{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T19:24:30Z","timestamp":1740165870447,"version":"3.37.3"},"reference-count":6,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T00:00:00Z","timestamp":1616025600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T00:00:00Z","timestamp":1616025600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["CEN Case Rep"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1007\/s13730-021-00591-0","type":"journal-article","created":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T19:12:58Z","timestamp":1616094778000},"page":"614-615","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["m.3243A&gt;G carriers develop syndromic or non-syndromic multisystem phenotypes over time"],"prefix":"10.1007","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2839-7305","authenticated-orcid":false,"given":"J.","family":"Finsterer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,3,18]]},"reference":[{"key":"591_CR1","doi-asserted-by":"publisher","DOI":"10.1007\/s13730-020-00547-w","author":"K Tanaka","year":"2020","unstructured":"Tanaka K, Ueno T, Yoshida M, Shimizu Y, Ogawa T, Nishisaka T, Kurashige T, Masaki T. Chronic kidney disease caused by maternally inherited diabetes and deafness: a case report. CEN Case Rep. 2020. https:\/\/doi.org\/10.1007\/s13730-020-00547-w.","journal-title":"CEN Case Rep"},{"key":"591_CR2","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.ymgme.2015.06.004","volume":"116","author":"AW El-Hattab","year":"2015","unstructured":"El-Hattab AW, Adesina AM, Jones J, Scaglia F. MELAS syndrome: clinical manifestations, pathogenesis, and treatment options. Mol Genet Metab. 2015;116:4\u201312.","journal-title":"Mol Genet Metab"},{"key":"591_CR3","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1111\/j.1464-5491.2008.02359.x","volume":"25","author":"R Murphy","year":"2008","unstructured":"Murphy R, Turnbull DM, Walker M, Hattersley AT. Clinical features, diagnosis and management of maternally inherited diabetes and deafness (MIDD) associated with the 3243A>G mitochondrial point mutation. Diabetes Med. 2008;25:383\u201399.","journal-title":"Diabetes Med"},{"key":"591_CR4","doi-asserted-by":"publisher","first-page":"487","DOI":"10.3892\/br.2017.892","volume":"6","author":"J Finsterer","year":"2017","unstructured":"Finsterer J, Scorza FA. Renal manifestations of primary mitochondrial disorders. Biomed Rep. 2017;6:487\u201394.","journal-title":"Biomed Rep"},{"key":"591_CR5","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.medcli.2017.03.053","volume":"149","author":"J Finsterer","year":"2017","unstructured":"Finsterer J, Frank M. Renal involvement in MELAS. Med Clin (Barc). 2017;149:314.","journal-title":"Med Clin (Barc)"},{"key":"591_CR6","doi-asserted-by":"publisher","first-page":"241","DOI":"10.4158\/EP-2019-0270","volume":"26","author":"KN Robinson","year":"2020","unstructured":"Robinson KN, Terrazas S, Giordano-Mooga S, Xavier NA. The role of heteroplasmy in the diagnosis and management of maternally inherited diabetes and deafness. Endocr Pract. 2020;26:241\u20136.","journal-title":"Endocr Pract"}],"container-title":["CEN Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13730-021-00591-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13730-021-00591-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13730-021-00591-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T09:34:58Z","timestamp":1633599298000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13730-021-00591-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,18]]},"references-count":6,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["591"],"URL":"https:\/\/doi.org\/10.1007\/s13730-021-00591-0","relation":{},"ISSN":["2192-4449"],"issn-type":[{"type":"electronic","value":"2192-4449"}],"subject":[],"published":{"date-parts":[[2021,3,18]]},"assertion":[{"value":"19 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 March 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 March 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by the institutional review board.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}