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Prod. Bioprospect."],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Alzheimer\u2019s disease (AD) is a complex neurodegenerative condition. 5<jats:italic>\u03b1<\/jats:italic>-epoxyalantolactone (5<jats:italic>\u03b1<\/jats:italic>-EAL), a eudesmane-type sesquiterpene isolated from the herb of <jats:italic>Inula macrophylla<\/jats:italic>, has various pharmacological effects. This work supposed to investigate the improved impact of 5<jats:italic>\u03b1<\/jats:italic>-EAL on cognitive impairment. 5<jats:italic>\u03b1<\/jats:italic>-EAL inhibited the generation of nitric oxide (NO) in BV-2 cells stimulated with lipopolysaccharide (LPS) with an EC<jats:sub>50<\/jats:sub> of 6.2\u00a0\u03bcM. 5<jats:italic>\u03b1<\/jats:italic>-EAL significantly reduced the production of prostaglandin E2 (PGE<jats:sub>2<\/jats:sub>) and tumor necrosis factor-\u03b1 (TNF-\u03b1), while also inhibiting the production of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) proteins. The ability of 5<jats:italic>\u03b1<\/jats:italic>-EAL to penetrate the blood\u2013brain barrier (BBB) was confirmed via a parallel artificial membrane permeation assay. Scopolamine (SCOP)-induced AD mice model was employed to assess the improved impacts of 5<jats:italic>\u03b1<\/jats:italic>-EAL on cognitive impairment in vivo. After the mice were pretreated with 5<jats:italic>\u03b1<\/jats:italic>-EAL (10 and 30\u00a0mg\/kg per day, <jats:italic>i.p.<\/jats:italic>) for 21\u00a0days, the behavioral experiments indicated that the administration of the 5<jats:italic>\u03b1<\/jats:italic>-EAL could alleviate the cognitive and memory impairments. 5<jats:italic>\u03b1<\/jats:italic>-EAL significantly reduced the AChE activity in the brain of SCOP-induced AD mice. In summary, these findings highlight the beneficial effects of the natural product 5<jats:italic>\u03b1<\/jats:italic>-EAL as a potential bioactive compound for attenuating cognitive deficits in AD due to its pharmacological profile.<\/jats:p>\n                <jats:p><jats:bold>Graphical Abstract<\/jats:bold><\/jats:p>","DOI":"10.1007\/s13659-024-00462-y","type":"journal-article","created":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T08:01:45Z","timestamp":1719907305000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["5\u03b1-Epoxyalantolactone from Inula macrophylla attenuates cognitive deficits in scopolamine-induced Alzheimer\u2019s disease mice model"],"prefix":"10.1007","volume":"14","author":[{"given":"Rui","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu-Yao","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang-Jiang","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Ha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Ping","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,2]]},"reference":[{"issue":"11","key":"462_CR1","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.jalz.2015.02.003","volume":"2015","author":"Alzheimer\u2019s Association","year":"2015","unstructured":"Alzheimer\u2019s Association. 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