{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T04:44:33Z","timestamp":1785818673314,"version":"3.56.0"},"reference-count":252,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Human Cell"],"DOI":"10.1007\/s13577-026-01425-w","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T01:32:36Z","timestamp":1785807156000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the role of CaMKII in exercise-induced cardioprotection"],"prefix":"10.1007","volume":"39","author":[{"given":"Yongchang","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,4]]},"reference":[{"issue":"12","key":"1425_CR1","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1038\/s41569-020-0403-y","volume":"17","author":"G Heusch","year":"2020","unstructured":"Heusch G. Myocardial ischaemia-reperfusion injury and cardioprotection in perspective. Nat Rev Cardiol. 2020;17(12):773\u201389.","journal-title":"Nat Rev Cardiol"},{"key":"1425_CR2","volume":"11","author":"C Tong","year":"2025","unstructured":"Tong C, Zhou B. Cardioprotective strategies in myocardial ischemia-reperfusion injury: implications for improving clinical translation. J Mol Cell Cardiol Plus. 2025;11:100278.","journal-title":"J Mol Cell Cardiol Plus"},{"key":"1425_CR3","doi-asserted-by":"publisher","DOI":"10.3390\/antiox14070889","author":"P Pagliaro","year":"2025","unstructured":"Pagliaro P, Alloatti G, Penna C. Cardioprotection reloaded: reflections on 40 years of research. Antioxidants (Basel). 2025. https:\/\/doi.org\/10.3390\/antiox14070889.","journal-title":"Antioxidants (Basel)"},{"key":"1425_CR4","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10071473","author":"NS Dhalla","year":"2022","unstructured":"Dhalla NS, et al. Role of oxidative stress in cardiac dysfunction and subcellular defects due to ischemia-reperfusion injury. Biomedicines. 2022. https:\/\/doi.org\/10.3390\/biomedicines10071473.","journal-title":"Biomedicines"},{"key":"1425_CR5","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25052667","author":"G Gallo","year":"2024","unstructured":"Gallo G, Rubattu S, Volpe M. Mitochondrial dysfunction in heart failure: from pathophysiological mechanisms to therapeutic opportunities. Int J Mol Sci. 2024. https:\/\/doi.org\/10.3390\/ijms25052667.","journal-title":"Int J Mol Sci"},{"key":"1425_CR6","doi-asserted-by":"publisher","DOI":"10.1113\/JP287770","author":"E Rozich","year":"2025","unstructured":"Rozich E, et al. Mitochondrial oxidative stress, calcium and dynamics in cardiac ischaemia-reperfusion injury. J Physiol. 2025. https:\/\/doi.org\/10.1113\/JP287770.","journal-title":"J Physiol"},{"issue":"12","key":"1425_CR7","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1038\/s41569-018-0065-1","volume":"15","author":"C Fiuza-Luces","year":"2018","unstructured":"Fiuza-Luces C, et al. Exercise benefits in cardiovascular disease: beyond attenuation of traditional risk factors. Nat Rev Cardiol. 2018;15(12):731\u201343.","journal-title":"Nat Rev Cardiol"},{"issue":"15","key":"1425_CR8","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1089\/ars.2019.8009","volume":"32","author":"C Penna","year":"2020","unstructured":"Penna C, Alloatti G, Crisafulli A. Mechanisms involved in cardioprotection induced by physical exercise. Antioxid Redox Signal. 2020;32(15):1115\u201334.","journal-title":"Antioxid Redox Signal"},{"key":"1425_CR9","doi-asserted-by":"publisher","DOI":"10.3390\/cells8101128","author":"D Sch\u00fcttler","year":"2019","unstructured":"Sch\u00fcttler D, et al. Molecular mechanisms of cardiac remodeling and regeneration in physical exercise. Cells. 2019. https:\/\/doi.org\/10.3390\/cells8101128.","journal-title":"Cells"},{"key":"1425_CR10","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.amjcard.2021.02.030","volume":"148","author":"JC Quindry","year":"2021","unstructured":"Quindry JC, Franklin BA. Exercise preconditioning as a cardioprotective phenotype. Am J Cardiol. 2021;148:8\u201315.","journal-title":"Am J Cardiol"},{"issue":"1","key":"1425_CR11","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s40798-023-00553-z","volume":"9","author":"L Fuertes-Kenneally","year":"2023","unstructured":"Fuertes-Kenneally L, et al. Effects and optimal dose of exercise on endothelial function in patients with heart failure: a systematic review and meta-analysis. Sports Med Open. 2023;9(1):8.","journal-title":"Sports Med Open"},{"issue":"5","key":"1425_CR12","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.smhs.2025.03.009","volume":"7","author":"JC Quindry","year":"2025","unstructured":"Quindry JC, Michalak RE. Exercise-induced cardioprotection: from endogenous to exogenous mechanisms. Sports Med Health Sci. 2025;7(5):366\u201374.","journal-title":"Sports Med Health Sci"},{"issue":"Pt 3","key":"1425_CR13","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1042\/bj20020228","volume":"364","author":"A Hudmon","year":"2002","unstructured":"Hudmon A, Schulman H. Structure-function of the multifunctional Ca2+\/calmodulin-dependent protein kinase II. Biochem J. 2002;364(Pt 3):593\u2013611.","journal-title":"Biochem J"},{"key":"1425_CR14","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.668129","volume":"8","author":"Y Yang","year":"2021","unstructured":"Yang Y, et al. CaMKII in regulation of cell death during myocardial reperfusion injury. Front Mol Biosci. 2021;8:668129.","journal-title":"Front Mol Biosci"},{"issue":"3","key":"1425_CR15","doi-asserted-by":"publisher","first-page":"401","DOI":"10.3390\/cells12030401","volume":"12","author":"JAP Rostas","year":"2023","unstructured":"Rostas JAP, Skelding KA. Calcium\/calmodulin-stimulated protein kinase II (CaMKII): different functional outcomes from activation, depending on the cellular microenvironment. Cells. 2023;12(3):401.","journal-title":"Cells"},{"issue":"7","key":"1425_CR16","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1016\/j.hrthm.2011.01.030","volume":"8","author":"DM Bers","year":"2011","unstructured":"Bers DM. Ca2\u207a-calmodulin-dependent protein kinase II regulation of cardiac excitation-transcription coupling. Heart Rhythm. 2011;8(7):1101\u20134.","journal-title":"Heart Rhythm"},{"issue":"4","key":"1425_CR17","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s00395-018-0688-8","volume":"113","author":"J Beckendorf","year":"2018","unstructured":"Beckendorf J, van den Hoogenhof MMG, Backs J. Physiological and unappreciated roles of CaMKII in the heart. Basic Res Cardiol. 2018;113(4):29.","journal-title":"Basic Res Cardiol"},{"issue":"9","key":"1425_CR18","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1161\/CIRCRESAHA.120.316947","volume":"127","author":"S Ljubojevic-Holzer","year":"2020","unstructured":"Ljubojevic-Holzer S, et al. CaMKII\u03b4C drives early adaptive Ca(2+) change and late eccentric cardiac hypertrophy. Circ Res. 2020;127(9):1159\u201378.","journal-title":"Circ Res"},{"key":"1425_CR19","doi-asserted-by":"publisher","DOI":"10.1113\/jp285941","author":"A Mattiazzi","year":"2025","unstructured":"Mattiazzi A, Jaquenod De Giusti C, Valverde CA. CaMKII at the crossroads: calcium dysregulation, and post-translational modifications driving cell death. J Physiol. 2025. https:\/\/doi.org\/10.1113\/jp285941.","journal-title":"J Physiol"},{"key":"1425_CR20","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.yjmcc.2019.01.001","volume":"127","author":"B Hegyi","year":"2019","unstructured":"Hegyi B, Bers DM, Bossuyt J. CaMKII signaling in heart diseases: emerging role in diabetic cardiomyopathy. J Mol Cell Cardiol. 2019;127:246\u201359.","journal-title":"J Mol Cell Cardiol"},{"issue":"2","key":"1425_CR21","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1001\/jamacardio.2017.4495","volume":"3","author":"DHJ Thijssen","year":"2018","unstructured":"Thijssen DHJ, et al. Association of exercise preconditioning with immediate cardioprotection: a review. JAMA Cardiol. 2018;3(2):169\u201376.","journal-title":"JAMA Cardiol"},{"issue":"3","key":"1425_CR22","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.yjmcc.2007.06.013","volume":"43","author":"OJ Kemi","year":"2007","unstructured":"Kemi OJ, et al. Aerobic interval training enhances cardiomyocyte contractility and Ca2+ cycling by phosphorylation of CaMKII and Thr-17 of phospholamban. J Mol Cell Cardiol. 2007;43(3):354\u201361.","journal-title":"J Mol Cell Cardiol"},{"issue":"1","key":"1425_CR23","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1152\/japplphysiol.00188.2016","volume":"121","author":"MA H\u00f8ydal","year":"1985","unstructured":"H\u00f8ydal MA, et al. Exercise training reverses myocardial dysfunction induced by CaMKII\u03b4C overexpression by restoring Ca2+ homeostasis. J Appl Physiol. 1985;121(1):212\u201320.","journal-title":"J Appl Physiol"},{"issue":"6","key":"1425_CR24","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1161\/01.RES.84.6.713","volume":"84","author":"B Hoch","year":"1999","unstructured":"Hoch B, et al. Identification and expression of delta-isoforms of the multifunctional Ca2+\/calmodulin-dependent protein kinase in failing and nonfailing human myocardium. Circ Res. 1999;84(6):713\u201321.","journal-title":"Circ Res"},{"key":"1425_CR25","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.yjmcc.2016.12.007","volume":"103","author":"N Feng","year":"2017","unstructured":"Feng N, Anderson ME. CaMKII is a nodal signal for multiple programmed cell death pathways in heart. J Mol Cell Cardiol. 2017;103:102\u20139.","journal-title":"J Mol Cell Cardiol"},{"key":"1425_CR26","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1146\/annurev-pharmtox-051421-111814","volume":"63","author":"OE Reyes Gaido","year":"2023","unstructured":"Reyes Gaido OE, et al. CaMKII as a therapeutic target in cardiovascular disease. Annu Rev Pharmacol Toxicol. 2023;63:249\u201372.","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"4","key":"1425_CR27","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1083\/jcb.126.4.839","volume":"126","author":"M Srinivasan","year":"1994","unstructured":"Srinivasan M, Edman CF, Schulman H. Alternative splicing introduces a nuclear localization signal that targets multifunctional CaM kinase to the nucleus. J Cell Biol. 1994;126(4):839\u201352.","journal-title":"J Cell Biol"},{"issue":"3","key":"1425_CR28","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1016\/j.cardiores.2004.04.026","volume":"63","author":"T Zhang","year":"2004","unstructured":"Zhang T, Brown JH. Role of Ca2+\/calmodulin-dependent protein kinase II in cardiac hypertrophy and heart failure. Cardiovasc Res. 2004;63(3):476\u201386.","journal-title":"Cardiovasc Res"},{"key":"1425_CR29","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.644630","volume":"9","author":"J Duran","year":"2021","unstructured":"Duran J, et al. CaMKII\u03b4 splice variants in the healthy and diseased heart. Front Cell Dev Biol. 2021;9:644630.","journal-title":"Front Cell Dev Biol"},{"issue":"9","key":"1425_CR30","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1038\/s41556-019-0380-8","volume":"21","author":"M Zhang","year":"2019","unstructured":"Zhang M, et al. CaMKII-\u03b49 promotes cardiomyopathy through disrupting UBE2T-dependent DNA repair. Nat Cell Biol. 2019;21(9):1152\u201363.","journal-title":"Nat Cell Biol"},{"issue":"6","key":"1425_CR31","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1161\/CIRCRESAHA.121.319478","volume":"130","author":"Y Yao","year":"2022","unstructured":"Yao Y, et al. Targeting CaMKII-\u03b49 ameliorates cardiac ischemia\/reperfusion injury by inhibiting myocardial inflammation. Circ Res. 2022;130(6):887\u2013903.","journal-title":"Circ Res"},{"issue":"13","key":"1425_CR32","doi-asserted-by":"publisher","first-page":"12484","DOI":"10.1074\/jbc.M313597200","volume":"279","author":"TR Gaertner","year":"2004","unstructured":"Gaertner TR, et al. Comparative analyses of the three-dimensional structures and enzymatic properties of alpha, beta, gamma and delta isoforms of Ca2+-calmodulin-dependent protein kinase II. J Biol Chem. 2004;279(13):12484\u201394.","journal-title":"J Biol Chem"},{"issue":"5","key":"1425_CR33","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/j.cell.2005.10.029","volume":"123","author":"OS Rosenberg","year":"2005","unstructured":"Rosenberg OS, et al. Structure of the autoinhibited kinase domain of CaMKII and SAXS analysis of the holoenzyme. Cell. 2005;123(5):849\u201360.","journal-title":"Cell"},{"issue":"5","key":"1425_CR34","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1016\/j.cell.2011.07.038","volume":"146","author":"LH Chao","year":"2011","unstructured":"Chao LH, et al. A mechanism for tunable autoinhibition in the structure of a human Ca2+\/calmodulin- dependent kinase II holoenzyme. Cell. 2011;146(5):732\u201345.","journal-title":"Cell"},{"issue":"7","key":"1425_CR35","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1038\/emboj.2011.40","volume":"30","author":"L Hoffman","year":"2011","unstructured":"Hoffman L, et al. Conformational changes underlying calcium\/calmodulin-dependent protein kinase II activation. EMBO J. 2011;30(7):1251\u201362.","journal-title":"EMBO J"},{"issue":"6","key":"1425_CR36","doi-asserted-by":"publisher","first-page":"a035147","DOI":"10.1101\/cshperspect.a035147","volume":"12","author":"M Bhattacharyya","year":"2020","unstructured":"Bhattacharyya M, Karandur D, Kuriyan J. Structural insights into the regulation of ca(2+)\/calmodulin-dependent protein kinase II (CaMKII). Cold Spring Harb Perspect Biol. 2020;12(6):a035147.","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"26","key":"1425_CR37","doi-asserted-by":"publisher","first-page":"eadh1069","DOI":"10.1126\/sciadv.adh1069","volume":"9","author":"S Tsujioka","year":"2023","unstructured":"Tsujioka S, et al. Imaging single CaMKII holoenzymes at work by high-speed atomic force microscopy. Sci Adv. 2023;9(26):eadh1069.","journal-title":"Sci Adv"},{"issue":"641","key":"1425_CR38","doi-asserted-by":"publisher","first-page":"eaaz0240","DOI":"10.1126\/scisignal.aaz0240","volume":"13","author":"R Sloutsky","year":"2020","unstructured":"Sloutsky R, et al. Heterogeneity in human hippocampal CaMKII transcripts reveals allosteric hub-dependent regulation. Sci Signal. 2020;13(641):eaaz0240.","journal-title":"Sci Signal"},{"issue":"1","key":"1425_CR39","doi-asserted-by":"publisher","first-page":"8461","DOI":"10.1038\/s41467-025-63249-w","volume":"16","author":"BV Nguyen","year":"2025","unstructured":"Nguyen BV, et al. A domain-swapped CaMKII conformation facilitates linker-mediated allosteric regulation. Nat Commun. 2025;16(1):8461.","journal-title":"Nat Commun"},{"issue":"12","key":"1425_CR40","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1161\/CIRCRESAHA.111.248401","volume":"109","author":"S Mishra","year":"2011","unstructured":"Mishra S, et al. Location matters: clarifying the concept of nuclear and cytosolic CaMKII subtypes. Circ Res. 2011;109(12):1354\u201362.","journal-title":"Circ Res"},{"issue":"48","key":"1425_CR41","doi-asserted-by":"publisher","first-page":"35078","DOI":"10.1074\/jbc.M707083200","volume":"282","author":"T Zhang","year":"2007","unstructured":"Zhang T, et al. CaMKIIdelta isoforms differentially affect calcium handling but similarly regulate HDAC\/MEF2 transcriptional responses. J Biol Chem. 2007;282(48):35078\u201387.","journal-title":"J Biol Chem"},{"key":"1425_CR42","doi-asserted-by":"publisher","first-page":"15","DOI":"10.3389\/fphar.2014.00015","volume":"5","author":"CB Gray","year":"2014","unstructured":"Gray CB, Heller Brown J. CaMKIIdelta subtypes: localization and function. Front Pharmacol. 2014;5:15.","journal-title":"Front Pharmacol."},{"key":"1425_CR43","doi-asserted-by":"publisher","first-page":"59","DOI":"10.3389\/fphar.2014.00059","volume":"5","author":"JR Erickson","year":"2014","unstructured":"Erickson JR. Mechanisms of CaMKII activation in the heart. Front Pharmacol. 2014;5:59.","journal-title":"Front Pharmacol"},{"key":"1425_CR44","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.yjmcc.2021.08.002","volume":"161","author":"M Simon","year":"2021","unstructured":"Simon M, et al. CaMKII\u03b4 post-translational modifications increase affinity for calmodulin inside cardiac ventricular myocytes. J Mol Cell Cardiol. 2021;161:53\u201361.","journal-title":"J Mol Cell Cardiol"},{"issue":"3","key":"1425_CR45","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1152\/physrev.00018.2010","volume":"91","author":"JR Erickson","year":"2011","unstructured":"Erickson JR, et al. CaMKII in the cardiovascular system: sensing redox states. Physiol Rev. 2011;91(3):889\u2013915.","journal-title":"Physiol Rev"},{"issue":"3","key":"1425_CR46","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/j.cell.2008.02.048","volume":"133","author":"JR Erickson","year":"2008","unstructured":"Erickson JR, et al. A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation. Cell. 2008;133(3):462\u201374.","journal-title":"Cell"},{"issue":"7471","key":"1425_CR47","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1038\/nature12537","volume":"502","author":"JR Erickson","year":"2013","unstructured":"Erickson JR, et al. Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation. Nature. 2013;502(7471):372\u20136.","journal-title":"Nature"},{"issue":"42","key":"1425_CR48","doi-asserted-by":"publisher","first-page":"25646","DOI":"10.1074\/jbc.M115.650234","volume":"290","author":"JR Erickson","year":"2015","unstructured":"Erickson JR, et al. S-Nitrosylation induces both autonomous activation and inhibition of calcium\/calmodulin-dependent protein kinase II \u03b4. J Biol Chem. 2015;290(42):25646\u201356.","journal-title":"J Biol Chem"},{"issue":"11","key":"1425_CR49","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2022.102579","volume":"298","author":"N Rocco-Machado","year":"2022","unstructured":"Rocco-Machado N, et al. Oxidative stress-induced autonomous activation of the calcium\/calmodulin-dependent kinase II involves disulfide formation in the regulatory domain. J Biol Chem. 2022;298(11):102579.","journal-title":"J Biol Chem"},{"key":"1425_CR50","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.113982","author":"CN Brown","year":"2024","unstructured":"Brown CN, Bayer KU. Studying CaMKII: tools and standards. Cell Rep. 2024. https:\/\/doi.org\/10.1016\/j.celrep.2024.113982.","journal-title":"Cell Rep"},{"issue":"12","key":"1425_CR51","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.1161\/01.RES.0000194329.41863.89","volume":"97","author":"X Ai","year":"2005","unstructured":"Ai X, et al. Ca2+\/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure. Circ Res. 2005;97(12):1314\u201322.","journal-title":"Circ Res"},{"key":"1425_CR52","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.yjmcc.2018.10.010","volume":"125","author":"BM Wood","year":"2018","unstructured":"Wood BM, et al. Cardiac CaMKII activation promotes rapid translocation to its extra-dyadic targets. J Mol Cell Cardiol. 2018;125:18\u201328.","journal-title":"J Mol Cell Cardiol"},{"issue":"7","key":"1425_CR53","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.1172\/JCI27438","volume":"116","author":"J Backs","year":"2006","unstructured":"Backs J, et al. CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy. J Clin Invest. 2006;116(7):1853\u201364.","journal-title":"J Clin Invest"},{"issue":"7423","key":"1425_CR54","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1038\/nature11444","volume":"491","author":"ML Joiner","year":"2012","unstructured":"Joiner ML, et al. CaMKII determines mitochondrial stress responses in heart. Nature. 2012;491(7423):269\u201373.","journal-title":"Nature"},{"issue":"7","key":"1425_CR55","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1113\/JP276766","volume":"598","author":"AG Nickel","year":"2020","unstructured":"Nickel AG, et al. CaMKII does not control mitochondrial Ca(2+) uptake in cardiac myocytes. J Physiol. 2020;598(7):1361\u201376.","journal-title":"J Physiol"},{"issue":"2","key":"1425_CR56","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1161\/CIRCRESAHA.117.310230","volume":"121","author":"DA Eisner","year":"2017","unstructured":"Eisner DA, et al. Calcium and excitation-contraction coupling in the heart. Circ Res. 2017;121(2):181\u201395.","journal-title":"Circ Res"},{"key":"1425_CR57","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.810408","volume":"12","author":"RE Dixon","year":"2021","unstructured":"Dixon RE. Nanoscale organization, regulation, and dynamic reorganization of cardiac calcium channels. Front Physiol. 2021;12:810408.","journal-title":"Front Physiol"},{"issue":"3","key":"1425_CR58","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1083\/jcb.200505155","volume":"171","author":"A Hudmon","year":"2005","unstructured":"Hudmon A, et al. CaMKII tethers to L-type Ca2+ channels, establishing a local and dedicated integrator of Ca2+ signals for facilitation. J Cell Biol. 2005;171(3):537\u201347.","journal-title":"J Cell Biol"},{"issue":"4","key":"1425_CR59","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/j.cardiores.2006.11.005","volume":"73","author":"LS Maier","year":"2007","unstructured":"Maier LS, Bers DM. Role of Ca2+\/calmodulin-dependent protein kinase (CaMK) in excitation-contraction coupling in the heart. Cardiovasc Res. 2007;73(4):631\u201340.","journal-title":"Cardiovasc Res"},{"issue":"6","key":"1425_CR60","doi-asserted-by":"publisher","first-page":"e61","DOI":"10.1161\/01.RES.0000125626.33738.E2","volume":"94","author":"XH Wehrens","year":"2004","unstructured":"Wehrens XH, et al. Ca2+\/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor. Circ Res. 2004;94(6):e61-70.","journal-title":"Circ Res"},{"issue":"22","key":"1425_CR61","doi-asserted-by":"publisher","first-page":"10274","DOI":"10.1073\/pnas.1005843107","volume":"107","author":"A Kushnir","year":"2010","unstructured":"Kushnir A, et al. Role of CaMKIIdelta phosphorylation of the cardiac ryanodine receptor in the force frequency relationship and heart failure. Proc Natl Acad Sci U S A. 2010;107(22):10274\u20139.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1425_CR62","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.yjmcc.2016.06.007","volume":"98","author":"H Uchinoumi","year":"2016","unstructured":"Uchinoumi H, et al. CaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift. J Mol Cell Cardiol. 2016;98:62\u201372.","journal-title":"J Mol Cell Cardiol"},{"issue":"10","key":"1425_CR63","doi-asserted-by":"publisher","first-page":"H1177","DOI":"10.1152\/ajpheart.00007.2015","volume":"308","author":"A Mattiazzi","year":"2015","unstructured":"Mattiazzi A, et al. Chasing cardiac physiology and pathology down the CaMKII cascade. Am J Physiol Heart Circ Physiol. 2015;308(10):H1177\u201391.","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"29","key":"1425_CR64","doi-asserted-by":"publisher","first-page":"22532","DOI":"10.1074\/jbc.C000253200","volume":"275","author":"D Hagemann","year":"2000","unstructured":"Hagemann D, et al. Frequency-encoding Thr17 phospholamban phosphorylation is independent of Ser16 phosphorylation in cardiac myocytes. J Biol Chem. 2000;275(29):22532\u20136.","journal-title":"J Biol Chem"},{"key":"1425_CR65","doi-asserted-by":"publisher","first-page":"5","DOI":"10.3389\/fphar.2014.00005","volume":"5","author":"A Mattiazzi","year":"2014","unstructured":"Mattiazzi A, Kranias EG. The role of CaMKII regulation of phospholamban activity in heart disease. Front Pharmacol. 2014;5:5.","journal-title":"Front Pharmacol"},{"issue":"1","key":"1425_CR66","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1111\/j.1469-7793.1997.017bo.x","volume":"501","author":"L Li","year":"1997","unstructured":"Li L, et al. The effect of Ca(2+)-calmodulin-dependent protein kinase II on cardiac excitation-contraction coupling in ferret ventricular myocytes. J Physiol. 1997;501(1):17\u201331.","journal-title":"J Physiol"},{"issue":"3","key":"1425_CR67","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.yjmcc.2012.06.019","volume":"53","author":"Y Wu","year":"2012","unstructured":"Wu Y, et al. CaMKII effects on inotropic but not lusitropic force frequency responses require phospholamban. J Mol Cell Cardiol. 2012;53(3):429\u201336.","journal-title":"J Mol Cell Cardiol"},{"issue":"11","key":"1425_CR68","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.1161\/CIRCRESAHA.112.268094","volume":"110","author":"JL Respress","year":"2012","unstructured":"Respress JL, et al. Role of RyR2 phosphorylation at S2814 during heart failure progression. Circ Res. 2012;110(11):1474\u201383.","journal-title":"Circ Res"},{"issue":"17","key":"1425_CR69","doi-asserted-by":"publisher","first-page":"2059","DOI":"10.1161\/CIRCULATIONAHA.111.067306","volume":"125","author":"N Voigt","year":"2012","unstructured":"Voigt N, et al. Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+-Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation. Circulation. 2012;125(17):2059\u201370.","journal-title":"Circulation"},{"issue":"9","key":"1425_CR70","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1161\/CIRCRESAHA.110.220418","volume":"107","author":"S Sossalla","year":"2010","unstructured":"Sossalla S, et al. Inhibition of elevated Ca2+\/calmodulin-dependent protein kinase II improves contractility in human failing myocardium. Circ Res. 2010;107(9):1150\u201361.","journal-title":"Circ Res"},{"issue":"12","key":"1425_CR71","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.1161\/CIRCRESAHA.111.243956","volume":"110","author":"PD Swaminathan","year":"2012","unstructured":"Swaminathan PD, et al. Calmodulin-dependent protein kinase II: linking heart failure and arrhythmias. Circ Res. 2012;110(12):1661\u201377.","journal-title":"Circ Res"},{"issue":"6","key":"1425_CR72","doi-asserted-by":"publisher","first-page":"H1227","DOI":"10.1152\/ajpheart.00185.2017","volume":"313","author":"B Onal","year":"2017","unstructured":"Onal B, Gratz D, Hund TJ. Ca2+\/calmodulin-dependent kinase II-dependent regulation of atrial myocyte late Na+ current, Ca2+ cycling, and excitability: a mathematical modeling study. Am J Physiol Heart Circ Physiol. 2017;313(6):H1227-h1239.","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"19","key":"1425_CR73","doi-asserted-by":"publisher","first-page":"1894","DOI":"10.1161\/CIRCULATIONAHA.120.048698","volume":"143","author":"X Liu","year":"2021","unstructured":"Liu X, et al. Increased reactive oxygen species-mediated Ca2+\/calmodulin-dependent protein kinase II activation contributes to calcium handling abnormalities and impaired contraction in Barth syndrome. Circulation. 2021;143(19):1894\u2013911.","journal-title":"Circulation"},{"issue":"8","key":"1425_CR74","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1161\/01.RES.0000145361.50017.aa","volume":"95","author":"W Wang","year":"2004","unstructured":"Wang W, et al. Sustained beta1-adrenergic stimulation modulates cardiac contractility by Ca2+\/calmodulin kinase signaling pathway. Circ Res. 2004;95(8):798\u2013806.","journal-title":"Circ Res"},{"issue":"15","key":"1425_CR75","doi-asserted-by":"publisher","first-page":"3129","DOI":"10.1113\/JP279607","volume":"598","author":"JC Reil","year":"2020","unstructured":"Reil JC, et al. CaMKII activity contributes to homeometric autoregulation of the heart: a novel mechanism for the Anrep effect. J Physiol. 2020;598(15):3129\u201353.","journal-title":"J Physiol"},{"issue":"22","key":"1425_CR76","doi-asserted-by":"publisher","first-page":"4865","DOI":"10.1113\/JP283427","volume":"600","author":"CC Alim","year":"2022","unstructured":"Alim CC, et al. Nitrosylation of cardiac CaMKII at Cys290 mediates mechanical afterload-induced increases in Ca(2+) transient and Ca(2+) sparks. J Physiol. 2022;600(22):4865\u201379.","journal-title":"J Physiol"},{"key":"1425_CR77","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.yjmcc.2019.12.002","volume":"138","author":"MJ Baier","year":"2020","unstructured":"Baier MJ, et al. Ca2+\/calmodulin-dependent protein kinase II is essential in hyperacute pressure overload. J Mol Cell Cardiol. 2020;138:212\u201321.","journal-title":"J Mol Cell Cardiol"},{"issue":"1","key":"1425_CR78","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1146\/annurev-pharmtox-051421-111814","volume":"63","author":"OE Reyes Gaido","year":"2023","unstructured":"Reyes Gaido OE, et al. CaMKII as a therapeutic target in cardiovascular disease. Annu Rev Pharmacol Toxicol. 2023;63(1):249\u201372.","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"Pt 1","key":"1425_CR79","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1113\/jphysiol.2003.054171","volume":"553","author":"AJ Rose","year":"2003","unstructured":"Rose AJ, Hargreaves M. Exercise increases Ca2+-calmodulin-dependent protein kinase II activity in human skeletal muscle. J Physiol. 2003;553(Pt 1):303\u20139.","journal-title":"J Physiol"},{"issue":"Pt 3","key":"1425_CR80","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1113\/jphysiol.2006.111757","volume":"574","author":"AJ Rose","year":"2006","unstructured":"Rose AJ, Kiens B, Richter EA. Ca2+-calmodulin-dependent protein kinase expression and signalling in skeletal muscle during exercise. J Physiol. 2006;574(Pt 3):889\u2013903.","journal-title":"J Physiol"},{"issue":"2","key":"1425_CR81","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1007\/s00421-011-1994-0","volume":"112","author":"G Kaurstad","year":"2012","unstructured":"Kaurstad G, et al. Chronic CaMKII inhibition blunts the cardiac contractile response to exercise training. Eur J Appl Physiol. 2012;112(2):579\u201388.","journal-title":"Eur J Appl Physiol"},{"issue":"6","key":"1425_CR82","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1161\/CIRCRESAHA.109.199810","volume":"105","author":"TO St\u00f8len","year":"2009","unstructured":"St\u00f8len TO, et al. Interval training normalizes cardiomyocyte function, diastolic Ca2+ control, and SR Ca2+ release synchronicity in a mouse model of diabetic cardiomyopathy. Circ Res. 2009;105(6):527\u201336.","journal-title":"Circ Res"},{"issue":"6","key":"1425_CR83","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066288","volume":"8","author":"AB Johnsen","year":"2013","unstructured":"Johnsen AB, et al. Aerobic interval training partly reverse contractile dysfunction and impaired Ca2+ handling in atrial myocytes from rats with post infarction heart failure. PLoS ONE. 2013;8(6):e66288.","journal-title":"PLoS ONE"},{"issue":"3","key":"1425_CR84","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1093\/cvr\/cvw095","volume":"111","author":"R Manotheepan","year":"2016","unstructured":"Manotheepan R, et al. Exercise training prevents ventricular tachycardia in CPVT1 due to reduced CaMKII-dependent arrhythmogenic Ca2+ release. Cardiovasc Res. 2016;111(3):295\u2013306.","journal-title":"Cardiovasc Res"},{"key":"1425_CR85","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2020.623922","volume":"7","author":"TK Danielsen","year":"2020","unstructured":"Danielsen TK, et al. Exercise training stabilizes RyR2-dependent Ca(2+) release in post-infarction heart failure. Front Cardiovasc Med. 2020;7:623922.","journal-title":"Front Cardiovasc Med"},{"issue":"5","key":"1425_CR86","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1007\/s12012-019-09514-z","volume":"19","author":"FH B\u00e6kkerud","year":"2019","unstructured":"B\u00e6kkerud FH, et al. High intensity interval training ameliorates mitochondrial dysfunction in the left ventricle of mice with type 2 diabetes. Cardiovasc Toxicol. 2019;19(5):422\u201331.","journal-title":"Cardiovasc Toxicol"},{"issue":"2","key":"1425_CR87","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s00424-019-02266-3","volume":"472","author":"DY Seo","year":"2020","unstructured":"Seo DY, et al. Cardiac adaptation to exercise training in health and disease. Pflugers Arch. 2020;472(2):155\u201368.","journal-title":"Pflugers Arch"},{"issue":"6","key":"1425_CR88","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2023.101100","volume":"11","author":"Y Wang","year":"2024","unstructured":"Wang Y, et al. Elevated meteorin-like protein from high-intensity interval training improves heart function via AMPK\/HDAC4 pathway. Genes Dis. 2024;11(6):101100.","journal-title":"Genes Dis"},{"issue":"4","key":"1425_CR89","doi-asserted-by":"publisher","first-page":"2471","DOI":"10.1007\/s11010-024-05124-8","volume":"480","author":"S Yuan","year":"2025","unstructured":"Yuan S, et al. Improving effect of physical exercise on heart failure: reducing oxidative stress-induced inflammation by restoring Ca(2+) homeostasis. Mol Cell Biochem. 2025;480(4):2471\u201386.","journal-title":"Mol Cell Biochem"},{"issue":"8","key":"1425_CR90","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1161\/CIRCRESAHA.116.304937","volume":"116","author":"RC Lyon","year":"2015","unstructured":"Lyon RC, et al. Mechanotransduction in cardiac hypertrophy and failure. Circ Res. 2015;116(8):1462\u201376.","journal-title":"Circ Res"},{"issue":"3","key":"1425_CR91","first-page":"H552","volume":"314","author":"J You","year":"2018","unstructured":"You J, et al. Differential cardiac hypertrophy and signaling pathways in pressure versus volume overload. Am J Physiol Heart Circ Physiol. 2018;314(3):H552-h562.","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"1","key":"1425_CR92","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1186\/s13102-025-01165-8","volume":"17","author":"N Pamart","year":"2025","unstructured":"Pamart N, et al. Association between muscle strength gains and biventricular cardiac remodeling in response to high-intensity resistance training in healthy untrained males: a longitudinal study. BMC Sports Sci Med Rehabil. 2025;17(1):116.","journal-title":"BMC Sports Sci Med Rehabil"},{"issue":"4","key":"1425_CR93","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/j.jacep.2022.12.002","volume":"9","author":"AD Elliott","year":"2023","unstructured":"Elliott AD, et al. An exercise and physical activity program in patients with atrial fibrillation: the ACTIVE-AF randomized controlled trial. JACC Clin Electrophysiol. 2023;9(4):455\u201365.","journal-title":"JACC Clin Electrophysiol"},{"issue":"6","key":"1425_CR94","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1007\/s10741-023-10310-9","volume":"28","author":"JL Taylor","year":"2023","unstructured":"Taylor JL, Myers J, Bonikowske AR. Practical guidelines for exercise prescription in patients with chronic heart failure. Heart Fail Rev. 2023;28(6):1285\u201396.","journal-title":"Heart Fail Rev"},{"issue":"1","key":"1425_CR95","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1038\/s41392-022-01153-1","volume":"7","author":"H Chen","year":"2022","unstructured":"Chen H, et al. Exercise training maintains cardiovascular health: signaling pathways involved and potential therapeutics. Signal Transduct Target Ther. 2022;7(1):306.","journal-title":"Signal Transduct Target Ther"},{"issue":"2","key":"1425_CR96","doi-asserted-by":"publisher","first-page":"025","DOI":"10.1093\/ehjopen\/oeaf025","volume":"5","author":"BJR Buckley","year":"2025","unstructured":"Buckley BJR, et al. Exercise-based cardiac rehabilitation for patients with atrial fibrillation: a narrative review. Eur Heart J Open. 2025;5(2):025.","journal-title":"Eur Heart J Open"},{"issue":"3","key":"1425_CR97","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0173449","volume":"12","author":"K Ljones","year":"2017","unstructured":"Ljones K, et al. Acute exhaustive aerobic exercise training impair cardiomyocyte function and calcium handling in Sprague-Dawley rats. PLoS ONE. 2017;12(3):e0173449.","journal-title":"PLoS ONE"},{"key":"1425_CR98","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101480","volume":"35","author":"AJ Cheng","year":"2020","unstructured":"Cheng AJ, Jude B, Lanner JT. Intramuscular mechanisms of overtraining. Redox Biol. 2020;35:101480.","journal-title":"Redox Biol"},{"issue":"4","key":"1425_CR99","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.smhs.2025.01.006","volume":"7","author":"O Fiala","year":"2025","unstructured":"Fiala O, et al. Beyond physical exhaustion: understanding overtraining syndrome through the lens of molecular mechanisms and clinical manifestation. Sports Med Health Sci. 2025;7(4):237\u201348.","journal-title":"Sports Med Health Sci"},{"key":"1425_CR100","first-page":"386","volume":"20","author":"JS Joseph","year":"2021","unstructured":"Joseph JS, et al. Exercise, CaMKII, and type 2 diabetes. EXCLI J. 2021;20:386.","journal-title":"EXCLI J"},{"issue":"1","key":"1425_CR101","doi-asserted-by":"publisher","first-page":"3175","DOI":"10.1038\/s41467-021-23549-3","volume":"12","author":"Q Wang","year":"2021","unstructured":"Wang Q, et al. CaMKII oxidation is a critical performance\/disease trade-off acquired at the dawn of vertebrate evolution. Nat Commun. 2021;12(1):3175.","journal-title":"Nat Commun"},{"key":"1425_CR102","doi-asserted-by":"publisher","first-page":"96","DOI":"10.3389\/fphar.2014.00096","volume":"5","author":"JR Bell","year":"2014","unstructured":"Bell JR, Vila-Petroff M, Delbridge LM. CaMKII-dependent responses to ischemia and reperfusion challenges in the heart. Front Pharmacol. 2014;5:96.","journal-title":"Front Pharmacol"},{"issue":"9","key":"1425_CR103","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1161\/CIRCULATIONAHA.113.001746","volume":"128","author":"TH Fischer","year":"2013","unstructured":"Fischer TH, et al. Ca2+\/calmodulin-dependent protein kinase II and protein kinase A differentially regulate sarcoplasmic reticulum Ca2+ leak in human cardiac pathology. Circulation. 2013;128(9):970\u201381.","journal-title":"Circulation"},{"issue":"7","key":"1425_CR104","doi-asserted-by":"publisher","first-page":"2342","DOI":"10.1073\/pnas.0813013106","volume":"106","author":"J Backs","year":"2009","unstructured":"Backs J, et al. The delta isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload. Proc Natl Acad Sci U S A. 2009;106(7):2342\u20137.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"1425_CR105","doi-asserted-by":"publisher","first-page":"7219","DOI":"10.1074\/jbc.M604281200","volume":"282","author":"GH Little","year":"2007","unstructured":"Little GH, et al. Nuclear calcium\/calmodulin-dependent protein kinase IIdelta preferentially transmits signals to histone deacetylase 4 in cardiac cells. J Biol Chem. 2007;282(10):7219\u201331.","journal-title":"J Biol Chem"},{"issue":"6","key":"1425_CR106","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1161\/CIRCRESAHA.107.169755","volume":"102","author":"J Bossuyt","year":"2008","unstructured":"Bossuyt J, et al. Ca2+\/calmodulin-dependent protein kinase IIdelta and protein kinase D overexpression reinforce the histone deacetylase 5 redistribution in heart failure. Circ Res. 2008;102(6):695\u2013702.","journal-title":"Circ Res"},{"issue":"1","key":"1425_CR107","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s00395-021-00850-2","volume":"116","author":"KG Helmstadter","year":"2021","unstructured":"Helmstadter KG, et al. CaMKII and PKA-dependent phosphorylation co-regulate nuclear localization of HDAC4 in adult cardiomyocytes. Basic Res Cardiol. 2021;116(1):11.","journal-title":"Basic Res Cardiol"},{"issue":"42","key":"1425_CR108","doi-asserted-by":"publisher","first-page":"25411","DOI":"10.1074\/jbc.M115.657775","volume":"290","author":"P Quijada","year":"2015","unstructured":"Quijada P, et al. Nuclear calcium\/calmodulin-dependent protein kinase II signaling enhances cardiac progenitor cell survival and cardiac lineage commitment. J Biol Chem. 2015;290(42):25411\u201326.","journal-title":"J Biol Chem"},{"issue":"2","key":"1425_CR109","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.freeradbiomed.2011.10.440","volume":"52","author":"VR Muthusamy","year":"2012","unstructured":"Muthusamy VR, et al. Acute exercise stress activates Nrf2\/ARE signaling and promotes antioxidant mechanisms in the myocardium. Free Radic Biol Med. 2012;52(2):366\u201376.","journal-title":"Free Radic Biol Med"},{"key":"1425_CR110","doi-asserted-by":"publisher","DOI":"10.3390\/biom10020320","author":"S Kasai","year":"2020","unstructured":"Kasai S, et al. Regulation of Nrf2 by mitochondrial reactive oxygen species in physiology and pathology. Biomolecules. 2020. https:\/\/doi.org\/10.3390\/biom10020320.","journal-title":"Biomolecules"},{"key":"1425_CR111","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102737","volume":"63","author":"V Lisi","year":"2023","unstructured":"Lisi V, et al. Plasma-derived extracellular vesicles released after endurance exercise exert cardioprotective activity through the activation of antioxidant pathways. Redox Biol. 2023;63:102737.","journal-title":"Redox Biol"},{"key":"1425_CR112","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13050573","author":"Q Meng","year":"2024","unstructured":"Meng Q, Su CH. The impact of physical exercise on oxidative and nitrosative stress: balancing the benefits and risks. Antioxidants (Basel). 2024. https:\/\/doi.org\/10.3390\/antiox13050573.","journal-title":"Antioxidants (Basel)"},{"issue":"5","key":"1425_CR113","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1161\/CIRCRESAHA.110.221911","volume":"108","author":"S Wagner","year":"2011","unstructured":"Wagner S, et al. Reactive oxygen species-activated Ca\/calmodulin kinase II\u03b4 is required for late I(Na) augmentation leading to cellular Na and Ca overload. Circ Res. 2011;108(5):555\u201365.","journal-title":"Circ Res"},{"issue":"4","key":"1425_CR114","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.117.005682","volume":"11","author":"Q Wang","year":"2018","unstructured":"Wang Q, et al. Oxidized CaMKII (Ca(2+)\/calmodulin-dependent protein kinase II) is essential for ventricular arrhythmia in a mouse model of Duchenne muscular dystrophy. Circ Arrhythm Electrophysiol. 2018;11(4):e005682.","journal-title":"Circ Arrhythm Electrophysiol"},{"issue":"1","key":"1425_CR115","doi-asserted-by":"publisher","first-page":"4416","DOI":"10.1038\/s41467-020-18165-6","volume":"11","author":"ED Luczak","year":"2020","unstructured":"Luczak ED, et al. Mitochondrial CaMKII causes adverse metabolic reprogramming and dilated cardiomyopathy. Nat Commun. 2020;11(1):4416.","journal-title":"Nat Commun"},{"issue":"6","key":"1425_CR116","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1007\/s10557-024-07582-0","volume":"38","author":"WD Watson","year":"2024","unstructured":"Watson WD, et al. A mitochondrial basis for heart failure progression. Cardiovasc Drugs Ther. 2024;38(6):1161\u201371.","journal-title":"Cardiovasc Drugs Ther"},{"key":"1425_CR117","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.12462","author":"A Combes","year":"2015","unstructured":"Combes A, et al. Exercise-induced metabolic fluctuations influence AMPK, p38-MAPK and CaMKII phosphorylation in human skeletal muscle. Physiol Rep. 2015. https:\/\/doi.org\/10.14814\/phy2.12462.","journal-title":"Physiol Rep"},{"key":"1425_CR118","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.semcdb.2022.05.016","volume":"143","author":"BJ Gurd","year":"2023","unstructured":"Gurd BJ, et al. Impacts of altered exercise volume, intensity, and duration on the activation of AMPK and CaMKII and increases in PGC-1\u03b1 mRNA. Semin Cell Dev Biol. 2023;143:17\u201327.","journal-title":"Semin Cell Dev Biol"},{"issue":"6","key":"1425_CR119","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1161\/CIRCRESAHA.112.276915","volume":"112","author":"H Ling","year":"2013","unstructured":"Ling H, et al. Ca2+\/Calmodulin-dependent protein kinase II \u03b4 mediates myocardial ischemia\/reperfusion injury through nuclear factor-\u03baB. Circ Res. 2013;112(6):935\u201344.","journal-title":"Circ Res"},{"issue":"5","key":"1425_CR120","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1038\/s41419-020-2605-y","volume":"11","author":"HT Lu","year":"2020","unstructured":"Lu HT, et al. CaMKII\/calpain interaction mediates ischemia\/reperfusion injury in isolated rat hearts. Cell Death Dis. 2020;11(5):388.","journal-title":"Cell Death Dis"},{"issue":"15","key":"1425_CR121","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1161\/CIRCULATIONAHA.121.055920","volume":"145","author":"J Zhang","year":"2022","unstructured":"Zhang J, et al. Novel CaMKII-\u03b4 inhibitor hesperadin exerts dual functions to ameliorate cardiac ischemia\/reperfusion injury and inhibit tumor growth. Circulation. 2022;145(15):1154\u201368.","journal-title":"Circulation"},{"issue":"2","key":"1425_CR122","doi-asserted-by":"publisher","first-page":"H735","DOI":"10.1152\/ajpheart.01164.2008","volume":"297","author":"Z Yu","year":"2009","unstructured":"Yu Z, Wang ZH, Yang HT. Calcium\/calmodulin-dependent protein kinase II mediates cardioprotection of intermittent hypoxia against ischemic-reperfusion-induced cardiac dysfunction. Am J Physiol Heart Circ Physiol. 2009;297(2):H735\u201342.","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"15","key":"1425_CR123","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1161\/CIRCULATIONAHA.114.006185","volume":"130","author":"MM Kreusser","year":"2014","unstructured":"Kreusser MM, et al. Cardiac CaM kinase II genes \u03b4 and \u03b3 contribute to adverse remodeling but redundantly inhibit calcineurin-induced myocardial hypertrophy. Circulation. 2014;130(15):1262\u201373.","journal-title":"Circulation"},{"issue":"5","key":"1425_CR124","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1172\/JCI38022","volume":"119","author":"H Ling","year":"2009","unstructured":"Ling H, et al. Requirement for Ca2+\/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice. J Clin Invest. 2009;119(5):1230\u201340.","journal-title":"J Clin Invest"},{"key":"1425_CR125","doi-asserted-by":"publisher","first-page":"36","DOI":"10.3389\/fphar.2014.00036","volume":"5","author":"MM Kreusser","year":"2014","unstructured":"Kreusser MM, Backs J. Integrated mechanisms of CaMKII-dependent ventricular remodeling. Front Pharmacol. 2014;5:36.","journal-title":"Front Pharmacol"},{"issue":"22","key":"1425_CR126","doi-asserted-by":"publisher","first-page":"2530","DOI":"10.1161\/CIRCULATIONAHA.118.034621","volume":"138","author":"T Suetomi","year":"2018","unstructured":"Suetomi T, et al. Inflammation and NLRP3 inflammasome activation initiated in response to pressure overload by Ca(2+)\/calmodulin-dependent protein kinase II \u03b4 signaling in cardiomyocytes are essential for adverse cardiac remodeling. Circulation. 2018;138(22):2530\u201344.","journal-title":"Circulation"},{"key":"1425_CR127","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.yjmcc.2020.09.007","volume":"149","author":"M Zhang","year":"2020","unstructured":"Zhang M, et al. CaMKII exacerbates heart failure progression by activating class I HDACs. J Mol Cell Cardiol. 2020;149:73\u201381.","journal-title":"J Mol Cell Cardiol"},{"key":"1425_CR128","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241512306","author":"VL da Silva","year":"2023","unstructured":"da Silva VL, et al. Aerobic exercise training improves calcium handling and cardiac function in rats with heart failure resulting from aortic stenosis. Int J Mol Sci. 2023. https:\/\/doi.org\/10.3390\/ijms241512306.","journal-title":"Int J Mol Sci"},{"issue":"4","key":"1425_CR129","doi-asserted-by":"publisher","first-page":"2191","DOI":"10.1002\/ehf2.14772","volume":"11","author":"M Dewenter","year":"2024","unstructured":"Dewenter M, et al. Ca2+\/calmodulin-dependent kinase II\u03b4C-induced chronic heart failure does not depend on sarcoplasmic reticulum Ca2+ leak. ESC Heart Fail. 2024;11(4):2191\u20139.","journal-title":"ESC Heart Fail"},{"issue":"7","key":"1425_CR130","first-page":"1940","volume":"119","author":"MG Chelu","year":"2009","unstructured":"Chelu MG, et al. Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice. J Clin Invest. 2009;119(7):1940\u201351.","journal-title":"J Clin Invest"},{"issue":"3","key":"1425_CR131","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/j.hrthm.2019.10.016","volume":"17","author":"A Greer-Short","year":"2020","unstructured":"Greer-Short A, et al. Calmodulin kinase II regulates atrial myocyte late sodium current, calcium handling, and atrial arrhythmia. Heart Rhythm. 2020;17(3):503\u201311.","journal-title":"Heart Rhythm"},{"issue":"5","key":"1425_CR132","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1161\/CIRCRESAHA.119.315755","volume":"126","author":"S Lebek","year":"2020","unstructured":"Lebek S, et al. Enhanced CaMKII-dependent late I(Na) induces atrial proarrhythmic activity in patients with sleep-disordered breathing. Circ Res. 2020;126(5):603\u201315.","journal-title":"Circ Res"},{"issue":"1","key":"1425_CR133","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1161\/CIRCRESAHA.120.318402","volume":"129","author":"B Hegyi","year":"2021","unstructured":"Hegyi B, et al. CaMKII serine 280 O-GlcNAcylation links diabetic hyperglycemia to proarrhythmia. Circ Res. 2021;129(1):98\u2013113.","journal-title":"Circ Res"},{"issue":"10","key":"1425_CR134","doi-asserted-by":"publisher","first-page":"e80","DOI":"10.1161\/CIRCRESAHA.119.316288","volume":"126","author":"S Lu","year":"2020","unstructured":"Lu S, et al. Hyperglycemia acutely increases cytosolic reactive oxygen species via O-linked GlcNAcylation and CaMKII activation in mouse ventricular myocytes. Circ Res. 2020;126(10):e80\u201396.","journal-title":"Circ Res"},{"issue":"6","key":"1425_CR135","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/s00395-020-00834-8","volume":"115","author":"B Hegyi","year":"2020","unstructured":"Hegyi B, et al. Hyperglycemia regulates cardiac K(+) channels via O-GlcNAc-CaMKII and NOX2-ROS-PKC pathways. Basic Res Cardiol. 2020;115(6):71.","journal-title":"Basic Res Cardiol"},{"issue":"17","key":"1425_CR136","doi-asserted-by":"publisher","first-page":"2084","DOI":"10.1161\/CIRCULATIONAHA.112.105320","volume":"126","author":"OM Koval","year":"2012","unstructured":"Koval OM, et al. Ca2+\/calmodulin-dependent protein kinase II-based regulation of voltage-gated Na+ channel in cardiac disease. Circulation. 2012;126(17):2084\u201394.","journal-title":"Circulation"},{"issue":"378","key":"1425_CR137","first-page":"20220163","volume":"2023","author":"X Liu","year":"1879","unstructured":"Liu X, et al. Late sodium current in synergism with Ca(2+)\/calmodulin-dependent protein kinase II contributes to \u03b2-adrenergic activation-induced atrial fibrillation. Philos Trans R Soc Lond B Biol Sci. 1879;2023(378):20220163.","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"issue":"1","key":"1425_CR138","doi-asserted-by":"publisher","first-page":"9291","DOI":"10.1038\/s41598-019-45743-6","volume":"9","author":"Y Wu","year":"2019","unstructured":"Wu Y, et al. Myocardial death and dysfunction after ischemia-reperfusion injury require CaMKII\u03b4 oxidation. Sci Rep. 2019;9(1):9291.","journal-title":"Sci Rep"},{"issue":"10","key":"1425_CR139","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.15252\/emmm.201403848","volume":"6","author":"M Weinreuter","year":"2014","unstructured":"Weinreuter M, et al. CaM kinase II mediates maladaptive post-infarct remodeling and pro-inflammatory chemoattractant signaling but not acute myocardial ischemia\/reperfusion injury. EMBO Mol Med. 2014;6(10):1231\u201345.","journal-title":"EMBO Mol Med"},{"key":"1425_CR140","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.freeradbiomed.2021.03.014","volume":"167","author":"Z Wei","year":"2021","unstructured":"Wei Z, et al. Loss of Camk2n1 aggravates cardiac remodeling and malignant ventricular arrhythmia after myocardial infarction in mice via NLRP3 inflammasome activation. Free Radic Biol Med. 2021;167:243\u201357.","journal-title":"Free Radic Biol Med"},{"issue":"6","key":"1425_CR141","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1161\/CIRCHEARTFAILURE.109.865279","volume":"2","author":"CM Sag","year":"2009","unstructured":"Sag CM, et al. Calcium\/calmodulin-dependent protein kinase II contributes to cardiac arrhythmogenesis in heart failure. Circ Heart Fail. 2009;2(6):664\u201375.","journal-title":"Circ Heart Fail"},{"issue":"2","key":"1425_CR142","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/s00424-020-02357-6","volume":"472","author":"MH No","year":"2020","unstructured":"No MH, et al. Effects of aging and exercise training on mitochondrial function and apoptosis in the rat heart. Pflugers Arch. 2020;472(2):179\u201393.","journal-title":"Pflugers Arch"},{"issue":"12","key":"1425_CR143","doi-asserted-by":"publisher","DOI":"10.1111\/eci.13829","volume":"52","author":"N Strutynska","year":"2022","unstructured":"Strutynska N, et al. Exercise restores endogenous H(2)S synthesis and mitochondrial function in the heart of old rats. Eur J Clin Invest. 2022;52(12):e13829.","journal-title":"Eur J Clin Invest"},{"issue":"2","key":"1425_CR144","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/s00109-019-01861-2","volume":"98","author":"SY Wang","year":"2020","unstructured":"Wang SY, et al. Exercise enhances cardiac function by improving mitochondrial dysfunction and maintaining energy homoeostasis in the development of diabetic cardiomyopathy. J Mol Med (Berl). 2020;98(2):245\u201361.","journal-title":"J Mol Med (Berl)"},{"key":"1425_CR145","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26052136","author":"H Jia","year":"2025","unstructured":"Jia H, et al. Molecular mechanism of aerobic exercise ameliorating myocardial mitochondrial injury in mice with heart failure. Int J Mol Sci. 2025. https:\/\/doi.org\/10.3390\/ijms26052136.","journal-title":"Int J Mol Sci"},{"key":"1425_CR146","doi-asserted-by":"publisher","first-page":"1052608","DOI":"10.3389\/fphys.2022.1052608","volume":"13","author":"A John","year":"2022","unstructured":"John A, Howarth FC, Raza H. Exercise alleviates diabetic complications by inhibiting oxidative stress-mediated signaling cascade and mitochondrial metabolic stress in GK diabetic rat tissues. Front Physiol. 2022;13:1052608.","journal-title":"Front Physiol"},{"key":"1425_CR147","doi-asserted-by":"publisher","first-page":"87","DOI":"10.3389\/fendo.2017.00087","volume":"8","author":"L Parker","year":"2017","unstructured":"Parker L, et al. Exercise and glycemic control: focus on redox homeostasis and redox-sensitive protein signaling. Front Endocrinol (Lausanne). 2017;8:87.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"1425_CR148","doi-asserted-by":"publisher","DOI":"10.3390\/antiox14010072","author":"A Caturano","year":"2025","unstructured":"Caturano A, et al. Oxidative stress and cardiovascular complications in type 2 diabetes: from pathophysiology to lifestyle modifications. Antioxidants (Basel). 2025. https:\/\/doi.org\/10.3390\/antiox14010072.","journal-title":"Antioxidants (Basel)"},{"issue":"6","key":"1425_CR149","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1016\/j.yjmcc.2008.12.022","volume":"46","author":"K Odagiri","year":"2009","unstructured":"Odagiri K, et al. Local control of mitochondrial membrane potential, permeability transition pore and reactive oxygen species by calcium and calmodulin in rat ventricular myocytes. J Mol Cell Cardiol. 2009;46(6):989\u201397.","journal-title":"J Mol Cell Cardiol"},{"key":"1425_CR150","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.redox.2018.08.008","volume":"19","author":"D Wu","year":"2018","unstructured":"Wu D, et al. Amelioration of mitochondrial dysfunction in heart failure through S-sulfhydration of Ca(2+)\/calmodulin-dependent protein kinase II. Redox Biol. 2018;19:250\u201362.","journal-title":"Redox Biol"},{"issue":"2","key":"1425_CR151","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1038\/nm.4017","volume":"22","author":"T Zhang","year":"2016","unstructured":"Zhang T, et al. CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress-induced myocardial necroptosis. Nat Med. 2016;22(2):175\u201382.","journal-title":"Nat Med"},{"key":"1425_CR152","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2023.5301","author":"S Chen","year":"2023","unstructured":"Chen S, et al. Role of RIPK3\u2011CaMKII\u2011mPTP signaling pathway\u2011mediated necroptosis in cardiovascular diseases (review). Int J Mol Med. 2023. https:\/\/doi.org\/10.3892\/ijmm.2023.5301.","journal-title":"Int J Mol Med"},{"issue":"15","key":"1425_CR153","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.008939","volume":"7","author":"R Yang","year":"2018","unstructured":"Yang R, et al. Mitochondrial-mediated oxidative Ca(2+)\/calmodulin-dependent kinase II activation induces early afterdepolarizations in guinea pig cardiomyocytes: an in silico study. J Am Heart Assoc. 2018;7(15):e008939.","journal-title":"J Am Heart Assoc"},{"issue":"12","key":"1425_CR154","doi-asserted-by":"publisher","first-page":"4089","DOI":"10.1113\/JP273714","volume":"595","author":"M Federico","year":"2017","unstructured":"Federico M, et al. Calcium-calmodulin-dependent protein kinase mediates the intracellular signalling pathways of cardiac apoptosis in mice with impaired glucose tolerance. J Physiol. 2017;595(12):4089\u2013108.","journal-title":"J Physiol"},{"key":"1425_CR155","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.811406","volume":"13","author":"J Huang","year":"2022","unstructured":"Huang J, et al. Understanding anthracycline cardiotoxicity from mitochondrial aspect. Front Pharmacol. 2022;13:811406.","journal-title":"Front Pharmacol"},{"issue":"8","key":"1425_CR156","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1080\/15548627.2017.1325062","volume":"13","author":"JC Campos","year":"2017","unstructured":"Campos JC, et al. Exercise reestablishes autophagic flux and mitochondrial quality control in heart failure. Autophagy. 2017;13(8):1304\u201317.","journal-title":"Autophagy"},{"key":"1425_CR157","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.949744","volume":"9","author":"MAD Viloria","year":"2022","unstructured":"Viloria MAD, et al. Effect of exercise training on cardiac mitochondrial respiration, biogenesis, dynamics, and mitophagy in ischemic heart disease. Front Cardiovasc Med. 2022;9:949744.","journal-title":"Front Cardiovasc Med"},{"key":"1425_CR158","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26010008","author":"IA Shah","year":"2024","unstructured":"Shah IA, et al. Effects of exercise training on cardiac mitochondrial functions in diabetic heart: a systematic review. Int J Mol Sci. 2024. https:\/\/doi.org\/10.3390\/ijms26010008.","journal-title":"Int J Mol Sci"},{"issue":"19","key":"1425_CR159","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.124.036555","volume":"13","author":"H Zhang","year":"2024","unstructured":"Zhang H, et al. Exercise alleviates cardiovascular diseases by improving mitochondrial homeostasis. J Am Heart Assoc. 2024;13(19):e036555.","journal-title":"J Am Heart Assoc"},{"key":"1425_CR160","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.freeradbiomed.2021.11.002","volume":"177","author":"X Zhang","year":"2021","unstructured":"Zhang X, Gao F. Exercise improves vascular health: role of mitochondria. Free Radic Biol Med. 2021;177:347\u201359.","journal-title":"Free Radic Biol Med"},{"key":"1425_CR161","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.yjmcc.2017.08.014","volume":"112","author":"JI Burgos","year":"2017","unstructured":"Burgos JI, et al. Nitric oxide and CaMKII: critical steps in the cardiac contractile response to IGF-1 and swim training. J Mol Cell Cardiol. 2017;112:16\u201326.","journal-title":"J Mol Cell Cardiol"},{"issue":"1","key":"1425_CR162","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1007\/s00395-021-00906-3","volume":"116","author":"D Boulghobra","year":"2021","unstructured":"Boulghobra D, et al. Increased protein S-nitrosylation in mitochondria: a key mechanism of exercise-induced cardioprotection. Basic Res Cardiol. 2021;116(1):66.","journal-title":"Basic Res Cardiol"},{"issue":"9","key":"1425_CR163","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.2174\/138920111798281063","volume":"12","author":"S Gielen","year":"2011","unstructured":"Gielen S, et al. Exercise-induced modulation of endothelial nitric oxide production. Curr Pharm Biotechnol. 2011;12(9):1375\u201384.","journal-title":"Curr Pharm Biotechnol"},{"issue":"6","key":"1425_CR164","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1007\/s00395-013-0389-2","volume":"108","author":"C Farah","year":"2013","unstructured":"Farah C, et al. Exercise-induced cardioprotection: a role for eNOS uncoupling and NO metabolites. Basic Res Cardiol. 2013;108(6):389.","journal-title":"Basic Res Cardiol"},{"key":"1425_CR165","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.yjmcc.2016.11.008","volume":"102","author":"C Farah","year":"2017","unstructured":"Farah C, et al. Key role of endothelium in the eNOS-dependent cardioprotection with exercise training. J Mol Cell Cardiol. 2017;102:26\u201330.","journal-title":"J Mol Cell Cardiol"},{"issue":"6","key":"1425_CR166","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1038\/s44161-022-00082-0","volume":"1","author":"ZY Yu","year":"2022","unstructured":"Yu ZY, et al. Piezo1 is the cardiac mechanosensor that initiates the cardiomyocyte hypertrophic response to pressure overload in adult mice. Nat Cardiovasc Res. 2022;1(6):577\u201391.","journal-title":"Nat Cardiovasc Res"},{"key":"1425_CR167","doi-asserted-by":"publisher","DOI":"10.3390\/cells13080664","author":"S Casarella","year":"2024","unstructured":"Casarella S, et al. Focal adhesion\u2019s role in cardiomyocytes function: from cardiomyogenesis to mechanotransduction. Cells (Basel). 2024. https:\/\/doi.org\/10.3390\/cells13080664.","journal-title":"Cells (Basel)"},{"issue":"1","key":"1425_CR168","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1161\/CIRCRESAHA.120.317976","volume":"130","author":"CR Carlson","year":"2022","unstructured":"Carlson CR, et al. AKAP18\u03b4 anchors and regulates CaMKII activity at phospholamban-SERCA2 and RYR. Circ Res. 2022;130(1):27\u201344.","journal-title":"Circ Res"},{"issue":"2","key":"1425_CR169","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.yjmcc.2009.10.016","volume":"48","author":"M Grimm","year":"2010","unstructured":"Grimm M, Brown JH. Beta-adrenergic receptor signaling in the heart: role of CaMKII. J Mol Cell Cardiol. 2010;48(2):322\u201330.","journal-title":"J Mol Cell Cardiol"},{"issue":"12","key":"1425_CR170","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.1161\/CIRCRESAHA.118.313417","volume":"124","author":"Y Zhang","year":"2019","unstructured":"Zhang Y, et al. Cardiomyocyte PKA ablation enhances basal contractility while eliminates cardiac \u03b2-adrenergic response without adverse effects on the heart. Circ Res. 2019;124(12):1760\u201377.","journal-title":"Circ Res"},{"issue":"5","key":"1425_CR171","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1172\/JCI200316326","volume":"111","author":"WZ Zhu","year":"2003","unstructured":"Zhu WZ, et al. Linkage of beta1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+\/calmodulin kinase II. J Clin Invest. 2003;111(5):617\u201325.","journal-title":"J Clin Invest"},{"key":"1425_CR172","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.yjmcc.2018.09.006","volume":"123","author":"B Hegyi","year":"2018","unstructured":"Hegyi B, et al. \u03b2-adrenergic regulation of late Na(+) current during cardiac action potential is mediated by both PKA and CaMKII. J Mol Cell Cardiol. 2018;123:168\u201379.","journal-title":"J Mol Cell Cardiol"},{"issue":"6","key":"1425_CR173","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1016\/j.hrthm.2018.01.024","volume":"15","author":"T Shugg","year":"2018","unstructured":"Shugg T, et al. Calcium\/calmodulin-dependent protein kinase II regulation of I(Ks) during sustained \u03b2-adrenergic receptor stimulation. Heart Rhythm. 2018;15(6):895\u2013904.","journal-title":"Heart Rhythm"},{"key":"1425_CR174","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2020.102267","volume":"91","author":"T Romero-Garc\u00eda","year":"2020","unstructured":"Romero-Garc\u00eda T, et al. Autonomous activation of CaMKII exacerbates diastolic calcium leak during beta-adrenergic stimulation in cardiomyocytes of metabolic syndrome rats. Cell Calcium. 2020;91:102267.","journal-title":"Cell Calcium"},{"issue":"6","key":"1425_CR175","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0130477","volume":"10","author":"E Cipolletta","year":"2015","unstructured":"Cipolletta E, et al. Targeting the CaMKII\/ERK interaction in the heart prevents cardiac hypertrophy. PLoS ONE. 2015;10(6):e0130477.","journal-title":"PLoS ONE"},{"issue":"6","key":"1425_CR176","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1161\/CIRCRESAHA.117.312536","volume":"122","author":"J Yan","year":"2018","unstructured":"Yan J, et al. Stress signaling JNK2 crosstalk with CaMKII underlies enhanced atrial arrhythmogenesis. Circ Res. 2018;122(6):821\u201335.","journal-title":"Circ Res"},{"issue":"1","key":"1425_CR177","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1093\/cvr\/cvw111","volume":"112","author":"M Frisk","year":"2016","unstructured":"Frisk M, et al. Elevated ventricular wall stress disrupts cardiomyocyte t-tubule structure and calcium homeostasis. Cardiovasc Res. 2016;112(1):443\u201351.","journal-title":"Cardiovasc Res"},{"issue":"8","key":"1425_CR178","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1161\/CIRCRESAHA.116.308698","volume":"119","author":"JL Sanchez-Alonso","year":"2016","unstructured":"Sanchez-Alonso JL, et al. Microdomain-specific modulation of L-type calcium channels leads to triggered ventricular arrhythmia in heart failure. Circ Res. 2016;119(8):944\u201355.","journal-title":"Circ Res"},{"key":"1425_CR179","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.3389\/fphys.2018.01737","volume":"9","author":"AD Loucks","year":"2018","unstructured":"Loucks AD, O\u2019Hara T, Trayanova NA. Degradation of T-tubular microdomains and altered cAMP compartmentation lead to emergence of arrhythmogenic triggers in heart failure myocytes: an in silico study. Front Physiol. 2018;9:1737.","journal-title":"Front Physiol"},{"issue":"4","key":"1425_CR180","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13972","volume":"7","author":"R Qin","year":"2019","unstructured":"Qin R, et al. Exercise training reduces ventricular arrhythmias through restoring calcium handling and sympathetic tone in myocardial infarction mice. Physiol Rep. 2019;7(4):e13972.","journal-title":"Physiol Rep"},{"issue":"12","key":"1425_CR181","doi-asserted-by":"publisher","first-page":"R1532","DOI":"10.1152\/ajpregu.00076.2015","volume":"309","author":"FF Conti","year":"2015","unstructured":"Conti FF, et al. Positive effect of combined exercise training in a model of metabolic syndrome and menopause: autonomic, inflammatory, and oxidative stress evaluations. Am J Physiol Regul Integr Comp Physiol. 2015;309(12):R1532\u20139.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"9","key":"1425_CR182","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0202731","volume":"13","author":"IC Sanches","year":"2018","unstructured":"Sanches IC, et al. Combined aerobic and resistance exercise training attenuates cardiac dysfunctions in a model of diabetes and menopause. PLoS ONE. 2018;13(9):e0202731.","journal-title":"PLoS ONE"},{"key":"1425_CR183","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232012559","author":"AY Lim","year":"2022","unstructured":"Lim AY, et al. The effects of exercise training on mitochondrial function in cardiovascular diseases: a systematic review and meta-analysis. Int J Mol Sci. 2022. https:\/\/doi.org\/10.3390\/ijms232012559.","journal-title":"Int J Mol Sci"},{"issue":"12","key":"1425_CR184","doi-asserted-by":"publisher","first-page":"23705","DOI":"10.1002\/jcp.28939","volume":"234","author":"D Jia","year":"2019","unstructured":"Jia D, et al. Postinfarction exercise training alleviates cardiac dysfunction and adverse remodeling via mitochondrial biogenesis and SIRT1\/PGC-1\u03b1\/PI3K\/Akt signaling. J Cell Physiol. 2019;234(12):23705\u201318.","journal-title":"J Cell Physiol"},{"key":"1425_CR185","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.lfs.2018.10.035","volume":"213","author":"R Ghahremani","year":"2018","unstructured":"Ghahremani R, et al. Mitochondrial dynamics as an underlying mechanism involved in aerobic exercise training-induced cardioprotection against ischemia-reperfusion injury. Life Sci. 2018;213:102\u20138.","journal-title":"Life Sci"},{"key":"1425_CR186","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.202313485","author":"M Dubois","year":"2024","unstructured":"Dubois M, et al. Exercise training may reduce fragmented mitochondria in the ischemic-reperfused heart through DRP1. J Gen Physiol. 2024. https:\/\/doi.org\/10.1085\/jgp.202313485.","journal-title":"J Gen Physiol"},{"key":"1425_CR187","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.788505","volume":"8","author":"C Gu","year":"2021","unstructured":"Gu C, et al. Regulation of mitochondrial dynamics by aerobic exercise in cardiovascular diseases. Front Cardiovasc Med. 2021;8:788505.","journal-title":"Front Cardiovasc Med"},{"issue":"1","key":"1425_CR188","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-99118-x","volume":"11","author":"M Federico","year":"2021","unstructured":"Federico M, et al. CaMKII activation in early diabetic hearts induces altered sarcoplasmic reticulum-mitochondria signaling. Sci Rep. 2021;11(1):20025.","journal-title":"Sci Rep"},{"issue":"1","key":"1425_CR189","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1007\/s00395-021-00900-9","volume":"116","author":"B Hegyi","year":"2021","unstructured":"Hegyi B, et al. Cardiomyocyte Na(+) and Ca(2+) mishandling drives vicious cycle involving CaMKII, ROS, and ryanodine receptors. Basic Res Cardiol. 2021;116(1):58.","journal-title":"Basic Res Cardiol"},{"issue":"4","key":"1425_CR190","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1007\/s00395-020-0797-z","volume":"115","author":"S Hamilton","year":"2020","unstructured":"Hamilton S, et al. Increased RyR2 activity is exacerbated by calcium leak-induced mitochondrial ROS. Basic Res Cardiol. 2020;115(4):38.","journal-title":"Basic Res Cardiol"},{"key":"1425_CR191","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2023.5329","author":"D Zhou","year":"2024","unstructured":"Zhou D, et al. MROS\u2011calcium feedback loop promotes lethal ventricular arrhythmias and sudden cardiac death in early myocardial ischemia. Int J Mol Med. 2024. https:\/\/doi.org\/10.3892\/ijmm.2023.5329.","journal-title":"Int J Mol Med"},{"issue":"2","key":"1425_CR192","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1073\/pnas.0606663104","volume":"104","author":"JR McMullen","year":"2007","unstructured":"McMullen JR, et al. Protective effects of exercise and phosphoinositide 3-kinase(p110alpha) signaling in dilated and hypertrophic cardiomyopathy. Proc Natl Acad Sci U S A. 2007;104(2):612\u20137.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1425_CR193","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.950927","volume":"10","author":"HA Pahlavani","year":"2022","unstructured":"Pahlavani HA. Exercise-induced signaling pathways to counteracting cardiac apoptotic processes. Front Cell Dev Biol. 2022;10:950927.","journal-title":"Front Cell Dev Biol"},{"issue":"Pt 10","key":"1425_CR194","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.1113\/jphysiol.2010.188011","volume":"588","author":"B Egan","year":"2010","unstructured":"Egan B, et al. Exercise intensity-dependent regulation of peroxisome proliferator-activated receptor coactivator-1 mRNA abundance is associated with differential activation of upstream signalling kinases in human skeletal muscle. J Physiol. 2010;588(Pt 10):1779\u201390.","journal-title":"J Physiol"},{"key":"1425_CR195","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.12008","author":"Y Zhang","year":"2014","unstructured":"Zhang Y, et al. Multiple signaling pathways regulate contractile activity-mediated PGC-1\u03b1 gene expression and activity in skeletal muscle cells. Physiol Rep. 2014. https:\/\/doi.org\/10.14814\/phy2.12008.","journal-title":"Physiol Rep"},{"issue":"5","key":"1425_CR196","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1007\/s40279-024-02007-2","volume":"54","author":"EG Reisman","year":"2024","unstructured":"Reisman EG, Hawley JA, Hoffman NJ. Exercise-regulated mitochondrial and nuclear signalling networks in skeletal muscle. Sports Med. 2024;54(5):1097\u2013119.","journal-title":"Sports Med"},{"issue":"1","key":"1425_CR197","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1146\/annurev-physiol-043024-114759","volume":"88","author":"A Mattiazzi","year":"2026","unstructured":"Mattiazzi A, Bers DM. CaMKII in the heart: from homeostasis to pathology. Annu Rev Physiol. 2026;88(1):99\u2013128.","journal-title":"Annu Rev Physiol"},{"issue":"3","key":"1425_CR198","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1093\/cvr\/cvt201","volume":"100","author":"DA Gutierrez","year":"2013","unstructured":"Gutierrez DA, et al. NO-dependent CaMKII activation during \u03b2-adrenergic stimulation of cardiac muscle. Cardiovasc Res. 2013;100(3):392\u2013401.","journal-title":"Cardiovasc Res"},{"issue":"18","key":"1425_CR199","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20184374","volume":"20","author":"MR Rusciano","year":"2019","unstructured":"Rusciano MR, et al. CaMKII activity in the inflammatory response of cardiac diseases. Int J Mol Sci. 2019;20(18):4374.","journal-title":"Int J Mol Sci"},{"issue":"2","key":"1425_CR200","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1007\/s00424-013-1326-9","volume":"466","author":"TP Martin","year":"2014","unstructured":"Martin TP, et al. Adult cardiac fibroblast proliferation is modulated by calcium\/calmodulin-dependent protein kinase II in normal and hypertrophied hearts. Pflugers Arch Eur J Physiol. 2014;466(2):319\u201330.","journal-title":"Pflugers Arch Eur J Physiol"},{"issue":"4","key":"1425_CR201","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1161\/CIRCRESAHA.117.311586","volume":"122","author":"G Jia","year":"2018","unstructured":"Jia G, Hill MA, Sowers JR. Diabetic cardiomyopathy: an update of mechanisms contributing to this clinical entity. Circ Res. 2018;122(4):624\u201338.","journal-title":"Circ Res"},{"key":"1425_CR202","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.695401","volume":"12","author":"CR Veitch","year":"2021","unstructured":"Veitch CR, Power AS, Erickson JR. CaMKII inhibition is a novel therapeutic strategy to prevent diabetic cardiomyopathy. Front Pharmacol. 2021;12:695401.","journal-title":"Front Pharmacol"},{"issue":"6","key":"1425_CR203","doi-asserted-by":"publisher","first-page":"2343","DOI":"10.1042\/BST20240262","volume":"52","author":"JC Chatham","year":"2024","unstructured":"Chatham JC, Wende AR. The role of protein O-GlcNAcylation in diabetic cardiomyopathy. Biochem Soc Trans. 2024;52(6):2343\u201358.","journal-title":"Biochem Soc Trans"},{"key":"1425_CR204","doi-asserted-by":"publisher","first-page":"30","DOI":"10.3389\/fphar.2014.00030","volume":"5","author":"J Heijman","year":"2014","unstructured":"Heijman J, et al. Calcium dysregulation in atrial fibrillation: the role of CaMKII. Front Pharmacol. 2014;5:30.","journal-title":"Front Pharmacol"},{"key":"1425_CR205","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.120728","author":"S Yoo","year":"2018","unstructured":"Yoo S, et al. Oxidative stress creates a unique, CaMKII-mediated substrate for atrial fibrillation in heart failure. JCI Insight. 2018. https:\/\/doi.org\/10.1172\/jci.insight.120728.","journal-title":"JCI Insight"},{"issue":"1","key":"1425_CR206","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1002\/med.21280","volume":"34","author":"FS Carvalho","year":"2014","unstructured":"Carvalho FS, et al. Doxorubicin-induced cardiotoxicity: from bioenergetic failure and cell death to cardiomyopathy. Med Res Rev. 2014;34(1):106\u201335.","journal-title":"Med Res Rev"},{"issue":"7","key":"1425_CR207","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1161\/CIRCRESAHA.119.314681","volume":"126","author":"KB Wallace","year":"2020","unstructured":"Wallace KB, Sard\u00e3o VA, Oliveira PJ. Mitochondrial determinants of doxorubicin-induced cardiomyopathy. Circ Res. 2020;126(7):926\u201341.","journal-title":"Circ Res"},{"key":"1425_CR208","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23031912","author":"BB Wu","year":"2022","unstructured":"Wu BB, Leung KT, Poon EN. Mitochondrial-targeted therapy for doxorubicin-induced cardiotoxicity. Int J Mol Sci. 2022. https:\/\/doi.org\/10.3390\/ijms23031912.","journal-title":"Int J Mol Sci"},{"key":"1425_CR209","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.mito.2014.10.008","volume":"20","author":"I Marques-Aleixo","year":"2015","unstructured":"Marques-Aleixo I, et al. Physical exercise prior and during treatment reduces sub-chronic doxorubicin-induced mitochondrial toxicity and oxidative stress. Mitochondrion. 2015;20:22\u201333.","journal-title":"Mitochondrion"},{"key":"1425_CR210","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24097689","author":"RN Montalvo","year":"2023","unstructured":"Montalvo RN, et al. Exercise and doxorubicin modify markers of iron overload and cardiolipin deficiency in cardiac mitochondria. Int J Mol Sci. 2023. https:\/\/doi.org\/10.3390\/ijms24097689.","journal-title":"Int J Mol Sci"},{"key":"1425_CR211","doi-asserted-by":"publisher","DOI":"10.3390\/cells12091312","author":"S Dozic","year":"2023","unstructured":"Dozic S, et al. Cellular mechanisms mediating exercise-induced protection against cardiotoxic anthracycline cancer therapy. Cells. 2023. https:\/\/doi.org\/10.3390\/cells12091312.","journal-title":"Cells"},{"key":"1425_CR212","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103079","volume":"70","author":"L Wang","year":"2024","unstructured":"Wang L, et al. Endurance exercise preconditioning alleviates ferroptosis induced by doxorubicin-induced cardiotoxicity through mitochondrial superoxide-dependent AMPK\u03b12 activation. Redox Biol. 2024;70:103079.","journal-title":"Redox Biol"},{"issue":"4","key":"1425_CR213","doi-asserted-by":"publisher","first-page":"e399","DOI":"10.1097\/CCM.0000000000002101","volume":"45","author":"M Sep\u00falveda","year":"2017","unstructured":"Sep\u00falveda M, et al. Calcium\/calmodulin protein kinase II-dependent ryanodine receptor phosphorylation mediates cardiac contractile dysfunction associated with sepsis. Crit Care Med. 2017;45(4):e399\u2013408.","journal-title":"Crit Care Med"},{"key":"1425_CR214","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12020315","author":"P Hegner","year":"2023","unstructured":"Hegner P, et al. CaMKII-dependent contractile dysfunction and pro-arrhythmic activity in a mouse model of obstructive sleep apnea. Antioxidants (Basel). 2023. https:\/\/doi.org\/10.3390\/antiox12020315.","journal-title":"Antioxidants (Basel)"},{"key":"1425_CR215","doi-asserted-by":"publisher","first-page":"35","DOI":"10.3389\/fphar.2020.00035","volume":"11","author":"D Nassal","year":"2020","unstructured":"Nassal D, Gratz D, Hund TJ. Challenges and opportunities for therapeutic targeting of calmodulin kinase II in heart. Front Pharmacol. 2020;11:35.","journal-title":"Front Pharmacol"},{"issue":"2","key":"1425_CR216","doi-asserted-by":"publisher","first-page":"52","DOI":"10.4330\/wjc.v7.i2.52","volume":"7","author":"MA Garza","year":"2015","unstructured":"Garza MA, Wason EA, Zhang JQ. Cardiac remodeling and physical training post myocardial infarction. World J Cardiol. 2015;7(2):52\u201364.","journal-title":"World J Cardiol"},{"issue":"4","key":"1425_CR217","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1097\/HCR.0000000000000665","volume":"42","author":"A Oesterle","year":"2022","unstructured":"Oesterle A, et al. Effects of supervised exercise training on atrial fibrillation: a meta-analysis of randomized controlled trials. J Cardiopulm Rehabil Prev. 2022;42(4):258\u201365.","journal-title":"J Cardiopulm Rehabil Prev"},{"issue":"4","key":"1425_CR218","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1152\/japplphysiol.91280.2008","volume":"106","author":"CH Shao","year":"1985","unstructured":"Shao CH, et al. Exercise training during diabetes attenuates cardiac ryanodine receptor dysregulation. J Appl Physiol (1985). 1985;106(4):1280\u201392.","journal-title":"J Appl Physiol (1985)"},{"key":"1425_CR219","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2025.110640","volume":"774","author":"Z Liu","year":"2025","unstructured":"Liu Z, et al. Exercise alleviates programmed necrosis in myocardial ischemia-reperfusion injury through adipose tissue-derived exosomal miR-17-3p targeting CAMKII. Arch Biochem Biophys. 2025;774:110640.","journal-title":"Arch Biochem Biophys"},{"key":"1425_CR220","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25179692","author":"P Suthivanich","year":"2024","unstructured":"Suthivanich P, et al. Aerobic exercise attenuates doxorubicin-induced cardiomyopathy by suppressing NLRP3 inflammasome activation in a rat model. Int J Mol Sci. 2024. https:\/\/doi.org\/10.3390\/ijms25179692.","journal-title":"Int J Mol Sci"},{"key":"1425_CR221","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.605993","volume":"8","author":"IL Gomes-Santos","year":"2021","unstructured":"Gomes-Santos IL, et al. Exercise training preserves myocardial strain and improves exercise tolerance in doxorubicin-induced cardiotoxicity. Front Cardiovasc Med. 2021;8:605993.","journal-title":"Front Cardiovasc Med"},{"issue":"24","key":"1425_CR222","doi-asserted-by":"publisher","first-page":"3086","DOI":"10.1161\/CIRCULATIONAHA.106.675041","volume":"115","author":"U Wisl\u00f8ff","year":"2007","unstructured":"Wisl\u00f8ff U, et al. Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients: a randomized study. Circulation. 2007;115(24):3086\u201394.","journal-title":"Circulation"},{"key":"1425_CR223","doi-asserted-by":"publisher","first-page":"869501","DOI":"10.3389\/fcvm.2022.869501","volume":"9","author":"P Eser","year":"2022","unstructured":"Eser P, et al. Short- and long-term effects of high-intensity interval training vs moderate-intensity continuous training on left ventricular remodeling in patients early after ST-segment elevation myocardial infarction-the HIIT-EARLY randomized controlled trial. Front Cardiovasc Med. 2022;9:869501.","journal-title":"Front Cardiovasc Med"},{"issue":"4","key":"1425_CR224","doi-asserted-by":"publisher","first-page":"5304","DOI":"10.3390\/ijms15045304","volume":"15","author":"HK Jiang","year":"2014","unstructured":"Jiang HK, et al. Aerobic interval training attenuates mitochondrial dysfunction in rats post-myocardial infarction: roles of mitochondrial network dynamics. Int J Mol Sci. 2014;15(4):5304\u201322.","journal-title":"Int J Mol Sci"},{"issue":"1","key":"1425_CR225","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1093\/cvr\/cvt080","volume":"99","author":"J Kraljevic","year":"2013","unstructured":"Kraljevic J, et al. Aerobic interval training attenuates remodelling and mitochondrial dysfunction in the post-infarction failing rat heart. Cardiovasc Res. 2013;99(1):55\u201364.","journal-title":"Cardiovasc Res"},{"issue":"4","key":"1425_CR226","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1016\/j.yjmcc.2011.01.012","volume":"51","author":"ME Anderson","year":"2011","unstructured":"Anderson ME, Brown JH, Bers DM. CaMKII in myocardial hypertrophy and heart failure. J Mol Cell Cardiol. 2011;51(4):468\u201373.","journal-title":"J Mol Cell Cardiol"},{"issue":"16","key":"1425_CR227","doi-asserted-by":"publisher","first-page":"1748","DOI":"10.1161\/CIRCULATIONAHA.113.003313","volume":"128","author":"A Purohit","year":"2013","unstructured":"Purohit A, et al. Oxidized Ca(2+)\/calmodulin-dependent protein kinase II triggers atrial fibrillation. Circulation. 2013;128(16):1748\u201357.","journal-title":"Circulation"},{"key":"1425_CR228","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11020331","author":"M Arzt","year":"2022","unstructured":"Arzt M, et al. Enhanced cardiac CaMKII oxidation and CaMKII-dependent SR Ca leak in patients with sleep-disordered breathing. Antioxidants (Basel). 2022. https:\/\/doi.org\/10.3390\/antiox11020331.","journal-title":"Antioxidants (Basel)"},{"issue":"37","key":"1425_CR229","doi-asserted-by":"publisher","first-page":"24857","DOI":"10.1074\/jbc.M109.003186","volume":"284","author":"GH Little","year":"2009","unstructured":"Little GH, et al. Critical role of nuclear calcium\/calmodulin-dependent protein kinase IIdeltaB in cardiomyocyte survival in cardiomyopathy. J Biol Chem. 2009;284(37):24857\u201368.","journal-title":"J Biol Chem"},{"issue":"701","key":"1425_CR230","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abq7839","volume":"15","author":"OE Reyes Gaido","year":"2023","unstructured":"Reyes Gaido OE, et al. An improved reporter identifies ruxolitinib as a potent and cardioprotective CaMKII inhibitor. Sci Transl Med. 2023;15(701):eabq7839.","journal-title":"Sci Transl Med"},{"issue":"6","key":"1425_CR231","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1007\/s00395-016-0582-1","volume":"111","author":"F Cuello","year":"2016","unstructured":"Cuello F, Lorenz K. Inhibition of cardiac CaMKII to cure heart failure: step by step towards translation? Basic Res Cardiol. 2016;111(6):66.","journal-title":"Basic Res Cardiol"},{"key":"1425_CR232","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.freeradbiomed.2021.02.040","volume":"166","author":"CJA Ramachandra","year":"2021","unstructured":"Ramachandra CJA, et al. Oxidative stress in cardiac hypertrophy: from molecular mechanisms to novel therapeutic targets. Free Radic Biol Med. 2021;166:297\u2013312.","journal-title":"Free Radic Biol Med"},{"key":"1425_CR233","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.ijcard.2018.02.092","volume":"264","author":"D de Gonzalo-Calvo","year":"2018","unstructured":"de Gonzalo-Calvo D, et al. Circulating microRNAs as emerging cardiac biomarkers responsive to acute exercise. Int J Cardiol. 2018;264:130\u20136.","journal-title":"Int J Cardiol"},{"key":"1425_CR234","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26073218","author":"VR Netala","year":"2025","unstructured":"Netala VR, et al. Cardiovascular biomarkers: tools for precision diagnosis and prognosis. Int J Mol Sci. 2025. https:\/\/doi.org\/10.3390\/ijms26073218.","journal-title":"Int J Mol Sci"},{"key":"1425_CR235","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/j.yjmcc.2015.06.007","volume":"85","author":"M Grimm","year":"2015","unstructured":"Grimm M, et al. CaMKII\u03b4 mediates \u03b2-adrenergic effects on RyR2 phosphorylation and SR Ca(2+) leak and the pathophysiological response to chronic \u03b2-adrenergic stimulation. J Mol Cell Cardiol. 2015;85:282\u201391.","journal-title":"J Mol Cell Cardiol"},{"issue":"20","key":"1425_CR236","doi-asserted-by":"publisher","first-page":"5179","DOI":"10.1113\/JP286453","volume":"602","author":"R Janicek","year":"2024","unstructured":"Janicek R, et al. Dual ablation of the RyR2-Ser2808 and RyR2-Ser2814 sites increases propensity for pro-arrhythmic spontaneous Ca(2+) releases. J Physiol. 2024;602(20):5179\u2013201.","journal-title":"J Physiol"},{"issue":"4","key":"1425_CR237","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.113982","volume":"43","author":"CN Brown","year":"2024","unstructured":"Brown CN, Bayer KU. Studying CaMKII: tools and standards. Cell Rep. 2024;43(4):113982.","journal-title":"Cell Rep"},{"key":"1425_CR238","doi-asserted-by":"crossref","unstructured":"Severino, A., et al., Cell type specific CaMKII activation patterns revealed by CaMKAR, a bioactivity reporter deployable in living cells. biorxiv, 2025: p. 2025.06. 11.658946.","DOI":"10.1101\/2025.06.11.658946"},{"issue":"31","key":"1425_CR239","doi-asserted-by":"publisher","first-page":"11876","DOI":"10.1074\/jbc.RA119.009235","volume":"294","author":"G Ardestani","year":"2019","unstructured":"Ardestani G, et al. FRET-based sensor for CaMKII activity (FRESCA): a useful tool for assessing CaMKII activity in response to Ca(2+) oscillations in live cells. J Biol Chem. 2019;294(31):11876\u201391.","journal-title":"J Biol Chem"},{"key":"1425_CR240","doi-asserted-by":"publisher","first-page":"1598878","DOI":"10.3389\/fcvm.2025.1598878","volume":"12","author":"J Fang","year":"2025","unstructured":"Fang J, Wang Z, Yu J. Advances in pathophysiological mechanisms and therapeutic efficacy of exercise rehabilitation in patients with heart failure with preserved ejection fraction. Front Cardiovasc Med. 2025;12:1598878.","journal-title":"Front Cardiovasc Med"},{"issue":"7","key":"1425_CR241","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1161\/CIRCRESAHA.111.247148","volume":"109","author":"JR Erickson","year":"2011","unstructured":"Erickson JR, et al. Fluorescence resonance energy transfer-based sensor Camui provides new insight into mechanisms of calcium\/calmodulin-dependent protein kinase II activation in intact cardiomyocytes. Circ Res. 2011;109(7):729\u201338.","journal-title":"Circ Res"},{"issue":"14","key":"1425_CR242","doi-asserted-by":"publisher","first-page":"2177","DOI":"10.1093\/cvr\/cvaf187","volume":"121","author":"A Bergan-Dahl","year":"2025","unstructured":"Bergan-Dahl A, et al. Activated CaMKII\u03b4 translocates to the RyR nanodomain in cardiomyocytes. Cardiovasc Res. 2025;121(14):2177\u201388.","journal-title":"Cardiovasc Res"},{"issue":"4","key":"1425_CR243","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.118.007045","volume":"12","author":"AH Ottesen","year":"2019","unstructured":"Ottesen AH, et al. Secretoneurin is an endogenous calcium\/calmodulin-dependent protein kinase II inhibitor that attenuates Ca(2+)-dependent arrhythmia. Circ Arrhythm Electrophysiol. 2019;12(4):e007045.","journal-title":"Circ Arrhythm Electrophysiol"},{"issue":"2","key":"1425_CR244","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.jaccao.2023.12.009","volume":"6","author":"HM Boen","year":"2024","unstructured":"Boen HM, et al. Circulating microRNA as biomarkers of anthracycline-induced cardiotoxicity: JACC: CardioOncology state-of-the-art review. JACC CardioOncol. 2024;6(2):183\u201399.","journal-title":"JACC CardioOncol"},{"key":"1425_CR245","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.yjmcc.2017.08.001","volume":"111","author":"H Guo","year":"2017","unstructured":"Guo H, et al. Exercise-responsive phosphoproteins in the heart. J Mol Cell Cardiol. 2017;111:61\u20138.","journal-title":"J Mol Cell Cardiol"},{"key":"1425_CR246","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.723858","volume":"8","author":"AS Al-Menhali","year":"2021","unstructured":"Al-Menhali AS, et al. Proteomic analysis of cardiac adaptation to exercise by high resolution mass spectrometry. Front Mol Biosci. 2021;8:723858.","journal-title":"Front Mol Biosci"},{"issue":"1","key":"1425_CR247","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s13073-024-01282-y","volume":"16","author":"P Kiessling","year":"2024","unstructured":"Kiessling P, Kuppe C. Spatial multi-omics: novel tools to study the complexity of cardiovascular diseases. Genome Med. 2024;16(1):14.","journal-title":"Genome Med"},{"issue":"1","key":"1425_CR248","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1007\/s11886-025-02226-7","volume":"27","author":"JF Mulvey","year":"2025","unstructured":"Mulvey JF, et al. Integrating -omic technologies across modality, space, and time to decipher remodeling in cardiac disease. Curr Cardiol Rep. 2025;27(1):74.","journal-title":"Curr Cardiol Rep"},{"key":"1425_CR249","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2023.1295852","volume":"14","author":"N Ali","year":"2023","unstructured":"Ali N, et al. Metabolic patterns of sweat-extracellular vesicles during exercise and recovery states using clinical grade patches. Front Physiol. 2023;14:1295852.","journal-title":"Front Physiol"},{"issue":"5","key":"1425_CR250","doi-asserted-by":"publisher","first-page":"143","DOI":"10.31083\/j.fbl2705143","volume":"27","author":"TM Pierdon\u00e1","year":"2022","unstructured":"Pierdon\u00e1 TM, et al. Extracellular vesicles as predictors of individual response to exercise training in youth living with obesity. Front Biosci (Landmark Ed). 2022;27(5):143.","journal-title":"Front Biosci (Landmark Ed)"},{"issue":"5","key":"1425_CR251","doi-asserted-by":"publisher","first-page":"2871","DOI":"10.1002\/ehf2.12895","volume":"7","author":"J Mustroph","year":"2020","unstructured":"Mustroph J, et al. The oral Ca\/calmodulin-dependent kinase II inhibitor RA608 improves contractile function and prevents arrhythmias in heart failure. ESC Heart Fail. 2020;7(5):2871\u201383.","journal-title":"ESC Heart Fail"},{"issue":"3","key":"1425_CR252","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1124\/jpet.120.000361","volume":"377","author":"Y Liu","year":"2021","unstructured":"Liu Y, et al. Chronic Ca(2+)\/calmodulin-dependent protein kinase II inhibition rescues advanced heart failure. J Pharmacol Exp Ther. 2021;377(3):316\u201325.","journal-title":"J Pharmacol Exp Ther"}],"container-title":["Human Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13577-026-01425-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13577-026-01425-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13577-026-01425-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T04:00:03Z","timestamp":1785816003000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13577-026-01425-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,4]]},"references-count":252,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["1425"],"URL":"https:\/\/doi.org\/10.1007\/s13577-026-01425-w","relation":{},"ISSN":["1749-0774"],"issn-type":[{"value":"1749-0774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,4]]},"assertion":[{"value":"24 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"There is no competing interest to be declared.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Ethical approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Consent to publish","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":4,"name":"Ethics","label":"Clinical trial number","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"120"}}