{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T15:04:53Z","timestamp":1779635093055,"version":"3.53.1"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T00:00:00Z","timestamp":1779580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T00:00:00Z","timestamp":1779580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82171196"],"award-info":[{"award-number":["82171196"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Henan Provincial Key Research and Development Special Program","award":["241111313500"],"award-info":[{"award-number":["241111313500"]}]},{"name":"the Henan Provincial Major Project of Medical Science and Technology Key Research Program under Provincial-Ministerial Co-Construction","award":["SBGJ202401002"],"award-info":[{"award-number":["SBGJ202401002"]}]},{"DOI":"10.13039\/501100004761","name":"the Natural Science Foundation of Henan Province","doi-asserted-by":"crossref","award":["262300420560"],"award-info":[{"award-number":["262300420560"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Human Cell"],"DOI":"10.1007\/s13577-026-01391-3","type":"journal-article","created":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T13:32:32Z","timestamp":1779629552000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["NOTCH3 signal activation by its extracellular domain accumulation in an iPSC line newly established from a CADASIL patient"],"prefix":"10.1007","volume":"39","author":[{"given":"Ruihua","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenxiang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningning","family":"Che","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyi","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anqi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junkui","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiewen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,24]]},"reference":[{"key":"1391_CR1","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1038\/ng0393-256","volume":"3","author":"E Tournier-Lasserve","year":"1993","unstructured":"Tournier-Lasserve E, Joutel A, Melki J, et al. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy maps to chromosome 19q12. Nat Genet. 1993;3:256\u20139.","journal-title":"Nat Genet"},{"key":"1391_CR2","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1161\/01.STR.25.3.704","volume":"25","author":"MG Bousser","year":"1994","unstructured":"Bousser MG, Tournier-Lasserve E. Summary of the proceedings of the first international workshop on CADASIL. Paris, May 19\u201321, 1993. Stroke. 1994;25:704\u20137.","journal-title":"Stroke"},{"key":"1391_CR3","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1136\/jnnp.74.2.249","volume":"74","author":"F Schon","year":"2003","unstructured":"Schon F, Martin RJ, Prevett M, Clough C, Enevoldson TP, Markus HS. \u201cCADASIL coma\u201d: an underdiagnosed acute encephalopathy. J Neurol Neurosurg Psychiatry. 2003;74:249\u201352.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"1391_CR4","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1212\/01.wnl.0000216270.02610.7e","volume":"66","author":"RA Charlton","year":"2006","unstructured":"Charlton RA, Morris RG, Nitkunan A, Markus HS. The cognitive profiles of CADASIL and sporadic small vessel disease. Neurology. 2006;66:1523\u20136.","journal-title":"Neurology"},{"key":"1391_CR5","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1111\/j.1600-0404.2008.01015.x","volume":"118","author":"R Valenti","year":"2008","unstructured":"Valenti R, Poggesi A, Pescini F, Inzitari D, Pantoni L. Psychiatric disturbances in CADASIL: a brief review. Acta Neurol Scand. 2008;118:291\u20135.","journal-title":"Acta Neurol Scand"},{"key":"1391_CR6","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/S1474-4422(09)70127-9","volume":"8","author":"H Chabriat","year":"2009","unstructured":"Chabriat H, Joutel A, Dichgans M, Tournier-Lasserve E, Bousser MG. CADASIL. Lancet Neurol. 2009;8:643\u201353.","journal-title":"Lancet Neurol"},{"key":"1391_CR7","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1177\/0333102415620909","volume":"36","author":"S Guey","year":"2016","unstructured":"Guey S, Mawet J, Herv\u00e9 D, et al. Prevalence and characteristics of migraine in CADASIL. Cephalalgia: Int J Headache. 2016;36:1038\u201347.","journal-title":"Cephalalgia: Int J Headache"},{"key":"1391_CR8","doi-asserted-by":"publisher","first-page":"E3569","DOI":"10.1073\/pnas.1800201115","volume":"115","author":"OF Harraz","year":"2018","unstructured":"Harraz OF, Longden TA, Dabertrand F, Hill-Eubanks D, Nelson MT. Endothelial GqPCR activity controls capillary electrical signaling and brain blood flow through PIP(2) depletion. Proc Natl Acad Sci U S A. 2018;115:E3569\u201377.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1391_CR9","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1161\/STROKEAHA.119.024152","volume":"51","author":"E Jouvent","year":"2020","unstructured":"Jouvent E, Duering M, Chabriat H. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: lessons from neuroimaging. Stroke. 2020;51:21\u20138.","journal-title":"Stroke"},{"key":"1391_CR10","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1038\/383707a0","volume":"383","author":"A Joutel","year":"1996","unstructured":"Joutel A, Corpechot C, Ducros A, et al. Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia. Nature. 1996;383:707\u201310.","journal-title":"Nature"},{"key":"1391_CR11","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1016\/S0140-6736(97)08083-5","volume":"350","author":"A Joutel","year":"1997","unstructured":"Joutel A, Vahedi K, Corpechot C, et al. Strong clustering and stereotyped nature of Notch3 mutations in CADASIL patients. Lancet (Lond, Engl). 1997;350:1511\u20135.","journal-title":"Lancet (Lond, Engl)"},{"key":"1391_CR12","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1038\/sj.ejhg.5200460","volume":"8","author":"M Dichgans","year":"2000","unstructured":"Dichgans M, Ludwig H, M\u00fcller-H\u00f6cker J, Messerschmidt A, Gasser T. Small in-frame deletions and missense mutations in CADASIL: 3D models predict misfolding of Notch3 EGF-like repeat domains. Eur J Hum Genet. 2000;8:280\u20135.","journal-title":"Eur J Hum Genet"},{"key":"1391_CR13","doi-asserted-by":"publisher","first-page":"3256","DOI":"10.1093\/hmg\/ddr237","volume":"20","author":"M Duering","year":"2011","unstructured":"Duering M, Karpinska A, Rosner S, et al. Co-aggregate formation of CADASIL-mutant NOTCH3: a single-particle analysis. Hum Mol Genet. 2011;20:3256\u201365.","journal-title":"Hum Mol Genet"},{"key":"1391_CR14","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1172\/JCI8047","volume":"105","author":"A Joutel","year":"2000","unstructured":"Joutel A, Andreux F, Gaulis S, et al. The ectodomain of the Notch3 receptor accumulates within the cerebrovasculature of CADASIL patients. J Clin Invest. 2000;105:597\u2013605.","journal-title":"J Clin Invest"},{"key":"1391_CR15","doi-asserted-by":"publisher","first-page":"2049","DOI":"10.1016\/S0140-6736(01)07142-2","volume":"358","author":"A Joutel","year":"2001","unstructured":"Joutel A, Favrole P, Labauge P, et al. Skin biopsy immunostaining with a Notch3 monoclonal antibody for CADASIL diagnosis. Lancet. 2001;358:2049\u201351.","journal-title":"Lancet"},{"key":"1391_CR16","doi-asserted-by":"publisher","first-page":"2598","DOI":"10.1161\/01.STR.0000143725.19053.60","volume":"35","author":"M Shibata","year":"2004","unstructured":"Shibata M, Ohtani R, Ihara M, Tomimoto H. White matter lesions and glial activation in a novel mouse model of chronic cerebral hypoperfusion. Stroke. 2004;35:2598\u2013603.","journal-title":"Stroke"},{"key":"1391_CR17","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1161\/01.STR.0000163080.82766.eb","volume":"36","author":"P Lacombe","year":"2005","unstructured":"Lacombe P, Oligo C, Domenga V, Tournier-Lasserve E, Joutel A. Impaired cerebral vasoreactivity in a transgenic mouse model of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy arteriopathy. Stroke. 2005;36:1053\u20138.","journal-title":"Stroke"},{"key":"1391_CR18","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1172\/JCI39733","volume":"120","author":"A Joutel","year":"2010","unstructured":"Joutel A, Monet-Lepr\u00eatre M, Gosele C, et al. Cerebrovascular dysfunction and microcirculation rarefaction precede white matter lesions in a mouse genetic model of cerebral ischemic small vessel disease. J Clin Invest. 2010;120:433\u201345.","journal-title":"J Clin Invest"},{"key":"1391_CR19","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1002\/bies.201000093","volume":"33","author":"A Joutel","year":"2011","unstructured":"Joutel A. Pathogenesis of CADASIL: transgenic and knock-out mice to probe function and dysfunction of the mutated gene, Notch3, in the cerebrovasculature. BioEssays: News Rev Mol Cell Dev Biol. 2011;33:73\u201380.","journal-title":"BioEssays: News Rev Mol Cell Dev Biol"},{"key":"1391_CR20","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","volume":"131","author":"K Takahashi","year":"2007","unstructured":"Takahashi K, Tanabe K, Ohnuki M, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007;131:861\u201372.","journal-title":"Cell"},{"key":"1391_CR21","doi-asserted-by":"publisher","first-page":"2709","DOI":"10.1242\/dev.004184","volume":"134","author":"T Gridley","year":"2007","unstructured":"Gridley T. Notch signaling in vascular development and physiology. Development. 2007;134:2709\u201318.","journal-title":"Development"},{"key":"1391_CR22","doi-asserted-by":"publisher","first-page":"2511","DOI":"10.1101\/gad.1589207","volume":"21","author":"C Roca","year":"2007","unstructured":"Roca C, Adams RH. Regulation of vascular morphogenesis by Notch signaling. Genes Dev. 2007;21:2511\u201324.","journal-title":"Genes Dev"},{"key":"1391_CR23","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1002\/jcp.10208","volume":"194","author":"T Iso","year":"2003","unstructured":"Iso T, Kedes L, Hamamori Y. HES and HERP families: multiple effectors of the Notch signaling pathway. J Cell Physiol. 2003;194:237\u201355.","journal-title":"J Cell Physiol"},{"key":"1391_CR24","doi-asserted-by":"publisher","first-page":"1885","DOI":"10.1101\/gad.908101","volume":"15","author":"E Lamar","year":"2001","unstructured":"Lamar E, Deblandre G, Wettstein D, et al. Nrarp is a novel intracellular component of the Notch signaling pathway. Genes Dev. 2001;15:1885\u201399.","journal-title":"Genes Dev"},{"key":"1391_CR25","doi-asserted-by":"publisher","first-page":"1830","DOI":"10.1093\/brain\/awt092","volume":"136","author":"M Monet-Lepr\u00eatre","year":"2013","unstructured":"Monet-Lepr\u00eatre M, Haddad I, Baron-Menguy C, et al. Abnormal recruitment of extracellular matrix proteins by excess Notch3 ECD: a new pathomechanism in CADASIL. Brain: J Neurol. 2013;136:1830\u201345.","journal-title":"Brain: J Neurol"},{"key":"1391_CR26","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.scr.2018.01.023","volume":"28","author":"H Fern\u00e1ndez-Susavila","year":"2018","unstructured":"Fern\u00e1ndez-Susavila H, Mora C, Aramburu-N\u00fa\u00f1ez M, et al. Generation and characterization of the human iPSC line IDISi001-A isolated from blood cells of a CADASIL patient carrying a NOTCH3 mutation. Stem Cell Res. 2018;28:16\u201320.","journal-title":"Stem Cell Res"},{"key":"1391_CR27","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1007\/s13238-019-0608-1","volume":"10","author":"C Ling","year":"2019","unstructured":"Ling C, Liu Z, Song M, et al. Modeling CADASIL vascular pathologies with patient-derived induced pluripotent stem cells. Protein Cell. 2019;10:249\u201371.","journal-title":"Protein Cell"},{"key":"1391_CR28","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1212\/WNL.59.8.1134","volume":"59","author":"HS Markus","year":"2002","unstructured":"Markus HS, Martin RJ, Simpson MA, et al. Diagnostic strategies in CADASIL. Neurology. 2002;59:1134\u20138.","journal-title":"Neurology"},{"key":"1391_CR29","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1001\/archneur.62.7.1091","volume":"62","author":"N Peters","year":"2005","unstructured":"Peters N, Opherk C, Bergmann T, Castro M, Herzog J, Dichgans M. Spectrum of mutations in biopsy-proven CADASIL: implications for diagnostic strategies. Arch Neurol. 2005;62:1091\u20134.","journal-title":"Arch Neurol"},{"key":"1391_CR30","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1007\/s00415-009-0091-3","volume":"256","author":"YC Lee","year":"2009","unstructured":"Lee YC, Liu CS, Chang MH, et al. Population-specific spectrum of NOTCH3 mutations, MRI features and founder effect of CADASIL in Chinese. J Neurol. 2009;256:249\u201355.","journal-title":"J Neurol"},{"key":"1391_CR31","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1136\/jnnp.2010.209247","volume":"82","author":"Z Wang","year":"2011","unstructured":"Wang Z, Yuan Y, Zhang W, et al. NOTCH3 mutations and clinical features in 33 mainland Chinese families with CADASIL. J Neurol Neurosurg Psychiatry. 2011;82:534\u20139.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"1391_CR32","doi-asserted-by":"publisher","first-page":"726.e1","DOI":"10.1016\/j.neurobiolaging.2013.09.004","volume":"35","author":"YE Kim","year":"2014","unstructured":"Kim YE, Yoon CW, Seo SW, et al. Spectrum of NOTCH3 mutations in Korean patients with clinically suspicious cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Neurobiol Aging. 2014;35:726.e1-6.","journal-title":"Neurobiol Aging"},{"key":"1391_CR33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0136501","volume":"10","author":"YC Liao","year":"2015","unstructured":"Liao YC, Hsiao CT, Fuh JL, et al. Characterization of CADASIL among the Han Chinese in Taiwan: distinct genotypic and phenotypic profiles. PLoS ONE. 2015;10:e0136501.","journal-title":"PLoS ONE"},{"key":"1391_CR34","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.705284","volume":"12","author":"Y Hu","year":"2021","unstructured":"Hu Y, Sun Q, Zhou Y, et al. NOTCH3 variants and genotype\u2013phenotype features in Chinese CADASIL patients. Front Genet. 2021;12:705284.","journal-title":"Front Genet"},{"key":"1391_CR35","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1016\/j.jstrokecerebrovasdis.2011.10.013","volume":"22","author":"JC Choi","year":"2013","unstructured":"Choi JC, Lee KH, Song SK, Lee JS, Kang SY, Kang JH. Screening for NOTCH3 gene mutations among 151 consecutive Korean patients with acute ischemic stroke. J Stroke Cerebrovasc Dis. 2013;22:608\u201314.","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"1391_CR36","doi-asserted-by":"publisher","first-page":"787","DOI":"10.3233\/JAD-2009-1112","volume":"17","author":"I Ampuero","year":"2009","unstructured":"Ampuero I, Alegre-Abarrategui J, Rodal I, et al. On the diagnosis of CADASIL. J Alzheimers Dis. 2009;17:787\u201394.","journal-title":"J Alzheimers Dis"},{"key":"1391_CR37","doi-asserted-by":"publisher","first-page":"348","DOI":"10.2183\/pjab.85.348","volume":"85","author":"N Fusaki","year":"2009","unstructured":"Fusaki N, Ban H, Nishiyama A, Saeki K, Hasegawa M. Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome. Proc Jpn Acad B. 2009;85:348\u201362.","journal-title":"Proc Jpn Acad B"},{"key":"1391_CR38","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/564612","volume":"2012","author":"CC Macarthur","year":"2012","unstructured":"Macarthur CC, Fontes A, Ravinder N, et al. Generation of human-induced pluripotent stem cells by a nonintegrating RNA Sendai virus vector in feeder-free or xeno-free conditions. Stem Cells Int. 2012;2012:564612.","journal-title":"Stem Cells Int"},{"key":"1391_CR39","doi-asserted-by":"publisher","DOI":"10.1016\/j.crmeth.2022.100317","volume":"2","author":"A Kunitomi","year":"2022","unstructured":"Kunitomi A, Hirohata R, Arreola V, et al. Improved Sendai viral system for reprogramming to naive pluripotency. Cell Rep Methods. 2022;2:100317.","journal-title":"Cell Rep Methods"},{"key":"1391_CR40","volume-title":"StemBook","author":"W Yang","year":"2008","unstructured":"Yang W, Mills JA, Sullivan S, Liu Y, French DL, Gadue P. iPSC reprogramming from human peripheral blood using sendai virus mediated gene transfer. In: StemBook. Cambridge, MA: Harvard Stem Cell Institute; 2008."},{"key":"1391_CR41","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2020.101905","volume":"47","author":"Y Yan","year":"2020","unstructured":"Yan Y, Wu S, Jiang L, et al. Generation of a human iPSC line CIBi007-A from a patient with young-onset Parkinson\u2019s disease carrying variants in PRKN and HTRA2. Stem Cell Res. 2020;47:101905.","journal-title":"Stem Cell Res"},{"key":"1391_CR42","volume":"3","author":"H Chabriat","year":"2022","unstructured":"Chabriat H, LesnikOberstein S. Cognition, mood and behavior in CADASIL. Cereb Circ Cognit Behav. 2022;3:100043.","journal-title":"Cereb Circ Cognit Behav"},{"key":"1391_CR43","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1136\/jnnp.2005.074583","volume":"77","author":"L Caeiro","year":"2006","unstructured":"Caeiro L, Ferro JM. Cognitive profile in CADASIL patients. J Neurol Neurosurg Psychiatry. 2006;77:144\u20135.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"1391_CR44","doi-asserted-by":"publisher","first-page":"e453","DOI":"10.1212\/WNL.0000000000200607","volume":"99","author":"AA Jolly","year":"2022","unstructured":"Jolly AA, Nannoni S, Edwards H, Morris RG, Markus HS. Prevalence and predictors of vascular cognitive impairment in patients with CADASIL. Neurology. 2022;99:e453\u201361.","journal-title":"Neurology"},{"key":"1391_CR45","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.neulet.2019.01.014","volume":"698","author":"D Schoemaker","year":"2019","unstructured":"Schoemaker D, Quiroz YT, Torrico-Teave H, Arboleda-Velasquez JF. Clinical and research applications of magnetic resonance imaging in the study of CADASIL. Neurosci Lett. 2019;698:173\u20139.","journal-title":"Neurosci Lett"},{"key":"1391_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.17305\/bjbms.2015.247","volume":"15","author":"D Stojanov","year":"2015","unstructured":"Stojanov D, Vojinovic S, Aracki-Trenkic A, et al. Imaging characteristics of cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL). Bosn J Basic Med Sci. 2015;15:1\u20138.","journal-title":"Bosn J Basic Med Sci"},{"key":"1391_CR47","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1212\/WNL.56.5.628","volume":"56","author":"M O\u2019Sullivan","year":"2001","unstructured":"O\u2019Sullivan M, Jarosz JM, Martin RJ, Deasy N, Powell JF, Markus HS. MRI hyperintensities of the temporal lobe and external capsule in patients with CADASIL. Neurology. 2001;56:628\u201334.","journal-title":"Neurology"},{"key":"1391_CR48","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2020.101821","volume":"45","author":"G Chen","year":"2020","unstructured":"Chen G, Li Z, Liu Y, et al. Generation of human induced pluripotent stem cells (NIHTVBi004-A, NIHTVBi005-A, NIHTVBi006-A, NIHTVBi007-A, NIHTVBi008-A) from 5 CADASIL patients with NOTCH3 mutation. Stem Cell Res. 2020;45:101821.","journal-title":"Stem Cell Res"},{"key":"1391_CR49","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s13041-020-00573-w","volume":"13","author":"Y Yamamoto","year":"2020","unstructured":"Yamamoto Y, Kojima K, Taura D, et al. Human iPS cell-derived mural cells as an in vitro model of hereditary cerebral small vessel disease. Mol Brain. 2020;13:38.","journal-title":"Mol Brain"},{"key":"1391_CR50","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1126\/science.282.5391.1145","volume":"282","author":"JA Thomson","year":"1998","unstructured":"Thomson JA, Itskovitz-Eldor J, Shapiro SS, et al. Embryonic stem cell lines derived from human blastocysts. Science. 1998;282:1145\u20137.","journal-title":"Science"},{"key":"1391_CR51","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1038\/nbt1318","volume":"25","author":"O Adewumi","year":"2007","unstructured":"Adewumi O, Aflatoonian B, Ahrlund-Richter L, et al. Characterization of human embryonic stem cell lines by the International Stem Cell Initiative. Nat Biotechnol. 2007;25:803\u201316.","journal-title":"Nat Biotechnol"},{"key":"1391_CR52","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1016\/j.stemcr.2021.05.012","volume":"16","author":"R Lovell-Badge","year":"2021","unstructured":"Lovell-Badge R, Anthony E, Barker RA, et al. ISSCR guidelines for stem cell research and clinical translation: the 2021 update. Stem Cell Rep. 2021;16:1398\u2013408.","journal-title":"Stem Cell Rep"}],"container-title":["Human Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13577-026-01391-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13577-026-01391-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13577-026-01391-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T15:01:41Z","timestamp":1779634901000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13577-026-01391-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,24]]},"references-count":52,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["1391"],"URL":"https:\/\/doi.org\/10.1007\/s13577-026-01391-3","relation":{},"ISSN":["1749-0774"],"issn-type":[{"value":"1749-0774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,24]]},"assertion":[{"value":"1 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no competing interests to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was performed in accordance with the Declaration of Helsinki. Approval was granted by the Ethics Committee of Henan Provincial People\u2019s Hospital. The use of human specimens in this study was approved by the Ethics Committee [Ethics Approval No. 77 (2020)], and written informed consent was obtained from the participant.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"77"}}