{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T04:03:43Z","timestamp":1789358623959,"version":"build-2803163510"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Curr Nutr Rep"],"DOI":"10.1007\/s13668-026-00799-5","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T03:26:35Z","timestamp":1789356395000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Potential Neuroprotective Role of Biotin in Neurorehabilitation: A Review"],"prefix":"10.1007","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8274-0194","authenticated-orcid":false,"given":"Esra","family":"Gunay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3202-3250","authenticated-orcid":false,"given":"Makbule","family":"Gezmen-Karadag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,14]]},"reference":[{"issue":"15","key":"799_CR1","doi-asserted-by":"publisher","first-page":"2444","DOI":"10.3390\/nu16152444","volume":"16","author":"M Sakurai-Yageta","year":"2024","unstructured":"Sakurai-Yageta M, Suzuki Y. Molecular mechanisms of biotin in modulating inflammatory diseases. Nutrients. 2024;16(15):2444. https:\/\/doi.org\/10.3390\/nu16152444.","journal-title":"Nutrients"},{"issue":"12","key":"799_CR2","doi-asserted-by":"publisher","first-page":"6578","DOI":"10.3390\/ijms25126578","volume":"25","author":"C-E Karachaliou","year":"2024","unstructured":"Karachaliou C-E, Livaniou E. Biotin homeostasis and human disorders: recent findings and perspectives. Int J Mol Sci. 2024;25(12):6578. https:\/\/doi.org\/10.3390\/ijms25126578.","journal-title":"Int J Mol Sci"},{"issue":"1","key":"799_CR3","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1038\/s42003-023-05379-9","volume":"6","author":"RJN Tiozon","year":"2023","unstructured":"Tiozon RJN, Sreenivasulu N, Alseekh S, Sartagoda KJD, Usadel B, Fernie AR. Metabolomics and machine learning technique revealed that germination enhances the multi-nutritional properties of pigmented rice. Commun biology. 2023;6(1):1000. https:\/\/doi.org\/10.1038\/s42003-023-05379-9.","journal-title":"Commun biology"},{"issue":"4","key":"799_CR4","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.1007\/s00394-021-02756-0","volume":"61","author":"A Jungert","year":"2022","unstructured":"Jungert A, Ellinger S, Watzl B, Richter M, Society GN. Revised DA-CH reference values for the intake of biotin. Eur J Nutr. 2022;61(4):1779\u201387. https:\/\/doi.org\/10.1007\/s00394-021-02756-0.","journal-title":"Eur J Nutr"},{"issue":"3","key":"799_CR5","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1093\/jalm\/jfz010","volume":"5","author":"D Li","year":"2020","unstructured":"Li D, Ferguson A, Cervinski MA, Lynch KL, Kyle PB. AACC guidance document on biotin interference in laboratory tests. J Appl Lab Med. 2020;5(3):575\u201387. https:\/\/doi.org\/10.1093\/jalm\/jfz010.","journal-title":"J Appl Lab Med"},{"issue":"1","key":"799_CR6","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1186\/s40795-023-00768-z","volume":"9","author":"KZ Kotnik","year":"2023","unstructured":"Kotnik KZ, Seljak BK, Gregori\u010d M, Jurak G, Golja P. Questionable advisability of vitamin and mineral dietary supplement use in adolescents. BMC Nutr. 2023;9(1):110. https:\/\/doi.org\/10.1186\/s40795-023-00768-z.","journal-title":"BMC Nutr"},{"issue":"8","key":"799_CR7","doi-asserted-by":"publisher","first-page":"5469","DOI":"10.3390\/ijerph20085469","volume":"20","author":"K Moss","year":"2023","unstructured":"Moss K, Kreutzer A, Graybeal AJ, Zhang Y, Braun-Trocchio R, Porter RR, Shah M. Nutrient adequacy in endurance athletes. Int J Environ Res Public Health. 2023;20(8):5469. https:\/\/doi.org\/10.3390\/ijerph20085469.","journal-title":"Int J Environ Res Public Health"},{"issue":"7","key":"799_CR8","doi-asserted-by":"publisher","first-page":"100251","DOI":"10.1016\/j.advnut.2024.100251","volume":"15","author":"CA Perry","year":"2024","unstructured":"Perry CA, Butterick TA, Biotin. Adv Nutr. 2024;15(7):100251. https:\/\/doi.org\/10.1016\/j.advnut.2024.100251.","journal-title":"Adv Nutr"},{"issue":"11","key":"799_CR9","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.3945\/jn.111.146126","volume":"141","author":"DM Mock","year":"2011","unstructured":"Mock DM, Stratton SL, Horvath TD, Bogusiewicz A, Matthews NI, Henrich CL, et al. Urinary excretion of 3-hydroxyisovaleric acid and 3-hydroxyisovaleryl carnitine increases in response to a leucine challenge in marginally biotin-deficient humans. J Nutr. 2011;141(11):1925\u201330. https:\/\/doi.org\/10.3945\/jn.111.146126.","journal-title":"J Nutr"},{"key":"799_CR10","doi-asserted-by":"publisher","first-page":"10290","DOI":"10.29219\/fnr.v67","volume":"67","author":"HS Strandler","year":"2023","unstructured":"Strandler HS, Strand TA, Thiamin. (Vitamin B1)\u2013A scoping review for Nordic Nutrition Recommendations 2023. Food Nutr Res. 2023;67:10290. https:\/\/doi.org\/10.29219\/fnr.v67.","journal-title":"Food Nutr Res"},{"key":"799_CR11","doi-asserted-by":"publisher","unstructured":"Said HM. Biotin: biochemical, physiological and clinical aspects. Subcell Biochem. 2012;56:1\u201319. https:\/\/doi.org\/10.1007\/978-94-007-2199-9_1","DOI":"10.1007\/978-94-007-2199-9_1"},{"key":"799_CR12","doi-asserted-by":"publisher","first-page":"836058","DOI":"10.3389\/fonc.2022.836058","volume":"12","author":"Y Wang","year":"2022","unstructured":"Wang Y, Yu W, Li S, Guo D, He J, Wang Y. Acetyl-CoA carboxylases and diseases. Front Oncol. 2022;12:836058. https:\/\/doi.org\/10.3389\/fonc.2022.836058.","journal-title":"Front Oncol"},{"key":"799_CR13","doi-asserted-by":"publisher","unstructured":"Gond\u00e1\u0161 E, Kr\u00e1\u013eov\u00e1 Tran\u010d\u00edkov\u00e1 A, Baranovi\u010dov\u00e1 E, \u0160ofranko J, Hatok J, Kowtharapu BS, et al. Expression of 3-methylcrotonyl-CoA carboxylase in brain tumors and capability to catabolize leucine by human neural cancer cells. Cancers (Basel). 2022;14(3):585. https:\/\/doi.org\/10.3390\/cancers14030585","DOI":"10.3390\/cancers14030585"},{"key":"799_CR14","doi-asserted-by":"publisher","unstructured":"Almasi S, Jafarzadeh Shirazi MR, Rezvani MR, Ramezani M, Salehi I, Pegah A, et al. The protective effect of biotin supplementation and swimming training on cognitive impairment and mental symptoms in a rat model of Alzheimer\u2019s disease: a behavioral, biochemical, and histological study. Heliyon. 2024;10(13):e32299. https:\/\/doi.org\/10.1016\/j.heliyon.2024.e32299","DOI":"10.1016\/j.heliyon.2024.e32299"},{"issue":"1","key":"799_CR15","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1515\/revneuro-2024-0080","volume":"36","author":"AA Mohamed Yusoff","year":"2025","unstructured":"Mohamed Yusoff AA, Mohd Khair SZN. Unraveling mitochondrial dysfunction: comprehensive perspectives on its impact on neurodegenerative diseases. Rev Neurosci. 2025;36(1):53\u201390. https:\/\/doi.org\/10.1515\/revneuro-2024-0080.","journal-title":"Rev Neurosci"},{"issue":"4","key":"799_CR16","doi-asserted-by":"publisher","first-page":"276","DOI":"10.3390\/cells14040276","volume":"14","author":"H-M Yang","year":"2025","unstructured":"Yang H-M. Mitochondrial Dysfunction in Neurodegenerative Diseases. Cells. 2025;14(4):276. https:\/\/doi.org\/10.3390\/cells14040276.","journal-title":"Cells"},{"issue":"52","key":"799_CR17","doi-asserted-by":"publisher","first-page":"33608","DOI":"10.1073\/pnas.1922392117","volume":"117","author":"KM Lohr","year":"2020","unstructured":"Lohr KM, Frost B, Scherzer C, Feany MB. Biotin rescues mitochondrial dysfunction and neurotoxicity in a tauopathy model. Proc Natl Acad Sci. 2020;117(52):33608\u201318. https:\/\/doi.org\/10.1073\/pnas.1922392117","journal-title":"Proc Natl Acad Sci"},{"key":"799_CR18","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.mehy.2017.10.012","volume":"109","author":"MF McCarty","year":"2017","unstructured":"McCarty MF, DiNicolantonio JJ. Neuroprotective potential of high-dose biotin. Med Hypotheses. 2017;109:145\u20139. https:\/\/doi.org\/10.1016\/j.mehy.2017.10.012.","journal-title":"Med Hypotheses"},{"issue":"7","key":"799_CR19","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.4103\/1673-5374.361542","volume":"18","author":"F Szepanowski","year":"2023","unstructured":"Szepanowski F, Steubing RD, G\u00fcng\u00f6r C, Zipfel J, Mausberg AK, Kleinschnitz C, Stettner M. High-dose biotin neither fosters remyelination nor stimulates malonyl coenzyme A synthesis in the regenerating nerve. Neural Regen Res. 2023;18(7):1623\u20134. https:\/\/doi.org\/10.4103\/1673-5374.361542.","journal-title":"Neural Regen Res"},{"key":"799_CR20","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/j.freeradbiomed.2022.11.022","volume":"193","author":"MR Tropea","year":"2022","unstructured":"Tropea MR, Gulisano W, Vacanti V, Arancio O, Puzzo D, Palmeri A. Nitric oxide\/cGMP\/CREB pathway and amyloid-beta crosstalk: from physiology to Alzheimer\u2019s disease. Free Radic Biol Med. 2022;193:657\u201368. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2022.11.022.","journal-title":"Free Radic Biol Med"},{"issue":"3","key":"799_CR21","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1007\/s004410051311","volume":"296","author":"H Wang","year":"1999","unstructured":"Wang H, Pevsner J. Detection of endogenous biotin in various tissues: novel functions in the hippocampus and implications for its use in avidin-biotin technology. Cell Tissue Res. 1999;296(3):511\u20136. https:\/\/doi.org\/10.1007\/s004410051311.","journal-title":"Cell Tissue Res"},{"key":"799_CR22","doi-asserted-by":"publisher","first-page":"148031","DOI":"10.1016\/j.brainres.2022.148031","volume":"1792","author":"M Munzuro\u011flu","year":"2022","unstructured":"Munzuro\u011flu M, Dan\u0131\u015fman B, Ak\u00e7ay G, Yelli \u0130, Aslan M, Derin N. Effects of biotin deficiency on short term memory: the role of glutamate, glutamic acid, dopamine and protein kinase A. Brain Res. 2022;1792:148031. https:\/\/doi.org\/10.1016\/j.brainres.2022.148031.","journal-title":"Brain Res"},{"issue":"2","key":"799_CR23","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.msard.2015.01.005","volume":"4","author":"F Sedel","year":"2015","unstructured":"Sedel F, Papeix C, Bellanger A, Touitou V, Lebrun-Frenay C, Galanaud D, et al. High doses of biotin in chronic progressive multiple sclerosis: a pilot study. Multiple Scler Relat disorders. 2015;4(2):159\u201369. https:\/\/doi.org\/10.1016\/j.msard.2015.01.005.","journal-title":"Multiple Scler Relat disorders"},{"issue":"13","key":"799_CR24","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1177\/1352458516667568","volume":"22","author":"A Tourbah","year":"2016","unstructured":"Tourbah A, Lebrun-Frenay C, Edan G, Clanet M, Papeix C, Vukusic S, et al. MD1003 (high-dose biotin) for the treatment of progressive multiple sclerosis: A randomised, double-blind, placebo-controlled study. Mult Scler. 2016;22(13):1719\u201331. https:\/\/doi.org\/10.1177\/1352458516667568.","journal-title":"Mult Scler"},{"issue":"12","key":"799_CR25","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1212\/wnl.94.15_supplement.680","volume":"19","author":"BAC Cree","year":"2020","unstructured":"Cree BAC, Cutter G, Wolinsky JS, Freedman MS, Comi G, Giovannoni G, et al. Safety and efficacy of MD1003 (high-dose biotin) in patients with progressive multiple sclerosis (SPI2): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Neurol. 2020;19(12):988\u201397. https:\/\/doi.org\/10.1212\/wnl.94.15_supplement.680.","journal-title":"Lancet Neurol"},{"issue":"1","key":"799_CR26","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1186\/s13256-023-04002-z","volume":"17","author":"A James","year":"2023","unstructured":"James A, Stalan J, Kuzhively J. Biotin induced biochemical hyperthyroidism: a case report and review of the literature. J Med Case Rep. 2023;17(1):266. https:\/\/doi.org\/10.1186\/s13256-023-04002-z.","journal-title":"J Med Case Rep"},{"key":"799_CR27","doi-asserted-by":"publisher","first-page":"103159","DOI":"10.1016\/j.msard.2021.103159","volume":"55","author":"AI Espiritu","year":"2021","unstructured":"Espiritu AI, Remalante-Rayco PPM. High-dose biotin for multiple sclerosis: A systematic review and meta-analyses of randomized controlled trials. Multiple Scler Relat Disorders. 2021;55:103159. https:\/\/doi.org\/10.1016\/j.msard.2021.103159.","journal-title":"Multiple Scler Relat Disorders"},{"key":"799_CR28","doi-asserted-by":"publisher","first-page":"100254","DOI":"10.1016\/j.eclinm.2019.100254","volume":"19","author":"R Juntas-Morales","year":"2020","unstructured":"Juntas-Morales R, Pageot N, Bendarraz A, Alphand\u00e9ry S, Sedel F, Seigle S, Camu W. High-dose pharmaceutical grade biotin (MD1003) in amyotrophic lateral sclerosis: a pilot study. EClinicalMedicine. 2020;19:100254. https:\/\/doi.org\/10.1016\/j.eclinm.2019.100254.","journal-title":"EClinicalMedicine"},{"issue":"870","key":"799_CR29","doi-asserted-by":"publisher","first-page":"eadn9868","DOI":"10.1126\/scisignal.adn9868","volume":"18","author":"Y Lai","year":"2025","unstructured":"Lai Y, Reina-Gonzalez P, Maor G, Miller GW, Sarkar S. Biotin mitigates the development of manganese-induced, Parkinson\u2019s disease\u2013related neurotoxicity in Drosophila and human neurons. Sci Signal. 2025;18(870):eadn9868. https:\/\/doi.org\/10.1126\/scisignal.adn9868.","journal-title":"Sci Signal"},{"issue":"9","key":"799_CR30","doi-asserted-by":"publisher","first-page":"e22519","DOI":"10.1002\/jbt.22519","volume":"34","author":"H Attia","year":"2020","unstructured":"Attia H, Albuhayri S, Alaraidh S, Alotaibi A, Yacoub H, Mohamad R, Al-Amin M. Biotin, coenzyme Q10, and their combination ameliorate aluminium chloride\u2010induced Alzheimer\u2019s disease via attenuating neuroinflammation and improving brain insulin signaling. J Biochem Mol Toxicol. 2020;34(9):e22519. https:\/\/doi.org\/10.1002\/jbt.22519.","journal-title":"J Biochem Mol Toxicol"},{"issue":"13","key":"799_CR31","doi-asserted-by":"publisher","first-page":"13441","DOI":"10.1007\/s11356-019-04806-x","volume":"26","author":"N Abdel-Magied","year":"2019","unstructured":"Abdel-Magied N, Shedid SM, Ahmed AG. Mitigating effect of biotin against irradiation-induced cerebral cortical and hippocampal damage in the rat brain tissue. Environ Sci Pollut Res. 2019;26(13):13441\u201352. https:\/\/doi.org\/10.1007\/s11356-019-04806-x.","journal-title":"Environ Sci Pollut Res"},{"key":"799_CR32","doi-asserted-by":"publisher","unstructured":"Reche-L\u00f3pez D, Romero-Gonz\u00e1lez A, \u00c1lvarez-C\u00f3rdoba M, Su\u00e1rez-Carrillo A, Cilleros-Holgado P, Pi\u00f1ero-P\u00e9rez R, et al. Biotin induces inactive chromosome X reactivation and corrects physiopathological alterations in beta-propeller-protein-associated neurodegeneration. Int J Mol Sci. 2025;26(3):1315. https:\/\/doi.org\/10.3390\/ijms26031315","DOI":"10.3390\/ijms26031315"},{"issue":"3","key":"799_CR33","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.3390\/ijms26031333","volume":"26","author":"K Orywal","year":"2025","unstructured":"Orywal K, Socha K, Iwaniuk P, Kaczy\u0144ski P, Farhan JA, Zo\u0144 W, et al. Vitamins in the prevention and support therapy of neurodegenerative diseases. Int J Mol Sci. 2025;26(3):1333. https:\/\/doi.org\/10.3390\/ijms26031333.","journal-title":"Int J Mol Sci"},{"issue":"4","key":"799_CR34","doi-asserted-by":"publisher","first-page":"1536","DOI":"10.1007\/s00415-023-12140-z","volume":"271","author":"C Tryfonos","year":"2024","unstructured":"Tryfonos C, Chrysafi M, Vadikolias K, Berberoglou L, Vorvolakos T, Dimoliani S, et al. Nutritional interventional studies in patients with multiple sclerosis: a scoping review of the current clinical evidence. J Neurol. 2024;271(4):1536\u201370. https:\/\/doi.org\/10.1007\/s00415-023-12140-z.","journal-title":"J Neurol"},{"issue":"5","key":"799_CR35","doi-asserted-by":"publisher","first-page":"e0233859","DOI":"10.1371\/journal.pone.0233859","volume":"15","author":"QL Cui","year":"2020","unstructured":"Cui QL, Lin YH, Xu YKT, Fernandes MGF, Rao VTS, Kennedy TE, Antel J. Effects of Biotin on survival, ensheathment, and ATP production by oligodendrocyte lineage cells in vitro. PLoS ONE. 2020;15(5):e0233859. https:\/\/doi.org\/10.1371\/journal.pone.0233859.","journal-title":"PLoS ONE"},{"issue":"1","key":"799_CR36","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1186\/s12883-023-03440-y","volume":"23","author":"A Cr\u00e9ange","year":"2023","unstructured":"Cr\u00e9ange A, Hutin E, Sedel F, Le Vigouroux L, Lefaucheur JP. High-dose pharmaceutical-grade biotin in patients with demyelinating neuropathies: a phase 2b open label, uncontrolled, pilot study. BMC Neurol. 2023;23(1):389. https:\/\/doi.org\/10.1186\/s12883-023-03440-y.","journal-title":"BMC Neurol"},{"issue":"5","key":"799_CR37","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1080\/10715762.2019.1612891","volume":"53","author":"R Sghaier","year":"2019","unstructured":"Sghaier R, Zarrouk A, Nury T, Badreddine I, O\u2019Brien N, Mackrill JJ, et al. Biotin attenuation of oxidative stress, mitochondrial dysfunction, lipid metabolism alteration and 7\u03b2-hydroxycholesterol-induced cell death in 158\u00a0N murine oligodendrocytes. Free Radic Res. 2019;53(5):535\u201361. https:\/\/doi.org\/10.1080\/10715762.2019.1612891.","journal-title":"Free Radic Res"},{"issue":"4","key":"799_CR38","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1172\/jci57256","volume":"122","author":"TR Bomfim","year":"2012","unstructured":"Bomfim TR, Forny-Germano L, Sathler LB, Brito-Moreira J, Houzel JC, Decker H, et al. An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer\u2019s disease- associated A\u03b2 oligomers. J Clin Invest. 2012;122(4):1339\u201353. https:\/\/doi.org\/10.1172\/jci57256.","journal-title":"J Clin Invest"},{"issue":"4","key":"799_CR39","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1039\/c2fo10175k","volume":"3","author":"Y Sasaki","year":"2012","unstructured":"Sasaki Y, Sone H, Kamiyama S, Shimizu M, Shirakawa H, Kagawa Y, et al. Administration of biotin prevents the development of insulin resistance in the skeletal muscles of Otsuka Long-Evans Tokushima Fatty rats. Food Funct. 2012;3(4):414\u20139. https:\/\/doi.org\/10.1039\/c2fo10175k.","journal-title":"Food Funct"},{"issue":"5","key":"799_CR40","doi-asserted-by":"publisher","first-page":"6503","DOI":"10.1007\/s12035-025-04686-y","volume":"62","author":"B Yulug","year":"2025","unstructured":"Yulug B, Kilic E, O\u011fuz T, Orhan C, Er B, Tuzcu M, et al. Dose-dependent effect of a new biotin compound in hippocampal remyelination in rats. Mol Neurobiol. 2025;62(5):6503\u201320. https:\/\/doi.org\/10.1007\/s12035-025-04686-y.","journal-title":"Mol Neurobiol"},{"key":"799_CR41","doi-asserted-by":"publisher","unstructured":"Sahin K, Orhan C, Karatoprak S, Tuzcu M, Deeh PBD, Ozercan IH, et al. Therapeutic effects of a novel form of biotin on propionic acid-induced autistic features in rats. Nutrients. 2022;14(6):1280. https:\/\/doi.org\/10.3390\/nu14061280","DOI":"10.3390\/nu14061280"}],"container-title":["Current Nutrition Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13668-026-00799-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13668-026-00799-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13668-026-00799-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T03:26:36Z","timestamp":1789356396000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13668-026-00799-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,14]]},"references-count":41,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["799"],"URL":"https:\/\/doi.org\/10.1007\/s13668-026-00799-5","relation":{},"ISSN":["2161-3311"],"issn-type":[{"value":"2161-3311","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,14]]},"assertion":[{"value":"5 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"77"}}