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Its deficiency can lead to significant adverse effects on overall health and well-being, including physical and psychological consequences. Evidence indicates that vitamin D may exert influences through receptors in the brain, modulating serotonin production and influencing emotional and cognitive processes. Recent studies propose that elevated serum vitamin D may enhance mood and alleviate depressive states. The impact of vitamin D on cognitive function and behavior remains an area of ongoing investigation. This literature review analyses the available evidence on how vitamin D intake impacts the severity of illness and medication requirements in diverse psychiatric disorders. A review of the literature suggests that there may be a correlation between vitamin D and serotonin, which could potentially contribute to more favorable outcomes in the context of illness. Vitamin D may increase the amount of serotonin in the synaptic gap, which is the intended use of selective serotonin reuptake inhibitors (SSRIs), with its effect on the increase in serotonin release.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Summary<\/jats:title>\n            <jats:p>According to reports, vitamin D supplementation in conjunction with SSRI group medication provides an additive effect for the management of psychiatric disorders.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s13668-025-00630-7","type":"journal-article","created":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T09:23:01Z","timestamp":1740820981000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Can V\u0131tam\u0131n D Reduce the Need for SSRI by Modulat\u0131ng Seroton\u0131n Synthes\u0131s?: A Rev\u0131ew of Recent L\u0131terature"],"prefix":"10.1007","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9783-0972","authenticated-orcid":false,"given":"Zekiye Zeynep","family":"Bostan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8223-3542","authenticated-orcid":false,"given":"Melike","family":"\u015eare Bulut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3202-3250","authenticated-orcid":false,"given":"Makbule","family":"Gezmen Karada\u011f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,1]]},"reference":[{"key":"630_CR1","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.jpsychires.2017.11.003","volume":"97","author":"NPM Paans","year":"2018","unstructured":"Paans NPM, Bot T, van Strien IA, Brouwer M, Visser BWJH. 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