a retrospective study. BMC Urol. 2023;23(1):174.","journal-title":"BMC Urol"},{"key":"1249_CR14","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/j.eururo.2016.11.015","volume":"71","author":"M Adam","year":"2017","unstructured":"Adam M, Tennstedt P, Lanwehr D, et al. Functional outcomes and quality of life after radical prostatectomy only versus a combination of prostatectomy with radiation and hormonal therapy. Eur Urol. 2017;71:330\u20136.","journal-title":"Eur Urol"},{"issue":"1","key":"1249_CR15","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s12943-020-1138-4","volume":"19","author":"X Li","year":"2020","unstructured":"Li X, He S, Ma B. Autophagy and autophagy-related proteins in cancer. Mol Cancer. 2020;19(1):12.","journal-title":"Mol Cancer"},{"issue":"3","key":"1249_CR16","doi-asserted-by":"publisher","first-page":"111","DOI":"10.2478\/abm-2022-0014","volume":"16","author":"A Arif","year":"2022","unstructured":"Arif A, Khawar MB, Mehmood R, Abbasi MH, Sheikh N. Dichotomous role of autophagy in cancer. Asian Biomed (Res Rev News). 2022;16(3):111\u201320.","journal-title":"Asian Biomed (Res Rev News)"},{"key":"1249_CR17","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.721624","volume":"11","author":"\u017d Frange\u017e","year":"2021","unstructured":"Frange\u017e \u017d, G\u00e9rard D, He Z, et al. ATG5 and ATG7 expression levels are reduced in cutaneous melanoma and regulated by NRF1. Front Oncol. 2021;11: 721624.","journal-title":"Front Oncol"},{"issue":"9","key":"1249_CR18","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1158\/2159-8290.CD-18-1409","volume":"9","author":"TJ Humpton","year":"2019","unstructured":"Humpton TJ, Alagesan B, DeNicola GM, et al. Oncogenic KRAS induces NIX-mediated mitophagy to promote pancreatic cancer. Cancer Discov. 2019;9(9):1268\u201387.","journal-title":"Cancer Discov"},{"issue":"2","key":"1249_CR19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0289904","volume":"19","author":"K Zafeiropoulou","year":"2024","unstructured":"Zafeiropoulou K, Kalampounias G, Alexis S, Anastasopoulos D, Symeonidis A, Katsoris P. Autophagy and oxidative stress modulation mediate Bortezomib resistance in prostate cancer. PLoS ONE. 2024;19(2): e0289904.","journal-title":"PLoS ONE"},{"issue":"1","key":"1249_CR20","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/s10555-024-10168-9","volume":"43","author":"M Ashrafizadeh","year":"2024","unstructured":"Ashrafizadeh M, Zhang W, Tian Y, Sethi G, Zhang X, Qiu A. Molecular panorama of therapy resistance in prostate cancer: a pre-clinical and bioinformatics analysis for clinical translation. Cancer Metastasis Rev. 2024;43(1):229\u201360.","journal-title":"Cancer Metastasis Rev"},{"key":"1249_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2024.102557","volume":"91","author":"F Fakhredini","year":"2024","unstructured":"Fakhredini F, Alidadi H, Mahdavinia M, Khorsandi L. Morin promotes autophagy in human PC3 prostate cancer cells by modulating AMPK\/mTOR\/ULK1 signaling pathway. Tissue Cell. 2024;91: 102557.","journal-title":"Tissue Cell"},{"issue":"3","key":"1249_CR22","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.7150\/ijbs.85443","volume":"20","author":"TM Chang","year":"2024","unstructured":"Chang TM, Chi MC, Chiang YC, et al. Promotion of ROS-mediated apoptosis, G2\/M arrest, and autophagy by naringenin in non-small cell lung cancer. Int J Biol Sci. 2024;20(3):1093\u2013109.","journal-title":"Int J Biol Sci"},{"issue":"7","key":"1249_CR23","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1080\/15548627.2019.1671643","volume":"16","author":"TY Lin","year":"2020","unstructured":"Lin TY, Chan HH, Chen SH, et al. BIRC5\/Survivin is a novel ATG12-ATG5 conjugate interactor and an autophagy-induced DNA damage suppressor in human cancer and mouse embryonic fibroblast cells. Autophagy. 2020;16(7):1296\u2013313.","journal-title":"Autophagy"},{"issue":"3","key":"1249_CR24","doi-asserted-by":"publisher","first-page":"424","DOI":"10.4161\/auto.22931","volume":"9","author":"M Walczak","year":"2013","unstructured":"Walczak M, Martens S. Dissecting the role of the Atg12-Atg5-Atg16 complex during autophagosome formation. Autophagy. 2013;9(3):424\u20135.","journal-title":"Autophagy"},{"key":"1249_CR25","doi-asserted-by":"publisher","first-page":"5770228","DOI":"10.1155\/2021\/5770228","volume":"2021","author":"R Feng","year":"2021","unstructured":"Feng R, Li J, Xuan W, Liu H, Cheng D, Wang G. An autophagy-related gene-based prognostic risk signature for hepatocellular carcinoma: construction and validation. Comput Math Methods Med. 2021;2021:5770228.","journal-title":"Comput Math Methods Med"},{"issue":"3","key":"1249_CR26","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1002\/mc.22278","volume":"55","author":"Y Gu","year":"2016","unstructured":"Gu Y, Li P, Peng F, et al. Autophagy-related prognostic signature for breast cancer. Mol Carcinog. 2016;55(3):292\u20139.","journal-title":"Mol Carcinog"},{"key":"1249_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2024.122788","volume":"350","author":"G Siragusa","year":"2024","unstructured":"Siragusa G, Tomasello L, Giordano C, Pizzolanti G. Survivin (BIRC5): implications in cancer therapy. Life Sci. 2024;350: 122788.","journal-title":"Life Sci"},{"issue":"1","key":"1249_CR28","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.6811","volume":"13","author":"Y Fan","year":"2024","unstructured":"Fan Y, Pan Y, Jia L, et al. BIRC5 facilitates cisplatin-chemoresistance in a m(6)A-dependent manner in ovarian cancer. Cancer Med. 2024;13(1): e6811.","journal-title":"Cancer Med"},{"issue":"6","key":"1249_CR29","doi-asserted-by":"publisher","first-page":"277","DOI":"10.3892\/ol.2024.14410","volume":"27","author":"R Zhou","year":"2024","unstructured":"Zhou R, Dai J, Zhou R, et al. Prognostic biomarker NRG2 correlates with autophagy and epithelial-mesenchymal transition in breast cancer. Oncol Lett. 2024;27(6):277.","journal-title":"Oncol Lett"},{"issue":"1","key":"1249_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1042\/CS20220472","volume":"137","author":"S Almaraz Postigo","year":"2023","unstructured":"Almaraz Postigo S, Montero JC. Neuregulin modulates hormone receptor levels in breast cancer through concerted action on multiple signaling pathways. Clin Sci (Lond). 2023;137(1):1\u201315.","journal-title":"Clin Sci (Lond)"},{"issue":"3","key":"1249_CR31","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.13560","volume":"57","author":"H Xu","year":"2024","unstructured":"Xu H, Wang J, Al-Nusaif M, Ma H, Le W. CCL2 promotes metastasis and epithelial-mesenchymal transition of non-small cell lung cancer via PI3K\/Akt\/mTOR and autophagy pathways. Cell Prolif. 2024;57(3): e13560.","journal-title":"Cell Prolif"},{"key":"1249_CR32","doi-asserted-by":"publisher","first-page":"1118217","DOI":"10.3389\/fphar.2023.1118217","volume":"14","author":"H Wang","year":"2023","unstructured":"Wang H, Wang Q, Wu Y, Lou J, Zhu S, Xu Y. Autophagy-related gene LAPTM4B promotes the progression of renal clear cell carcinoma and is associated with immunity. Front Pharmacol. 2023;14:1118217.","journal-title":"Front Pharmacol"},{"key":"1249_CR33","doi-asserted-by":"publisher","first-page":"1109683","DOI":"10.3389\/fgene.2023.1109683","volume":"14","author":"Y Luo","year":"2023","unstructured":"Luo Y, Deng X, Liao W, Huang Y, Lu C. Prognostic value of autophagy-related genes based on single-cell RNA-sequencing in colorectal cancer. Front Genet. 2023;14:1109683.","journal-title":"Front Genet"},{"issue":"10","key":"1249_CR34","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1111\/jop.13231","volume":"50","author":"Y Jiang","year":"2021","unstructured":"Jiang Y, Li Y, Ge H, et al. Identification of an autophagy-related prognostic signature in head and neck squamous cell carcinoma. J Oral Pathol Med. 2021;50(10):1040\u20139.","journal-title":"J Oral Pathol Med"},{"issue":"6","key":"1249_CR35","first-page":"997","volume":"23","author":"B Ma","year":"2023","unstructured":"Ma B, Li H, Zheng M, Cao R, Yu R. A novel autophagy-related subtypes to distinguish immune phenotypes and predict immunotherapy response in head and neck squamous cell carcinoma. Biomol Biomed. 2023;23(6):997\u20131013.","journal-title":"Biomol Biomed"}],"container-title":["Human Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13577-025-01249-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13577-025-01249-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13577-025-01249-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T06:27:48Z","timestamp":1751696868000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13577-025-01249-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,23]]},"references-count":35,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,7]]}},"alternative-id":["1249"],"URL":"https:\/\/doi.org\/10.1007\/s13577-025-01249-0","relation":{},"ISSN":["1749-0774"],"issn-type":[{"value":"1749-0774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,23]]},"assertion":[{"value":"16 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. The research protocol was approved by the Medical Ethics Committee of Hongqi Hospital Affiliated to Mudanjiang Medical University (Ethics Approval Number: 202047).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Written informed consent was obtained from all participants prior to enrollment.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}],"article-number":"120"}}