{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T15:46:56Z","timestamp":1757778416568,"version":"3.37.3"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T00:00:00Z","timestamp":1615766400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T00:00:00Z","timestamp":1615766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["CEN Case Rep"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1007\/s13730-021-00592-z","type":"journal-article","created":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T16:03:04Z","timestamp":1615824184000},"page":"476-482","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A case of hypertensive disorders of pregnancy that developed at 9\u00a0weeks of gestation"],"prefix":"10.1007","volume":"10","author":[{"given":"Saki","family":"Hayashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7023-1638","authenticated-orcid":false,"given":"Naro","family":"Ohashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daiki","family":"Goto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi","family":"Isomura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinsuke","family":"Isobe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Fujikura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihide","family":"Fujigaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideo","family":"Yasuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,3,15]]},"reference":[{"key":"592_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.14390\/jsshp.HRP2019-010","volume":"7","author":"S Makino","year":"2019","unstructured":"Makino S, Takeda J, Takeda S, Watanabe K, Matsubara K, Nakamoto O, Ushijima J, Ohkuchi A, Koide K, Mimura K, Morikawa M, Naruse K, Tanaka K, Nohira T, Metoki H, Kawabata I, Takagi K, Yamasaki M, Ichihara A, Kimura T, Saito S, Seki H. New definition and classification of \u201chypertensive disorders of pregnancy (HDP). Hypertens Res Pregnancy. 2019;7:1\u20135.","journal-title":"Hypertens Res Pregnancy"},{"key":"592_CR2","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1111\/j.1471-0528.2003.02134.x","volume":"110","author":"S Hazra","year":"2003","unstructured":"Hazra S, Waugh J, Bosio P. \u2018Pure\u2019 pre-eclampsia before 20 weeks of gestation: a unique entity. BJOG. 2003;110:1034\u20135.","journal-title":"BJOG"},{"key":"592_CR3","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1053\/j.ajkd.2006.05.024","volume":"48","author":"T Imasawa","year":"2006","unstructured":"Imasawa T, Nishiwaki T, Nishimura M, Shikama N, Matsumura R, Nagai M, Soyama A, Koike K, Kitamura H, Joh K. A case of \u201cpure\u201d preeclampsia with nephrotic syndrome before 15 weeks of gestation in a patient whose renal biopsy showed glomerular capillary endotheliosis. Am J Kidney Dis. 2006;48:495\u2013501.","journal-title":"Am J Kidney Dis"},{"key":"592_CR4","doi-asserted-by":"publisher","first-page":"2281","DOI":"10.1681\/ASN.2007020255","volume":"18","author":"IE Stillman","year":"2007","unstructured":"Stillman IE, Karumanchi SA. The glomerular injury of preeclampsia. J Am Soc Nephrol. 2007;18:2281\u20134.","journal-title":"J Am Soc Nephrol"},{"key":"592_CR5","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1053\/j.ajkd.2007.08.026","volume":"51","author":"ID Maya","year":"2008","unstructured":"Maya ID. Hypertension and proteinuria in a 17-year-old at 19weeks\u2019gestation. Am J Kidney Dis. 2008;51:155\u20139.","journal-title":"Am J Kidney Dis"},{"key":"592_CR6","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s13730-014-0140-3","volume":"4","author":"M Tanaka","year":"2015","unstructured":"Tanaka M, Tsujimoto Y, Goto K, Kumahara K, Onishi S, Iwanari S, Fumihara D, Miki S, Ikeda M, Sato K, Sato H, Hirose M, Takeoka H. Preeclampsia before 20 weeks of gestation: a case report and review of the literature. CEN Case Rep. 2015;4:55\u201360.","journal-title":"CEN Case Rep"},{"key":"592_CR7","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1038\/ajg.2017.54","volume":"112","author":"J Liu","year":"2017","unstructured":"Liu J, Ghaziani TT, Wolf JL. Acute fatty liver disease of pregnancy: updates in pathogenesis, diagnosis, and management. Am J Gastroenterol. 2017;112:838\u201346.","journal-title":"Am J Gastroenterol"},{"key":"592_CR8","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1681\/ASN.V92314","volume":"9","author":"MS Paller","year":"1998","unstructured":"Paller MS. Hypertension in pregnancy. J Am Soc Nehorol. 1998;9:314\u201321.","journal-title":"J Am Soc Nehorol"},{"key":"592_CR9","doi-asserted-by":"publisher","first-page":"562","DOI":"10.3324\/haematol.2019.221945","volume":"105","author":"P Pignatelli","year":"2020","unstructured":"Pignatelli P, Ettorre E, Menichelli D, Pani A, Violi F, Pastori D. Seronegative antiphospholipid syndrome:refining the value of \u201cnon-criteria\u201d antibodies for diagnosis and clinical management. Haematologica. 2020;105:562\u201372.","journal-title":"Haematologica"},{"key":"592_CR10","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1681\/ASN.2009070706","volume":"21","author":"F Fakhouri","year":"2010","unstructured":"Fakhouri F, Roumenina L, Provot F, Sall\u00e9e M, Caillard S, Couzi L, Essig M, Ribes D, Dragon-Durey MA, Bridoux F, Rondeau E, Fr\u00e9meaux-Bacchi V. Pregnancy-associated hemolytic uremic syndrome revisited in the era of complement gene mutations. J Am Soc Nephrol. 2010;21:859\u201367.","journal-title":"J Am Soc Nephrol"},{"key":"592_CR11","doi-asserted-by":"publisher","first-page":"e001340","DOI":"10.1136\/rmdopen-2020-001340","volume":"6","author":"N Abisror","year":"2020","unstructured":"Abisror N, Nguyen Y, Marozio L, Valverde EE, Udry S, Pleguezuelo DE, Billoria P, Mayer PK, Urbanski G, Zigon P, Moreuil CD, Hoxha A, Bezanahary H, Carbillion L, Kayem G, Bornes M, Yelnik C, Johanet C, Nicaise RP, Lambert M, Salle V, Latino OJ, Hachulla E, Benedetto C, Bourrienne MC, Benhamou Y, Alijotas RJ, Fain O, Mekinian A. Obstetrical outcome, and treatments in seronegative primary APS: data from European retrospective study. RMD Open. 2020;6:e001340.","journal-title":"RMD Open"},{"key":"592_CR12","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1136\/ard.2008.090670","volume":"68","author":"K Oku","year":"2009","unstructured":"Oku K, Atsumi T, Bohgaki M, Amengual O, Kataoka H, Horita T, Yasuda S, Koike T. Complement activation in patients with primary antiphospholipid syndrome. Ann Rheum Dis. 2009;68:1030\u20135.","journal-title":"Ann Rheum Dis"},{"key":"592_CR13","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1681\/ASN.V103507","volume":"10","author":"D Nochy","year":"1999","unstructured":"Nochy D, Daugas E, Droz D, Beaufils H, Grunfeld JP, Piette JC, Bariety J, Hill G. The intrarenal vascular lesions associated with primary antiphospholipid syndrome. J Am Soc Nephrol. 1999;10:507\u201318.","journal-title":"J Am Soc Nephrol"},{"key":"592_CR14","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.semarthrit.2016.05.006","volume":"46","author":"A Mekinian","year":"2016","unstructured":"Mekinian A, Bourrienne MC, Carbillon L, Benbara A, Noemie A, Chollet MS, Tigaizin A, Montestruc F, Fain O, Nicaise RP. Non-conventional antiphospholipid antibodies in patients with clinical obstetrical APS: Precvalence and treatment efficacy in pregnancies. Semin Arthritis Rheum. 2016;46:232\u20137.","journal-title":"Semin Arthritis Rheum"},{"unstructured":"Japan Society for the Study of HYPERTENSION IN PREGNANCY. Best Practice Guide 2015 for Care and Treatment of Hypertension in Pregnancy. 1st ed. Medical View; 2015","key":"592_CR15"},{"key":"592_CR16","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/0002-9378(94)90276-3","volume":"171","author":"E Rey","year":"1994","unstructured":"Rey E, Couturier A. The prognosis of pregnancy in women with chronic hypertension. Am J Obstet Gynecol. 1994;171:410\u20136.","journal-title":"Am J Obstet Gynecol"},{"key":"592_CR17","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.fertnstert.2015.09.007","volume":"105","author":"J Qin","year":"2016","unstructured":"Qin J, Liu X, Sheng X, Wang H, Gao D. Assisted reproductive technology and the risk of pregnancy-related complications and adverse pregnancy-related complications and adverse pregnancy outcomes in singleton pregnancies: a meta-analysis of cohort studies. Fertil Steril. 2016;105:73\u201385.","journal-title":"Fertil Steril"},{"key":"592_CR18","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1016\/j.fertnstert.2017.08.035","volume":"108","author":"CK Sites","year":"2017","unstructured":"Sites CK, Wilson D, Barsky M, Bernson D, Bernstein IM, Boulet S, Zhang Y. Embryo cryopreservation and preeclampsia risk. Fertil Steril. 2017;108:784\u201390.","journal-title":"Fertil Steril"},{"key":"592_CR19","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1056\/NEJMoa1414838","volume":"374","author":"H Zeisler","year":"2016","unstructured":"Zeisler H, Llurba E, Chantraine F, Vatish M, Staff AC, Sennstr\u00f6m M, Olovsson M, Brennecke SP, Stepan H, Allegranza D, Dilba P, Schoedl M, Hund M, Verlohren S. Predictive Value of the sFlt-1: PlGF Ratio in Women with Suspected Preeclampsia. N Engl J Med. 2016;374:13\u201322.","journal-title":"N Engl J Med"},{"key":"592_CR20","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1681\/ASN.2015020157","volume":"27","author":"R Thadhani","year":"2016","unstructured":"Thadhani R, Hagmann H, Schaarschmidt W, Roth B, Cingoez T, Karumanchi SA, Wenger J, Lucchesi KJ, Tamez H, Lindner T, Fridman A, Thome U, Kribs A, Danner M, Hamacher S, Mallmann P, Stepan H, Benzing T. Removal of soluble fms-like tyrosine kinase-1 by dextran sulfate apheresis in preeclampsia. J Am Soc Nephrol. 2016;27:903\u201313.","journal-title":"J Am Soc Nephrol"},{"key":"592_CR21","doi-asserted-by":"publisher","first-page":"303","DOI":"10.4161\/auto.22927","volume":"9","author":"A Nakashima","year":"2013","unstructured":"Nakashima A, Yamanaka-Tatematsu M, Fujita N, Koizumi K, Shima T, Yoshida T, Nikaido T, Okamoto A, Yoshimori T, Saito S. Impaired autophagy by soluble endoglin, under physiological hypoxia in early pregnant period, is involved in poor placentation in preeclampsia. Autophagy. 2013;9:303\u201316.","journal-title":"Autophagy"},{"key":"592_CR22","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1111\/aogs.12473","volume":"93","author":"H Seki","year":"2014","unstructured":"Seki H. Balance of antiangiogenic and angiogenic factors in the context of the etiology of preeclampsia. Acta Obstet Gynecol Scand. 2014;93:959\u201364.","journal-title":"Acta Obstet Gynecol Scand"},{"key":"592_CR23","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/j.biopha.2018.10.082","volume":"109","author":"HM Sani","year":"2019","unstructured":"Sani HM, Vahed SZ, Ardalan M. Preeclampsia: a close look at renal dysfunction. Biomed Pharmacother. 2019;109:408\u201316.","journal-title":"Biomed Pharmacother"},{"key":"592_CR24","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1056\/NEJMoa031884","volume":"350","author":"RJ Levine","year":"2004","unstructured":"Levine RJ, Maynard SE, Qian C, Lim K, England LJ, Yu KF, Schisterman EF, Thadhani R, Sachs BP, Epstein FH, Sibai BM, Sukhatme VP, Karumanchi SA. Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med. 2004;350:672\u201383.","journal-title":"N Engl J Med"},{"key":"592_CR25","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.jri.2007.08.002","volume":"76","author":"S Saito","year":"2007","unstructured":"Saito S, Sakai M, Sasaki Y, Nakashima A, Shiozaki A. Inadequate tolerance induction may induce preeclampsia. J Reprod Immunol. 2007;76:30\u20139.","journal-title":"J Reprod Immunol"},{"key":"592_CR26","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1111\/j.1365-2249.2007.03397.x","volume":"149","author":"Y Sasaki","year":"2007","unstructured":"Sasaki Y, Kolarz DD, Suzuki D, Sakai M, Ito M, Shima T, Shiozaki A, Rolinski J, Saito S. Proportion of peripheral blood and decidual CD4+ CD25bright regulatory T cells in pre-eclampsia. Clin Exp Immunol. 2007;149:139\u201345.","journal-title":"Clin Exp Immunol"},{"key":"592_CR27","first-page":"773","volume-title":"Heptinstall\u2019s pathology of the kidney: hypertensive disorders of pregnancy","author":"JC Jennette","year":"2007","unstructured":"Jennette JC, Olson JL, Schwartz MM, Silva FG. Heptinstall\u2019s pathology of the kidney: hypertensive disorders of pregnancy, vol. 6. Netherlands: Wolters Kluwer; 2007. p. 773\u201385."},{"key":"592_CR28","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1046\/j.1365-3016.2001.00347.x","volume":"15","author":"J Zhang","year":"2001","unstructured":"Zhang J, Troendle JF, Levine RJ. Risks of hypertensive disorders in the second pregnancy. Paediatr Perinat Epidemiol. 2001;15:226\u201331.","journal-title":"Paediatr Perinat Epidemiol"}],"container-title":["CEN Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13730-021-00592-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13730-021-00592-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13730-021-00592-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T09:34:02Z","timestamp":1633599242000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13730-021-00592-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,15]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["592"],"URL":"https:\/\/doi.org\/10.1007\/s13730-021-00592-z","relation":{},"ISSN":["2192-4449"],"issn-type":[{"type":"electronic","value":"2192-4449"}],"subject":[],"published":{"date-parts":[[2021,3,15]]},"assertion":[{"value":"3 December 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 March 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 March 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}