{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:58:28Z","timestamp":1788350308547,"version":"build-2803163510"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2020,10,4]],"date-time":"2020-10-04T00:00:00Z","timestamp":1601769600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,10,4]],"date-time":"2020-10-04T00:00:00Z","timestamp":1601769600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["CEN Case Rep"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The coronavirus disease 2019 (COVID-19) pandemic is now a major global health threat. More than half a year have passed since the first discovery of severe acute respiratory syndrome coronavirus-2 (SARS-CoV2), no effective treatment has been established especially in intensive care unit. Inflammatory cytokine storm caused by SARS-CoV-2 infection has been reported to play a central role in COVID-19; therefore, treatments for suppressing cytokines, including extracorporeal treatments, are considered to be beneficial. However, until today the efficacy of removing cytokines by extracorporeal treatments in patients with COVID-19 is unclear. Herein, we report our experience with a 66-year-old male patient undergoing maintenance peritoneal dialysis who became critically ill with COVID-19 and underwent several extracorporeal treatment approaches including plasma exchange, direct hemoperfusion using a polymyxin B-immobilized fiber column and continuous hemodiafiltration. Though the patient developed acute respiratory distress syndrome (ARDS) repeatedly and subacute cerebral infarction and finally died for respiratory failure on day 30 after admission, these attempts appeared to dampen the cytokine storm based on the observed decline in serum IL-6 levels and were effective against ARDS and secondary haemophagocytic lymphohistiocytosis. This case suggests the significance of timely initiation of extracorporeal treatment approaches in critically ill patients with COVID-19.<\/jats:p>","DOI":"10.1007\/s13730-020-00538-x","type":"journal-article","created":{"date-parts":[[2020,10,4]],"date-time":"2020-10-04T02:02:25Z","timestamp":1601776945000},"page":"172-177","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Continuous extracorporeal treatments in a dialysis patient with COVID-19"],"prefix":"10.1007","volume":"10","author":[{"given":"Yoshihito","family":"Nihei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Nagasawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Fukao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Kihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohito","family":"Gohda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,10,4]]},"reference":[{"issue":"8","key":"538_CR1","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1056\/NEJMoa2001017","volume":"382","author":"N Zhu","year":"2020","unstructured":"Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020;382(8):727\u201333. https:\/\/doi.org\/10.1056\/NEJMoa2001017.","journal-title":"N Engl J Med"},{"issue":"10229","key":"538_CR2","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1016\/s0140-6736(20)30628-0","volume":"395","author":"P Mehta","year":"2020","unstructured":"Mehta P, McAuley DF, Brown M, Sanchez E, Tattersall RS, Manson JJ. COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet. 2020;395(10229):1033\u20134. https:\/\/doi.org\/10.1016\/s0140-6736(20)30628-0.","journal-title":"Lancet"},{"issue":"3","key":"538_CR3","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/j.ccc.2012.04.009","volume":"28","author":"TC Nguyen","year":"2012","unstructured":"Nguyen TC, Kiss JE, Goldman JR, Carcillo JA. The role of plasmapheresis in critical illness. Crit Care Clin. 2012;28(3):453\u201368. https:\/\/doi.org\/10.1016\/j.ccc.2012.04.009.","journal-title":"Crit Care Clin"},{"issue":"2","key":"538_CR4","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1002\/rcr2.100","volume":"3","author":"NG Binh","year":"2015","unstructured":"Binh NG, Manabe T, Co DX, Tuan ND, Thach PT, Kudo K. Polymyxin-B-immobilized-fiber column hemoperfusion with oseltamivir treatment for ARDS due to influenza H1N1\/09. Respirol Case Rep. 2015;3(2):57\u201360. https:\/\/doi.org\/10.1002\/rcr2.100.","journal-title":"Respirol Case Rep"},{"key":"538_CR5","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.tmaid.2019.03.004","volume":"29","author":"SH Alfaraj","year":"2019","unstructured":"Alfaraj SH, Al-Tawfiq JA, Assiri AY, Alzahrani NA, Alanazi AA, Memish ZA. Clinical predictors of mortality of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection: a cohort study. Travel Med Infect Dis. 2019;29:48\u201350. https:\/\/doi.org\/10.1016\/j.tmaid.2019.03.004.","journal-title":"Travel Med Infect Dis"},{"issue":"2","key":"538_CR6","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.cell.2020.02.052","volume":"181","author":"M Hoffmann","year":"2020","unstructured":"Hoffmann M, Kleine-Weber H, Schroeder S, Kr\u00fcger N, Herrler T, Erichsen S, et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020;181(2):271\u201380.e8. https:\/\/doi.org\/10.1016\/j.cell.2020.02.052.","journal-title":"Cell"},{"issue":"12","key":"538_CR7","doi-asserted-by":"publisher","first-page":"2153","DOI":"10.1093\/ndt\/17.12.2153","volume":"17","author":"EA Hoste","year":"2002","unstructured":"Hoste EA, Vanholder RC, Lameire NH, Roosens CD, Decruyenaere JM, Blot SI, et al. No early respiratory benefit with CVVHDF in patients with acute renal failure and acute lung injury. Nephrol Dial Transplant. 2002;17(12):2153\u20138. https:\/\/doi.org\/10.1093\/ndt\/17.12.2153.","journal-title":"Nephrol Dial Transplant"},{"issue":"10229","key":"538_CR8","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1016\/s0140-6736(20)30566-3","volume":"395","author":"F Zhou","year":"2020","unstructured":"Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395(10229):1054\u201362. https:\/\/doi.org\/10.1016\/s0140-6736(20)30566-3.","journal-title":"Lancet"},{"issue":"5","key":"538_CR9","doi-asserted-by":"publisher","first-page":"457","DOI":"10.3851\/imp3210","volume":"23","author":"LM Favi\u00e9","year":"2018","unstructured":"Favi\u00e9 LM, Murk JL, Meijer A, Nijstad AL, van Maarseveen EM, Sikma MA. Pharmacokinetics of favipiravir during continuous venovenous haemofiltration in a critically ill patient with influenza. Antivir Ther. 2018;23(5):457\u201361. https:\/\/doi.org\/10.3851\/imp3210.","journal-title":"Antivir Ther"},{"key":"538_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2020.105974","author":"H Shi","year":"2020","unstructured":"Shi H, Zhou C, He P, Huang S, Duan Y, Wang X, et al. Successful treatment with plasma exchange followed by intravenous immunoglobulin in a critically ill patient with COVID-19. Int J Antimicrob Agents. 2020. https:\/\/doi.org\/10.1016\/j.ijantimicag.2020.105974.","journal-title":"Int J Antimicrob Agents"},{"issue":"6490","key":"538_CR11","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1126\/science.abb8925","volume":"368","author":"JB Moore","year":"2020","unstructured":"Moore JB, June CH. Cytokine release syndrome in severe COVID-19. Science. 2020;368(6490):473\u20134. https:\/\/doi.org\/10.1126\/science.abb8925.","journal-title":"Science"},{"issue":"5","key":"538_CR12","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/nrneph.2013.44","volume":"9","author":"MG Betjes","year":"2013","unstructured":"Betjes MG. Immune cell dysfunction and inflammation in end-stage renal disease. Nat Rev Nephrol. 2013;9(5):255\u201365. https:\/\/doi.org\/10.1038\/nrneph.2013.44.","journal-title":"Nat Rev Nephrol"},{"issue":"1","key":"538_CR13","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.jaci.2020.04.013","volume":"146","author":"I Quinti","year":"2020","unstructured":"Quinti I, Lougaris V, Milito C, Cinetto F, Pecoraro A, Mezzaroma I, et al. A possible role for B cells in COVID-19 Lesson from patients with agammaglobulinemia. J Allergy Clin Immunol. 2020;146(1):211\u20133.e4. https:\/\/doi.org\/10.1016\/j.jaci.2020.04.013.","journal-title":"J Allergy Clin Immunol"},{"issue":"3","key":"538_CR14","doi-asserted-by":"publisher","first-page":"offa102","DOI":"10.1093\/ofid\/ofaa102","volume":"7","author":"W Cao","year":"2020","unstructured":"Cao W, Liu X, Bai T, Fan H, Hong K, Song H, et al. High-dose intravenous immunoglobulin as a therapeutic option for deteriorating patients with coronavirus disease 2019. Open Forum Infect Dis. 2020;7(3):offa102. https:\/\/doi.org\/10.1093\/ofid\/ofaa102.","journal-title":"Open Forum Infect Dis"},{"issue":"4","key":"538_CR15","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1111\/jth.14768","volume":"18","author":"N Tang","year":"2020","unstructured":"Tang N, Li D, Wang X, Sun Z. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost. 2020;18(4):844\u20137. https:\/\/doi.org\/10.1111\/jth.14768.","journal-title":"J Thromb Haemost"}],"container-title":["CEN Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13730-020-00538-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13730-020-00538-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13730-020-00538-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T19:36:52Z","timestamp":1633376212000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13730-020-00538-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,4]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["538"],"URL":"https:\/\/doi.org\/10.1007\/s13730-020-00538-x","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-63251\/v1","asserted-by":"object"},{"id-type":"doi","id":"10.21203\/rs.3.rs-63251\/v2","asserted-by":"object"}]},"ISSN":["2192-4449"],"issn-type":[{"value":"2192-4449","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,4]]},"assertion":[{"value":"7 August 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 September 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 October 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any studies with animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and animal rights"}},{"value":"Informed consent was obtained from the patient in the present case. The patient consented to publish their case, clinical data and accompanying images.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}