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The clerodane diterpenoids possessing a 6-OH group and no substitution at C-7 exhibited greater cytotoxic activity than others, with their IC<jats:sub>50<\/jats:sub> values ranging from 0.3 to 2.9\u00a0\u03bcM. Isocaseamembrin E (<jats:bold>7<\/jats:bold>) exhibited antibacterial activity against <jats:italic>Staphylococcus aureus<\/jats:italic>, while isocaseamembrin E (<jats:bold>7<\/jats:bold>), corymbulosin X (<jats:bold>8<\/jats:bold>), caseargrewiin A (<jats:bold>9<\/jats:bold>), kurzipene A (<jats:bold>10<\/jats:bold>), and balanspene F (<jats:bold>11<\/jats:bold>) exhibited antibacterial activity against <jats:italic>Bacillus cereus<\/jats:italic>.<\/jats:p>\n                <jats:p><jats:bold>Graphical Abstract<\/jats:bold><\/jats:p>","DOI":"10.1007\/s13659-024-00475-7","type":"journal-article","created":{"date-parts":[[2024,9,14]],"date-time":"2024-09-14T09:02:25Z","timestamp":1726304545000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Grewiifopenes A\u2013K, bioactive clerodane diterpenoids from Casearia grewiifolia Vent."],"prefix":"10.1007","volume":"14","author":[{"given":"Phanruethai","family":"Pailee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paratchata","family":"Batsomboon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiriya","family":"Yaosanit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theerawat","family":"Thananthaisong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chulabhorn","family":"Mahidol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poonsakdi","family":"Ploypradith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanthawan","family":"Reuk-ngam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panita","family":"Khlaychan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supanna","family":"Techasakul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somsak","family":"Ruchirawat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vilailak","family":"Prachyawarakorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,14]]},"reference":[{"key":"475_CR1","first-page":"52","volume-title":"Medicinal plants in Thailand","author":"W Chuakul","year":"1997","unstructured":"Chuakul W, Saralamp P, Paonil W, Temsiririrkkul R, Clayton T. 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