{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:52:02Z","timestamp":1782604322578,"version":"3.54.5"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T00:00:00Z","timestamp":1549324800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["CEN Case Rep"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1007\/s13730-019-00382-8","type":"journal-article","created":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T13:00:26Z","timestamp":1549371626000},"page":"159-165","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Remission of light chain proximal tubulopathy in IgG \u03bb-type multiple myeloma by lenalidomide and dexamethasone therapy"],"prefix":"10.1007","volume":"8","author":[{"given":"Shinya","family":"Kawamoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Hidaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Misawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhiro","family":"Nagahori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsunori","family":"Yoshino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takamitsu","family":"Okamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Ban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiko","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuro","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,2,5]]},"reference":[{"key":"382_CR1","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1053\/j.ackd.2013.08.009","volume":"21","author":"N Leung","year":"2014","unstructured":"Leung N, Nasr SH. Myeloma-related kidney disease. Adv Chronic Kidney Dis. 2014;21:36\u201347.","journal-title":"Adv Chronic Kidney Dis"},{"key":"382_CR2","doi-asserted-by":"publisher","first-page":"21","DOI":"10.4065\/78.1.21","volume":"78","author":"RA Kyle","year":"2003","unstructured":"Kyle RA, Gertz MA, Witzig TE. Review of 1027 patients with newly diagnosed multiple myeloma. Mayo Clin Proc. 2003;78:21\u201333.","journal-title":"Mayo Clin Proc"},{"key":"382_CR3","doi-asserted-by":"crossref","unstructured":"Nasr SH, Valeri AM, Sethi S. Clinicopathologic correlations in multiple myeloma: a case series of 190 patients with kidney biopsies. 2012;5+:786\u2013794.","DOI":"10.1053\/j.ajkd.2011.12.028"},{"key":"382_CR4","doi-asserted-by":"publisher","first-page":"713","DOI":"10.5858\/arpa.2011-0565-RA","volume":"136","author":"LC Herlitz","year":"2012","unstructured":"Herlitz LC, D\u2019Agati VD, Markowitz GS. Crystalline nephropathies. Arch Pathol Lab Med. 2012;136:713\u201320.","journal-title":"Arch Pathol Lab Med"},{"key":"382_CR5","first-page":"959","volume-title":"Heptinstall\u2019s pathology of the kidney","author":"GA Herrera","year":"2015","unstructured":"Herrera GA. Proximal tubulopathies monoclonal light chain mediated (proximal light chain tubulopathy). In: Jennette JC, editor. Heptinstall\u2019s pathology of the kidney, 7th ed. Philadelphia: Wolters Kluwer; 2015. pp.\u00a0959\u201363.","edition":"7"},{"key":"382_CR6","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1038\/modpathol.2011.104","volume":"24","author":"CP Larsen","year":"2011","unstructured":"Larsen CP, Bell JM, Harris AA. The morphologic spectrum and clinical significance of light chain proximal tubulopathy with and without crystal formation. Mod Pathol. 2011;24:1462\u20139.","journal-title":"Mod Pathol"},{"key":"382_CR7","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.5858\/arpa.2013-0493-OA","volume":"138","author":"GA Herrera","year":"2014","unstructured":"Herrera GA. Proximal tubulopathies associated with monoclonal light chains: the spectrum of clinicopathologic manifestations and molecular pathogenesis. Arch Pathol Lab Med. 2014;138:1365\u201380.","journal-title":"Arch Pathol Lab Med"},{"key":"382_CR8","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1681\/ASN.2015020185","volume":"27","author":"MB Stokes","year":"2016","unstructured":"Stokes MB, Valeri AM, Herlitz L, Khan AM, Sjegel DS, Markowiz GS, D\u2019Agati VD. Light chain proximal tubulopathy: clinical and pathologic characteristics in the modern treatment era. J Am Soc Nephrol. 2016;27:1555\u201365.","journal-title":"J Am Soc Nephrol"},{"issue":"4","key":"382_CR9","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.ekir.2016.08.005","volume":"1","author":"AJ Gallan","year":"2016","unstructured":"Gallan AJ, Khalighi MA. Lambda light chain crystalline cast nephropathy and proximal tubulopathy. Kidney Int Rep. 2016;1(4):316\u201320.","journal-title":"Kidney Int Rep"},{"issue":"4","key":"382_CR10","doi-asserted-by":"publisher","first-page":"813","DOI":"10.2169\/naika.106.813","volume":"106","author":"M Yamashige","year":"2017","unstructured":"Yamashige M, Gotoh S, Nakano J, Gotoh K, Nakai K, Fujii H, Hara S, Nishi S. A case of Fanconi syndrome due to light chain proximal tubulopathy. J Jpn Soc Intern Med. 2017;106(4):813\u20137.","journal-title":"J Jpn Soc Intern Med"},{"key":"382_CR11","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1038\/ki.2008.666","volume":"76","author":"LC Herlitz","year":"2009","unstructured":"Herlitz LC, Roglieri J, Resta R, Bhagat G, Markowitz GS. Light chain proximal tubulopathy. Kidney Int. 2009;76:792\u20137.","journal-title":"Kidney Int"},{"key":"382_CR12","doi-asserted-by":"crossref","first-page":"3561","DOI":"10.4049\/jimmunol.150.8.3561","volume":"150","author":"P Aucounturier","year":"1993","unstructured":"Aucounturier P, Bauwens M, Khamlichi AA, Denoroy L, Spinelli S, Touchard G, Preud\u2019homme JL, Cogn\u00e9 M. Monoclonal Ig L chain and L chain V domain fragment crystallization in myeloma-associated Fanconi syndrome. J Immunol. 1993;150:3561\u20138.","journal-title":"J Immunol"},{"key":"382_CR13","doi-asserted-by":"publisher","first-page":"2148","DOI":"10.1038\/sj.ki.5001990","volume":"70","author":"SH Nasr","year":"2006","unstructured":"Nasr SH, Galgano SJ, Markowitz GS, Stokes MB, D\u2019Agati VD. Immunofluorescence on pronase-digested paraffin sections: a valuable salvage technique for renal biopsies. Kidney Int. 2006;70:2148\u201351.","journal-title":"Kidney Int"},{"key":"382_CR14","doi-asserted-by":"publisher","first-page":"3583","DOI":"10.1182\/blood-2013-05-495929","volume":"122","author":"JP Fermand","year":"2013","unstructured":"Fermand JP, Bridoux F, Kyle RA. How I treat monoclonal gammopathy of renal significance (MGRS). Blood. 2013;122:3583\u201390.","journal-title":"Blood"},{"key":"382_CR15","doi-asserted-by":"publisher","first-page":"2533","DOI":"10.1681\/ASN.2006020139","volume":"17","author":"SM Korbet","year":"2006","unstructured":"Korbet SM, Schwartz MM. Multiple myeloma. J Am Soc Nephrol. 2006;17:2533\u201345.","journal-title":"J Am Soc Nephrol"},{"key":"382_CR16","doi-asserted-by":"publisher","first-page":"2123","DOI":"10.1056\/NEJMoa070594","volume":"357","author":"M Dimopoulos","year":"2007","unstructured":"Dimopoulos M, Spencer A, Attal M, Prince M, Harousseau JL, Dmoszynska A, Miguel JS, Hellmann A, Facon T, Fo\u00e0 R, Corso A, Masliak Z. Lenalidomide plus dexamethasone for relapsed or refractory multiple myeloma. N Engl J Med. 2007;357:2123\u201332.","journal-title":"N Engl J Med"},{"key":"382_CR17","doi-asserted-by":"publisher","first-page":"1770","DOI":"10.1056\/NEJMoa1114083","volume":"366","author":"PL McCarthy","year":"2012","unstructured":"McCarthy PL, Owzar K, Hofmeister CC, Hurd DD, Hassoun H, Richardson PG, Giralt S, Stadtmauer EA, Weisdorf DJ, Vij R, Moreb JS, Callander NS. Lenalidomide after stem-cell transplantation for multiple myeloma. N Engl J Med. 2012;366:1770\u201381.","journal-title":"N Engl J Med"},{"key":"382_CR18","doi-asserted-by":"publisher","first-page":"4280","DOI":"10.1074\/jbc.M116.733030","volume":"292","author":"M Furukawa","year":"2017","unstructured":"Furukawa M, Ohkawara H, Ogawa K, Ikeda K, Ueda K, Nakamura AS, Ito M, Imai J, Yanagisawa Y, Honma R, Watanabe S, Waguri S, Ikezoe T, Takahashi H. Autocrine and paracrine interactions between multiple myeloma cells and bone marrow stromal cells by growth arrest-specific gene 6 cross-talk with interleukin-6. J Biol Chem. 2017;292:4280\u201392.","journal-title":"J Biol Chem"},{"key":"382_CR19","doi-asserted-by":"publisher","unstructured":"Kimura S, Ohkawara H, Ogawa K, Tanaka M, Sano T, Shirado HK, Takahashi H, Ueda K, Nakamura AS, Matsumoto H, Kazama JJ, Hashimoto Y, Ikezoe T. Lenalidomide as a beneficial treatment option for renal impairment caused by light chain deposition disease: a case series. Intern Med Adv Publ. https:\/\/doi.org\/10.2169\/internalmedicine.1018-18 .","DOI":"10.2169\/internalmedicine.1018-18"}],"container-title":["CEN Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s13730-019-00382-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13730-019-00382-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s13730-019-00382-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T11:46:28Z","timestamp":1694605588000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s13730-019-00382-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,5]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["382"],"URL":"https:\/\/doi.org\/10.1007\/s13730-019-00382-8","relation":{},"ISSN":["2192-4449"],"issn-type":[{"value":"2192-4449","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,5]]},"assertion":[{"value":"28 August 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 January 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 February 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any studies with human participants performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and animal rights"}},{"value":"Informed consent was obtained from participants included in the article.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}