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The purpose of this review was to examine recent pre-clinical and clinical studies to understand how maternal probiotics exposure affects offspring health outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title><jats:italic>Recent Findings<\/jats:italic><\/jats:title><jats:p>Effects were investigated in the context of supporting offspring growth, intestinal health, and gut microbiota, preventing allergic diseases, supporting neurodevelopment, and preventing metabolic disorders in pre-clinical and clinical studies. Most human studies focused on infancy outcomes, whereas pre-clinical studies also examined outcomes at adolescence and young adulthood. While still understudied, both pre-clinical and clinical studies propose epigenetic modifications as an underlying mechanism. Optimal timing of intervention remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title><jats:italic>Summary<\/jats:italic><\/jats:title><jats:p>Administration of selected probiotics to mothers has programming potential for sustaining life-long health of offspring. Administration protocols, specific windows of susceptibility, and individual-specific responses need to be further studied.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s13668-022-00429-w","type":"journal-article","created":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T07:03:00Z","timestamp":1660978980000},"page":"537-562","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Maternal Intake of Probiotics to Program Offspring Health"],"prefix":"10.1007","volume":"11","author":[{"given":"C\u00e9line","family":"Cuinat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara E.","family":"Stinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy E.","family":"Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5201-5437","authenticated-orcid":false,"given":"Elena M.","family":"Comelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,8,20]]},"reference":[{"key":"429_CR1","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1038\/nrgastro.2014.66","volume":"11","author":"C Hill","year":"2014","unstructured":"Hill C, Guarner F, Reid G, et al. 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