{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:53:08Z","timestamp":1788457988484,"version":"build-2803163510"},"reference-count":174,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T00:00:00Z","timestamp":1737504000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T00:00:00Z","timestamp":1737504000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["5\/4\/8-10\/Obs\/MPP\/2022-NCD-II"],"award-info":[{"award-number":["5\/4\/8-10\/Obs\/MPP\/2022-NCD-II"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["5\/4\/8-10\/Obs\/MPP\/2022-NCD-II"],"award-info":[{"award-number":["5\/4\/8-10\/Obs\/MPP\/2022-NCD-II"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["5\/4\/8-10\/Obs\/MPP\/2022-NCD-II"],"award-info":[{"award-number":["5\/4\/8-10\/Obs\/MPP\/2022-NCD-II"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["5\/4\/8-10\/Obs\/MPP\/2022-NCD-II"],"award-info":[{"award-number":["5\/4\/8-10\/Obs\/MPP\/2022-NCD-II"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Curr Nutr Rep"],"DOI":"10.1007\/s13668-024-00598-w","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T00:41:31Z","timestamp":1737506491000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Mitigating Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD): The Role of Bioactive Phytoconstituents in Indian Culinary Spices"],"prefix":"10.1007","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7483-0857","authenticated-orcid":false,"given":"Pervej Alom","family":"Barbhuiya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7512-3959","authenticated-orcid":false,"given":"Ameena","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0907-3030","authenticated-orcid":false,"given":"Partha Pratim","family":"Dutta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5279-1532","authenticated-orcid":false,"given":"Saikat","family":"Sen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9182-7948","authenticated-orcid":false,"given":"Manash Pratim","family":"Pathak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,22]]},"reference":[{"key":"598_CR1","doi-asserted-by":"crossref","unstructured":"Safaei M, Sundararajan EA, Driss M, Boulila W, Shapi\u2019i A. A systematic literature review on obesity: Understanding the causes & consequences of obesity and reviewing various machine learning approaches used to predict obesity. Comput Biol Med. 2021;136:104754.","DOI":"10.1016\/j.compbiomed.2021.104754"},{"key":"598_CR2","doi-asserted-by":"publisher","first-page":"e027693","DOI":"10.1161\/JAHA.122.027693","volume":"12","author":"JM Clark","year":"2023","unstructured":"Clark JM, Garvey WT, Niswender KD, Schmidt AM, Ahima RS, Aleman JO, et al. Obesity and overweight: Probing causes, consequences, and novel therapeutic approaches through the american heart association\u2019s strategically focused research network. J Am Heart Assoc. 2023;12:e027693.","journal-title":"J Am Heart Assoc"},{"key":"598_CR3","doi-asserted-by":"publisher","first-page":"706978","DOI":"10.3389\/fendo.2021.706978","volume":"12","author":"X Lin","year":"2021","unstructured":"Lin X, Li H. Obesity: Epidemiology, pathophysiology, and therapeutics. Front Endocrinol. 2021;12:706978.","journal-title":"Front Endocrinol"},{"key":"598_CR4","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1038\/s42003-024-06035-6","volume":"7","author":"C Burelle","year":"2024","unstructured":"Burelle C, Clapatiuc V, Desch\u00eanes S, Cuillerier A, De Loof M, Higgins M-\u00c8, et al. A genetic mouse model of lean-NAFLD unveils sexual dimorphism in the liver-heart axis. Commun Biol. 2024;7:356.","journal-title":"Commun Biol"},{"key":"598_CR5","first-page":"302","volume":"47","author":"B Nath","year":"2022","unstructured":"Nath B, Kankaria A, Kumari R, Kapil U. Nonalcoholic fatty liver disease: Role of medical colleges in its prevention and control. Indian J Community Med Off Publ Indian Assoc Prev Soc Med. 2022;47:302\u20133.","journal-title":"Indian J Community Med Off Publ Indian Assoc Prev Soc Med"},{"key":"598_CR6","doi-asserted-by":"publisher","first-page":"197","DOI":"10.7570\/jomes23052","volume":"32","author":"W-K Chan","year":"2023","unstructured":"Chan W-K, Chuah K-H, Rajaram RB, Lim L-L, Ratnasingam J, Vethakkan SR. Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A state-of-the-art review. J Obes Metab Syndr. 2023;32:197\u2013213.","journal-title":"J Obes Metab Syndr"},{"key":"598_CR7","doi-asserted-by":"publisher","first-page":"e76","DOI":"10.1016\/j.jhep.2023.08.026","volume":"80","author":"H Hagstr\u00f6m","year":"2024","unstructured":"Hagstr\u00f6m H, Vessby J, Ekstedt M, Shang Y. 99% of patients with NAFLD meet MASLD criteria and natural history is therefore identical. J Hepatol. 2024;80:e76\u20137.","journal-title":"J Hepatol"},{"key":"598_CR8","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1016\/j.jhep.2024.01.014","volume":"80","author":"ZM Younossi","year":"2024","unstructured":"Younossi ZM, Paik JM, Stepanova M, Ong J, Alqahtani S, Henry L. Clinical profiles and mortality rates are similar for metabolic dysfunction-associated steatotic liver disease and non-alcoholic fatty liver disease. J Hepatol. 2024;80:694\u2013701.","journal-title":"J Hepatol"},{"key":"598_CR9","doi-asserted-by":"publisher","first-page":"8391","DOI":"10.1038\/s41467-023-44242-7","volume":"14","author":"M Chen","year":"2023","unstructured":"Chen M, Zhu J-Y, Mu W-J, Luo H-Y, Li Y, Li S, et al. Cdo1-Camkk2-AMPK axis confers the protective effects of exercise against NAFLD in mice. Nat Commun. 2023;14:8391.","journal-title":"Nat Commun"},{"key":"598_CR10","doi-asserted-by":"publisher","first-page":"1974","DOI":"10.1038\/s12276-023-01072-3","volume":"55","author":"H Sun","year":"2023","unstructured":"Sun H, Kemper JK. MicroRNA regulation of AMPK in nonalcoholic fatty liver disease. Exp Mol Med. 2023;55:1974\u201381.","journal-title":"Exp Mol Med"},{"key":"598_CR11","doi-asserted-by":"crossref","unstructured":"Shalimar null, Elhence A, Bansal B, Gupta H, Anand A, Singh TP, et al. Prevalence of non-alcoholic fatty liver disease in India: A systematic review and meta-analysis. J Clin Exp Hepatol. 2022;12:818\u201329.","DOI":"10.1016\/j.jceh.2021.11.010"},{"key":"598_CR12","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1177\/1203475420943270","volume":"24","author":"KC Metzger","year":"2020","unstructured":"Metzger KC, Crowley EL, Kadlubowska D, Gooderham MJ. Uncommon adverse effects of deoxycholic acid injection for submental fullness: Beyond the clinical trials. J Cutan Med Surg. 2020;24:619\u201324.","journal-title":"J Cutan Med Surg"},{"key":"598_CR13","doi-asserted-by":"publisher","unstructured":"Barbhuiya PA, Sen S, Pathak MP. Ameliorative role of bioactive phytoconstituents targeting obesity associated NAFLD by modulation of inflammation and lipogenesis pathways: a comprehensive review. Phytochem Rev. 2024;3:969\u2013996. https:\/\/doi.org\/10.1007\/s11101-023-09912-w.","DOI":"10.1007\/s11101-023-09912-w"},{"key":"598_CR14","unstructured":"Abdullah M, Jamil R, Attia F. Vitamin C (Ascorbic Acid). StatPearls Publishing; 2023."},{"key":"598_CR15","unstructured":"Krupa K, Fritz K, Parmar M. Omega-3 Fatty Acids. StatPearls Publishing; 2023."},{"key":"598_CR16","doi-asserted-by":"publisher","first-page":"7571","DOI":"10.3390\/ijms22147571","volume":"22","author":"C Zhang","year":"2021","unstructured":"Zhang C, Yang M. Current options and future directions for NAFLD and NASH treatment. Int J Mol Sci. 2021;22:7571.","journal-title":"Int J Mol Sci"},{"key":"598_CR17","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.jfutfo.2023.02.004","volume":"3","author":"X Wang","year":"2023","unstructured":"Wang X, Wang X, Wen M, Li X. Bibliometric analysis of literature on prevention and treatment of gastric ulcer with natural medicines. J Future Foods. 2023;3:225\u201333.","journal-title":"J Future Foods"},{"key":"598_CR18","doi-asserted-by":"publisher","first-page":"149","DOI":"10.3831\/KPI.2022.25.3.149","volume":"25","author":"PA Barbhuiya","year":"2022","unstructured":"Barbhuiya PA, Laskar AM, Mazumdar H, Dutta PP, Pathak MP, Dey BK, et al. Ethnomedicinal practices and traditional medicinal plants of Barak Valley, Assam: A systematic review. J Pharmacopuncture. 2022;25:149\u201385.","journal-title":"J Pharmacopuncture"},{"key":"598_CR19","doi-asserted-by":"publisher","first-page":"5986","DOI":"10.1080\/87559129.2022.2097692","volume":"39","author":"C Wang","year":"2023","unstructured":"Wang C, Li M, Duan X, Abu-Izneid T, Rauf A, Khan Z, et al. Phytochemical and nutritional profiling of tomatoes; Impact of processing on bioavailability - A comprehensive review. Food Rev Int. 2023;39:5986\u20136010.","journal-title":"Food Rev Int"},{"key":"598_CR20","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1016\/j.jpha.2023.04.018","volume":"13","author":"S Khan","year":"2023","unstructured":"Khan S, Rai AK, Singh A, Singh S, Dubey BK, Lal RK, et al. Rapid metabolic fingerprinting with the aid of chemometric models to identify authenticity of natural medicines: Turmeric, Ocimum, and Withania somnifera study. J Pharm Anal. 2023;13:1041\u201357.","journal-title":"J Pharm Anal"},{"key":"598_CR21","doi-asserted-by":"publisher","first-page":"690","DOI":"10.2174\/1568026623666230419102140","volume":"23","author":"NR Chanu","year":"2023","unstructured":"Chanu NR, Gogoi P, Barbhuiya PA, Dutta PP, Pathak MP, Sen S. Natural flavonoids as potential therapeutics in the management of diabetic wound: A review. Curr Top Med Chem. 2023;23:690\u2013710.","journal-title":"Curr Top Med Chem"},{"key":"598_CR22","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.3390\/antiox11061158","volume":"11","author":"M Shi","year":"2022","unstructured":"Shi M, Gu J, Wu H, Rauf A, Emran TB, Khan Z, et al. Phytochemicals, nutrition, metabolism, bioavailability, and health benefits in lettuce\u2014A comprehensive review. Antioxidants. 2022;11:1158.","journal-title":"Antioxidants"},{"key":"598_CR23","first-page":"5125","volume":"18","author":"C-T Che","year":"2013","unstructured":"Che C-T, Wang ZJ, Chow MSS, Lam CWK. Herb-herb combination for therapeutic enhancement and advancement: theory, Practice and future perspectives. Mol Basel Switz. 2013;18:5125\u201341.","journal-title":"Mol Basel Switz"},{"key":"598_CR24","doi-asserted-by":"crossref","unstructured":"Lesa KN, Khandaker MU, Mohammad Rashed Iqbal F, Sharma R, Islam F, Mitra S, et al. Nutritional value, medicinal importance, and health-promoting effects of dietary mushroom (Pleurotus ostreatus). Akbar A, editor. J Food Qual. 2022;2022:1\u20139.","DOI":"10.1155\/2022\/2454180"},{"key":"598_CR25","doi-asserted-by":"publisher","unstructured":"Tapsell LC, Hemphill I, Cobiac L, Sullivan DR, Fenech M, Patch CS, et al. Health benefits of herbs and spices: the past, the present, the future. Med J Aust. 2006;185:S1\u2013S24. https:\/\/doi.org\/10.5694\/j.1326-5377.2006.tb00548.x.","DOI":"10.5694\/j.1326-5377.2006.tb00548.x"},{"key":"598_CR26","doi-asserted-by":"crossref","unstructured":"Peter KV, Shylaja MR. Introduction to herbs and spices: definitions, trade and applications. Handb Herbs Spices. Elsevier; 2012.","DOI":"10.1533\/9780857095671"},{"key":"598_CR27","doi-asserted-by":"publisher","first-page":"274","DOI":"10.2174\/157340310793566172","volume":"6","author":"HR Vasanthi","year":"2010","unstructured":"Vasanthi HR, Parameswari RP. Indian spices for healthy heart - an overview. Curr Cardiol Rev. 2010;6:274\u20139.","journal-title":"Curr Cardiol Rev"},{"key":"598_CR28","doi-asserted-by":"publisher","first-page":"86","DOI":"10.5958\/2249-7307.2014.00976.1","volume":"4","author":"MS Yogesh","year":"2014","unstructured":"Yogesh MS, Mokshapathy S. An analysis of spices production in India. Asian J Res Bus Econ Manag. 2014;4:86.","journal-title":"Asian J Res Bus Econ Manag"},{"key":"598_CR29","doi-asserted-by":"publisher","unstructured":"Sharangi AB, Acharya SK. Spices in India and beyond: The origin, history, tradition and culture. In: Sharangi AB, editor Indian Spices [Internet]. Springer International Publishing, Cham; 2018 [cited 2024 Oct 2]. p. 1\u201311. Available from: http:\/\/link.springer.com\/https:\/\/doi.org\/10.1007\/978-3-319-75016-3_1.","DOI":"10.1007\/978-3-319-75016-3_1"},{"key":"598_CR30","first-page":"265","volume":"17","author":"K Krishnaswamy","year":"2008","unstructured":"Krishnaswamy K. Traditional Indian spices and their health significance. Asia Pac J Clinl Nutr. 2008;17:265\u20138.","journal-title":"Asia Pac J Clinl Nutr"},{"key":"598_CR31","doi-asserted-by":"publisher","first-page":"e79","DOI":"10.1017\/jns.2023.52","volume":"12","author":"AS Al Dhaheri","year":"2023","unstructured":"Al Dhaheri AS, Alkhatib DH, Jaleel A, Tariq MNM, Feehan J, Apostolopoulos V, et al. Proximate composition and mineral content of spices increasingly employed in the Mediterranean diet. J Nutr Sci. 2023;12:e79.","journal-title":"J Nutr Sci"},{"key":"598_CR32","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1080\/J157v07n02_04","volume":"7","author":"GA Agbor","year":"2008","unstructured":"Agbor GA, Vinson JA, Oben JE, Ngogang JY. In Vitro Antioxidant Activity of Three Piper Species. J Herb Pharmacother. 2008;7:49\u201364.","journal-title":"J Herb Pharmacother"},{"key":"598_CR33","doi-asserted-by":"publisher","first-page":"395","DOI":"10.5740\/jaoacint.18-0418","volume":"102","author":"TA Jiang","year":"2019","unstructured":"Jiang TA. Health benefits of culinary herbs and spices. J AOAC Int. 2019;102:395\u2013411.","journal-title":"J AOAC Int"},{"key":"598_CR34","doi-asserted-by":"crossref","unstructured":"Pathak K, Pathak MP, Saikia R, Gogoi U, Sahariah JJ, Das A, et al. Cardioprotective activities of some Indian spices: an insight intopharmacology and phytochemical investigation. Curr Tradit Med. 2024;10:e100223213570.","DOI":"10.2174\/2215083809666230210105442"},{"key":"598_CR35","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1002\/biof.1074","volume":"39","author":"PG Bradford","year":"2013","unstructured":"Bradford PG. Curcumin and obesity. BioFactors Oxf Engl. 2013;39:78\u201387.","journal-title":"BioFactors Oxf Engl"},{"key":"598_CR36","first-page":"1350","volume":"17","author":"CM White","year":"2019","unstructured":"White CM, Lee J-Y. The impact of turmeric or its curcumin extract on nonalcoholic fatty liver disease: a systematic review of clinical trials. Pharm Pract. 2019;17:1350.","journal-title":"Pharm Pract"},{"key":"598_CR37","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1093\/jpp\/rgab032","volume":"73","author":"MH Fawzy","year":"2021","unstructured":"Fawzy MH, Saeed NM, El-Sherbiny DA, El-Demerdash E. Eugenol modulates insulin sensitivity by upregulating insulin receptor substrate-2 in non-alcoholic fatty liver disease in rats. J Pharm Pharmacol. 2021;73:846\u201354.","journal-title":"J Pharm Pharmacol"},{"key":"598_CR38","doi-asserted-by":"publisher","first-page":"14003","DOI":"10.1038\/s41598-019-50352-4","volume":"9","author":"AA Harb","year":"2019","unstructured":"Harb AA, Bustanji YK, Almasri IM, Abdalla SS. Eugenol reduces LDL cholesterol and hepatic steatosis in hypercholesterolemic rats by modulating TRPV1 receptor. Sci Rep. 2019;9:14003.","journal-title":"Sci Rep"},{"key":"598_CR39","doi-asserted-by":"publisher","first-page":"9561613","DOI":"10.1155\/2021\/9561613","volume":"2021","author":"Y Wu","year":"2021","unstructured":"Wu Y, Wang M, Yang T, Qin L, Hu Y, Zhao D, et al. Cinnamic acid ameliorates nonalcoholic fatty liver disease by suppressing hepatic lipogenesis and promoting fatty acid oxidation. Evid-Based Complement Altern Med ECAM. 2021;2021:9561613.","journal-title":"Evid-Based Complement Altern Med ECAM"},{"key":"598_CR40","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1002\/hep.23280","volume":"51","author":"E Fabbrini","year":"2010","unstructured":"Fabbrini E, Sullivan S, Klein S. Obesity and nonalcoholic fatty liver disease: Biochemical, metabolic, and clinical implications. Hepatology. 2010;51:679\u201389.","journal-title":"Hepatology"},{"key":"598_CR41","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1111\/j.1600-065X.2012.01151.x","volume":"249","author":"AR Johnson","year":"2012","unstructured":"Johnson AR, Justin Milner J, Makowski L. The inflammation highway: metabolism accelerates inflammatory traffic in obesity. Immunol Rev. 2012;249:218\u201338.","journal-title":"Immunol Rev"},{"key":"598_CR42","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.livres.2023.11.003","volume":"7","author":"Z Zhu","year":"2023","unstructured":"Zhu Z, Zhang X, Pan Q, Zhang L, Chai J. In-depth analysis of de novo lipogenesis in non-alcoholic fatty liver disease: Mechanism and pharmacological interventions. Liver Res. 2023;7:285\u201395.","journal-title":"Liver Res"},{"key":"598_CR43","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1038\/nrgastro.2016.85","volume":"13","author":"C Leung","year":"2016","unstructured":"Leung C, Rivera L, Furness JB, Angus PW. The role of the gut microbiota in NAFLD. Nat Rev Gastroenterol Hepatol. 2016;13:412\u201325.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"598_CR44","first-page":"1","volume":"2016","author":"J Yu","year":"2016","unstructured":"Yu J, Marsh S, Hu J, Feng W, Wu C. The pathogenesis of nonalcoholic fatty liver disease: interplay between diet, gut microbiota, and genetic background. Gastroenterol Res Pract. 2016;2016:1\u201313.","journal-title":"Gastroenterol Res Pract"},{"key":"598_CR45","doi-asserted-by":"publisher","first-page":"1941","DOI":"10.2174\/138161210791208875","volume":"16","author":"E Bugianesi","year":"2010","unstructured":"Bugianesi E, Moscatiello S, Ciaravella MF, Marchesini G. Insulin resistance in nonalcoholic fatty liver disease. Curr Pharm Des. 2010;16:1941\u201351.","journal-title":"Curr Pharm Des"},{"key":"598_CR46","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1097\/MOL.0000000000000080","volume":"25","author":"MM Jacome-Sosa","year":"2014","unstructured":"Jacome-Sosa MM, Parks EJ. Fatty acid sources and their fluxes as they contribute to plasma triglyceride concentrations and fatty liver in humans. Curr Opin Lipidol. 2014;25:213\u201320.","journal-title":"Curr Opin Lipidol"},{"key":"598_CR47","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.plipres.2012.11.002","volume":"52","author":"G Musso","year":"2013","unstructured":"Musso G, Gambino R, Cassader M. Cholesterol metabolism and the pathogenesis of non-alcoholic steatohepatitis. Prog Lipid Res. 2013;52:175\u201391.","journal-title":"Prog Lipid Res"},{"key":"598_CR48","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1002\/hep.21655","volume":"45","author":"K Yamaguchi","year":"2007","unstructured":"Yamaguchi K, Yang L, McCall S, Huang J, Yu XX, Pandey SK, et al. Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis. Hepatology. 2007;45:1366\u201374.","journal-title":"Hepatology"},{"key":"598_CR49","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1055\/s-0028-1091981","volume":"28","author":"J Jou","year":"2008","unstructured":"Jou J, Choi S, Diehl A. Mechanisms of disease progression in nonalcoholic fatty liver disease. Semin Liver Dis. 2008;28:370\u20139.","journal-title":"Semin Liver Dis"},{"key":"598_CR50","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1053\/j.gastro.2013.11.049","volume":"146","author":"JE Lambert","year":"2014","unstructured":"Lambert JE, Ramos-Roman MA, Browning JD, Parks EJ. Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease. Gastroenterology. 2014;146:726\u201335.","journal-title":"Gastroenterology"},{"key":"598_CR51","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1021\/mp700110z","volume":"5","author":"J George","year":"2008","unstructured":"George J, Liddle C. Nonalcoholic fatty liver disease: pathogenesis and potential for nuclear receptors as therapeutic targets. Mol Pharm. 2008;5:49\u201359.","journal-title":"Mol Pharm"},{"key":"598_CR52","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.cld.2012.05.005","volume":"16","author":"SC Matherly","year":"2012","unstructured":"Matherly SC, Puri P. Mechanisms of simple hepatic steatosis. Clin Liver Dis. 2012;16:505\u201324.","journal-title":"Clin Liver Dis"},{"key":"598_CR53","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1677\/JOE-07-0234","volume":"194","author":"R Barbuio","year":"2007","unstructured":"Barbuio R, Milanski M, Bertolo MB, Saad MJ, Velloso LA. Infliximab reverses steatosis and improves insulin signal transduction in liver of rats fed a high-fat diet. J Endocrinol. 2007;194:539\u201350.","journal-title":"J Endocrinol"},{"key":"598_CR54","doi-asserted-by":"publisher","first-page":"153610","DOI":"10.1016\/j.phymed.2021.153610","volume":"89","author":"MP Pathak","year":"2021","unstructured":"Pathak MP, Patowary P, Goyary D, Das A, Chattopadhyay P. \u03b2-caryophyllene ameliorated obesity-associated airway hyperresponsiveness through some non-conventional targets. Phytomedicine. 2021;89:153610.","journal-title":"Phytomedicine"},{"key":"598_CR55","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.mce.2012.06.018","volume":"366","author":"CM Hasenour","year":"2013","unstructured":"Hasenour CM, Berglund ED, Wasserman DH. Emerging role of AMP-activated protein kinase in endocrine control of metabolism in the liver. Mol Cell Endocrinol. 2013;366:152\u201362.","journal-title":"Mol Cell Endocrinol"},{"key":"598_CR56","doi-asserted-by":"publisher","first-page":"2769","DOI":"10.3390\/nu12092769","volume":"12","author":"C-H Lee","year":"2020","unstructured":"Lee C-H, Fu Y, Yang S-J, Chi C-C. Effects of Omega-3 polyunsaturated fatty acid supplementation on non-alcoholic fatty liver: A systematic review and meta-analysis. Nutrients. 2020;12:2769.","journal-title":"Nutrients"},{"key":"598_CR57","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.3390\/nu10101383","volume":"10","author":"Z Song","year":"2018","unstructured":"Song Z, Xiaoli A, Yang F. Regulation and metabolic significance of de novo lipogenesis in adipose tissues. Nutrients. 2018;10:1383.","journal-title":"Nutrients"},{"key":"598_CR58","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1159\/000100426","volume":"68","author":"P Ferr\u00e9","year":"2007","unstructured":"Ferr\u00e9 P, Foufelle F. SREBP-1c transcription factor and lipid homeostasis: clinical perspective. Horm Res Paediatr. 2007;68:72\u201382.","journal-title":"Horm Res Paediatr"},{"key":"598_CR59","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1042\/bj20020430","volume":"366","author":"F Foufelle","year":"2002","unstructured":"Foufelle F, Ferr\u00e9 P. New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c. Biochem J. 2002;366:377\u201391.","journal-title":"Biochem J"},{"key":"598_CR60","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1146\/annurev.nutr.012809.104729","volume":"30","author":"LS Csaki","year":"2010","unstructured":"Csaki LS, Reue K. Lipins: multifunctional lipid metabolism proteins. Annu Rev Nutr. 2010;30:257\u201372.","journal-title":"Annu Rev Nutr"},{"key":"598_CR61","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1172\/JCI0215593","volume":"109","author":"JD Horton","year":"2002","unstructured":"Horton JD, Goldstein JL, Brown MS. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest. 2002;109:1125\u201331.","journal-title":"J Clin Invest"},{"key":"598_CR62","doi-asserted-by":"publisher","first-page":"934113","DOI":"10.3389\/fnut.2022.934113","volume":"9","author":"Q Zhang","year":"2022","unstructured":"Zhang Q, Xing W, Wang Q, Tang Z, Wang Y, Gao W. Gut microbiota-mitochondrial inter-talk in non-alcoholic fatty liver disease. Front Nutr. 2022;9:934113.","journal-title":"Front Nutr"},{"key":"598_CR63","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.cmet.2015.07.007","volume":"22","author":"S Ussar","year":"2015","unstructured":"Ussar S, Griffin NW, Bezy O, Fujisaka S, Vienberg S, Softic S, et al. Interactions between gut microbiota, host genetics and diet modulate the predisposition to obesity and metabolic syndrome. Cell Metab. 2015;22:516\u201330.","journal-title":"Cell Metab"},{"key":"598_CR64","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1097\/MOG.0000000000000349","volume":"33","author":"K Brandl","year":"2017","unstructured":"Brandl K, Schnabl B. Intestinal microbiota and nonalcoholic steatohepatitis. Curr Opin Gastroenterol. 2017;33:128\u201333.","journal-title":"Curr Opin Gastroenterol"},{"key":"598_CR65","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1016\/j.jhep.2019.08.005","volume":"71","author":"J Mouries","year":"2019","unstructured":"Mouries J, Brescia P, Silvestri A, Spadoni I, Sorribas M, Wiest R, et al. Microbiota-driven gut vascular barrier disruption is a prerequisite for non-alcoholic steatohepatitis development. J Hepatol. 2019;71:1216\u201328.","journal-title":"J Hepatol"},{"key":"598_CR66","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.3390\/nu4081095","volume":"4","author":"K Brown","year":"2012","unstructured":"Brown K, DeCoffe D, Molcan E, Gibson DL. Diet-Induced dysbiosis of the intestinal microbiota and the effects on immunity and disease. Nutrients. 2012;4:1095\u2013119.","journal-title":"Nutrients"},{"key":"598_CR67","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1002\/hep.28356","volume":"63","author":"J Boursier","year":"2016","unstructured":"Boursier J, Mueller O, Barret M, Machado M, Fizanne L, Araujo-Perez F, et al. The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota. Hepatol Baltim Md. 2016;63:764\u201375.","journal-title":"Hepatol Baltim Md"},{"key":"598_CR68","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/S1499-3872(17)60019-5","volume":"16","author":"F Shen","year":"2017","unstructured":"Shen F, Zheng R-D, Sun X-Q, Ding W-J, Wang X-Y, Fan J-G. Gut microbiota dysbiosis in patients with non-alcoholic fatty liver disease. Hepatobiliary Pancreat Dis Int HBPD INT. 2017;16:375\u201381.","journal-title":"Hepatobiliary Pancreat Dis Int HBPD INT"},{"key":"598_CR69","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/j.tim.2004.10.008","volume":"12","author":"MC Noverr","year":"2004","unstructured":"Noverr MC, Huffnagle GB. Does the microbiota regulate immune responses outside the gut? Trends Microbiol. 2004;12:562\u20138.","journal-title":"Trends Microbiol"},{"key":"598_CR70","doi-asserted-by":"publisher","first-page":"1877","DOI":"10.1002\/hep.22848","volume":"49","author":"L Miele","year":"2009","unstructured":"Miele L, Valenza V, La Torre G, Montalto M, Cammarota G, Ricci R, et al. Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease. Hepatol Baltim Md. 2009;49:1877\u201387.","journal-title":"Hepatol Baltim Md"},{"key":"598_CR71","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1136\/gut.48.2.206","volume":"48","author":"AJ Wigg","year":"2001","unstructured":"Wigg AJ, Roberts-Thomson IC, Dymock RB, McCarthy PJ, Grose RH, Cummins AG. The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumour necrosis factor alpha in the pathogenesis of non-alcoholic steatohepatitis. Gut. 2001;48:206\u201311.","journal-title":"Gut"},{"key":"598_CR72","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/j.jhep.2007.04.019","volume":"47","author":"CA Rivera","year":"2007","unstructured":"Rivera CA, Adegboyega P, Van Rooijen N, Tagalicud A, Allman M, Wallace M. Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis. J Hepatol. 2007;47:571\u20139.","journal-title":"J Hepatol"},{"key":"598_CR73","doi-asserted-by":"publisher","first-page":"e1004559","DOI":"10.1371\/journal.ppat.1004559","volume":"11","author":"J Boursier","year":"2015","unstructured":"Boursier J, Diehl AM. Implication of gut microbiota in nonalcoholic fatty liver disease. PLoS Pathog. 2015;11:e1004559.","journal-title":"PLoS Pathog"},{"key":"598_CR74","doi-asserted-by":"publisher","first-page":"1881","DOI":"10.1053\/j.gastro.2020.01.049","volume":"158","author":"J Aron-Wisnewsky","year":"2020","unstructured":"Aron-Wisnewsky J, Warmbrunn MV, Nieuwdorp M, Cl\u00e9ment K. Nonalcoholic fatty liver disease: modulating gut microbiota to improve severity? Gastroenterology. 2020;158:1881\u201398.","journal-title":"Gastroenterology"},{"key":"598_CR75","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1155\/2014\/757929","volume":"28","author":"MG Neuman","year":"2014","unstructured":"Neuman MG, Cohen LB, Nanau RM. Biomarkers in nonalcoholic fatty liver disease. Can J Gastroenterol Hepatol. 2014;28:607\u201318.","journal-title":"Can J Gastroenterol Hepatol"},{"key":"598_CR76","doi-asserted-by":"publisher","first-page":"214567","DOI":"10.1016\/j.ccr.2022.214567","volume":"465","author":"SM Shaban","year":"2022","unstructured":"Shaban SM, Byeok Jo S, Hafez E, Ho Cho J, Kim D-H. A comprehensive overview on alkaline phosphatase targeting and reporting assays. Coord Chem Rev. 2022;465:214567.","journal-title":"Coord Chem Rev"},{"key":"598_CR77","first-page":"51","volume":"7","author":"R Dong","year":"2019","unstructured":"Dong R, Wan B, Lin S, Wang M, Huang J, Wu Y, et al. Procalcitonin and liver disease: a literature review. J Clin Transl Hepatol. 2019;7:51\u20135.","journal-title":"J Clin Transl Hepatol"},{"key":"598_CR78","doi-asserted-by":"publisher","first-page":"152","DOI":"10.3138\/canlivj-2021-0002","volume":"5","author":"R Trasolini","year":"2022","unstructured":"Trasolini R, Cox B, Galts C, Yoshida EM, Marquez V. Elevated serum ferritin in non-alcoholic fatty liver disease is not predictive of fibrosis. Can Liver J. 2022;5:152\u20139.","journal-title":"Can Liver J"},{"key":"598_CR79","doi-asserted-by":"publisher","first-page":"2839","DOI":"10.1002\/hep.32072","volume":"74","author":"J Zhou","year":"2021","unstructured":"Zhou J, Bai L, Zhang X-J, Li H, Cai J. Nonalcoholic fatty liver disease and cardiac remodeling risk: pathophysiological mechanisms and clinical implications. Hepatol Baltim Md. 2021;74:2839\u201347.","journal-title":"Hepatol Baltim Md"},{"key":"598_CR80","doi-asserted-by":"publisher","first-page":"897","DOI":"10.3389\/fimmu.2017.00897","volume":"8","author":"BA Rader","year":"2017","unstructured":"Rader BA. Alkaline phosphatase, an unconventional immune protein. Front Immunol. 2017;8:897.","journal-title":"Front Immunol"},{"key":"598_CR81","doi-asserted-by":"publisher","first-page":"121","DOI":"10.2174\/157016111793744715","volume":"9","author":"M Yoshida","year":"2011","unstructured":"Yoshida M. Novel role of NPC1L1 in the regulation of hepatic metabolism: potential contribution of ezetimibe in NAFLD\/NASH treatment. Curr Vasc Pharmacol. 2011;9:121\u20133.","journal-title":"Curr Vasc Pharmacol"},{"key":"598_CR82","first-page":"234","volume":"7","author":"N Rafiq","year":"2009","unstructured":"Rafiq N, Bai C, Fang Y, Srishord M, McCullough A, Gramlich T, et al. Long-term follow-up of patients with nonalcoholic fatty liver. Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc. 2009;7:234\u20138.","journal-title":"Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc"},{"key":"598_CR83","unstructured":"Moriles K, Azer S. Alanine amino transferase. StatPearls Publishing; 2022."},{"key":"598_CR84","doi-asserted-by":"crossref","unstructured":"Aulbach AD, Amuzie CJ. Biomarkers in nonclinical drug development. Compr Guide Toxicol Nonclinical Drug Dev. Elsevier; 2017.","DOI":"10.1016\/B978-0-12-803620-4.00017-7"},{"key":"598_CR85","doi-asserted-by":"publisher","first-page":"11","DOI":"10.4291\/wjgp.v8.i2.11","volume":"8","author":"F Hadizadeh","year":"2017","unstructured":"Hadizadeh F, Faghihimani E, Adibi P. Nonalcoholic fatty liver disease: Diagnostic biomarkers. World J Gastrointest Pathophysiol. 2017;8:11\u201326.","journal-title":"World J Gastrointest Pathophysiol"},{"key":"598_CR86","doi-asserted-by":"publisher","first-page":"181","DOI":"10.2147\/DMSO.S189544","volume":"12","author":"AR Khang","year":"2019","unstructured":"Khang AR, Lee HW, Yi D, Kang YH, Son SM. The fatty liver index, a simple and useful predictor of metabolic syndrome: analysis of the Korea National Health and Nutrition Examination Survey 2010\u20132011. Diabetes Metab Syndr Obes Targets Ther. 2019;12:181\u201390.","journal-title":"Diabetes Metab Syndr Obes Targets Ther"},{"key":"598_CR87","doi-asserted-by":"publisher","first-page":"12830","DOI":"10.1038\/s41598-021-92292-y","volume":"11","author":"Y Higashiura","year":"2021","unstructured":"Higashiura Y, Furuhashi M, Tanaka M, Takahashi S, Koyama M, Ohnishi H, et al. High level of fatty liver index predicts new onset of diabetes mellitus during a 10-year period in healthy subjects. Sci Rep. 2021;11:12830.","journal-title":"Sci Rep"},{"key":"598_CR88","doi-asserted-by":"publisher","first-page":"3316","DOI":"10.3390\/diagnostics13213316","volume":"13","author":"T Biciusca","year":"2023","unstructured":"Biciusca T, Stan SI, Balteanu MA, Cioboata R, Ghenea AE, Danoiu S, et al. The role of the Fatty Liver Index (FLI) in the management of non-alcoholic fatty liver disease: a systematic review. Diagnostics. 2023;13:3316.","journal-title":"Diagnostics"},{"key":"598_CR89","doi-asserted-by":"publisher","first-page":"S25","DOI":"10.1016\/j.dsx.2015.09.005","volume":"10","author":"IA Hossain","year":"2016","unstructured":"Hossain IA, Rahman Shah MM, Rahman MK, Ali L. Gamma glutamyl transferase is an independent determinant for the association of insulin resistance with nonalcoholic fatty liver disease in Bangladeshi adults. Diabetes Metab Syndr Clin Res Rev. 2016;10:S25\u20139.","journal-title":"Diabetes Metab Syndr Clin Res Rev"},{"key":"598_CR90","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1097\/MEG.0b013e328354044a","volume":"24","author":"DZ Banderas","year":"2012","unstructured":"Banderas DZ, Escobedo J, Gonzalez E, Liceaga MG, Ram\u00edrez JC, Castro MG. \u03b3-Glutamyl transferase: a marker of nonalcoholic fatty liver disease in patients with the metabolic syndrome. Eur J Gastroenterol Hepatol. 2012;24:805\u201310.","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"598_CR91","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1503\/cmaj.1040752","volume":"172","author":"EG Giannini","year":"2005","unstructured":"Giannini EG, Testa R, Savarino V. Liver enzyme alteration: a guide for clinicians. CMAJ Can Med Assoc J J Assoc Medicale Can. 2005;172:367\u201379.","journal-title":"CMAJ Can Med Assoc J J Assoc Medicale Can"},{"key":"598_CR92","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1093\/bioinformatics\/bti042","volume":"21","author":"I Yanai","year":"2005","unstructured":"Yanai I, Benjamin H, Shmoish M, Chalifa-Caspi V, Shklar M, Ophir R, et al. Genome-wide midrange transcription profiles reveal expression level relationships in human tissue specification. Bioinforma Oxf Engl. 2005;21:650\u20139.","journal-title":"Bioinforma Oxf Engl"},{"key":"598_CR93","doi-asserted-by":"publisher","first-page":"93","DOI":"10.7326\/0003-4819-152-2-201001190-00008","volume":"152","author":"T Kelesidis","year":"2010","unstructured":"Kelesidis T. Narrative review: the role of leptin in human physiology: emerging clinical applications. Ann Intern Med. 2010;152:93.","journal-title":"Ann Intern Med"},{"key":"598_CR94","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1189\/jlb.68.4.437","volume":"68","author":"G Fantuzzi","year":"2000","unstructured":"Fantuzzi G, Faggioni R. Leptin in the regulation of immunity, inflammation, and hematopoiesis. J Leukoc Biol. 2000;68:437\u201346.","journal-title":"J Leukoc Biol"},{"key":"598_CR95","doi-asserted-by":"publisher","first-page":"9368","DOI":"10.3390\/ijms21249368","volume":"21","author":"M Mart\u00ednez-U\u00f1a","year":"2020","unstructured":"Mart\u00ednez-U\u00f1a M, L\u00f3pez-Manche\u00f1o Y, Di\u00e9guez C, Fern\u00e1ndez-Rojo MA, Novelle MG. Unraveling the role of leptin in liver function and its relationship with liver diseases. Int J Mol Sci. 2020;21:9368.","journal-title":"Int J Mol Sci"},{"key":"598_CR96","doi-asserted-by":"publisher","first-page":"392","DOI":"10.3350\/cmh.2018.0011","volume":"24","author":"L Rotundo","year":"2018","unstructured":"Rotundo L, Persaud A, Feurdean M, Ahlawat S, Kim H-S. The association of leptin with severity of non-alcoholic fatty liver disease: A population-based study. Clin Mol Hepatol. 2018;24:392\u2013401.","journal-title":"Clin Mol Hepatol"},{"key":"598_CR97","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.1002\/hep.23890","volume":"52","author":"L Pacifico","year":"2010","unstructured":"Pacifico L, Anania C, Martino F, Cantisani V, Pascone R, Marcantonio A, et al. Functional and morphological vascular changes in pediatric nonalcoholic fatty liver disease. Hepatology. 2010;52:1643\u201351.","journal-title":"Hepatology"},{"key":"598_CR98","doi-asserted-by":"publisher","first-page":"6495793","DOI":"10.1155\/2016\/6495793","volume":"2016","author":"Q Tan","year":"2016","unstructured":"Tan Q, Hu J, Yu X, Guan W, Lu H, Yu Y, et al. The role of IL-1 family members and kupffer cells in liver regeneration. BioMed Res Int. 2016;2016:6495793.","journal-title":"BioMed Res Int"},{"key":"598_CR99","doi-asserted-by":"publisher","first-page":"e107265","DOI":"10.1371\/journal.pone.0107265","volume":"9","author":"KA Negrin","year":"2014","unstructured":"Negrin KA, Roth Flach RJ, DiStefano MT, Matevossian A, Friedline RH, Jung D, et al. IL-1 signaling in obesity-induced hepatic lipogenesis and steatosis. PLoS ONE. 2014;9:e107265.","journal-title":"PLoS ONE"},{"key":"598_CR100","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1080\/13543784.2020.1681397","volume":"29","author":"H Tilg","year":"2020","unstructured":"Tilg H, Effenberger M, Adolph TE. A role for IL-1 inhibitors in the treatment of non-alcoholic fatty liver disease (NAFLD)? Expert Opin Investig Drugs. 2020;29:103\u20136.","journal-title":"Expert Opin Investig Drugs"},{"key":"598_CR101","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1016\/j.immuni.2013.11.010","volume":"39","author":"C Garlanda","year":"2013","unstructured":"Garlanda C, Dinarello CA, Mantovani A. The interleukin-1 family: back to the future. Immunity. 2013;39:1003\u201318.","journal-title":"Immunity"},{"key":"598_CR102","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.livres.2018.03.003","volume":"2","author":"L Niederreiter","year":"2018","unstructured":"Niederreiter L, Tilg H. Cytokines and fatty liver diseases. Liver Res. 2018;2:14\u201320.","journal-title":"Liver Res"},{"key":"598_CR103","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1093\/intimm\/dxx031","volume":"29","author":"KF Kernan","year":"2017","unstructured":"Kernan KF, Carcillo JA. Hyperferritinemia and inflammation. Int Immunol. 2017;29:401\u20139.","journal-title":"Int Immunol"},{"key":"598_CR104","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1055\/s-0039-1693114","volume":"39","author":"W Moris","year":"2019","unstructured":"Moris W, Verhaegh P, Jonkers D, Deursen CV, Koek G. Hyperferritinemia in nonalcoholic fatty liver disease: Iron accumulation or inflammation? Semin Liver Dis. 2019;39:476\u201382.","journal-title":"Semin Liver Dis"},{"key":"598_CR105","doi-asserted-by":"publisher","first-page":"7718","DOI":"10.3748\/wjg.v20.i24.7718","volume":"20","author":"K-C Hu","year":"2014","unstructured":"Hu K-C. Nonalcoholic fatty liver disease: Updates in noninvasive diagnosis and correlation with cardiovascular disease. World J Gastroenterol. 2014;20:7718.","journal-title":"World J Gastroenterol"},{"key":"598_CR106","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/1471-230X-9-16","volume":"9","author":"N Oruc","year":"2009","unstructured":"Oruc N, Ozutemiz O, Yuce G, Akarca US, Ersoz G, Gunsar F, et al. Serum procalcitonin and CRP levels in non-alcoholic fatty liver disease: a case control study. BMC Gastroenterol. 2009;9:16.","journal-title":"BMC Gastroenterol"},{"key":"598_CR107","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1086\/421997","volume":"39","author":"L Simon","year":"2004","unstructured":"Simon L, Gauvin F, Amre DK, Saint-Louis P, Lacroix J. Serum procalcitonin and C-Reactive protein levels as markers of bacterial infection: a systematic review and meta-analysis. Clin Infect Dis. 2004;39:206\u201317.","journal-title":"Clin Infect Dis"},{"key":"598_CR108","doi-asserted-by":"crossref","unstructured":"Rule JA, Hynan LS, Attar N, Sanders C, Korzun WJ, Lee WM, et al. Procalcitonin identifies cell injury, not bacterial infection. In: Bruns H, editor. Acute liver failure. PLOS ONE. 2015;10:e0138566.","DOI":"10.1371\/journal.pone.0138566"},{"key":"598_CR109","first-page":"40","volume":"60","author":"T Sugihara","year":"2017","unstructured":"Sugihara T, Koda M, Okamoto T, Miyoshi K, Matono T, Oyama K, et al. Serum procalcitonin in patients with acute liver failure. Yonago Acta Med. 2017;60:40\u20136.","journal-title":"Yonago Acta Med"},{"key":"598_CR110","doi-asserted-by":"publisher","first-page":"18070","DOI":"10.3748\/wjg.v20.i48.18070","volume":"20","author":"S Stojsavljevi\u0107","year":"2014","unstructured":"Stojsavljevi\u0107 S. Adipokines and proinflammatory cytokines, the key mediators in the pathogenesis of nonalcoholic fatty liver disease. World J Gastroenterol. 2014;20:18070.","journal-title":"World J Gastroenterol"},{"key":"598_CR111","doi-asserted-by":"publisher","unstructured":"Engin A. The Pathogenesis of Obesity-Associated Adipose Tissue Inflammation. In: Engin AB, Engin A, editors. Obes Lipotoxicity [Internet]. Cham: Springer International Publishing; 2017 [cited 2023 Jul 18]. p. 221\u201345. Available from: http:\/\/link.springer.com\/https:\/\/doi.org\/10.1007\/978-3-319-48382-5_9","DOI":"10.1007\/978-3-319-48382-5_9"},{"key":"598_CR112","doi-asserted-by":"publisher","unstructured":"Ezquerro S, Mocha F, Fr\u00fchbeck G, Guzm\u00e1n-Ruiz R, Valent\u00ed V, Mugueta C, et al. Ghrelin reduces TNF-\u03b1-induced human hepatocyte apoptosis, autophagy and pyroptosis: role in obesity-associated NAFLD. J Clin Endocrinol Metab. 2018;104:21\u201337. https:\/\/doi.org\/10.1210\/jc.2018-01171\/5075998.","DOI":"10.1210\/jc.2018-01171\/5075998"},{"key":"598_CR113","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1038\/83316","volume":"7","author":"RA Memon","year":"2001","unstructured":"Memon RA, Grunfeld C, Feingold KR. TNF-\u03b1 is not the cause of fatty liver disease in obese diabetic mice. Nat Med. 2001;7:2\u20132.","journal-title":"Nat Med"},{"key":"598_CR114","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1007\/s40139-015-0093-z","volume":"3","author":"YM Yang","year":"2015","unstructured":"Yang YM, Seki E. TNF\u03b1 in liver fibrosis. Curr Pathobiol Rep. 2015;3:253\u201361.","journal-title":"Curr Pathobiol Rep"},{"key":"598_CR115","doi-asserted-by":"publisher","first-page":"4156","DOI":"10.3390\/ijms22084156","volume":"22","author":"Y Sakurai","year":"2021","unstructured":"Sakurai Y, Kubota N, Yamauchi T, Kadowaki T. Role of insulin resistance in MAFLD. Int J Mol Sci. 2021;22:4156.","journal-title":"Int J Mol Sci"},{"key":"598_CR116","doi-asserted-by":"publisher","first-page":"e15347","DOI":"10.1016\/j.heliyon.2023.e15347","volume":"9","author":"MP Pathak","year":"2023","unstructured":"Pathak MP, Pathak K, Saikia R, Gogoi U, Patowary P, Chattopadhyay P, et al. Therapeutic potential of bioactive phytoconstituents found in fruits in the treatment of non-alcoholic fatty liver disease: A comprehensive review. Heliyon. 2023;9:e15347.","journal-title":"Heliyon"},{"key":"598_CR117","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1186\/1471-230X-13-140","volume":"13","author":"Z Xiang","year":"2013","unstructured":"Xiang Z, Chen Y, Ma K, Ye Y, Zheng L, Yang Y, et al. The role of Ursodeoxycholic acid in non-alcoholic steatohepatitis: a systematic review. BMC Gastroenterol. 2013;13:140.","journal-title":"BMC Gastroenterol"},{"key":"598_CR118","doi-asserted-by":"publisher","first-page":"959","DOI":"10.3748\/wjg.v27.i10.959","volume":"27","author":"M Nadinskaia","year":"2021","unstructured":"Nadinskaia M, Maevskaya M, Ivashkin V, Kodzoeva K, Pirogova I, Chesnokov E, et al. Ursodeoxycholic acid as a means of preventing atherosclerosis, steatosis and liver fibrosis in patients with nonalcoholic fatty liver disease. World J Gastroenterol. 2021;27:959\u201375.","journal-title":"World J Gastroenterol"},{"key":"598_CR119","doi-asserted-by":"publisher","first-page":"111092","DOI":"10.1016\/j.nut.2020.111092","volume":"83","author":"G Kalopitas","year":"2021","unstructured":"Kalopitas G, Antza C, Doundoulakis I, Siargkas A, Kouroumalis E, Germanidis G, et al. Impact of Silymarin in individuals with nonalcoholic fatty liver disease: A systematic review and meta-analysis. Nutrition. 2021;83:111092.","journal-title":"Nutrition"},{"key":"598_CR120","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1186\/s13063-023-07210-6","volume":"24","author":"CR de Avelar","year":"2023","unstructured":"de Avelar CR, Nunes BVC, da Silva SB, Dos Santos VM, de Oliveira LPM, Lyra AC, et al. Efficacy of silymarin in patients with non-alcoholic fatty liver disease - the Siliver trial: a study protocol for a randomized controlled clinical trial. Trials. 2023;24:177.","journal-title":"Trials"},{"key":"598_CR121","doi-asserted-by":"publisher","first-page":"101174","DOI":"10.1016\/j.aohep.2023.101174","volume":"29","author":"S Li","year":"2024","unstructured":"Li S, Duan F, Li S, Lu B. Administration of silymarin in NAFLD\/NASH: A systematic review and meta-analysis. Ann Hepatol. 2024;29:101174.","journal-title":"Ann Hepatol"},{"key":"598_CR122","unstructured":"Mulrow C, Lawrence V, Jacobs B. Milk Thistle: effects on liver disease and cirrhosis and clinical adverse effects: Summary [Internet]. AHRQ Evidence Report Summaries. Rockville (MD): Agency for Healthcare Research and Quality (US); 1998\u20132005; 2000 [cited 2024 Jan 17]. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK11896\/"},{"key":"598_CR123","doi-asserted-by":"publisher","first-page":"779912","DOI":"10.3389\/fnut.2021.779912","volume":"8","author":"X Luo","year":"2022","unstructured":"Luo X, Zhang W, He Z, Yang H, Gao J, Wu P, et al. Dietary vitamin c intake is associated with improved liver function and glucose metabolism in chinese adults. Front Nutr. 2022;8:779912.","journal-title":"Front Nutr"},{"key":"598_CR124","doi-asserted-by":"publisher","first-page":"745609","DOI":"10.3389\/fnut.2021.745609","volume":"8","author":"Z He","year":"2021","unstructured":"He Z, Li X, Yang H, Wu P, Wang S, Cao D, et al. Effects of oral vitamin c supplementation on liver health and associated parameters in patients with non-alcoholic fatty liver disease: a randomized clinical trial. Front Nutr. 2021;8:745609.","journal-title":"Front Nutr"},{"key":"598_CR125","doi-asserted-by":"crossref","unstructured":"Oliveira CPMS, Gayotto LC da C, Tatai C, Della Nina BI, Lima ES, Abdalla DSP, et al. Vitamin C and vitamin E in prevention of Nonalcoholic Fatty Liver Disease (NAFLD) in choline deficient diet fed rats. Nutr J. 2003;2:9.","DOI":"10.1186\/1475-2891-2-9"},{"key":"598_CR126","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3390\/antiox7010012","volume":"7","author":"H El Hadi","year":"2018","unstructured":"El Hadi H, Vettor R, Rossato M. Vitamin E as a treatment for nonalcoholic fatty liver disease: reality or myth? Antioxid Basel Switz. 2018;7:12.","journal-title":"Antioxid Basel Switz"},{"key":"598_CR127","doi-asserted-by":"publisher","first-page":"2592","DOI":"10.1038\/s41598-024-52482-w","volume":"14","author":"X Qi","year":"2024","unstructured":"Qi X, Guo J, Li Y, Fang C, Lin J, Chen X, et al. Vitamin E intake is inversely associated with NAFLD measured by liver ultrasound transient elastography. Sci Rep. 2024;14:2592.","journal-title":"Sci Rep"},{"key":"598_CR128","first-page":"e30091","volume":"14","author":"IM Dighriri","year":"2022","unstructured":"Dighriri IM, Alsubaie AM, Hakami FM, Hamithi DM, Alshekh MM, Khobrani FA, et al. Effects of omega-3 polyunsaturated fatty acids on brain functions: a systematic review. Cureus. 2022;14:e30091.","journal-title":"Cureus"},{"key":"598_CR129","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1111\/j.1365-2036.2006.02885.x","volume":"23","author":"M Capanni","year":"2006","unstructured":"Capanni M, Calella F, Biagini MR, Genise S, Raimondi L, Bedogni G, et al. Prolonged n-3 polyunsaturated fatty acid supplementation ameliorates hepatic steatosis in patients with non-alcoholic fatty liver disease: a pilot study. Aliment Pharmacol Ther. 2006;23:1143\u201351.","journal-title":"Aliment Pharmacol Ther"},{"key":"598_CR130","first-page":"495","volume":"11","author":"A Eidi","year":"2012","unstructured":"Eidi A, Mortazavi P, Bazargan M, Zaringhalam J. Hepatoprotective activity of cinnamon ethanolic extract against CCI4-induced liver injury in rats. EXCLI J. 2012;11:495\u2013507.","journal-title":"EXCLI J"},{"key":"598_CR131","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.3109\/13880209.2015.1078381","volume":"54","author":"AE El-Hadary","year":"2016","unstructured":"El-Hadary AE, Ramadan Hassanien MF. Hepatoprotective effect of cold-pressed Syzygium aromaticum oil against carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. Pharm Biol. 2016;54:1364\u201372.","journal-title":"Pharm Biol"},{"key":"598_CR132","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/1472-6882-13-56","volume":"13","author":"SM Salama","year":"2013","unstructured":"Salama SM, Abdulla MA, AlRashdi AS, Ismail S, Alkiyumi SS, Golbabapour S. Hepatoprotective effect of ethanolic extract of Curcuma longa on thioacetamide induced liver cirrhosis in rats. BMC Complement Altern Med. 2013;13:56.","journal-title":"BMC Complement Altern Med"},{"key":"598_CR133","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.jep.2018.08.019","volume":"227","author":"M Das","year":"2018","unstructured":"Das M, Basu S, Banerjee B, Sen A, Jana K, Datta G. Hepatoprotective effects of green Capsicum annum against ethanol induced oxidative stress, inflammation and apoptosis in rats. J Ethnopharmacol. 2018;227:69\u201381.","journal-title":"J Ethnopharmacol"},{"key":"598_CR134","doi-asserted-by":"crossref","unstructured":"Zhang C, Zhao J, Famous E, Pan S, Peng X, Tian J. Antioxidant, hepatoprotective and antifungal activities of black pepper (Piper nigrum L.) essential oil. Food Chem. 2021;346:128845.","DOI":"10.1016\/j.foodchem.2020.128845"},{"key":"598_CR135","doi-asserted-by":"publisher","first-page":"2765","DOI":"10.1007\/s11033-021-07088-0","volume":"49","author":"NN Farshori","year":"2022","unstructured":"Farshori NN. Hepatoprotective effect of Trigonella foenum graecum against ethanol-induced cell death in human liver cells (HepG2 and Huh7). Mol Biol Rep. 2022;49:2765\u201376.","journal-title":"Mol Biol Rep"},{"key":"598_CR136","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1007\/BF02536055","volume":"28","author":"R Gebhardt","year":"1993","unstructured":"Gebhardt R. Multiple inhibitory effects of garlic extracts on cholesterol biosynthesis in hepatocytes. Lipids. 1993;28:613\u20139.","journal-title":"Lipids"},{"key":"598_CR137","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1016\/j.biopha.2017.10.125","volume":"96","author":"J Lu","year":"2017","unstructured":"Lu J, Cheng B, Fang B, Meng Z, Zheng Y, Tian X, et al. Protective effects of allicin on 1,3-DCP-induced lipid metabolism disorder in HepG2 cells. Biomed Pharmacother Biomed Pharmacother. 2017;96:1411\u20137.","journal-title":"Biomed Pharmacother Biomed Pharmacother"},{"key":"598_CR138","doi-asserted-by":"publisher","first-page":"3956504","DOI":"10.1155\/2021\/3956504","volume":"2021","author":"B Cheng","year":"2021","unstructured":"Cheng B, Li T, Li F. Use of network pharmacology to investigate the mechanism by which allicin ameliorates lipid metabolism disorder in HepG2 cells. Evid-Based Complement Altern Med ECAM. 2021;2021:3956504.","journal-title":"Evid-Based Complement Altern Med ECAM"},{"key":"598_CR139","doi-asserted-by":"publisher","first-page":"931","DOI":"10.3390\/molecules21080931","volume":"21","author":"A Chapa-Oliver","year":"2016","unstructured":"Chapa-Oliver A, Mej\u00eda-Teniente L. Capsaicin: from plants to a cancer-suppressing agent. Molecules. 2016;21:931.","journal-title":"Molecules"},{"key":"598_CR140","doi-asserted-by":"crossref","unstructured":"Murrin LC. Capsaicin. XPharm Compr Pharmacol Ref. Elsevier; 2007.","DOI":"10.1016\/B978-008055232-3.61375-3"},{"key":"598_CR141","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1016\/j.biopha.2017.11.124","volume":"96","author":"P Patowary","year":"2017","unstructured":"Patowary P, Pathak MP, Zaman K, Raju PS, Chattopadhyay P. Research progress of capsaicin responses to various pharmacological challenges. Biomed Pharmacother Biomed Pharmacother. 2017;96:1501\u201312.","journal-title":"Biomed Pharmacother Biomed Pharmacother"},{"key":"598_CR142","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1080\/19768354.2020.1810771","volume":"24","author":"MK Shin","year":"2020","unstructured":"Shin MK, Yang S-M, Han I-S. Capsaicin suppresses liver fat accumulation in high-fat diet-induced NAFLD mice. Anim Cells Syst. 2020;24:214\u20139.","journal-title":"Anim Cells Syst"},{"key":"598_CR143","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1007\/s00424-013-1274-4","volume":"465","author":"Q Li","year":"2013","unstructured":"Li Q, Li L, Wang F, Chen J, Zhao Y, Wang P, et al. Dietary capsaicin prevents nonalcoholic fatty liver disease through transient receptor potential vanilloid 1-mediated peroxisome proliferator-activated receptor \u03b4 activation. Pfl\u00fcg Arch - Eur J Physiol. 2013;465:1303\u201316.","journal-title":"Pfl\u00fcg Arch - Eur J Physiol"},{"key":"598_CR144","doi-asserted-by":"publisher","first-page":"642942","DOI":"10.1155\/2014\/642942","volume":"2014","author":"PV Rao","year":"2014","unstructured":"Rao PV, Gan SH. Cinnamon: a multifaceted medicinal plant. Evid-Based Complement Altern Med ECAM. 2014;2014:642942.","journal-title":"Evid-Based Complement Altern Med ECAM"},{"key":"598_CR145","doi-asserted-by":"publisher","first-page":"4369","DOI":"10.1007\/s13197-014-1488-2","volume":"52","author":"K Mnafgui","year":"2015","unstructured":"Mnafgui K, Derbali A, Sayadi S, Gharsallah N, Elfeki A, Allouche N. Anti-obesity and cardioprotective effects of cinnamic acid in high fat diet- induced obese rats. J Food Sci Technol. 2015;52:4369\u201377.","journal-title":"J Food Sci Technol"},{"key":"598_CR146","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.3390\/pharmaceutics14081675","volume":"14","author":"AG Lee","year":"2022","unstructured":"Lee AG, Kang S, Im S, Pak YK. Cinnamic acid attenuates peripheral and hypothalamic inflammation in high-fat diet-induced obese mice. Pharmaceutics. 2022;14:1675.","journal-title":"Pharmaceutics"},{"key":"598_CR147","doi-asserted-by":"publisher","first-page":"111148","DOI":"10.1016\/j.fct.2020.111148","volume":"137","author":"Z Wang","year":"2020","unstructured":"Wang Z, Ge S, Li S, Lin H, Lin S. Anti-obesity effect of trans-cinnamic acid on HepG2 cells and HFD-fed mice. Food Chem Toxicol. 2020;137:111148.","journal-title":"Food Chem Toxicol"},{"key":"598_CR148","doi-asserted-by":"crossref","unstructured":"Omosa LK, Midiwo JO, Kuete V. Curcuma longa. Med Spices Veg Afr. Elsevier; 2017.","DOI":"10.1016\/B978-0-12-809286-6.00019-4"},{"key":"598_CR149","doi-asserted-by":"publisher","first-page":"92","DOI":"10.3390\/foods6100092","volume":"6","author":"S Hewlings","year":"2017","unstructured":"Hewlings S, Kalman D. Curcumin: a review of its effects on human health. Foods. 2017;6:92.","journal-title":"Foods"},{"key":"598_CR150","doi-asserted-by":"publisher","first-page":"e13789","DOI":"10.14814\/phy2.13789","volume":"6","author":"RP Cunningham","year":"2018","unstructured":"Cunningham RP, Moore MP, Moore AN, Healy JC, Roberts MD, Rector RS, et al. Curcumin supplementation mitigates NASH development and progression in female Wistar rats. Physiol Rep. 2018;6:e13789.","journal-title":"Physiol Rep"},{"key":"598_CR151","doi-asserted-by":"crossref","unstructured":"Mahmoud AA, Abdelrahman A, Abd El Aziz HO. Protective effect of curcumin on the liver of high fat diet-fed rats. Gene Rep. 2018;11:18\u201322.","DOI":"10.1016\/j.genrep.2018.01.004"},{"key":"598_CR152","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1111\/bcpt.12076","volume":"113","author":"MY Um","year":"2013","unstructured":"Um MY, Hwang KH, Ahn J, Ha TY. Curcumin attenuates diet-induced hepatic steatosis by activating AMP -Activated Protein Kinase. Basic Clin Pharmacol Toxicol. 2013;113:152\u20137.","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"598_CR153","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1016\/j.jhep.2004.08.010","volume":"41","author":"IA Leclercq","year":"2004","unstructured":"Leclercq IA, Farrell GC, Sempoux C, Pe\u00f1a AD, Horsmans Y. Curcumin inhibits NF-\u03baB activation and reduces the severity of experimental steatohepatitis in mice. J Hepatol. 2004;41:926\u201334.","journal-title":"J Hepatol"},{"key":"598_CR154","unstructured":"Department of Health and Aged Care. Medicines containing turmeric or curcumin - risk of liver injury [Internet]. 2023 [cited 2024 Feb 10]. Available from: https:\/\/www.tga.gov.au\/news\/safety-alerts\/medicines-containing-turmeric-or-curcumin-risk-liver-injury"},{"key":"598_CR155","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1089\/jmf.2013.0033","volume":"17","author":"SY Al-Okbi","year":"2014","unstructured":"Al-Okbi SY, Mohamed DA, Hamed TE, Edris AE. Protective effect of clove oil and eugenol microemulsions on fatty liver and dyslipidemia as components of metabolic syndrome. J Med Food. 2014;17:764\u201371.","journal-title":"J Med Food"},{"key":"598_CR156","doi-asserted-by":"publisher","first-page":"42","DOI":"10.4103\/abr.abr_237_20","volume":"10","author":"AA Niazi","year":"2021","unstructured":"Niazi AA, Kourkinejad Gharaei F, Saebinasab Z, Maleki M, Maghool F, Fereidooni F, et al. Eugenol administration improves liver damage induced by a fructose-rich diet. Adv Biomed Res. 2021;10:42.","journal-title":"Adv Biomed Res"},{"key":"598_CR157","doi-asserted-by":"publisher","first-page":"2497354","DOI":"10.1155\/2021\/2497354","volume":"2021","author":"MF Nisar","year":"2021","unstructured":"Nisar MF, Khadim M, Rafiq M, Chen J, Yang Y, Wan CC. Pharmacological properties and health benefits of eugenol: a comprehensive review. Oxid Med Cell Longev. 2021;2021:2497354.","journal-title":"Oxid Med Cell Longev"},{"key":"598_CR158","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1248\/bpb.b14-00281","volume":"37","author":"HK Jo","year":"2014","unstructured":"Jo HK, Kim GW, Jeong KJ, Kim DY, Chung SH. Eugenol ameliorates hepatic steatosis and fibrosis by down-regulating SREBP1 gene expression via AMPK-mTOR-p70S6K signaling pathway. Biol Pharm Bull. 2014;37:1341\u201351.","journal-title":"Biol Pharm Bull"},{"key":"598_CR159","doi-asserted-by":"publisher","first-page":"6285","DOI":"10.3390\/ijms24076285","volume":"24","author":"Y Liu","year":"2023","unstructured":"Liu Y, Li D, Wang S, Peng Z, Tan Q, He Q, et al. 6-Gingerol ameliorates hepatic steatosis, inflammation and oxidative stress in high-fat diet-fed mice through activating LKB1\/AMPK signaling. Int J Mol Sci. 2023;24:6285.","journal-title":"Int J Mol Sci"},{"key":"598_CR160","doi-asserted-by":"publisher","first-page":"e18020","DOI":"10.1590\/s2175-979020200003181020","volume":"57","author":"A Sarrafan","year":"2021","unstructured":"Sarrafan A, Ghobeh M, Yaghmaei P. The effect of 6-gingerol on biochemical and histological parameters in cholesterol-induced nonalcoholic fatty liver disease in NMRI mice. Braz J Pharm Sci. 2021;57:e18020.","journal-title":"Braz J Pharm Sci"},{"key":"598_CR161","doi-asserted-by":"publisher","first-page":"115467","DOI":"10.1016\/j.biopha.2023.115467","volume":"167","author":"CC Hoch","year":"2023","unstructured":"Hoch CC, Petry J, Griesbaum L, Weiser T, Werner K, Ploch M, et al. 1,8-cineole (eucalyptol): A versatile phytochemical with therapeutic applications across multiple diseases. Biomed Pharmacother. 2023;167:115467.","journal-title":"Biomed Pharmacother"},{"key":"598_CR162","doi-asserted-by":"publisher","first-page":"12051","DOI":"10.3390\/ijms160612051","volume":"16","author":"S Murata","year":"2015","unstructured":"Murata S, Ogawa K, Matsuzaka T, Chiba M, Nakayama K, Iwasaki K, et al. 1,8-Cineole ameliorates steatosis of pten liver specific KO mice via Akt inactivation. Int J Mol Sci. 2015;16:12051\u201363.","journal-title":"Int J Mol Sci"},{"key":"598_CR163","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1016\/j.colsurfb.2018.08.001","volume":"171","author":"I Pereira","year":"2018","unstructured":"Pereira I, Severino P, Santos AC, Silva AM, Souto EB. Linalool bioactive properties and potential applicability in drug delivery systems. Colloids Surf B Biointerfaces. 2018;171:566\u201378.","journal-title":"Colloids Surf B Biointerfaces"},{"key":"598_CR164","doi-asserted-by":"publisher","first-page":"10370","DOI":"10.1039\/D1FO02120F","volume":"12","author":"Q An","year":"2021","unstructured":"An Q, Ren J-N, Li X, Fan G, Qu S-S, Song Y, et al. Recent updates on bioactive properties of linalool. Food Funct. 2021;12:10370\u201389.","journal-title":"Food Funct"},{"key":"598_CR165","doi-asserted-by":"crossref","unstructured":"Tamilmani P, Sathibabu Uddandrao VV, Chandrasekaran P, Saravanan G, Brahma Naidu P, Sengottuvelu S, et al. Linalool attenuates lipid accumulation and oxidative stress in metabolic dysfunction-associated steatotic liver disease via Sirt1\/Akt\/PPRA-\u03b1\/AMPK and Nrf-2\/HO-1 signaling pathways. Clin Res Hepatol Gastroenterol. 2023;47:102231.","DOI":"10.1016\/j.clinre.2023.102231"},{"key":"598_CR166","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1007\/s43450-023-00395-6","volume":"33","author":"T Periyasamy","year":"2023","unstructured":"Periyasamy T, Sathibabu Uddandrao VV, Ponnusamy C, Ganapathy S, Pudhupalayam SP, Singaravel S, et al. Linalool mitigated high-fat diet-induced non-alcoholic fatty liver disease by regulating the intestinal-hepatic axis via TGF-\u03b2\/NF-kB\/TLR4\/ZO-1 pathway. Rev Bras Farmacogn. 2023;33:617\u201328.","journal-title":"Rev Bras Farmacogn"},{"key":"598_CR167","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1080\/10408398.2011.571799","volume":"53","author":"MS Butt","year":"2013","unstructured":"Butt MS, Pasha I, Sultan MT, Randhawa MA, Saeed F, Ahmed W. Black pepper and health claims: a comprehensive treatise. Crit Rev Food Sci Nutr. 2013;53:875\u201386.","journal-title":"Crit Rev Food Sci Nutr"},{"key":"598_CR168","doi-asserted-by":"crossref","unstructured":"Ashokkumar K, Murugan M, Dhanya MK, Pandian A, Warkentin TD. Phytochemistry and therapeutic potential of black pepper [Piper nigrum (L.)] essential oil and piperine: a review. Clin Phytosci. 2021;7:52.","DOI":"10.1186\/s40816-021-00292-2"},{"key":"598_CR169","doi-asserted-by":"crossref","unstructured":"Tripathi AK, Ray AK, Mishra SK. Molecular and pharmacological aspects of piperine as a potential molecule for disease prevention and management: evidence from clinical trials. Beni-Suef Univ J Basic Appl Sci. 2022;11:16.","DOI":"10.1186\/s43088-022-00196-1"},{"key":"598_CR170","doi-asserted-by":"publisher","first-page":"104011","DOI":"10.1016\/j.jff.2020.104011","volume":"71","author":"Y Du","year":"2020","unstructured":"Du Y, Chen Y, Fu X, Gu J, Sun Y, Zhang Z, et al. Effects of piperine on lipid metabolism in high-fat diet induced obese mice. J Funct Foods. 2020;71:104011.","journal-title":"J Funct Foods"},{"key":"598_CR171","doi-asserted-by":"crossref","unstructured":"Visuvanathan T, Than LTL, Stanslas J, Chew SY, Vellasamy S. Revisiting Trigonella foenum-graecum L.: pharmacology and therapeutic potentialities. Plants Basel Switz. 2022;11:1450.","DOI":"10.3390\/plants11111450"},{"key":"598_CR172","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.sajb.2022.04.014","volume":"151","author":"P Ruwali","year":"2022","unstructured":"Ruwali P, Pandey N, Jindal K, Singh RV. Fenugreek (Trigonella foenum-graecum): nutraceutical values, phytochemical, ethnomedicinal and pharmacological overview. S Afr J Bot. 2022;151:423\u201331.","journal-title":"S Afr J Bot"},{"key":"598_CR173","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/j.apjtm.2015.07.012","volume":"8","author":"D-F Zhang","year":"2015","unstructured":"Zhang D-F, Zhang F, Zhang J, Zhang R-M, Li R. Protection effect of trigonelline on liver of rats with non-alcoholic fatty liver diseases. Asian Pac J Trop Med. 2015;8:651\u20134.","journal-title":"Asian Pac J Trop Med"},{"key":"598_CR174","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.fct.2018.09.011","volume":"121","author":"L Sharma","year":"2018","unstructured":"Sharma L, Lone NA, Knott RM, Hassan A, Abdullah T. Trigonelline prevents high cholesterol and high fat diet induced hepatic lipid accumulation and lipo-toxicity in C57BL\/6J mice, via restoration of hepatic autophagy. Food Chem Toxicol Int J Publ Br Ind Biol Res Assoc. 2018;121:283\u201396.","journal-title":"Food Chem Toxicol Int J Publ Br Ind Biol Res Assoc"}],"container-title":["Current Nutrition Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13668-024-00598-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13668-024-00598-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13668-024-00598-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T12:35:14Z","timestamp":1737549314000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13668-024-00598-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,22]]},"references-count":174,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["598"],"URL":"https:\/\/doi.org\/10.1007\/s13668-024-00598-w","relation":{},"ISSN":["2161-3311"],"issn-type":[{"value":"2161-3311","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,22]]},"assertion":[{"value":"11 November 2024","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of Interest"}}],"article-number":"20"}}