{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T08:31:03Z","timestamp":1763713863961,"version":"3.45.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Curr Nutr Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>A dozen medical articles describe poor vision from copper deficiency. They are collected here along with some ideas about copper nutrition, epidemiology, patient evaluation and treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Recent findings<\/jats:title>\n                    <jats:p>Clinical descriptions have been brief. Severe vision loss of a middle-aged woman improved from 20\/400 to 20\/25 with copper replacement for 10 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>The optimal chemical form, dose, duration or route of copper repletion are defined poorly. Copper gluconate is the preferred supplement; several mg of elemental copper usually should be given daily for months. Superoxide dismutase in erythrocytes is one of the more sensitive tests of deficiency.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s13668-025-00712-6","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T08:27:46Z","timestamp":1763713666000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Poor Vision from Copper Deficiency"],"prefix":"10.1007","volume":"14","author":[{"given":"Leslie M.","family":"Klevay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,21]]},"reference":[{"issue":"3","key":"712_CR1","doi-asserted-by":"publisher","first-page":"430","DOI":"10.4103\/ijmr.IJMR_246_17","volume":"146","author":"LM Klevay","year":"2017","unstructured":"Klevay LM. Ocular lesions from copper deficiency. Indian J Med Res. 2017;146(3):430\u20131.","journal-title":"Indian J Med Res"},{"issue":"4","key":"712_CR2","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1182\/blood-2002-01-0256","volume":"100","author":"XT Gregg","year":"2002","unstructured":"Gregg XT, Reddy V, Prchal JT. Copper deficiency masquerading as myelodysplastic syndrome. Blood. 2002;100(4):1493\u20135.","journal-title":"Blood"},{"issue":"8","key":"712_CR3","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1007\/s00415-006-0479-2","volume":"254","author":"M Spinazzi","year":"2007","unstructured":"Spinazzi M, De Lazzari F, Tavolato B, Angelini C, Manara R, Armani M. Myelo-optico-neuropathy in copper deficiency occurring after partial gastrectomy. Do small bowel bacterial overgrowth syndrome and occult zinc ingestion tip the balance? J Neurol. 2007;254(8):1012\u20137.","journal-title":"J Neurol"},{"issue":"8","key":"712_CR4","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1001\/archneurol.2009.70","volume":"66","author":"RT Naismith","year":"2009","unstructured":"Naismith RT, Shepherd JB, Weihl CC, Tutlam NT, Cross AH. Acute and bilateral blindness due to optic neuropathy associated with copper deficiency. Arch Neurol. 2009;66(8):1025\u20137.","journal-title":"Arch Neurol"},{"key":"712_CR5","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c508","volume":"340","author":"Z Khaleeli","year":"2010","unstructured":"Khaleeli Z, Healy DG, Briddon A, Lunn MP, Reilly MM, Land J, et al. Copper deficiency as a treatable cause of poor balance. 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Sirajuddin, Evaluation of status of zinc, copper, and iron levels in biological samples of normal children and children with night blindness with age groups of 3\u20137 and 8\u201312 years, Biol Trace Element Res 2011;142(3):323\u2009\u2013\u200934.","DOI":"10.1007\/s12011-010-8789-8"},{"issue":"10","key":"712_CR8","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1097\/MCG.0000000000000092","volume":"48","author":"SS Yarandi","year":"2014","unstructured":"Yarandi SS, Griffith DP, Sharma R, Mohan A, Zhao VM, Ziegler TR. Optic neuropathy, myelopathy, anemia, and neutropenia caused by acquired copper deficiency after gastric bypass surgery. J Clin Gastroenterol. 2014;48(10):862\u20135.","journal-title":"J Clin Gastroenterol"},{"issue":"8","key":"712_CR9","doi-asserted-by":"publisher","first-page":"575","DOI":"10.7326\/L20-0016","volume":"172","author":"R Harrison","year":"2020","unstructured":"Harrison R, Warburton V, Lux A, Atan D. Blindness caused by a junk food diet. 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