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In adipose tissue, liver, skeletal muscle, pancreatic \u03b2 cells, and immune cells, dysregulated mTORC1-AMPK signaling, defective mitophagy, and impaired lysosomal function contribute to insulin resistance, ectopic lipid accumulation, and metaflammation. However, most human studies rely on static markers such as LC3, p62, and Beclin-1, which do not reliably reflect dynamic autophagic flux. Recent advances, including organelle-specific biomarkers, ex vivo functional assays, and circulating exosomal cargo, offer new translational opportunities, although standardization remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>Autophagy in metabolic disease represents a context-dependent maladaptation rather than a uniformly protective pathway. Future progress will depend on harmonized biomarker panels, functional assessment of autophagic flux in humans, and integration with metabolic phenotyping to enable precision-based therapeutic strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s13679-026-00716-5","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T04:39:59Z","timestamp":1778215199000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Autophagy in Obesity and Type 2 Diabetes: Beyond the Protective Paradigm"],"prefix":"10.1007","volume":"15","author":[{"given":"M. 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