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Phytochemical exploration of the\n                    <jats:italic>R. tomentosa<\/jats:italic>\n                    fruits led to the identification of eight new polymethylated phloroglucinols, designated as rhodotomentodione F (\n                    <jats:bold>1<\/jats:bold>\n                    ) and rhodotomentodimers H\u2012N (\n                    <jats:bold>2<\/jats:bold>\n                    \u2012\n                    <jats:bold>8<\/jats:bold>\n                    ), along with six previously described congeners (\n                    <jats:bold>9<\/jats:bold>\n                    \u2012\n                    <jats:bold>14<\/jats:bold>\n                    ). Based on the detailed inspection of comprehensive spectroscopic data, electronic circular dichroism (ECD) simulations, and nuclear magnetic resonance (NMR) calculations, and DP4+\u2009analyses, the structures of phloroglucinols\n                    <jats:bold>1<\/jats:bold>\n                    \u2012\n                    <jats:bold>8<\/jats:bold>\n                    were determined. Heterodimeric phloroglucinols\n                    <jats:bold>3<\/jats:bold>\n                    \u2012\n                    <jats:bold>14<\/jats:bold>\n                    exhibited human acetylcholinesterase (\n                    <jats:italic>h<\/jats:italic>\n                    AChE) inhibitory activities, with\n                    <jats:bold>13<\/jats:bold>\n                    exhibiting the highest potency (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u2009=\u20091.04\u00a0\u03bcM). Moreover, molecular docking analysis clarified the potential binding interactions between the most active phloroglucinol\n                    <jats:bold>13<\/jats:bold>\n                    with\n                    <jats:italic>h<\/jats:italic>\n                    AChE. In addition, phloroglucinols\n                    <jats:bold>11<\/jats:bold>\n                    and\n                    <jats:bold>12<\/jats:bold>\n                    displayed significant anti-VRE (vancomycin-resistant\n                    <jats:italic>Enterococci<\/jats:italic>\n                    ) activities, with MIC values reaching as low as 1\u00a0\u03bcg\/mL.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Graphical Abstract<\/jats:bold>\n                  <\/jats:p>","DOI":"10.1007\/s13659-025-00557-0","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T23:02:27Z","timestamp":1767826947000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Diverse phloroglucinols with hAChE inhibitory and anti-VRE effects from Rhodomyrtus tomentosa fruits"],"prefix":"10.1007","volume":"16","author":[{"given":"Ling-Yun","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mu-Yuan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E-E","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Ying","family":"Zong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Mei","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai-Chun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Qin","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0853-0028","authenticated-orcid":false,"given":"Xu-Jie","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"issue":"1","key":"557_CR1","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1007\/s11101-020-09697-2","volume":"20","author":"O Celaj","year":"2021","unstructured":"Celaj O, Duar\u00e1n AG, Cennamo P, Scognamiglio M, Fiorentino A, Esposito A, et al. 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