{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T20:04:12Z","timestamp":1779912252142,"version":"3.53.1"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2014,3,14]],"date-time":"2014-03-14T00:00:00Z","timestamp":1394755200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CEN Case Rep"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1007\/s13730-014-0114-5","type":"journal-article","created":{"date-parts":[[2014,3,13]],"date-time":"2014-03-13T18:23:22Z","timestamp":1394735002000},"page":"183-187","source":"Crossref","is-referenced-by-count":3,"title":["Adefovir-induced Fanconi syndrome: diagnostic pearls and perils of late or missed diagnosis"],"prefix":"10.1007","volume":"3","author":[{"given":"Samuel Shang Ming","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy Peng Lim","family":"Quek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cherng Jye","family":"Seow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melvin Khee Shing","family":"Leow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,3,14]]},"reference":[{"key":"114_CR1","first-page":"195","volume":"4","author":"F Assadi","year":"2010","unstructured":"Assadi F. Hypophosphatemia: an evidence-based problem-solving approach to clinical cases. Iran J Kidney Dis. 2010;4:195\u2013201.","journal-title":"Iran J Kidney Dis"},{"key":"114_CR2","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0140-6736(75)92736-1","volume":"2","author":"RJ Walton","year":"1975","unstructured":"Walton RJ, Bijvoet OL. Nomogram for derivation of renal threshold phosphate concentration. Lancet. 1975;2:309\u201310.","journal-title":"Lancet"},{"key":"114_CR3","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1210\/jc.2011-1319","volume":"97","author":"EA Imel","year":"2012","unstructured":"Imel EA, Econs MJ. Approach to the hypophosphatemic patient. J Clin Endocrinol Metab. 2012;97:696\u2013706.","journal-title":"J Clin Endocrinol Metab"},{"key":"114_CR4","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3350\/kjhep.2008.14.3.381","volume":"14","author":"HJ Lee","year":"2008","unstructured":"Lee HJ, Choi JW, Kim TN, Eun JR. A case of severe hypophosphatemia related to adefovir dipivoxil treatment in a patient with liver cirrhosis related to hepatitis B virus. Korean J Hepatol. 2008;14:381\u20136.","journal-title":"Korean J Hepatol"},{"key":"114_CR5","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1097\/QAD.0b013e32832407f7","volume":"23","author":"H Izzedine","year":"2009","unstructured":"Izzedine H, Kheder-Elfekih R, Housset P, Sarkozy C, Brocheriou I, Deray G. Adefovir dipivoxil-induced acute tubular necrosis and Fanconi syndrome in a renal transplant patient. AIDS. 2009;23:544\u20135.","journal-title":"AIDS"},{"key":"114_CR6","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1210\/jc.2009-2051","volume":"95","author":"T Wong","year":"2010","unstructured":"Wong T, Girgis CM, Ngu MC, et al. Hypophosphatemic osteomalacia after low-dose adefovir dipivoxil therapy for hepatitis B. J Clin Endocrinol Metab. 2010;95:479\u201380.","journal-title":"J Clin Endocrinol Metab"},{"key":"114_CR7","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1097\/MCG.0b013e3181e12ed3","volume":"45","author":"CM Girgis","year":"2011","unstructured":"Girgis CM, Wong T, Ngu MC, et al. Hypophosphatemic osteomalacia in patients on adefovir dipivoxil. J Clin Gastroenterol. 2011;45:468\u201373.","journal-title":"J Clin Gastroenterol"},{"key":"114_CR8","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/j.1365-2710.2011.01278.x","volume":"37","author":"ST Law","year":"2012","unstructured":"Law ST, Li KK, Ho YY. Nephrotoxicity, including acquired Fanconi\u2019s syndrome, caused by adefovir dipivoxil\u2014is there a safe dose? J Clin Pharm Ther. 2012;37:128\u201331.","journal-title":"J Clin Pharm Ther"},{"key":"114_CR9","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/1746-1596-7-108","volume":"7","author":"M Tanaka","year":"2012","unstructured":"Tanaka M, Setoguchi T, Ishidou Y, et al. Pathological femoral fractures due to osteomalacia associated with adefovir dipivoxil treatment for hepatitis B: a case report. Diagn Pathol. 2012;7:108.","journal-title":"Diagn Pathol"},{"key":"114_CR10","doi-asserted-by":"crossref","first-page":"389","DOI":"10.5009\/gnl.2010.4.3.389","volume":"4","author":"YK Jung","year":"2010","unstructured":"Jung YK, Yeon JE, Choi JH, et al. Fanconi\u2019s syndrome associated with prolonged adefovir dipivoxil therapy in a hepatitis B virus patient. Gut Liver. 2010;4:389\u201393.","journal-title":"Gut Liver"},{"key":"114_CR11","doi-asserted-by":"crossref","first-page":"442","DOI":"10.4254\/wjh.v2.i12.442","volume":"2","author":"M Minemura","year":"2010","unstructured":"Minemura M, Tokimitsu Y, Tajiri K, et al. Development of osteomalacia in a post-liver transplant patient receiving adefovir dipivoxil. World J Hepatol. 2010;2:442\u20136.","journal-title":"World J Hepatol"},{"key":"114_CR12","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/jcpt.12050","volume":"38","author":"C Wu","year":"2013","unstructured":"Wu C, Zhang H, Qian Y, Wang L, Gu X, Dai Z. Hypophosphatemic osteomalacia and renal Fanconi syndrome induced by low-dose adefovir dipivoxil: a case report and literature review suggesting ethnic predisposition. J Clin Pharm Ther. 2013;38:321\u20136.","journal-title":"J Clin Pharm Ther"},{"key":"114_CR13","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1111\/j.1523-1755.2004.00866.x","volume":"66","author":"H Izzedine","year":"2004","unstructured":"Izzedine H, Hulot JS, Launay-Vacher V, et al. Renal safety of adefovir dipivoxil in patients with chronic hepatitis B: two double-blind, randomized, placebo-controlled studies. Kidney Int. 2004;66:1153\u20138.","journal-title":"Kidney Int"},{"key":"114_CR14","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1056\/NEJMoa042957","volume":"352","author":"SJ Hadziyannis","year":"2005","unstructured":"Hadziyannis SJ, Tassopoulos NC, Heathcote EJ, et al. Long-term therapy with adefovir dipivoxil for HBeAg-negative chronic hepatitis B. N Engl J Med. 2005;352:2673\u201381.","journal-title":"N Engl J Med"},{"key":"114_CR15","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1097\/00002030-200109070-00013","volume":"15","author":"EJ Fisher","year":"2001","unstructured":"Fisher EJ, Chaloner K, Cohn DL, et al. The safety and efficacy of adefovir dipivoxil in patients with advanced HIV disease: a randomized, placebo-controlled trial. AIDS. 2001;15:1695\u2013700.","journal-title":"AIDS"},{"key":"114_CR16","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1053\/hupa.2001.25586","volume":"32","author":"N Tanji","year":"2001","unstructured":"Tanji N, Tanji K, Kambham N, Markowitz GS, Bell A, D\u2019agati VD. Adefovir nephrotoxicity: possible role of mitochondrial DNA depletion. Hum Pathol. 2001;32:734\u201340.","journal-title":"Hum Pathol"},{"key":"114_CR17","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s00223-004-0285-8","volume":"77","author":"A Brandao-Burch","year":"2005","unstructured":"Brandao-Burch A, Utting JC, Orriss IR, Arnett TR. Acidosis inhibits bone formation by osteoblasts in vitro by preventing mineralization. Calcif Tissue Int. 2005;77:167\u201374.","journal-title":"Calcif Tissue Int"},{"key":"114_CR18","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/j.1365-2265.1995.tb02621.x","volume":"43","author":"BL Clarke","year":"1995","unstructured":"Clarke BL, Wynne AG, Wilson DM, Fitzpatrick LA. Osteomalacia associated with adult Fanconi\u2019s syndrome: clinical and diagnostic features. Clin Endocrinol (Oxf). 1995;43:479\u201390.","journal-title":"Clin Endocrinol (Oxf)"}],"container-title":["CEN Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13730-014-0114-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13730-014-0114-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13730-014-0114-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T12:44:57Z","timestamp":1559479497000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13730-014-0114-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,14]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["114"],"URL":"https:\/\/doi.org\/10.1007\/s13730-014-0114-5","relation":{},"ISSN":["2192-4449"],"issn-type":[{"value":"2192-4449","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,14]]}}}