{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:50:36Z","timestamp":1790351436423,"version":"4.1.0"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T00:00:00Z","timestamp":1740096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T00:00:00Z","timestamp":1740096000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Curr Nutr Rep"],"DOI":"10.1007\/s13668-025-00626-3","type":"journal-article","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T13:18:49Z","timestamp":1740143929000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Effect of Polyphenol Supplementation on Adiposity: A Systematic Review of Randomized Clinical Trials"],"prefix":"10.1007","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1368-6020","authenticated-orcid":false,"given":"Isabella","family":"Mendes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2658-6519","authenticated-orcid":false,"given":"Madalena Geralda Cupertino","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5145-7860","authenticated-orcid":false,"given":"Layla Fagundes","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1463-3055","authenticated-orcid":false,"given":"Carla de Oliveira Barbosa","family":"Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4441-6572","authenticated-orcid":false,"given":"Helen Hermana Miranda","family":"Hermsdorff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4993-9436","authenticated-orcid":false,"given":"Josefina","family":"Bressan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,21]]},"reference":[{"key":"626_CR1","doi-asserted-by":"publisher","unstructured":"Amirabdollahian F, Haghighatdoost F. Anthropometric indicators of adiposity related to body weight and body shape as cardiometabolic risk predictors in British young adults: superiority of waist-to-height ratio. J Obes. 2018;8370304. https:\/\/doi.org\/10.1155\/2018\/8370304","DOI":"10.1155\/2018\/8370304"},{"issue":"23","key":"626_CR2","doi-asserted-by":"publisher","first-page":"9338","DOI":"10.3390\/ijms23169338","volume":"19","author":"H Li","year":"2022","unstructured":"Li H, Konja D, Wang L, Wang Y. Sex differences in adiposity and cardiovascular diseases. Int J Mol Sci. 2022;19(23):9338. https:\/\/doi.org\/10.3390\/ijms23169338.","journal-title":"Int J Mol Sci"},{"issue":"1","key":"626_CR3","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1515\/hmbci-2015-0073","volume":"26","author":"A Booth","year":"2016","unstructured":"Booth A, Magnuson A, Fouts J, Foster MT. Adipose tissue: an endocrine organ playing a role in metabolic regulation. Horm Mol Biol Clin Investig. 2016;26(1):25\u201342. https:\/\/doi.org\/10.1515\/hmbci-2015-0073.","journal-title":"Horm Mol Biol Clin Investig"},{"key":"626_CR4","doi-asserted-by":"publisher","first-page":"22","DOI":"10.3389\/fcvm.2020.00022","volume":"7","author":"A Chait","year":"2020","unstructured":"Chait A, den Hartigh LJ. Adipose tissue distribution, inflammation and its metabolic consequences, including diabetes and cardiovascular disease. Front Cardiovasc Med. 2020;7:22. https:\/\/doi.org\/10.3389\/fcvm.2020.00022.","journal-title":"Front Cardiovasc Med"},{"key":"626_CR5","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s00394-018-1663-8","volume":"58","author":"M Khalilpourfarshbafi","year":"2019","unstructured":"Khalilpourfarshbafi M, Gholami K, Murugan DD, Abdul Sattar MZ, Abdullah NA. Differential effects of dietary flavonoids on adipogenesis. Eur J N. 2019;58:5\u201325. https:\/\/doi.org\/10.1007\/s00394-018-1663-8.","journal-title":"Eur J N"},{"key":"626_CR6","doi-asserted-by":"publisher","first-page":"67","DOI":"10.2147\/DMSO.S281186","volume":"14","author":"J Jakab","year":"2021","unstructured":"Jakab J, Mi\u0161ki\u0107 B, Mik\u0161i\u0107 \u0160, Jurani\u0107 B, \u0106osi\u0107 V, Schwarz D. Adipogenesis as a potential anti-obesity target: A review of pharmacological treatment and natural products. Diabetes Metab Syndr Obes. 2021;14:67\u201383. https:\/\/doi.org\/10.2147\/DMSO.S281186.","journal-title":"Diabetes Metab Syndr Obes"},{"issue":"16","key":"626_CR7","doi-asserted-by":"publisher","first-page":"5642","DOI":"10.3390\/ijms21165642","volume":"21","author":"M Boccellino","year":"2020","unstructured":"Boccellino M, D\u2019Angelo S. Anti-obesity effects of polyphenol intake: Current status and future possibilities. Int J Mol Sci. 2020;21(16):5642. https:\/\/doi.org\/10.3390\/ijms21165642.","journal-title":"Int J Mol Sci"},{"key":"626_CR8","doi-asserted-by":"publisher","first-page":"127535","DOI":"10.1016\/j.foodchem.2020.127535","volume":"338","author":"FF Ara\u00fajo","year":"2021","unstructured":"Ara\u00fajo FF, Farias DP, Neri-Numa I, Pastore GM. Polyphenols and their applications: An approach in food chemistry and innovation potential. Food Chem. 2021;338:127535. https:\/\/doi.org\/10.1016\/j.foodchem.2020.127535.","journal-title":"Food Chem"},{"issue":"10","key":"626_CR9","doi-asserted-by":"publisher","first-page":"1177897","DOI":"10.3389\/fnut.2023.1177897","volume":"12","author":"A Mahboob","year":"2023","unstructured":"Mahboob A, Samuel SM, Mohamed A, Wani MY, Ghorbel S, Miled N, B\u00fcsselberg D, Chaari A. Role of flavonoids in controlling obesity: molecular targets and mechanisms. Front Nutr. 2023;12(10):1177897. https:\/\/doi.org\/10.3389\/fnut.2023.1177897.","journal-title":"Front Nutr"},{"key":"626_CR10","doi-asserted-by":"publisher","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, Chou R, Glanville J, Grimshaw JM, Hr\u00f3bjartsson A, Lalu MM, Li T, Loder EW, Mayo-Wilson E, McDonald S, McGuinness LA, Stewart LA, Thomas J, Tricco AC, Welch VA, Whiting P, Moher D. The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. BMJ. 2021;372(71). https:\/\/doi.org\/10.1136\/bmj.n71","DOI":"10.1136\/bmj.n71"},{"key":"626_CR11","doi-asserted-by":"publisher","unstructured":"Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid AK. Rayyan-a web and mobile app for systematic reviews. Syst Rev. 2016;5(1). https:\/\/doi.org\/10.1186\/s13643-016-0384-4.","DOI":"10.1186\/s13643-016-0384-4"},{"key":"626_CR12","doi-asserted-by":"publisher","first-page":"l4898","DOI":"10.1136\/bmj.l4898","volume":"366","author":"JAC Sterne","year":"2019","unstructured":"Sterne JAC, Savovi\u0107 J, Page MJ, Elbers RG, Blencowe NS, Boutron I, Cates CJ, Cheng HY, Corbett MS, Eldridge SM, Emberson JR, Hern\u00e1n MA, Hopewell S, Hr\u00f3bjartsson A, Junqueira DR, J\u00fcni P, Kirkham JJ, Lasserson T, Li T, McAleenan A, Reeves BC, Shepperd S, Shrier I, Stewart LA, Tilling K, White IR, Whiting PF, Higgins JPT. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019;366:l4898. https:\/\/doi.org\/10.1136\/bmj.l4898.","journal-title":"BMJ"},{"issue":"1","key":"626_CR13","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1002\/jrsm.1411","volume":"12","author":"LA McGuinness","year":"2021","unstructured":"McGuinness LA, Higgins JPT. Risk-of-bias VISualization (robvis): An R package and Shiny web app for visualizing risk-of-bias assessments. Res Synth Methods. 2021;12(1):55\u201361. https:\/\/doi.org\/10.1002\/jrsm.1411.","journal-title":"Res Synth Methods"},{"issue":"7","key":"626_CR14","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1007\/s00394-011-0264-6","volume":"51","author":"SW Barth","year":"2012","unstructured":"Barth SW, Koch TC, Watzl B, Dietrich H, Will F, Bub A. Moderate effects of apple juice consumption on obesity-related markers in obese men: impact of diet-gene interaction on body fat content. Eur J Nutr. 2012;51(7):841\u201350. https:\/\/doi.org\/10.1007\/s00394-011-0264-6.","journal-title":"Eur J Nutr"},{"issue":"5","key":"626_CR15","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1017\/S0007114511005095","volume":"107","author":"HY Yang","year":"2012","unstructured":"Yang HY, Yang SC, Chao JC, Chen JR. Beneficial effects of catechin-rich green tea and inulin on the body composition of overweight adults. Br J Nutr. 2012;107(5):749\u201354. https:\/\/doi.org\/10.1017\/S0007114511005095.","journal-title":"Br J Nutr"},{"issue":"10","key":"626_CR16","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1186\/s12916-022-02525-8","volume":"20","author":"H Zelicha","year":"2022","unstructured":"Zelicha H, Kloting N, Kaplan A, Yaskolka Meir A, Rinott E, Tsaban G, Chassidim Y, Bluher M, Ceglarek U, Isermann B, Stumvoll M, Quayson RN, von Bergen M, Engelmann B, Rolle-Kampczyk UE, Haange SB, Tuohy KM, Diotallevi C, Shelef I, Hu FB, Stampfer MJ, Shai I. The effect of high-polyphenol Mediterranean diet on visceral adiposity: the DIRECT PLUS randomized controlled trial. BMC Med. 2022;20(10):327. https:\/\/doi.org\/10.1186\/s12916-022-02525-8.","journal-title":"BMC Med"},{"issue":"1","key":"626_CR17","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/sj.ijo.0803351","volume":"31","author":"A Belza","year":"2005","unstructured":"Belza A, Frandsen E, Kondrup J. Body fat loss achieved by stimulation of thermogenesis by a combination of bioactive food ingredients: a placebo-controlled, double-blind 8-week intervention in obese subjects. Int J Obes (Lond). 2005;31(1):121\u201330. https:\/\/doi.org\/10.1038\/sj.ijo.0803351.","journal-title":"Int J Obes (Lond)"},{"issue":"6","key":"626_CR18","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1038\/oby.2007.176","volume":"15","author":"T Nagao","year":"2007","unstructured":"Nagao T, Hase T, Tokimitsu I. A green tea extract high in catechins reduces body fat and cardiovascular risks in humans. Obesity (Silver Spring, Md). 2007;15(6):1473\u201383. https:\/\/doi.org\/10.1038\/oby.2007.176.","journal-title":"Obesity (Silver Spring, Md.)."},{"key":"626_CR19","doi-asserted-by":"publisher","unstructured":"Bell ZW, Canale RE, Blommer RJ. A dual investigation of the effect of dietary supplementation with licorice flavonoid oil on anthropometric and biochemical markers of health and adiposity. Lipids Health Dis. 2011;10(29). https:\/\/doi.org\/10.1186\/1476-511X-10-29.","DOI":"10.1186\/1476-511X-10-29"},{"issue":"3","key":"626_CR20","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1038\/ijo.2013.155","volume":"38","author":"E Konings","year":"2014","unstructured":"Konings E, Timmers S, Boekschoten MV, Goossens GH, Jocken JW, Afman LA, M\u00fcller M, Schrauwen P, Mariman EC, Blaak EE. The effects of 30 days resveratrol supplementation on adipose tissue morphology and gene expression patterns in obese men. Int J Obes (Lond). 2014;38(3):470\u20133. https:\/\/doi.org\/10.1038\/ijo.2013.155.","journal-title":"Int J Obes (Lond)"},{"issue":"3","key":"626_CR21","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1080\/21623945.2018.1469942","volume":"7","author":"J Most","year":"2018","unstructured":"Most J, Warnke I, Boekschoten MV, Jocken JWE, de Groot P, Friedel A, Bendik I, Goossens GH, Blaak EE. The effects of polyphenol supplementation on adipose tissue morphology and gene expression in overweight and obese humans. Adipocyte. 2018;7(3):190\u20136. https:\/\/doi.org\/10.1080\/21623945.2018.1469942.","journal-title":"Adipocyte"},{"issue":"1","key":"626_CR22","doi-asserted-by":"publisher","first-page":"2999","DOI":"10.1038\/s41598-019-39159-5","volume":"9","author":"M Herranz-L\u00f3pez","year":"2019","unstructured":"Herranz-L\u00f3pez M, Olivares-Vicente M, Boix-Castej\u00f3n M, Caturla N, Roche E, Micol V. Differential effects of a combination of Hibiscus sabdariffa and Lippia citriodora polyphenols in overweight\/obese subjects: A randomized controlled trial. Sci Rep. 2019;9(1):2999. https:\/\/doi.org\/10.1038\/s41598-019-39159-5.","journal-title":"Sci Rep"},{"key":"626_CR23","doi-asserted-by":"publisher","first-page":"108430","DOI":"10.1016\/j.jnutbio.2020.108430","volume":"83","author":"G Jamar","year":"2020","unstructured":"Jamar G, Santamarina AB, Flygare AC, Gagliardi A, de Rosso VV, Dourado VZ, Pisani LP. Effects of the ju\u00e7ara fruit supplementation on metabolic parameters in individuals with obesity: a double-blind randomized controlled trial. J Nutr Biochem. 2020;83:108430. https:\/\/doi.org\/10.1016\/j.jnutbio.2020.108430.","journal-title":"J Nutr Biochem"},{"issue":"2","key":"626_CR24","doi-asserted-by":"publisher","first-page":"492","DOI":"10.3390\/nu13020492","volume":"13","author":"C Romain","year":"2021","unstructured":"Romain C, Chung LH, Mar\u00edn-Cascales E, Rubio-Arias JA, Gaillet S, Laurent C, Morillas-Ruiz JM, Mart\u00ednez-Rodriguez A, Alcaraz PE, Cases J. Sixteen weeks of supplementation with a nutritional quantity of a diversity of polyphenols from foodstuff extracts improves the health-related quality of life of overweight and obese volunteers: a randomized, double-blind, parallel clinical trial. Nutrients. 2021;13(2):492. https:\/\/doi.org\/10.3390\/nu13020492.","journal-title":"Nutrients"},{"issue":"4","key":"626_CR25","doi-asserted-by":"publisher","first-page":"2045","DOI":"10.1002\/ptr.6950","volume":"35","author":"M Rondanelli","year":"2021","unstructured":"Rondanelli M, Peroni G, Riva A, Petrangolini G, Allegrini P, Fazia T, Bernardinelli L, Naso M, Faliva MA, Tartara A, Gasparri C, Infantino V, Perna S. Bergamot phytosome improved visceral fat and plasma lipid profiles in overweight and obese class I subject with mild hypercholesterolemia: A randomized placebo controlled trial. Phytother Res. 2021;35(4):2045\u201356. https:\/\/doi.org\/10.1002\/ptr.6950.","journal-title":"Phytother Res"},{"key":"626_CR26","doi-asserted-by":"publisher","unstructured":"Yousefi R, Parandoosh M, Khorsandi H, Hosseinzadeh N, Madani Tonekaboni M, Saidpour A, Babaei H, Ghorbani. Grape seed extract supplementation along with a restricted-calorie diet improves cardiovascular risk factors in obese or overweight adult individuals: A randomized, placebo-controlled trial. Phytother Res. 2021;35(2):987\u2013995. https:\/\/doi.org\/10.1002\/ptr.6859","DOI":"10.1002\/ptr.6859"},{"key":"626_CR27","unstructured":"Abeso - Associa\u00e7\u00e3o Brasileira para o Estudo da Obesidade e da S\u00edndrome Metab\u00f3lica. Diretrizes brasileiras de Obesidade. 4rd.ed. S\u00e3o Paulo:2016. https:\/\/abeso.org.br\/wp-content\/uploads\/2019\/12\/Diretrizes-Download-Diretrizes-Brasileiras-de-Obesidade-2016.pdf"},{"issue":"10","key":"626_CR28","doi-asserted-by":"publisher","first-page":"006351","DOI":"10.1136\/bmjgh-2021-006351","volume":"6","author":"A Okunogbe","year":"2021","unstructured":"Okunogbe A, Nugent R, Spencer G, Ralston J, Wilding J. Economic impacts of overweight and obesity: current and future estimates for 161 countries. BMJ Glob Health. 2021;6(10):006351. https:\/\/doi.org\/10.1136\/bmjgh-2021-006351.","journal-title":"BMJ Glob Health"},{"issue":"20","key":"626_CR29","doi-asserted-by":"publisher","first-page":"2000","DOI":"10.1001\/jama.2023.19897","volume":"330","author":"A Elmaleh-Sachs","year":"2023","unstructured":"Elmaleh-Sachs A, Schwartz JL, Bramante CT, Nicklas JM, Gudzune KA, Jay M. Obesity Management in Adults: A Review. JAMA. 2023;330(20):2000\u201315. https:\/\/doi.org\/10.1001\/jama.2023.19897.","journal-title":"JAMA"},{"key":"626_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.fufo.2020.100002","volume":"1\u20132","author":"M Singh","year":"2020","unstructured":"Singh M, Thrimawithana T, Shukla R, Adhikari B. Managing obesity through natural polyphenols: a review. Future Foods. 2020;1\u20132: 100002. https:\/\/doi.org\/10.1016\/j.fufo.2020.100002.","journal-title":"Future Foods"},{"issue":"3","key":"626_CR31","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1016\/j.clnu.2015.05.003","volume":"35","author":"IJ Chen","year":"2016","unstructured":"Chen IJ, Liu CY, Chiu JP, Hsu CH. Therapeutic effect of high-dose green tea extract on weight reduction: A randomized, double-blind, placebo-controlled clinical trial. Clin Nutr. 2016;35(3):592\u20139. https:\/\/doi.org\/10.1016\/j.clnu.2015.05.003.","journal-title":"Clin Nutr"},{"key":"626_CR32","doi-asserted-by":"publisher","first-page":"736724","DOI":"10.3389\/fendo.2021.736724","volume":"12","author":"L Xie","year":"2021","unstructured":"Xie L, Tang Q, Yao D, Gu Q, Zheng H, Wang X, Yu Z, Shen X. Effect of decaffeinated green tea polyphenols on body fat and precocious puberty in obese girls: a randomized controlled trial. Front Endocrinol. 2021;12:736724. https:\/\/doi.org\/10.3389\/fendo.2021.736724.","journal-title":"Front Endocrinol"},{"key":"626_CR33","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.jnutbio.2018.03.024","volume":"57","author":"R Otton","year":"2018","unstructured":"Otton R, Bolin AP, Ferreira LT, Marinovic MP, Rocha ALS, Mori MA. Polyphenol-rich green tea extract improves adipose tissue metabolism by down-regulating miR-335 expression and mitigating insulin resistance and inflammation. J Nutr Biochem. 2018;57:170\u20139. https:\/\/doi.org\/10.1016\/j.jnutbio.2018.03.024.","journal-title":"J Nutr Biochem"},{"issue":"2","key":"626_CR34","doi-asserted-by":"publisher","first-page":"221","DOI":"10.3390\/biom14020221","volume":"14","author":"MAA Mamun","year":"2024","unstructured":"Mamun MAA, Rakib A, Mandal M, Kumar S, Singla B, Singh UP. Polyphenols: role in modulating immune function and obesity. Biomolecules. 2024;14(2):221. https:\/\/doi.org\/10.3390\/biom14020221.","journal-title":"Biomolecules"},{"issue":"3","key":"626_CR35","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1016\/j.physbeh.2007.10.009","volume":"93","author":"P Auvichayapat","year":"2008","unstructured":"Auvichayapat P, Prapochanung M, Tunkamnerdthai O, Sripanidkulchai BO, Auvichayapat N, Thinkhamrop B, Kunhasura S, Wongpratoom S, Sinawat S, Hongprapas P. Effectiveness of green tea on weight reduction in obese: a randomized, controlled trial. Physiol Behav. 2008;93(3):486\u201391. https:\/\/doi.org\/10.1016\/j.physbeh.2007.10.009.","journal-title":"Physiol Behav"},{"issue":"4","key":"626_CR36","doi-asserted-by":"publisher","first-page":"e0153134","DOI":"10.1371\/journal.pone.0153134","volume":"11","author":"PL Janssens","year":"2016","unstructured":"Janssens PL, Penders J, Hursel R, Budding AE, Savelkoul PH, Westerterp-Plantenga MS. Long-term green tea supplementation does not change the human gut microbiota. PLoS ONE. 2016;11(4):e0153134. https:\/\/doi.org\/10.1371\/journal.pone.0153134.","journal-title":"PLoS ONE"},{"issue":"5","key":"626_CR37","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1016\/j.physbeh.2011.12.022","volume":"105","author":"CA Hardman","year":"2012","unstructured":"Hardman CA, Herbert V, Brunstrom J, Munafo MR, Rogers P. Dopamine and food reward: effects of acute tyrosine\/phenylalanine depletion on appetite. Physiol Behav. 2012;105(5):1202\u20137. https:\/\/doi.org\/10.1016\/j.physbeh.2011.12.022.","journal-title":"Physiol Behav"},{"issue":"4","key":"626_CR38","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1159\/000471889","volume":"70","author":"M Taghizadeh","year":"2017","unstructured":"Taghizadeh M, Farzin N, Taheri S, Mahlouji M, Akbari H, Karamali F, Asemi Z. The effect of dietary supplements containing green tea, capsaicin and ginger extracts on weight loss and metabolic profiles in overweight women: a randomized double-blind placebo-controlled clinical trial. Ann Nutr Metab. 2017;70(4):277\u201385. https:\/\/doi.org\/10.1159\/000471889.","journal-title":"Ann Nutr Metab"},{"issue":"3","key":"626_CR39","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1016\/j.cmet.2016.12.021","volume":"25","author":"M Maus","year":"2012","unstructured":"Maus M, Cuk M, Patel B, Lian J, Ouimet M, Kaufmann U, Yang J, Horvath R, Hornig-Do HT, Chrzanowska-Lightowlers ZM, Moore KJ, Cuervo AM, Feske S. Store-operated Ca2+ entry controls induction of lipolysis and the transcriptional reprogramming to lipid metabolism. Cell Metab. 2012;25(3):698\u2013712. https:\/\/doi.org\/10.1016\/j.cmet.2016.12.021.","journal-title":"Cell Metab"},{"issue":"5","key":"626_CR40","doi-asserted-by":"publisher","first-page":"694","DOI":"10.3945\/an.117.015792","volume":"8","author":"L Mele","year":"2017","unstructured":"Mele L, Bidault G, Mena P, Crozier A, Brighenti F, Vidal-Puig A, Del Rio D. Dietary (Poly)phenols, brown adipose tissue activation, and energy expenditure: a narrative review. Adv Nutr. 2017;8(5):694\u2013704. https:\/\/doi.org\/10.3945\/an.117.015792.","journal-title":"Adv Nutr"},{"issue":"1","key":"626_CR41","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/s12986-022-00685-1","volume":"19","author":"H Nakajima","year":"2022","unstructured":"Nakajima H, Nakanishi N, Miyoshi T, Okamura T, Hashimoto Y, Senmaru T, Majima S, Ushigome E, Asano M, Yamaguchi M, Mori J, Sakui N, Sasano R, Yamazaki M, Hamaguchi M, Fukui M. Inulin reduces visceral adipose tissue mass and improves glucose tolerance through altering gut metabolites. Nutr Metab (Lond). 2022;19(1):50. https:\/\/doi.org\/10.1186\/s12986-022-00685-1.","journal-title":"Nutr Metab (Lond)"},{"key":"626_CR42","doi-asserted-by":"publisher","first-page":"115252","DOI":"10.1016\/j.bone.2020.115252","volume":"133","author":"D Ali","year":"2020","unstructured":"Ali D, Chen L, Kowal JM, Okla M, Manikandan M, AlShehri M, AlMana Y, AlObaidan R, AlOtaibi N, Hamam R, Alajez NM, Aldahmash A, Kassem M, Alfayez M. Resveratrol inhibits adipocyte differentiation and cellular senescence of human bone marrow stromal stem cells. Bone. 2020;133:115252. https:\/\/doi.org\/10.1016\/j.bone.2020.115252.","journal-title":"Bone"},{"issue":"3","key":"626_CR43","doi-asserted-by":"publisher","first-page":"554","DOI":"10.3390\/ijms18030554","volume":"18","author":"AS Korsholm","year":"2017","unstructured":"Korsholm AS, Kj\u00e6r TN, Ornstrup MJ, Pedersen SB. Comprehensive metabolomic analysis in blood, urine, fat, and muscle in men with metabolic syndrome: a randomized, placebo-controlled clinical trial on the effects of resveratrol after four months\u2019 treatment. Int J Mol Sci. 2017;18(3):554. https:\/\/doi.org\/10.3390\/ijms18030554.","journal-title":"Int J Mol Sci."},{"issue":"46","key":"626_CR44","doi-asserted-by":"publisher","first-page":"17788","DOI":"10.1021\/acs.jafc.3c03559","volume":"71","author":"P Natraj","year":"2023","unstructured":"Natraj P, Rajan P, Jeon YA, Kim SS, Lee YJ. Antiadipogenic effect of citrus flavonoids: evidence from RNA sequencing analysis and activation of AMPK in 3T3-L1 adipocytes. J Agric Food Chem. 2023;71(46):17788\u2013800. https:\/\/doi.org\/10.1021\/acs.jafc.3c03559.","journal-title":"J Agric Food Chem"},{"key":"626_CR45","doi-asserted-by":"publisher","first-page":"S8","DOI":"10.1016\/j.phanu.2016.05.001","volume":"4","author":"E Janda","year":"2016","unstructured":"Janda E, Lascala A, Martino C, Ragusa S, Nucera S, Walker R, Gratteri S, Mollace V. Molecular mechanisms of lipid- and glucose-lowering activities of bergamot flavonoids. PharmaNutrition. 2016;4:S8\u201318. https:\/\/doi.org\/10.1016\/j.phanu.2016.05.001.","journal-title":"PharmaNutrition"},{"issue":"5","key":"626_CR46","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1111\/j.1740-0929.2009.00670.x","volume":"80","author":"K Honda","year":"2009","unstructured":"Honda K, Kamisoyama H, Tominaga Y, Yokota S, Hasegawa S. The molecular mechanism underlying the reduction in abdominal fat accumulation by licorice flavonoid oil in high fat diet-induced obese rats. Anim Sci J. 2009;80(5):562\u20139. https:\/\/doi.org\/10.1111\/j.1740-0929.2009.00670.x.","journal-title":"Anim Sci J"},{"issue":"6","key":"626_CR47","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/j.phymed.2015.03.015","volume":"22","author":"M Herranz-L\u00f3pez","year":"2015","unstructured":"Herranz-L\u00f3pez M, Barraj\u00f3n-Catal\u00e1n E, Segura-Carretero A, Men\u00e9ndez JA, Joven J, Micol V. Lemon verbena (Lippia citriodora) polyphenols alleviate obesity-related disturbances in hypertrophic adipocytes through AMPK-dependent mechanisms. Phytomedicine. 2015;22(6):605\u201314. https:\/\/doi.org\/10.1016\/j.phymed.2015.03.015.","journal-title":"Phytomedicine"},{"issue":"3","key":"626_CR48","doi-asserted-by":"publisher","first-page":"2108","DOI":"10.3390\/ijms24032108","volume":"24","author":"JW Hong","year":"2023","unstructured":"Hong JW, Park HY, Kim HA, Hwang YS, Lee EJ, Kim JW. Inhibition Effect of Adipogenesis and Lipogenesis via Activation of AMPK in Preadipocytes Treated with Canavalia gladiata Extract. Int J Mol Sci. 2023;24(3):2108. https:\/\/doi.org\/10.3390\/ijms24032108.","journal-title":"Int J Mol Sci"},{"issue":"8","key":"626_CR49","doi-asserted-by":"publisher","first-page":"E975","DOI":"10.1152\/ajpendo.00699.2013","volume":"306","author":"Y Liu","year":"2014","unstructured":"Liu Y, Li D, Zhang Y, Sun R, Xia M. Anthocyanin increases adiponectin secretion and protects against diabetes-related endothelial dysfunction. Am J Physiol Endocrinol Metab. 2014;306(8):E975\u201388. https:\/\/doi.org\/10.1152\/ajpendo.00699.2013.","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"5","key":"626_CR50","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1016\/j.cmet.2016.04.011","volume":"23","author":"JH Stern","year":"2016","unstructured":"Stern JH, Rutkowski JM, Scherer PE. Adiponectin, leptin, and fatty acids in the maintenance of metabolic homeostasis through adipose tissue crosstalk. Cell Metab. 2016;23(5):770\u201384. https:\/\/doi.org\/10.1016\/j.cmet.2016.04.011.","journal-title":"Cell Metab"},{"key":"626_CR51","doi-asserted-by":"publisher","unstructured":"Strand E, Lysne V, Grinna ML, Bohov P, Svardal A, Nyg\u00e5rd O, Berge RK, Bj\u00f8rndal B. Short-term activation of peroxisome proliferator-activated receptors \u03b1 and \u03b3 induces tissue-specific effects on lipid metabolism and fatty acid composition in male wistar rats. PPAR research. 2019;8047627. https:\/\/doi.org\/10.1155\/2019\/8047627.","DOI":"10.1155\/2019\/8047627"},{"issue":"5","key":"626_CR52","doi-asserted-by":"publisher","first-page":"406","DOI":"10.3177\/jnsv.61.406","volume":"61","author":"N Mori","year":"2015","unstructured":"Mori N, Nakanishi S, Shiomi S, Kiyokawa S, Kakimoto S, Nakagawa K, Hosoe K, Minami K, Nadamoto T. Enhancement of fat oxidation by licorice flavonoid oil in healthy humans during light exercise. J Nutr Sci Vitaminol (Tokyo). 2015;61(5):406\u201316. https:\/\/doi.org\/10.3177\/jnsv.61.406.","journal-title":"J Nutr Sci Vitaminol (Tokyo)"},{"issue":"2","key":"626_CR53","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1002\/ptr.6529","volume":"34","author":"M Parandoosh","year":"2020","unstructured":"Parandoosh M, Yousefi R, Khorsandi H, Nikpayam O, Saidpour A, Babaei H. The effects of grape seed extract (Vitis vinifera) supplement on inflammatory markers, neuropeptide Y, anthropometric measures, and appetite in obese or overweight individuals: A randomized clinical trial. Phytother Res. 2020;34(2):379\u201387. https:\/\/doi.org\/10.1002\/ptr.6529.","journal-title":"Phytother Res"},{"issue":"4","key":"626_CR54","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1038\/sj.ejcn.1601863","volume":"58","author":"N Vogels","year":"2004","unstructured":"Vogels N, Nijs IM, Westerterp-Plantenga MS. The effect of grape-seed extract on 24 h energy intake in humans. Eur J Clin Nutr. 2004;58(4):667\u201373. https:\/\/doi.org\/10.1038\/sj.ejcn.1601863.","journal-title":"Eur J Clin Nutr"},{"key":"626_CR55","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.nutres.2019.09.007","volume":"73","author":"M Tanaka","year":"2020","unstructured":"Tanaka M, Sugama A, Sumi K, Shimizu K, Kishimoto Y, Kondo K, Iida K. Gallic acid regulates adipocyte hypertrophy and suppresses inflammatory gene expression induced by the paracrine interaction between adipocytes and macrophages in vitro and in vivo. Nutr Res. 2020;73:58\u201366. https:\/\/doi.org\/10.1016\/j.nutres.2019.09.007.","journal-title":"Nutr Res"},{"key":"626_CR56","doi-asserted-by":"publisher","first-page":"3167","DOI":"10.2147\/JMDH.S471372","volume":"17","author":"Y Jia","year":"2024","unstructured":"Jia Y, Zhang Q, Zhang Y, Wang H, Niu Q, Zhu R, Li J, Fan W, Zhang Y. Effects of polyphenol-rich foods on lipids and oxidative stress status in patients with hyperlipidemia: a systematic review of randomized controlled trials. J Multidiscip Health. 2024;17:3167\u201379. https:\/\/doi.org\/10.2147\/JMDH.S471372.","journal-title":"J Multidiscip Health"},{"issue":"3","key":"626_CR57","doi-asserted-by":"publisher","first-page":"545","DOI":"10.3390\/nu14030545","volume":"14","author":"G Grosso","year":"2022","unstructured":"Grosso G, Godos J, Currenti W, Micek A, Falzone L, Libra M, Giampieri F, Forbes-Hern\u00e1ndez TY, Quiles JL, Battino M, La Vignera S, Galvano F. The effect of dietary polyphenols on vascular health and hypertension: current evidence and mechanisms of action. Nutrients. 2022;14(3):545. https:\/\/doi.org\/10.3390\/nu14030545.","journal-title":"Nutrients"},{"issue":"10","key":"626_CR58","doi-asserted-by":"publisher","first-page":"3135","DOI":"10.3390\/nu12103135","volume":"12","author":"G Williamson","year":"2020","unstructured":"Williamson G, Sheedy K. Effects of polyphenols on insulin Resistance. Nutrients. 2020;12(10):3135. https:\/\/doi.org\/10.3390\/nu12103135.","journal-title":"Nutrients"},{"issue":"3","key":"626_CR59","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.rec.2014.04.021","volume":"68","author":"G Vilahur","year":"2015","unstructured":"Vilahur G, Padr\u00f3 T, Casan\u00ed L, Mendieta G, L\u00f3pez JA, Streitenberger S, Badimon L. Polyphenol-enriched diet prevents coronary endothelial dysfunction by activating the Akt\/eNOS pathway. Rev Esp Cardiol (Engl Ed). 2015;68(3):216\u201325. https:\/\/doi.org\/10.1016\/j.rec.2014.04.021.","journal-title":"Rev Esp Cardiol (Engl Ed)"},{"key":"626_CR60","doi-asserted-by":"publisher","first-page":"103856","DOI":"10.1016\/j.jff.2020.103856","volume":"67","author":"J Soto-covasich","year":"2020","unstructured":"Soto-covasich J, Reyes-Farias M, Torres RF, Vasquez K, Duarte L, Quezada J, Jimenez P, Pino MT, Garcia-Nannig L, Mercado L, Garcia-Diaz DF. A polyphenol-rich Calafate (Berberis microphylla) extract rescues glucose tolerance in mice fed with cafeteria diet. J Funct Foods. 2020;67:103856. https:\/\/doi.org\/10.1016\/j.jff.2020.103856.","journal-title":"J Funct Foods"},{"issue":"4","key":"626_CR61","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1002\/biof.13657","volume":"43","author":"G Jamar","year":"2017","unstructured":"Jamar G, Estadella D, Pisani LP. Contribution of anthocyanin-rich foods in obesity control through gut microbiota interactions. BioFactors. 2017;43(4):507\u201316. https:\/\/doi.org\/10.1002\/biof.13657.","journal-title":"BioFactors"},{"issue":"7","key":"626_CR62","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1016\/j.tem.2020.02.011","volume":"31","author":"S Davinelli","year":"2020","unstructured":"Davinelli S, De Stefani D, De Vivo I, Scapagnini G. Polyphenols as caloric restriction mimetics regulating mitochondrial biogenesis and mitophagy. Trends Endocrinol Metabol. 2020;31(7):536\u201350. https:\/\/doi.org\/10.1016\/j.tem.2020.02.011.","journal-title":"Trends Endocrinol Metabol"},{"key":"626_CR63","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11130-022-01034-6","volume":"78","author":"CS Dzah","year":"2023","unstructured":"Dzah CS, Asante-Donyinah D, Letsyo E, Dzikunoo J, Adams ZS. Dietary polyphenols and obesity: a review of polyphenol effects on lipid and glucose metabolism, mitochondrial homeostasis, and starch digestibility and absorption. Plant Foods Hum Nutr. 2023;78:1\u201312. https:\/\/doi.org\/10.1007\/s11130-022-01034-6.","journal-title":"Plant Foods Hum Nutr"}],"container-title":["Current Nutrition Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13668-025-00626-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13668-025-00626-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13668-025-00626-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T13:18:53Z","timestamp":1740143933000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13668-025-00626-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,21]]},"references-count":63,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["626"],"URL":"https:\/\/doi.org\/10.1007\/s13668-025-00626-3","relation":{},"ISSN":["2161-3311"],"issn-type":[{"value":"2161-3311","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,21]]},"assertion":[{"value":"4 February 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 February 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This article does not contain any studies with human or animal subjects performed by any of the authors.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and Animal Rights and Informed Consent"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}],"article-number":"36"}}