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Among them, coggygrenoids A\u2212D (\n                    <jats:bold>1<\/jats:bold>\n                    \u2212\n                    <jats:bold>4<\/jats:bold>\n                    ), coggygrerol A (\n                    <jats:bold>5<\/jats:bold>\n                    ), and coggygrerol B (\n                    <jats:bold>6<\/jats:bold>\n                    ) are undescribed compounds. Additionally, seven flavonoids (\n                    <jats:bold>27<\/jats:bold>\n                    \u2212\n                    <jats:bold>33<\/jats:bold>\n                    ) were also isolated from this plant\n                    <jats:italic>.<\/jats:italic>\n                    Compound\n                    <jats:bold>15<\/jats:bold>\n                    displayed inhibitory activities in LPS-induced RAW 264.7 cells with an IC\n                    <jats:sub>50<\/jats:sub>\n                    value 6.81\u2009\u00b1\u20090.15\u00a0\u03bcM. Molecular docking demonstrated that\n                    <jats:bold>15<\/jats:bold>\n                    exhibited favorable affinity for NLRP3 and iNOS. In vitro and in vivo antibacterial evaluations indicated that coggygrnoid C (\n                    <jats:bold>3<\/jats:bold>\n                    ) exhibited significant inhibitory activity against methicillin-resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    ATCC BAA-1717 (USA300), with An MIC of 8\u00a0\u03bcg\/mL. Further mechanistic investigations demonstrated that\n                    <jats:bold>3<\/jats:bold>\n                    exerted antibacterial activity by compromising the integrity of the cell wall and membrane. Notably, the combination of\n                    <jats:bold>3<\/jats:bold>\n                    with ampicillin exhibited an additive antibacterial effect. In the\n                    <jats:italic>Galleria mellonella<\/jats:italic>\n                    infection model, compound\n                    <jats:bold>3<\/jats:bold>\n                    exhibited comparable activity to that of the positive control at 20\u00a0mg\/kg. These findings suggest that triterpenoids of\n                    <jats:italic>C. coggygria<\/jats:italic>\n                    are potential antibacterial lead agents.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Graphical Abstract<\/jats:bold>\n                  <\/jats:p>","DOI":"10.1007\/s13659-025-00553-4","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T03:53:13Z","timestamp":1767585193000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["First discovery of triterpenoids and sterols from Cotinus coggygria var. cinereus Engl. with anti-inflammatory and antibacterial activities"],"prefix":"10.1007","volume":"16","author":[{"given":"Yue-Tong","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze-Rui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren-Hao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Hao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Qi","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Huan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Ming","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,5]]},"reference":[{"key":"553_CR1","unstructured":"Editorial Committee of the Flora of China, Chinese Academy of Sciences. 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