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Among the five indole alkaloids, the maximum tolerance dose in mice ranged from 0.75 to 4\u00a0g\/kg bw. The TA-treated rats did not die and showed no adverse effects or dose-dependent changes in weight or food and water consumption, despite fluctuations in hematological and biochemical parameters compared with historical data. Furthermore, both gross and histopathological observations revealed no abnormalities in any organ. With daily oral administration to rats, the non-observed-adverse-effect-level of TA was 100\u00a0mg\/kg bw. The results indicate that TA is safe for clinical use.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Graphic Abstract<\/jats:title>\n                \n              <\/jats:sec>","DOI":"10.1007\/s13659-020-00237-1","type":"journal-article","created":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T12:02:42Z","timestamp":1585656162000},"page":"77-88","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Acute and Chronic Toxicity of Indole Alkaloids from Leaves of Alstonia scholaris (L.) R. 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