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Prod. Bioprospect."],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    New dearomatized isoprenylated acylphloroglucinols hyperprzewones A (\n                    <jats:bold>1<\/jats:bold>\n                    ) and B (\n                    <jats:bold>2<\/jats:bold>\n                    ) were isolated and characterized from the dried aerial parts of\n                    <jats:italic>Hypericum przewalskii<\/jats:italic>\n                    . The structures of these compounds were confirmed by extensive spectroscopic experiments. A facile synthetic route to\n                    <jats:bold>1<\/jats:bold>\n                    and\n                    <jats:bold>2<\/jats:bold>\n                    was developed via Friedel-Crafts acylation, alkylation, dearomatization, and oxidative [4\u2009+\u20092] cyclization, giving a 17% overall yield. Moreover, the synthetic derivative\n                    <jats:bold>8<\/jats:bold>\n                    exhibited moderate inhibition on T-type calcium channels Ca\n                    <jats:sub>v<\/jats:sub>\n                    3.2.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Graphical Abstract<\/jats:bold>\n                  <\/jats:p>","DOI":"10.1007\/s13659-026-00626-y","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T10:08:47Z","timestamp":1775038127000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Isolation, total synthesis, and biological evaluation of dearomatized isoprenylated acylphloroglucinols from Hypericum przewalskii"],"prefix":"10.1007","volume":"16","author":[{"given":"Yong","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei-Fei","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Yang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing-Ren","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dao-Feng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Nian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4799-6784","authenticated-orcid":false,"given":"Li-Dong","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,1]]},"reference":[{"key":"626_CR1","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1039\/b600518g","volume":"23","author":"IP Singh","year":"2006","unstructured":"Singh IP, Bharate SB. 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