{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T19:21:36Z","timestamp":1740165696190,"version":"3.37.3"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T00:00:00Z","timestamp":1721952000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T00:00:00Z","timestamp":1721952000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Canc Conf J"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Patients with hereditary breast and ovarian cancer syndrome (HBOC) are associated with an increased risk of developing pancreatic cancer (PC) than the general population. There is no consensus about the clinical value of F-18-fluorodeoxyglucose (FDG)-positron emission tomography\/computed tomography (PET\/CT) in patients with HBOC. We report a patient with HBOC in whom PC was detected incidentally by PET\/CT. A 48-year-old woman complaining of a right breast mass sought evaluation at our hospital. Her older brother died of PC at 49 years of age. Histologic analysis of the breast mass revealed breast cancer (BC). FDG-PET\/CT showed unanticipated FDG accumulation in the pancreas. Magnetic resonance cholangiopancreatography (MRCP) revealed a mass in the pancreas approximately 25mm in size. Endoscopic ultrasound guided-fine needle aspiration biopsy (EUS-FNA) demonstrated PC.\u00a0Genetic testing showed a <jats:italic>BRCA2<\/jats:italic> pathologic variant [NM_000059.4(BRCA2): c.9076C\u2009&gt;\u2009T (p.Gln3026Ter)]. She was referred to a university hospital and underwent surgery after neoadjuvant chemotherapy for PC. It is difficult to detect operable PC in most patients. The diagnostic utility of PET\/CT for PC in high-risk patients, such as those with HBOC, is undetermined. Our case has demonstrated the clinical value of PET\/CT in detecting incidental PC in HBOC patients.<\/jats:p>","DOI":"10.1007\/s13691-024-00705-2","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T21:02:35Z","timestamp":1722027755000},"page":"433-439","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Incidental detection of pancreatic cancer by F-18-fluorodeoxyglucose positron emission tomography\/computed tomography in a patient with hereditary breast and ovarian cancer syndrome"],"prefix":"10.1007","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6842-8527","authenticated-orcid":false,"given":"Naotaka","family":"Uchida","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miho","family":"Takehita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takako","family":"Suda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,7,26]]},"reference":[{"key":"705_CR1","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1001\/jamaoncol.2022.0476","volume":"8","author":"Y Momozawa","year":"2022","unstructured":"Momozawa Y, Sasai R, Usui Y et al (2022) Expansion of cancer risk profile for BRCA1 and BRCA2 pathogenic variants. JAMA Oncol 8:871\u2013878","journal-title":"JAMA Oncol"},{"key":"705_CR2","unstructured":"NCCN org. (2024) NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines\u00ae). Genetic\/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic. Version 2.2024 \u2014 September 27, https:\/\/www.nccn.org., Accessed Jan 2024."},{"key":"705_CR3","unstructured":"NCBI ClinVar HP. https:\/\/www.ncbi.nlm.nih.gov\/clinvar\/variation\/38207\/?new_evidence=true., Accessed Feb 2023."},{"key":"705_CR4","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1136\/gutjnl-2012-303108","volume":"62","author":"MI Canto","year":"2013","unstructured":"Canto MI, Harinck F, Hruban RH et al (2013) International Cancer of the Pancreas Screening (CAPS) Consortium summit on the management of patients with increased risk for familial pancreatic cancer. 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