{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T07:07:01Z","timestamp":1789110421001,"version":"build-2803163510"},"reference-count":125,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Curr Obes Rep"],"DOI":"10.1007\/s13679-026-00759-8","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T06:33:50Z","timestamp":1789108430000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Obesity-Related Tendon Pathology: Cardiometabolic Mechanisms, Clinical Implications, and Management"],"prefix":"10.1007","volume":"15","author":[{"given":"Hang","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5792-1860","authenticated-orcid":false,"given":"Jun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"key":"759_CR1","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/s41572-025-00602-9","volume":"11","author":"A Traweger","year":"2025","unstructured":"Traweger A, Scott A, Kjaer M, Wezenbeek E, Scattone Silva R, Kennedy JG, et al. Achilles tendinopathy. Nature reviews Disease primers. England. 2025;11:20. https:\/\/doi.org\/10.1038\/s41572-025-00602-9.","journal-title":"England"},{"key":"759_CR2","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1186\/s12891-019-2629-6","volume":"20","author":"H Riel","year":"2019","unstructured":"Riel H, Lindstr\u00f8m CF, Rathleff MS, Jensen MB, Olesen JL. Prevalence and incidence rate of lower-extremity tendinopathies in a Danish general practice: a registry-based study. BMC Musculoskelet disorders Engl. 2019;20:239. https:\/\/doi.org\/10.1186\/s12891-019-2629-6.","journal-title":"BMC Musculoskelet disorders Engl"},{"key":"759_CR3","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1007\/s12178-025-09993-4","volume":"18","author":"TJ Meredith","year":"2025","unstructured":"Meredith TJ, Hornsby H, Bagby J, Goodsell S. Diagnosis and management of common tendinopathies. Current reviews in musculoskeletal medicine. United States. 2025;18:620\u20136. https:\/\/doi.org\/10.1007\/s12178-025-09993-4.","journal-title":"United States"},{"key":"759_CR4","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1007\/s40279-026-02397-5","volume":"56","author":"R Kotsifaki","year":"2026","unstructured":"Kotsifaki R, Malliaras P, Byron C, Marques J, Korakakis V. Incidence temporal trends, and surgical shift of achilles tendon rupture: a systematic review and meta-analysis. Sports medicine (Auckland, NZ). New Z. 2026;56:1467\u201387. https:\/\/doi.org\/10.1007\/s40279-026-02397-5.","journal-title":"New Z"},{"key":"759_CR5","doi-asserted-by":"publisher","first-page":"2027","DOI":"10.1056\/NEJMcp1909797","volume":"391","author":"NB Jain","year":"2024","unstructured":"Jain NB, Khazzam MS. Degenerative rotator-cuff disorders. The New England journal of medicine. United States. 2024;391:2027\u201334. https:\/\/doi.org\/10.1056\/NEJMcp1909797.","journal-title":"United States"},{"key":"759_CR6","doi-asserted-by":"publisher","first-page":"2492","DOI":"10.1177\/0363546518781826","volume":"46","author":"P Eliasson","year":"2018","unstructured":"Eliasson P, Agergaard A-S, Coupp\u00e9 C, Svensson R, Hoeffner R, Warming S, et al. The ruptured achilles tendon elongates for 6 months after surgical repair regardless of early or late weightbearing in combination with ankle mobilization: a randomized clinical trial. The American journal of sports medicine. United States. 2018;46:2492\u2013502. https:\/\/doi.org\/10.1177\/0363546518781826.","journal-title":"United States"},{"key":"759_CR7","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1080\/03007995.2021.1918074","volume":"37","author":"N Parikh","year":"2021","unstructured":"Parikh N, Martinez DJ, Winer I, Costa L, Dua D, Trueman P. Direct and indirect economic burden associated with rotator cuff tears and repairs in the US. Current medical research and opinion. England. 2021;37:1199\u2013211. https:\/\/doi.org\/10.1080\/03007995.2021.1918074.","journal-title":"England"},{"key":"759_CR8","doi-asserted-by":"publisher","first-page":"6492597","DOI":"10.1155\/2016\/6492597","volume":"2016","author":"H-Y Li","year":"2016","unstructured":"Li H-Y, Hua Y-H. Achilles tendinopathy: current concepts about the basic science and clinical treatments. BioMed Res Int United States. 2016;2016:6492597. https:\/\/doi.org\/10.1155\/2016\/6492597.","journal-title":"BioMed Res Int United States"},{"key":"759_CR9","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.1016\/j.jse.2014.08.001","volume":"23","author":"T Teunis","year":"2014","unstructured":"Teunis T, Lubberts B, Reilly BT, Ring D. A systematic review and pooled analysis of the prevalence of rotator cuff disease with increasing age. J shoulder Elb Surg United States. 2014;23:1913\u201321. https:\/\/doi.org\/10.1016\/j.jse.2014.08.001.","journal-title":"J shoulder Elb Surg United States"},{"key":"759_CR10","doi-asserted-by":"publisher","first-page":"627","DOI":"10.2340\/16501977-2598","volume":"51","author":"HT Leong","year":"2019","unstructured":"Leong HT, Fu SC, He X, Oh JH, Yamamoto N, Hang S. Risk factors for rotator cuff tendinopathy: a systematic review and meta-analysis. J rehabilitation Med Swed. 2019;51:627\u201337. https:\/\/doi.org\/10.2340\/16501977-2598.","journal-title":"J rehabilitation Med Swed"},{"key":"759_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41572-020-00234-1","volume":"7","author":"NL Millar","year":"2021","unstructured":"Millar NL, Silbernagel KG, Thorborg K, Kirwan PD, Galatz LM, Abrams GD, et al. Tendinopathy. Nature reviews Disease primers. England. 2021;7:1. https:\/\/doi.org\/10.1038\/s41572-020-00234-1.","journal-title":"England"},{"key":"759_CR12","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.jsams.2014.06.004","volume":"18","author":"SI Docking","year":"2015","unstructured":"Docking SI, Rosengarten SD, Daffy J, Cook J. Structural integrity is decreased in both Achilles tendons in people with unilateral Achilles tendinopathy. Journal of science and medicine in sport. Australia. 2015;18:383\u20137. https:\/\/doi.org\/10.1016\/j.jsams.2014.06.004.","journal-title":"Australia"},{"key":"759_CR13","doi-asserted-by":"publisher","first-page":"2660","DOI":"10.1016\/j.jse.2021.05.010","volume":"30","author":"J Zhao","year":"2021","unstructured":"Zhao J, Luo M, Pan J, Liang G, Feng W, Zeng L, et al. Risk factors affecting rotator cuff retear after arthroscopic repair: a meta-analysis and systematic review. J shoulder Elb Surg United States. 2021;30:2660\u201370. https:\/\/doi.org\/10.1016\/j.jse.2021.05.010.","journal-title":"J shoulder Elb Surg United States"},{"key":"759_CR14","doi-asserted-by":"publisher","first-page":"2400","DOI":"10.1016\/j.jse.2023.05.030","volume":"32","author":"Z Yang","year":"2023","unstructured":"Yang Z, Chen W, Liang J, Liu T, Zhang B, Wang X, et al. Association of obesity with high retears and complication rates, and low functional scores after rotator cuff repair: a systematic review and meta-analysis. J shoulder Elb Surg United States. 2023;32:2400\u201311. https:\/\/doi.org\/10.1016\/j.jse.2023.05.030.","journal-title":"J shoulder Elb Surg United States"},{"key":"759_CR15","doi-asserted-by":"publisher","first-page":"1822","DOI":"10.1111\/sms.13984","volume":"31","author":"D Skovgaard","year":"2021","unstructured":"Skovgaard D, Siersma VD, Klausen SB, Visnes H, Haukenes I, Bang CW, et al. Chronic hyperglycemia, hypercholesterolemia, and metabolic syndrome are associated with risk of tendon injury. Scandinavian J Med Sci sports Denmark. 2021;31:1822\u201331. https:\/\/doi.org\/10.1111\/sms.13984.","journal-title":"Scandinavian J Med Sci sports Denmark"},{"key":"759_CR16","doi-asserted-by":"publisher","first-page":"e3417","DOI":"10.1002\/dmrr.3417","volume":"37","author":"F Cannata","year":"2021","unstructured":"Cannata F, Vadal\u00e0 G, Ambrosio L, Napoli N, Papalia R, Denaro V, et al. The impact of type 2 diabetes on the development of tendinopathy. Diabetes\/metabolism research and reviews. England. 2021;37:e3417. https:\/\/doi.org\/10.1002\/dmrr.3417.","journal-title":"England"},{"key":"759_CR17","doi-asserted-by":"publisher","first-page":"1839","DOI":"10.1097\/CORR.0000000000001261","volume":"478","author":"M Macchi","year":"2020","unstructured":"Macchi M, Spezia M, Elli S, Schiaffini G, Chisari E. Obesity Increases the Risk of Tendinopathy, Tendon Tear and Rupture, and Postoperative Complications: A Systematic Review of Clinical Studies. Clinical orthopaedics and related research. United States. 2020;478:1839\u201347. https:\/\/doi.org\/10.1097\/CORR.0000000000001261.","journal-title":"United States"},{"key":"759_CR18","doi-asserted-by":"publisher","unstructured":"Ndumele CE, Rodriguez F, Dixon DL, Khan SS, Mukherjee D, Bajaj M et al. 2026 AHA\/ACC\/ADA\/ASN Guideline for the prevention, detection, evaluation, and management of cardiovascular-kidney-metabolic syndrome: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. United States, 2026; https:\/\/doi.org\/10.1161\/CIR.0000000000001453.","DOI":"10.1161\/CIR.0000000000001453"},{"key":"759_CR19","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1016\/j.jacc.2015.06.1328","volume":"66","author":"LS Sperling","year":"2015","unstructured":"Sperling LS, Mechanick JI, Neeland IJ, Herrick CJ, Despr\u00e9s J-P, Ndumele CE, et al. The CardioMetabolic Health Alliance: Working Toward a New Care Model for the Metabolic Syndrome. J Am Coll Cardiol United States. 2015;66:1050\u201367. https:\/\/doi.org\/10.1016\/j.jacc.2015.06.1328.","journal-title":"J Am Coll Cardiol United States"},{"key":"759_CR20","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1016\/j.jacc.2010.05.034","volume":"56","author":"S Mottillo","year":"2010","unstructured":"Mottillo S, Filion KB, Genest J, Joseph L, Pilote L, Poirier P, et al. The metabolic syndrome and cardiovascular risk a systematic review and meta-analysis. J Am Coll Cardiol United States. 2010;56:1113\u201332. https:\/\/doi.org\/10.1016\/j.jacc.2010.05.034.","journal-title":"J Am Coll Cardiol United States"},{"key":"759_CR21","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1249\/MSS.0b013e31819794c3","volume":"41","author":"JE Gaida","year":"2009","unstructured":"Gaida JE, Alfredson L, Kiss ZS, Wilson AM, Alfredson H, Cook JL. Dyslipidemia in Achilles tendinopathy is characteristic of insulin resistance. Medicine and science in sports and exercise. United States. 2009;41:1194\u20137. https:\/\/doi.org\/10.1249\/MSS.0b013e31819794c3.","journal-title":"United States"},{"key":"759_CR22","doi-asserted-by":"publisher","first-page":"1491633","DOI":"10.3389\/fphar.2024.1491633","volume":"15","author":"J Xu","year":"2024","unstructured":"Xu J, Wang J, Ji Y, Liu Y, Jiang J, Wang Y, et al. The impact of diabetes mellitus on tendon pathology: a review. Front Pharmacol Switz. 2024;15:1491633. https:\/\/doi.org\/10.3389\/fphar.2024.1491633.","journal-title":"Front Pharmacol Switz"},{"key":"759_CR23","doi-asserted-by":"publisher","first-page":"2126","DOI":"10.1177\/0363546515588173","volume":"43","author":"TT-L Lin","year":"2015","unstructured":"Lin TT-L, Lin C-H, Chang C-L, Chi C-H, Chang S-T, Sheu WH-H. The effect of diabetes, hyperlipidemia, and statins on the development of rotator cuff disease: a nationwide, 11-year, longitudinal, population-based follow-up study. Am J sports Med United States. 2015;43:2126\u201332. https:\/\/doi.org\/10.1177\/0363546515588173.","journal-title":"Am J sports Med United States"},{"key":"759_CR24","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1093\/rheumatology\/kes395","volume":"52","author":"M Abate","year":"2013","unstructured":"Abate M, Schiavone C, Salini V, Andia I. Occurrence of tendon pathologies in metabolic disorders. Rheumatology (Oxford, England). England. 2013;52:599\u2013608. https:\/\/doi.org\/10.1093\/rheumatology\/kes395.","journal-title":"England"},{"key":"759_CR25","doi-asserted-by":"publisher","first-page":"e0257269","DOI":"10.1371\/journal.pone.0257269","volume":"16","author":"K Squier","year":"2021","unstructured":"Squier K, Scott A, Hunt MA, Brunham LR, Wilson DR, Screen H, et al. The effects of cholesterol accumulation on Achilles tendon biomechanics: A cross-sectional study. PloS one United States. 2021;16:e0257269. https:\/\/doi.org\/10.1371\/journal.pone.0257269.","journal-title":"PloS one United States"},{"key":"759_CR26","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1161\/HYPERTENSIONAHA.122.19465","volume":"80","author":"C De Ciuceis","year":"2023","unstructured":"De Ciuceis C, Rizzoni D, Palatini P. Microcirculation and Physical Exercise In Hypertension. Hypertension (Dallas, Tex: 1979). United States. 2023;80:730\u20139. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.122.19465.","journal-title":"United States"},{"key":"759_CR27","doi-asserted-by":"publisher","unstructured":"Park H, Bin, Gwark J-Y, Im J-H, Jung J, Na J-B, Yoon CH. Factors associated with atraumatic posterosuperior rotator cuff tears. The Journal of bone and joint surgery American volume. United States; 2018;100:1397\u2013405. https:\/\/doi.org\/10.2106\/JBJS.16.01592","DOI":"10.2106\/JBJS.16.01592"},{"key":"759_CR28","doi-asserted-by":"publisher","first-page":"e47818","DOI":"10.1097\/MD.0000000000047818","volume":"105","author":"Z Junbo","year":"2026","unstructured":"Junbo Z, Xiaodong L, Jie Y, Jiulong L. Impact of preoperative blood lipid levels on early outcomes following arthroscopic rotator cuff repair: A retrospective analysis. Med United States. 2026;105:e47818. https:\/\/doi.org\/10.1097\/MD.0000000000047818.","journal-title":"Med United States"},{"key":"759_CR29","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1002\/jor.26038","volume":"43","author":"KD Seymore","year":"2025","unstructured":"Seymore KD, Smitheman HP, Smith AK, Pohlig RT, Coupp\u00e9 C, Silbernagel KG. Metabolic Risk Factors Relate to Worse Tendon Health in Individuals With Achilles Tendinopathy. J Orthop research: official publication Orthop Res Soc United States. 2025;43:728\u201338. https:\/\/doi.org\/10.1002\/jor.26038.","journal-title":"J Orthop research: official publication Orthop Res Soc United States"},{"key":"759_CR30","doi-asserted-by":"publisher","first-page":"e70429","DOI":"10.1002\/jeo2.70429","volume":"12","author":"P De Luca","year":"2025","unstructured":"De Luca P, Grieco G, Bargeri S, Colombo C, Guida S, Taiana MM, et al. The interplay between metabolic disorders and tendinopathies: Systematic review and meta-analysis. J experimental Orthop United States. 2025;12:e70429. https:\/\/doi.org\/10.1002\/jeo2.70429.","journal-title":"J experimental Orthop United States"},{"key":"759_CR31","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.14670\/HH-18-712","volume":"39","author":"E Asomugha","year":"2024","unstructured":"Asomugha E, Cho Y, Paudel S, Guo Y, Schon L, Zhang Z. Localization of advanced glycation end-products and their receptor in tendinopathic lesions. Histology and histopathology. Spain. 2024;39:1209\u201315. https:\/\/doi.org\/10.14670\/HH-18-712.","journal-title":"Spain"},{"key":"759_CR32","doi-asserted-by":"publisher","unstructured":"Lee JM, Veres SP. Advanced glycation end-product cross-linking inhibits biomechanical plasticity and characteristic failure morphology of native tendon. Journal of applied physiology (Bethesda, Md: 1985). United States; 2019;126:832\u201341. https:\/\/doi.org\/10.1152\/japplphysiol.00430.2018","DOI":"10.1152\/japplphysiol.00430.2018"},{"key":"759_CR33","doi-asserted-by":"publisher","first-page":"17810","DOI":"10.1074\/jbc.272.28.17810","volume":"272","author":"HM Lander","year":"1997","unstructured":"Lander HM, Tauras JM, Ogiste JS, Hori O, Moss RA, Schmidt AM. Activation of the receptor for advanced glycation end products triggers a p21(ras)-dependent mitogen-activated protein kinase pathway regulated by oxidant stress. J Biol Chem United States. 1997;272:17810\u20134. https:\/\/doi.org\/10.1074\/jbc.272.28.17810.","journal-title":"J Biol Chem United States"},{"key":"759_CR34","doi-asserted-by":"publisher","first-page":"12614","DOI":"10.1038\/s41598-019-49062-8","volume":"9","author":"SH Patel","year":"2019","unstructured":"Patel SH, Yue F, Saw SK, Foguth R, Cannon JR, Shannahan JH, et al. Advanced glycation end-products suppress mitochondrial function and proliferative capacity of achilles tendon-derived fibroblasts. Sci Rep Engl. 2019;9:12614.https:\/\/doi.org\/10.1038\/s41598-019-49062-8.","journal-title":"Sci Rep Engl"},{"key":"759_CR35","doi-asserted-by":"publisher","first-page":"2335270","DOI":"10.1155\/2024\/2335270","volume":"2024","author":"P Lu","year":"2024","unstructured":"Lu P, Dai G, Shi L, Li Y, Zhang M, Wang H, et al. HMGB1 Modulates High Glucose-Induced Erroneous Differentiation of Tendon Stem\/Progenitor Cells through RAGE\/\u03b2-Catenin Pathway. Stem cells Int United States. 2024;2024:2335270. https:\/\/doi.org\/10.1155\/2024\/2335270.","journal-title":"Stem cells Int United States"},{"key":"759_CR36","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.atherosclerosis.2017.04.025","volume":"263","author":"LC Mangili","year":"2017","unstructured":"Mangili LC, Miname MH, Silva PRS, Bittencourt MS, Rocha VZ, Mangili OC, et al. Achilles tendon xanthomas are associated with the presence and burden of subclinical coronary atherosclerosis in heterozygous familial hypercholesterolemia: A pilot study. Atherosclerosis Irel. 2017;263:393\u20137. https:\/\/doi.org\/10.1016\/j.atherosclerosis.2017.04.025.","journal-title":"Atherosclerosis Irel"},{"key":"759_CR37","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1186\/s12967-021-03166-w","volume":"19","author":"M-M Liu","year":"2021","unstructured":"Liu M-M, Peng J, Guo Y-L, Zhu C-G, Wu N-Q, Xu R-X, et al. Relations of physical signs to genotype, lipid and inflammatory markers, coronary stenosis or calcification, and outcomes in patients with heterozygous familial hypercholesterolemia. J translational Med Engl. 2021;19:498. https:\/\/doi.org\/10.1186\/s12967-021-03166-w.","journal-title":"J translational Med Engl"},{"key":"759_CR38","doi-asserted-by":"publisher","first-page":"1871","DOI":"10.1002\/jor.25546","volume":"41","author":"CM Waugh","year":"2023","unstructured":"Waugh CM, Mousavizadeh R, Lee J, Screen HRC, Scott A. The impact of mild hypercholesterolemia on injury repair in the rat patellar tendon. J Orthop research: official publication Orthop Res Soc United States. 2023;41:1871\u201381. https:\/\/doi.org\/10.1002\/jor.25546.","journal-title":"J Orthop research: official publication Orthop Res Soc United States"},{"key":"759_CR39","doi-asserted-by":"publisher","first-page":"e114214","DOI":"10.1371\/journal.pone.0114214","volume":"9","author":"N Grewal","year":"2014","unstructured":"Grewal N, Thornton GM, Behzad H, Sharma A, Lu A, Zhang P, et al. Accumulation of oxidized LDL in the tendon tissues of C57BL\/6 or apolipoprotein E knock-out mice that consume a high fat diet: potential impact on tendon health. PloS one United States. 2014;9:e114214. https:\/\/doi.org\/10.1371\/journal.pone.0114214.","journal-title":"PloS one United States"},{"key":"759_CR40","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1186\/s12891-023-06308-x","volume":"24","author":"R Mousavizadeh","year":"2023","unstructured":"Mousavizadeh R, Waugh CM, DeBruin E, McCormack RG, Duronio V, Scott A. Exposure to oxLDL impairs TGF-\u03b2 activity in human tendon cells. BMC Musculoskelet disorders Engl. 2023;24:197. https:\/\/doi.org\/10.1186\/s12891-023-06308-x.","journal-title":"BMC Musculoskelet disorders Engl"},{"key":"759_CR41","doi-asserted-by":"publisher","first-page":"1820393","DOI":"10.3389\/fmed.2026.1820393","volume":"13","author":"P Shang","year":"2026","unstructured":"Shang P, Li R, Xia Y, Wang Z, Yang R, Fu Q. Hyperlipidemia-induced metabolic dysregulation impairs tendon homeostasis: the role of TGF-\u03b2\/Smad2 signaling pathway in lipid-mediated extracellular matrix remodeling. Front Med Switz. 2026;13:1820393. https:\/\/doi.org\/10.3389\/fmed.2026.1820393.","journal-title":"Front Med Switz"},{"key":"759_CR42","doi-asserted-by":"publisher","first-page":"102392","DOI":"10.1016\/j.tice.2024.102392","volume":"88","author":"SS Park","year":"2024","unstructured":"Park SS, Cho W, Lim DS, Gwon HJ, Choi SW, Abd El-Aty AM, et al. AMPK\/autophagy-mediated alleviation of tendinopathy by IL-38: A novel strategy for the treatment of obesity-related tendinopathy. Tissue cell Scotl. 2024;88:102392. https:\/\/doi.org\/10.1016\/j.tice.2024.102392.","journal-title":"Tissue cell Scotl"},{"key":"759_CR43","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/978-3-319-33943-6_14","volume":"920","author":"LJ Soslowsky","year":"2016","unstructured":"Soslowsky LJ, Fryhofer GW. Tendon Homeostasis in Hypercholesterolemia. Advances in experimental medicine and biology. United States. 2016;920:151\u201365. https:\/\/doi.org\/10.1007\/978-3-319-33943-6_14.","journal-title":"United States"},{"key":"759_CR44","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1093\/bmb\/ldab007","volume":"138","author":"S Elli","year":"2021","unstructured":"Elli S, Schiaffini G, Macchi M, Spezia M, Chisari E, Maffulli N. High-fat diet, adipokines and low-grade inflammation are associated with disrupted tendon healing: a systematic review of preclinical studies. Br Med Bull Engl. 2021;138:126\u201343. https:\/\/doi.org\/10.1093\/bmb\/ldab007.","journal-title":"Br Med Bull Engl"},{"key":"759_CR45","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1016\/S2213-8587(19)30084-1","volume":"7","author":"IJ Neeland","year":"2019","unstructured":"Neeland IJ, Ross R, Despr\u00e9s J-P, Matsuzawa Y, Yamashita S, Shai I, et al. Visceral and ectopic fat, atherosclerosis, and cardiometabolic disease: a position statement. lancet Diabetes Endocrinol Engl. 2019;7:715\u201325. https:\/\/doi.org\/10.1016\/S2213-8587(19)30084-1.","journal-title":"lancet Diabetes Endocrinol Engl"},{"key":"759_CR46","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.jot.2024.06.007","volume":"47","author":"Z Ma","year":"2024","unstructured":"Ma Z, Lee AYW, Kot CH, Yung PSH, Chen S-C, Lui PPY. Upregulation of FABP4 induced inflammation in the pathogenesis of chronic tendinopathy. J Orthop translation Singap. 2024;47:105\u201315. https:\/\/doi.org\/10.1016\/j.jot.2024.06.007.","journal-title":"J Orthop translation Singap"},{"key":"759_CR47","doi-asserted-by":"publisher","first-page":"114274","DOI":"10.1016\/j.yexcr.2024.114274","volume":"442","author":"C Lei","year":"2024","unstructured":"Lei C, Li Y, Chen J, Nie D, Song X, Lei C, et al. Leptin promotes tendon stem\/progenitor cell senescence through the AKT-mTOR signaling pathway. Experimental cell Res United States. 2024;442:114274. https:\/\/doi.org\/10.1016\/j.yexcr.2024.114274.","journal-title":"Experimental cell Res United States"},{"key":"759_CR48","doi-asserted-by":"publisher","first-page":"501","DOI":"10.55563\/clinexprheumatol\/avcj31","volume":"40","author":"C-W Zhao","year":"2022","unstructured":"Zhao C-W, Song W-X, Liu B, Gao Y-H, Ding L, Huang Y-F, et al. Resistin induces chemokine and matrix metalloproteinase production via CAP1 receptor and activation of p38-MAPK and NF-\u03baB signalling pathways in human chondrocytes. Clinical and experimental rheumatology. Italy. 2022;40:501\u201313. https:\/\/doi.org\/10.55563\/clinexprheumatol\/avcj31.","journal-title":"Italy"},{"key":"759_CR49","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1007\/s00441-022-03726-6","volume":"391","author":"EJ Smith","year":"2023","unstructured":"Smith EJ, Beaumont RE, McClellan A, Sze C, Palomino Lago E, Hazelgrove L, et al. Tumour necrosis factor alpha, interleukin 1 beta and interferon gamma have detrimental effects on equine tenocytes that cannot be rescued by IL-1RA or mesenchymal stromal cell-derived factors. Cell tissue Res Ger. 2023;391:523\u201344. https:\/\/doi.org\/10.1007\/s00441-022-03726-6.","journal-title":"Cell tissue Res Ger"},{"key":"759_CR50","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1186\/s13075-019-1855-5","volume":"21","author":"F Bergqvist","year":"2019","unstructured":"Bergqvist F, Carr AJ, Wheway K, Watkins B, Oppermann U, Jakobsson P-J, et al. Divergent roles of prostacyclin and PGE(2) in human tendinopathy. Arthritis Res therapy Engl. 2019;21:74. https:\/\/doi.org\/10.1186\/s13075-019-1855-5.","journal-title":"Arthritis Res therapy Engl"},{"key":"759_CR51","doi-asserted-by":"publisher","first-page":"9218","DOI":"10.1038\/s41598-018-27634-4","volume":"8","author":"V Studentsova","year":"2018","unstructured":"Studentsova V, Mora KM, Glasner MF, Buckley MR, Loiselle AE. Obesity\/Type II Diabetes Promotes Function-limiting Changes in Murine Tendons that are not reversed by Restoring Normal Metabolic Function. Scientific reports. England. 2018;8:9218. https:\/\/doi.org\/10.1038\/s41598-018-27634-4.","journal-title":"England"},{"key":"759_CR52","doi-asserted-by":"publisher","first-page":"e8740","DOI":"10.7717\/peerj.8740","volume":"8","author":"HY Tan","year":"2020","unstructured":"Tan HY, Tan SL, Teo SH, Roebuck MM, Frostick SP, Kamarul T. Development of a novel in vitro insulin resistance model in primary human tenocytes for diabetic tendinopathy research. PeerJ United States. 2020;8:e8740. https:\/\/doi.org\/10.7717\/peerj.8740.","journal-title":"PeerJ United States"},{"key":"759_CR53","doi-asserted-by":"publisher","first-page":"e293","DOI":"10.1016\/S2665-9913(23)00074-7","volume":"5","author":"LAN Crowe","year":"2023","unstructured":"Crowe LAN, Akbar M, de Vos R-J, Kirwan PD, Kjaer M, Pedret C, et al. Pathways driving tendinopathy and enthesitis: siblings or distant cousins in musculoskeletal medicine? Lancet Rheumatol Engl. 2023;5:e293\u2013304. https:\/\/doi.org\/10.1016\/S2665-9913(23)00074-7.","journal-title":"Lancet Rheumatol Engl"},{"key":"759_CR54","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1093\/jb\/mvad023","volume":"174","author":"R Kuan","year":"2023","unstructured":"Kuan R, Nath S, Agrawal DK, Thankam FG. Response to acute hyperglycemia and high fructose in cultured tenocytes. J Biochem Engl. 2023;174:71\u201380. https:\/\/doi.org\/10.1093\/jb\/mvad023.","journal-title":"J Biochem Engl"},{"key":"759_CR55","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1186\/s13287-020-01643-5","volume":"11","author":"K Li","year":"2020","unstructured":"Li K, Deng Y, Deng G, Chen P, Wang Y, Wu H, et al. High cholesterol induces apoptosis and autophagy through the ROS-activated AKT\/FOXO1 pathway in tendon-derived stem cells. Stem cell Res therapy Engl. 2020;11:131. https:\/\/doi.org\/10.1186\/s13287-020-01643-5.","journal-title":"Stem cell Res therapy Engl"},{"key":"759_CR56","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s00441-014-1871-3","volume":"357","author":"AS Ahmed","year":"2014","unstructured":"Ahmed AS, Li J, Schizas N, Ahmed M, Ostenson C-G, Salo P, et al. Expressional changes in growth and inflammatory mediators during Achilles tendon repair in diabetic rats: new insights into a possible basis for compromised healing. Cell tissue Res Ger. 2014;357:109\u201317. https:\/\/doi.org\/10.1007\/s00441-014-1871-3.","journal-title":"Cell tissue Res Ger"},{"key":"759_CR57","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.1001\/jama.295.14.1681","volume":"295","author":"L Monnier","year":"2006","unstructured":"Monnier L, Mas E, Ginet C, Michel F, Villon L, Cristol J-P, et al. Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes. JAMA United States. 2006;295:1681\u20137. https:\/\/doi.org\/10.1001\/jama.295.14.1681.","journal-title":"JAMA United States"},{"key":"759_CR58","doi-asserted-by":"publisher","first-page":"112652","DOI":"10.1016\/j.intimp.2024.112652","volume":"138","author":"Y Gao","year":"2024","unstructured":"Gao Y, Sun W, Wang J, Zhao D, Tian H, Qiu Y, et al. Oxidative stress induces ferroptosis in tendon stem cells by regulating mitophagy through cGAS-STING pathway. Int Immunopharmacol Neth. 2024;138:112652. https:\/\/doi.org\/10.1016\/j.intimp.2024.112652.","journal-title":"Int Immunopharmacol Neth"},{"key":"759_CR59","doi-asserted-by":"publisher","first-page":"e1074","DOI":"10.1038\/cddis.2014.52","volume":"5","author":"RC Poulsen","year":"2014","unstructured":"Poulsen RC, Knowles HJ, Carr AJ, Hulley PA. Cell differentiation versus cell death: extracellular glucose is a key determinant of cell fate following oxidative stress exposure. Cell death disease Engl. 2014;5:e1074. https:\/\/doi.org\/10.1038\/cddis.2014.52.","journal-title":"Cell death disease Engl"},{"key":"759_CR60","doi-asserted-by":"publisher","first-page":"8785042","DOI":"10.1155\/2017\/8785042","volume":"2017","author":"YW Lee","year":"2017","unstructured":"Lee YW, Fu SC, Yeung MY, Lau CML, Chan KM, Hung LK. Effects of redox modulation on cell proliferation, viability, and migration in cultured rat and human tendon progenitor cells. Oxid Med Cell Longev United States. 2017;2017:8785042. https:\/\/doi.org\/10.1155\/2017\/8785042","journal-title":"Oxid Med Cell Longev United States"},{"key":"759_CR61","doi-asserted-by":"publisher","first-page":"3268","DOI":"10.1002\/jor.24119","volume":"36","author":"S-C Fu","year":"2018","unstructured":"Fu S-C, Yeung M-Y, Rolf CG, Yung PS-H, Chan K-M, Hung L-K. Hydrogen peroxide induced tendinopathic changes in a rat model of patellar tendon injury. J Orthop research: official publication Orthop Res Soc United States. 2018;36:3268\u201374. https:\/\/doi.org\/10.1002\/jor.24119.","journal-title":"J Orthop research: official publication Orthop Res Soc United States"},{"key":"759_CR62","doi-asserted-by":"publisher","first-page":"256043","DOI":"10.1155\/2013\/256043","volume":"2013","author":"J Berlanga-Acosta","year":"2013","unstructured":"Berlanga-Acosta J, Schultz GS, L\u00f3pez-Mola E, Guillen-Nieto G, Garc\u00eda-Siverio M, Herrera-Mart\u00ednez L. Glucose toxic effects on granulation tissue productive cells: the diabetics\u2019 impaired healing. BioMed Res Int United States. 2013;2013:256043. https:\/\/doi.org\/10.1155\/2013\/256043.","journal-title":"BioMed Res Int United States"},{"key":"759_CR63","doi-asserted-by":"publisher","first-page":"1596","DOI":"10.1177\/03635465231160772","volume":"51","author":"H Uehara","year":"2023","unstructured":"Uehara H, Itoigawa Y, Morikawa D, Koga A, Tsurukami H, Maruyama Y, et al. The Effect of Vitamin C and N-Acetylcysteine on Tendon-to-Bone Healing in a Rodent Model of Rotator Cuff Repair. Am J sports Med United States. 2023;51:1596\u2013607. https:\/\/doi.org\/10.1177\/03635465231160772.","journal-title":"Am J sports Med United States"},{"key":"759_CR64","doi-asserted-by":"publisher","first-page":"10562","DOI":"10.1074\/jbc.RA119.011031","volume":"295","author":"M Stammers","year":"2020","unstructured":"Stammers M, Ivanova IM, Niewczas IS, Segonds-Pichon A, Streeter M, Spiegel DA, et al. Age-related changes in the physical properties, cross-linking, and glycation of collagen from mouse tail tendon. J Biol Chem United States. 2020;295:10562\u201371. https:\/\/doi.org\/10.1074\/jbc.RA119.011031.","journal-title":"J Biol Chem United States"},{"key":"759_CR65","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1038\/s12276-024-01183-5","volume":"56","author":"Z Chen","year":"2024","unstructured":"Chen Z, Li M, Chen P, Tai A, Li J, Bassonga EL, et al. Mechanical overload-induced release of extracellular mitochondrial particles from tendon cells leads to inflammation in tendinopathy. Experimental Mol Med United States. 2024;56:583\u201399. https:\/\/doi.org\/10.1038\/s12276-024-01183-5.","journal-title":"Experimental Mol Med United States"},{"key":"759_CR66","doi-asserted-by":"publisher","first-page":"104406","DOI":"10.1016\/j.knee.2026.104406","volume":"60","author":"T \u00c7atal","year":"2026","unstructured":"\u00c7atal T, Bayrak A. Quadriceps fat pad impingement: where patellofemoral maltracking meets the metabolic-inflammatory axis. Knee Neth. 2026;60:104406. https:\/\/doi.org\/10.1016\/j.knee.2026.104406.","journal-title":"Knee Neth"},{"key":"759_CR67","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.cca.2019.06.019","volume":"496","author":"P Reddy","year":"2019","unstructured":"Reddy P, Lent-Schochet D, Ramakrishnan N, McLaughlin M, Jialal I. Metabolic syndrome is an inflammatory disorder: A conspiracy between adipose tissue and phagocytes. Clinica chimica acta; international journal of clinical chemistry. Netherlands. 2019;496:35\u201344. https:\/\/doi.org\/10.1016\/j.cca.2019.06.019.","journal-title":"Netherlands"},{"key":"759_CR68","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1038\/s41440-020-00601-1","volume":"44","author":"J Gel\u017einsk\u00fd","year":"2021","unstructured":"Gel\u017einsk\u00fd J, Mayer OJ, Seidlerov\u00e1 J, Mate\u0159\u00e1nkov\u00e1 M, Mare\u0161 \u0160, Kord\u00edkova V, et al. Serum biomarkers, skin autofluorescence and other methods. Which parameter better illustrates the relationship between advanced glycation end products and arterial stiffness in the general population? Hypertens research: official J Japanese Soc Hypertens Engl. 2021;44:518\u201327. https:\/\/doi.org\/10.1038\/s41440-020-00601-1.","journal-title":"Hypertens research: official J Japanese Soc Hypertens Engl"},{"key":"759_CR69","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1186\/s12891-024-07760-z","volume":"25","author":"J Yang","year":"2024","unstructured":"Yang J, He J, Yang L. Advanced glycation end products impair the repair of injured tendon: a study in rats. BMC Musculoskelet disorders Engl. 2024;25:700. https:\/\/doi.org\/10.1186\/s12891-024-07760-z.","journal-title":"BMC Musculoskelet disorders Engl"},{"key":"759_CR70","doi-asserted-by":"publisher","first-page":"e70121","DOI":"10.1002\/jor.70121","volume":"44","author":"M An","year":"2026","unstructured":"An M, Gao F, Zhang B, Wu Y, Yu K, Li Z, et al. M2 Macrophage-Derived TGF-\u03b21 Drives Tendon Fibrosis in Rodent Tendinopathy Models. J Orthop research: official publication Orthop Res Soc United States. 2026;44:e70121. https:\/\/doi.org\/10.1002\/jor.70121.","journal-title":"J Orthop research: official publication Orthop Res Soc United States"},{"key":"759_CR71","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1016\/j.jacc.2018.05.044","volume":"72","author":"AC Sturm","year":"2018","unstructured":"Sturm AC, Knowles JW, Gidding SS, Ahmad ZS, Ahmed CD, Ballantyne CM, et al. Clinical Genetic Testing for Familial Hypercholesterolemia: JACC Scientific Expert Panel. J Am Coll Cardiol United States. 2018;72:662\u201380. https:\/\/doi.org\/10.1016\/j.jacc.2018.05.044.","journal-title":"J Am Coll Cardiol United States"},{"key":"759_CR72","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1016\/j.jacl.2026.01.011","volume":"20","author":"Z Ahmad","year":"2026","unstructured":"Ahmad Z, Agarwala A, Cuchel M, Barton Duell P, Hegele RA, Hudgins L, et al. Update on familial hypercholesterolemia: An expert clinical consensus from the National Lipid Association. J Clin Lipidol United States. 2026;20:708\u201337. https:\/\/doi.org\/10.1016\/j.jacl.2026.01.011.","journal-title":"J Clin Lipidol United States"},{"key":"759_CR73","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.atherosclerosis.2022.08.014","volume":"358","author":"M Michikura","year":"2022","unstructured":"Michikura M, Hori M, Ogura M, Hosoda K, Harada-Shiba M. The impact of gene variants on the thickness and softness of the Achilles tendon in familial hypercholesterolemia. Atherosclerosis Irel. 2022;358:41\u20136. https:\/\/doi.org\/10.1016\/j.atherosclerosis.2022.08.014.","journal-title":"Atherosclerosis Irel"},{"key":"759_CR74","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1186\/s12944-018-0765-x","volume":"17","author":"B Wang","year":"2018","unstructured":"Wang B, Zhang Q, Lin L, Pan L-L, He C-Y, Wan X-X, et al. Association of Achilles tendon thickness and LDL-cholesterol levels in patients with hypercholesterolemia. Lipids in health and disease. England. 2018;17:131. https:\/\/doi.org\/10.1186\/s12944-018-0765-x.","journal-title":"England"},{"key":"759_CR75","doi-asserted-by":"publisher","first-page":"e825","DOI":"10.1016\/j.jacl.2024.06.008","volume":"18","author":"H Tada","year":"2024","unstructured":"Tada H, Nohara A, Usui S, Sakata K, Kawashiri M-A, Takamura M. Validation of physical examinations of tendon xanthomas and changes in the cutoff values of Achilles tendon thickness on radiography in the clinical criteria of heterozygous familial hypercholesterolemia in Japan. J Clin Lipidol United States. 2024;18:e825\u201331. https:\/\/doi.org\/10.1016\/j.jacl.2024.06.008.","journal-title":"J Clin Lipidol United States"},{"key":"759_CR76","doi-asserted-by":"publisher","first-page":"578","DOI":"10.5551\/jat.65995","volume":"33","author":"S Fujioka","year":"2026","unstructured":"Fujioka S, Shishikura D, Sakaguchi K, Kusumoto H, Michikura M, Kanzaki Y, et al. Association of Achilles Tendon Thickness with Severity of Coronary Artery Disease in Non -Familial Hypercholesterolemia. J atherosclerosis Thromb Japan. 2026;33:578\u201388. https:\/\/doi.org\/10.5551\/jat.65995.","journal-title":"J atherosclerosis Thromb Japan"},{"key":"759_CR77","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1177\/00033197251326624","volume":"77","author":"A Tanita","year":"2026","unstructured":"Tanita A, Sunamura S, Suzuki M, Ogata T, Noda K, Takii T, et al. Structural Abnormalities of the Achilles Tendon are Associated With Coronary Artery Disease Even Without Achilles Tendon Thickening. Angiol United States. 2026;77:584\u201391. https:\/\/doi.org\/10.1177\/00033197251326624.","journal-title":"Angiol United States"},{"key":"759_CR78","doi-asserted-by":"publisher","unstructured":"Oyama Y, Ueki Y, Otagiri K, Itagaki T, Iguchi J, Okawa K, et al. Association between achilles tendon thickness as assessed by ultrasound and coronary artery disease severity in patients undergoing percutaneous coronary intervention. Angiol United States. 2026;33197261418308. https:\/\/doi.org\/10.1177\/00033197261418308.","DOI":"10.1177\/00033197261418308"},{"key":"759_CR79","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1177\/0003319720928226","volume":"71","author":"V Genkel","year":"2020","unstructured":"Genkel V, Kuznetsova A, Lebedev E, Sinitskii A, Pykhova L, Shaposhnik I. Achilles Tendon Thickness Is an Independent Predictor of Carotid Atherosclerosis and Is Associated With a Carotid Plaque Burden. Angiol United States. 2020;71:734\u20139. https:\/\/doi.org\/10.1177\/0003319720928226.","journal-title":"Angiol United States"},{"key":"759_CR80","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1136\/bjsports-2024-109185","volume":"59","author":"P Malliaras","year":"2025","unstructured":"Malliaras P, Gravare Silbernagel K, de Vos R-J, Bourke J, Sancho I, Hanlon SL, et al. Diagnostic domains, differential diagnosis and conditions requiring further medical attention that are considered important in the assessment for Achilles tendinopathy: a Delphi consensus study. Br J sports Med Engl. 2025;59:891\u2013901. https:\/\/doi.org\/10.1136\/bjsports-2024-109185.","journal-title":"Br J sports Med Engl"},{"key":"759_CR81","doi-asserted-by":"publisher","first-page":"40127","DOI":"10.57187\/smw.2023.40127","volume":"153","author":"M De Montmollin","year":"2023","unstructured":"De Montmollin M, B\u00e9trisey S, Feller M, Moutzouri E, Blum MR, Amsler J, et al. Achilles tendon ultrasonography in the clinical screening of familial hypercholesterolaemia - a cross-sectional analysis. Swiss Med Wkly Switz. 2023;153:40127. https:\/\/doi.org\/10.57187\/smw.2023.40127.","journal-title":"Swiss Med Wkly Switz"},{"key":"759_CR82","doi-asserted-by":"publisher","first-page":"816","DOI":"10.5551\/jat.62869","volume":"29","author":"H Tada","year":"2022","unstructured":"Tada H, Hori M, Matsuki K, Ogura M, Nohara A, Kawashiri M-A, et al. Achilles Tendon Thickness Assessed by X-ray Predicting a Pathogenic Mutation in Familial Hypercholesterolemia Gene. J atherosclerosis Thromb Japan. 2022;29:816\u201324. https:\/\/doi.org\/10.5551\/jat.62869.","journal-title":"J atherosclerosis Thromb Japan"},{"key":"759_CR83","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1093\/clinchem\/hvad080","volume":"69","author":"DB Sacks","year":"2023","unstructured":"Sacks DB, Arnold M, Bakris GL, Bruns DE, Horvath AR, Lernmark \u00c5, et al. Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus. Clin Chem Engl. 2023;69:808\u201368. https:\/\/doi.org\/10.1093\/clinchem\/hvad080.","journal-title":"Clin Chem Engl"},{"key":"759_CR84","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1001\/jama.2025.5956","volume":"334","author":"RR Kalyani","year":"2025","unstructured":"Kalyani RR, Neumiller JJ, Maruthur NM, Wexler DJ. Diagnosis and Treatment of Type 2 Diabetes in Adults: A Review. JAMA United States. 2025;334:984\u20131002. https:\/\/doi.org\/10.1001\/jama.2025.5956.","journal-title":"JAMA United States"},{"key":"759_CR85","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1001\/jama.2021.12531","volume":"326","author":"KW Davidson","year":"2021","unstructured":"Davidson KW, Barry MJ, Mangione CM, Cabana M, Caughey AB, Davis EM, et al. Screening for Prediabetes and Type 2 Diabetes: US Preventive Services Task Force Recommendation Statement. JAMA United States. 2021;326:736\u201343. https:\/\/doi.org\/10.1001\/jama.2021.12531.","journal-title":"JAMA United States"},{"key":"759_CR86","doi-asserted-by":"publisher","first-page":"1935","DOI":"10.1016\/j.jacc.2014.01.060","volume":"63","author":"AD Sniderman","year":"2014","unstructured":"Sniderman AD, Tsimikas S, Fazio S. The severe hypercholesterolemia phenotype: clinical diagnosis, management, and emerging therapies. J Am Coll Cardiol United States. 2014;63:1935\u201347. https:\/\/doi.org\/10.1016\/j.jacc.2014.01.060.","journal-title":"J Am Coll Cardiol United States"},{"key":"759_CR87","doi-asserted-by":"publisher","first-page":"2167","DOI":"10.1161\/CIR.0000000000000297","volume":"132","author":"SS Gidding","year":"2015","unstructured":"Gidding SS, Champagne MA, de Ferranti SD, Defesche J, Ito MK, Knowles JW, et al. The Agenda for Familial Hypercholesterolemia: A Scientific Statement From the American Heart Association. Circulation United States. 2015;132:2167\u201392. https:\/\/doi.org\/10.1161\/CIR.0000000000000297.","journal-title":"Circulation United States"},{"key":"759_CR88","doi-asserted-by":"publisher","first-page":"CD012985","DOI":"10.1002\/14651858.CD012985.pub2","volume":"10","author":"N Qureshi","year":"2021","unstructured":"Qureshi N, Da Silva MLR, Abdul-Hamid H, Weng SF, Kai J, Leonardi-Bee J. Strategies for screening for familial hypercholesterolaemia in primary care and other community settings. The Cochrane database of systematic reviews. England. 2021;10:CD012985. https:\/\/doi.org\/10.1002\/14651858.CD012985.pub2.","journal-title":"England"},{"key":"759_CR89","doi-asserted-by":"publisher","first-page":"1640","DOI":"10.1161\/CIRCULATIONAHA.109.192644","volume":"120","author":"KGMM Alberti","year":"2009","unstructured":"Alberti KGMM, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association. Harmonizing the metabolic syndrome: a joint interim statement of. Circulation United States. 2009;120:1640\u20135. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.109.192644. World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity.","journal-title":"Circulation United States"},{"key":"759_CR90","doi-asserted-by":"publisher","first-page":"CPG1","DOI":"10.2519\/jospt.2024.0302","volume":"54","author":"RL Chimenti","year":"2024","unstructured":"Chimenti RL, Neville C, Houck J, Cuddeford T, Carreira D, Martin RL. Achilles Pain, Stiffness, and Muscle Power Deficits: Midportion Achilles Tendinopathy Revision\u2009\u2013\u20092024. J Orthop sports Phys therapy United States. 2024;54:CPG1\u201332. https:\/\/doi.org\/10.2519\/jospt.2024.0302.","journal-title":"J Orthop sports Phys therapy United States"},{"key":"759_CR91","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1111\/sms.12824","volume":"27","author":"PPY Lui","year":"2017","unstructured":"Lui PPY. Tendinopathy in diabetes mellitus patients-Epidemiology, pathogenesis, and management. Scandinavian journal of medicine & science in sports. Denmark. 2017;27:776\u201387. https:\/\/doi.org\/10.1111\/sms.12824.","journal-title":"Denmark"},{"key":"759_CR92","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ejrad.2018.10.003","volume":"109","author":"L Zhang","year":"2018","unstructured":"Zhang L, Yong Q, Pu T, Zheng C, Wang M, Shi S, et al. Grayscale ultrasonic and shear wave elastographic characteristics of the Achilles\u2019 tendon in patients with familial hypercholesterolemia: A pilot study. Eur J Radiol Irel. 2018;109:1\u20137. https:\/\/doi.org\/10.1016\/j.ejrad.2018.10.003.","journal-title":"Eur J Radiol Irel"},{"key":"759_CR93","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1186\/s12891-021-04494-0","volume":"22","author":"TM Zahradnik","year":"2021","unstructured":"Zahradnik TM, Cresswell M, Squier K, Waugh C, Brunham L, Screen H, et al. Can Achilles tendon xanthoma be distinguished from Achilles tendinopathy using Dixon method MRI? A cross-sectional exploratory study. BMC Musculoskelet disorders Engl. 2021;22:627. https:\/\/doi.org\/10.1186\/s12891-021-04494-0.","journal-title":"BMC Musculoskelet disorders Engl"},{"key":"759_CR94","doi-asserted-by":"publisher","first-page":"2989","DOI":"10.1016\/j.ultrasmedbio.2020.07.023","volume":"46","author":"CS Harish","year":"2020","unstructured":"Harish CS, Dixit R, Singh S, Garg S. Sonoelastographic Evaluation of the Achilles Tendon in Patients With Type 2 Diabetes Mellitus. Ultrasound in medicine & biology. England. 2020;46:2989\u201397. https:\/\/doi.org\/10.1016\/j.ultrasmedbio.2020.07.023.","journal-title":"England"},{"key":"759_CR95","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1186\/s12891-025-08864-w","volume":"26","author":"T Wang","year":"2025","unstructured":"Wang T, He Y, Yi W, Xie H, Wang D, Zeng J, et al. Shear wave elastography of the supraspinatus tendon with early degeneration in asymptomatic type II diabetes mellitus patients: a multicenter study. BMC Musculoskelet disorders Engl. 2025;26:637. https:\/\/doi.org\/10.1186\/s12891-025-08864-w.","journal-title":"BMC Musculoskelet disorders Engl"},{"key":"759_CR96","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1016\/j.eprac.2022.08.002","volume":"28","author":"L Blonde","year":"2022","unstructured":"Blonde L, Umpierrez GE, Reddy SS, McGill JB, Berga SL, Bush M, et al. American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update. Endocrine practice: official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. United States. 2022;28:923\u20131049. https:\/\/doi.org\/10.1016\/j.eprac.2022.08.002.","journal-title":"United States"},{"key":"759_CR97","doi-asserted-by":"publisher","unstructured":"Oliva F, Marsilio E, Asparago G, Giai Via A, Biz C, Padulo J, et al. Achilles tendon rupture and dysmetabolic diseases: a multicentric, epidemiologic study. Journal of clinical medicine. Switzerland. 2022;11. https:\/\/doi.org\/10.3390\/jcm11133698.","DOI":"10.3390\/jcm11133698"},{"key":"759_CR98","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1001\/jama.2020.7840","volume":"324","author":"NR Smilowitz","year":"2020","unstructured":"Smilowitz NR, Berger JS. Perioperative Cardiovascular Risk Assessment and Management for Noncardiac Surgery: A Review. JAMA United States. 2020;324:279\u201390. https:\/\/doi.org\/10.1001\/jama.2020.7840.","journal-title":"JAMA United States"},{"key":"759_CR99","doi-asserted-by":"publisher","first-page":"e351","DOI":"10.1161\/CIR.0000000000001285","volume":"150","author":"A de Thompson","year":"2024","unstructured":"Thompson A, Fleischmann KE, Smilowitz NR, de Las Fuentes L, Mukherjee D, Aggarwal NR, et al. AHA\/ACC\/ACS\/ASNC\/HRS\/SCA\/SCCT\/SCMR\/SVM Guideline for perioperative cardiovascular management for noncardiac surgery: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation United States. 2024;150:e351\u2013442. https:\/\/doi.org\/10.1161\/CIR.0000000000001285.","journal-title":"Circulation United States"},{"key":"759_CR100","doi-asserted-by":"publisher","first-page":"1636","DOI":"10.1161\/CIR.0000000000001186","volume":"148","author":"CE Ndumele","year":"2023","unstructured":"Ndumele CE, Neeland IJ, Tuttle KR, Chow SL, Mathew RO, Khan SS, et al. A Synopsis of the Evidence for the Science and Clinical Management of Cardiovascular-Kidney-Metabolic (CKM) Syndrome: A Scientific Statement From the American Heart Association. Circulation United States. 2023;148:1636\u201364. https:\/\/doi.org\/10.1161\/CIR.0000000000001186.","journal-title":"Circulation United States"},{"key":"759_CR101","doi-asserted-by":"publisher","first-page":"264","DOI":"10.2519\/jospt.2021.10428","volume":"51","author":"C Gleadhill","year":"2021","unstructured":"Gleadhill C, Kamper SJ, Lee H, Williams CM. Exploring Integrated Care for Musculoskeletal and Chronic Health Conditions. The Journal of orthopaedic and sports physical therapy. United States. 2021;51:264\u20138. https:\/\/doi.org\/10.2519\/jospt.2021.10428.","journal-title":"United States"},{"issue":"2","key":"759_CR102","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1111\/dom.16296","volume":"27","author":"I Idris","year":"2025","unstructured":"Idris I, Anyiam O. The latest evidence and guidance in lifestyle and surgical interventions to achieve weight loss in people with overweight or obesity. Diabetes Obes Metab Engl. 2025;27(2):20\u201334. https:\/\/doi.org\/10.1111\/dom.16296.","journal-title":"Diabetes Obes Metab Engl"},{"key":"759_CR103","doi-asserted-by":"publisher","first-page":"116010","DOI":"10.1016\/j.intimp.2025.116010","volume":"169","author":"X Zhang","year":"2026","unstructured":"Zhang X, Chi R, Xu J, Meng C, Wang Z, Ruo W, et al. GLP-1 receptor agonist liraglutide facilitates rotator cuff healing by reducing tendon cell inflammation and endoplasmic reticulum stress through the GLP-1R-AMPK\/SIRT1 pathway. Int Immunopharmacol Neth. 2026;169:116010. https:\/\/doi.org\/10.1016\/j.intimp.2025.116010.","journal-title":"Int Immunopharmacol Neth"},{"key":"759_CR104","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.arthro.2024.09.057","volume":"41","author":"AE Seddio","year":"2025","unstructured":"Seddio AE, Moran J, Gouzoulis MJ, Garbis NG, Salazar DH, Grauer JN et al. Lower Risk of postoperative complications and rotator cuff retear associated with semaglutide use in patients with type II diabetes mellitus undergoing arthroscopic rotator cuff repair. Arthroscopy: the journal of arthroscopic & related surgery: official publication of the Arthroscopy Association of North America and the International Arthroscopy Association. United States, 2025;41:199\u2013206. https:\/\/doi.org\/10.1016\/j.arthro.2024.09.057.","journal-title":"Arthroscopy: the journal of arthroscopic &amp; related surgery: official publication of the Arthroscopy Association of North America and the International Arthroscopy Association. United States"},{"key":"759_CR105","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.jor.2025.08.016","volume":"70","author":"ST Rasmussen","year":"2025","unstructured":"Rasmussen ST, Ilyas AM. Glucagon-like Peptide-1 receptor agonist use is not associated with increased reoperation risk following rotator cuff repair. J Orthop India. 2025;70:235\u201340. https:\/\/doi.org\/10.1016\/j.jor.2025.08.016.","journal-title":"J Orthop India"},{"key":"759_CR106","doi-asserted-by":"publisher","first-page":"1810","DOI":"10.1111\/sms.13734","volume":"30","author":"A Irby","year":"2020","unstructured":"Irby A, Gutierrez J, Chamberlin C, Thomas SJ, Rosen AB. Clinical management of tendinopathy: A systematic review of systematic reviews evaluating the effectiveness of tendinopathy treatments. Scandinavian J Med Sci sports Denmark. 2020;30:1810\u201326. https:\/\/doi.org\/10.1111\/sms.13734.","journal-title":"Scandinavian J Med Sci sports Denmark"},{"key":"759_CR107","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1177\/0363546515584760","volume":"43","author":"R Beyer","year":"2015","unstructured":"Beyer R, Kongsgaard M, Hougs Kj\u00e6r B, \u00d8hlenschl\u00e6ger T, Kj\u00e6r M, Magnusson SP. Heavy Slow Resistance Versus Eccentric Training as Treatment for Achilles Tendinopathy: A Randomized Controlled Trial. The American journal of sports medicine. United States. 2015;43:1704\u201311. https:\/\/doi.org\/10.1177\/0363546515584760.","journal-title":"United States"},{"key":"759_CR108","doi-asserted-by":"publisher","first-page":"e39171","DOI":"10.1016\/j.heliyon.2024.e39171","volume":"10","author":"Y Li","year":"2024","unstructured":"Li Y, Sun D, Fang Y, Lu Z, Shi F, Liu G, et al. Mixed comparison of intervention with eccentric, isometric, and heavy slow resistance for Victorian Institute of Sport Assessment Patella Questionnaire in adults with patellar tendinopathy: A systematic review and network meta-analysis. Heliyon Engl. 2024;10:e39171. https:\/\/doi.org\/10.1016\/j.heliyon.2024.e39171.","journal-title":"Heliyon Engl"},{"key":"759_CR109","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1053\/j.jfas.2021.03.020","volume":"61","author":"YH Park","year":"2022","unstructured":"Park YH, Kim W, Kim JY, Choi GW, Kim HJ. Clinical impact of metabolic syndrome on eccentric exercises for chronic insertional achilles tendinopathy. J Foot Ankle Surg United States. 2022;61:726\u20139. https:\/\/doi.org\/10.1053\/j.jfas.2021.03.020.","journal-title":"J Foot Ankle Surg United States"},{"key":"759_CR110","doi-asserted-by":"publisher","first-page":"100925","DOI":"10.1016\/j.rh.2025.100925","volume":"59","author":"R Tedeschi","year":"2025","unstructured":"Tedeschi R. Rethinking pain in lower limb rehabilitation: A call to address nociplastic mechanisms. Rehabilitacion Spain. 2025;59:100925. https:\/\/doi.org\/10.1016\/j.rh.2025.100925.","journal-title":"Rehabilitacion Spain"},{"key":"759_CR111","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1007\/s00337-024-01112-7","volume":"63","author":"R Tedeschi","year":"2025","unstructured":"Tedeschi R, Platano D, Donati D, Giorgi F. Functional approaches in tendinopathy rehabilitation: exploring the role of tendon neuroplastic training. Manuelle Medizin [Internet]. 2025;63:177\u201383. https:\/\/doi.org\/10.1007\/s00337-024-01112-7.","journal-title":"Manuelle Medizin [Internet]"},{"key":"759_CR112","doi-asserted-by":"publisher","first-page":"e0172797","DOI":"10.1371\/journal.pone.0172797","volume":"12","author":"P Eliasson","year":"2017","unstructured":"Eliasson P, Svensson RB, Giannopoulos A, Eismark C, Kj\u00e6r M, Schjerling P, et al. Simvastatin and atorvastatin reduce the mechanical properties of tendon constructs in vitro and introduce catabolic changes in the gene expression pattern. PloS one United States. 2017;12:e0172797. https:\/\/doi.org\/10.1371\/journal.pone.0172797.","journal-title":"PloS one United States"},{"key":"759_CR113","doi-asserted-by":"publisher","first-page":"17958","DOI":"10.1038\/s41598-019-53238-7","volume":"9","author":"P Eliasson","year":"2019","unstructured":"Eliasson P, Dietrich-Zagonel F, Lundin A-C, Aspenberg P, Wolk A, Micha\u00eblsson K. Statin treatment increases the clinical risk of tendinopathy through matrix metalloproteinase release - a cohort study design combined with an experimental study. Sci Rep Engl. 2019;9:17958. https:\/\/doi.org\/10.1038\/s41598-019-53238-7.","journal-title":"Sci Rep Engl"},{"key":"759_CR114","doi-asserted-by":"publisher","first-page":"457","DOI":"10.26355\/eurrev_202510_37466","volume":"29","author":"G Anzillotti","year":"2025","unstructured":"Anzillotti G, Vespasiano F, \u00d6ttl F, Conte P, Minelli M, Raspugli GF, et al. Statins: bitter enemies of tendons or not? A systematic review of clinical evidence. European review for medical and pharmacological sciences. Italy. 2025;29:457\u201369. https:\/\/doi.org\/10.26355\/eurrev_202510_37466.","journal-title":"Italy"},{"key":"759_CR115","doi-asserted-by":"publisher","unstructured":"Manocchio N, Pirri C, Sorbino A, Giordani L, Vita G, Ljoka C, et al. Shoulder tendinopathy induced by statins: a case report and systematic review. J personalized Med Switz. 2025;15. https:\/\/doi.org\/10.3390\/jpm15050198.","DOI":"10.3390\/jpm15050198"},{"key":"759_CR116","doi-asserted-by":"publisher","first-page":"e38","DOI":"10.1161\/ATV.0000000000000073","volume":"39","author":"CB Newman","year":"2019","unstructured":"Newman CB, Preiss D, Tobert JA, Jacobson TA, Page RL 2nd, Goldstein LB, et al. Statin Safety and Associated Adverse Events: A Scientific Statement From the American Heart Association. Arteriosclerosis, thrombosis, and vascular biology. United States. 2019;39:e38\u201381. https:\/\/doi.org\/10.1161\/ATV.0000000000000073.","journal-title":"United States"},{"key":"759_CR117","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1001\/jama.2021.6986","volume":"326","author":"RS Kearney","year":"2021","unstructured":"Kearney RS, Ji C, Warwick J, Parsons N, Brown J, Harrison P, et al. Effect of Platelet-Rich Plasma Injection vs Sham Injection on Tendon Dysfunction in Patients With Chronic Midportion Achilles Tendinopathy: A Randomized Clinical Trial. JAMA United States. 2021;326:137\u201344. https:\/\/doi.org\/10.1001\/jama.2021.6986.","journal-title":"JAMA United States"},{"key":"759_CR118","doi-asserted-by":"publisher","first-page":"2117","DOI":"10.2106\/JBJS.22.00149","volume":"104","author":"DL Lamanna","year":"2022","unstructured":"Lamanna DL, McDonnell ME, Chen AF, Gallagher JM. Perioperative Identification and Management of Hyperglycemia in Orthopaedic Surgery. The Journal of bone and joint surgery American volume. United States. 2022;104:2117\u201326. https:\/\/doi.org\/10.2106\/JBJS.22.00149.","journal-title":"United States"},{"key":"759_CR119","doi-asserted-by":"publisher","first-page":"902142","DOI":"10.3389\/fendo.2022.902142","volume":"13","author":"L He","year":"2022","unstructured":"He L, Yu T, Zhang W, Wang B, Ma Y, Li S. Causal Associations of Obesity With Achilles Tendinopathy: A Two-Sample Mendelian Randomization Study. Frontiers in endocrinology. Switzerland. 2022;13:902142. https:\/\/doi.org\/10.3389\/fendo.2022.902142.","journal-title":"Switzerland"},{"key":"759_CR120","doi-asserted-by":"publisher","first-page":"5273198","DOI":"10.1155\/2024\/5273198","volume":"2024","author":"M Marzagalli","year":"2024","unstructured":"Marzagalli M, Battaglia S, Raimondi M, Fontana F, Cozzi M, Ranieri FR, et al. Anti-Inflammatory and Antioxidant Properties of a New Mixture of Vitamin C, Collagen Peptides, Resveratrol, and Astaxanthin in Tenocytes: Molecular Basis for Future Applications in Tendinopathies. Mediators Inflamm United States. 2024;2024:5273198. https:\/\/doi.org\/10.1155\/2024\/5273198.","journal-title":"Mediators Inflamm United States"},{"key":"759_CR121","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1111\/nyas.14599","volume":"1490","author":"X Zhang","year":"2021","unstructured":"Zhang X, Eliasberg CD, Rodeo SA. Mitochondrial dysfunction and potential mitochondrial protectant treatments in tendinopathy. Ann N Y Acad Sci. 2021;1490:29\u201341. https:\/\/doi.org\/10.1111\/nyas.14599.","journal-title":"Ann N Y Acad Sci"},{"key":"759_CR122","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1186\/s12915-023-01613-2","volume":"21","author":"W Fu","year":"2023","unstructured":"Fu W, Yang R, Li J. Single-cell and spatial transcriptomics reveal changes in cell heterogeneity during progression of human tendinopathy. BMC biology Engl. 2023;21:132. https:\/\/doi.org\/10.1186\/s12915-023-01613-2.","journal-title":"BMC biology Engl"},{"key":"759_CR123","doi-asserted-by":"publisher","first-page":"1092778","DOI":"10.3389\/fimmu.2023.1092778","volume":"14","author":"J Guo","year":"2023","unstructured":"Guo J, Tang H, Huang P, Ye X, Tang C, Shu Z, et al. Integrative single-cell RNA and ATAC sequencing reveals that the FOXO1-PRDX2-TNF axis regulates tendinopathy. Front Immunol Switz. 2023;14:1092778. https:\/\/doi.org\/10.3389\/fimmu.2023.1092778.","journal-title":"Front Immunol Switz"},{"key":"759_CR124","doi-asserted-by":"publisher","first-page":"117085","DOI":"10.1016\/j.celrep.2026.117085","volume":"45","author":"A Kurjan","year":"2026","unstructured":"Kurjan A, Mimpen JY, Ramos-Mucci L, Aksu AC, Cohen CJ, Naszai M, et al. Cellular and molecular landscapes of human tendons across the lifespan revealed by spatial and single-cell transcriptomics. Cell Rep United States. 2026;45:117085. https:\/\/doi.org\/10.1016\/j.celrep.2026.117085.","journal-title":"Cell Rep United States"},{"key":"759_CR125","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1002\/jor.25112","volume":"40","author":"KJ Sikes","year":"2022","unstructured":"Sikes KJ, McConnell A, Serkova N, Cole B, Frisbie D. Untargeted metabolomics analysis identifies creatine, myo-inositol, and lipid pathway modulation in a murine model of tendinopathy. J Orthop research: official publication Orthop Res Soc United States. 2022;40:965\u201376. https:\/\/doi.org\/10.1002\/jor.25112.","journal-title":"J Orthop research: official publication Orthop Res Soc United States"}],"container-title":["Current Obesity Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13679-026-00759-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13679-026-00759-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13679-026-00759-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T06:33:52Z","timestamp":1789108432000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13679-026-00759-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,11]]},"references-count":125,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["759"],"URL":"https:\/\/doi.org\/10.1007\/s13679-026-00759-8","relation":{},"ISSN":["2162-4968"],"issn-type":[{"value":"2162-4968","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,11]]},"assertion":[{"value":"1 July 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This manuscript is a narrative review based on previously published studies. It involved no new research with human participants or animals; therefore, ethical approval and informed consent were not applicable.","order":1,"name":"Ethics","label":"Ethics statement","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for Publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"81"}}