{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T12:20:49Z","timestamp":1773836449714,"version":"3.50.1"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T00:00:00Z","timestamp":1709510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T00:00:00Z","timestamp":1709510400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["CEN Case Rep"],"DOI":"10.1007\/s13730-024-00857-3","type":"journal-article","created":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T12:02:29Z","timestamp":1709553749000},"page":"391-396","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clostridium perfringens-induced massive hemolysis treatment with blood purification to target toxins: a case report"],"prefix":"10.1007","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8512-4138","authenticated-orcid":false,"given":"I.","family":"Reffo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Domini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Cevolani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Del Fabro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Rufolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Venturini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Pinciroli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Tonin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Avolio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Crapis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Basaglia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Balbi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Nadalin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,3,4]]},"reference":[{"key":"857_CR1","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1177\/0885066613498043","volume":"29","author":"TG Simon","year":"2014","unstructured":"Simon TG, Bradley J, Jones A, et al. Massive intravascular hemolysis from Clostridium perfringens septicemia: a review. J Intensive Care Med. 2014;29:327\u201333.","journal-title":"J Intensive Care Med"},{"issue":"4","key":"857_CR2","doi-asserted-by":"publisher","first-page":"824","DOI":"10.3390\/microorganisms11040824","volume":"11","author":"A Suzaki","year":"2023","unstructured":"Suzaki A, Hayakawa S. Clinical and microbiological features of fulminant haemolysis caused by Clostridium perfringens bacteraemia: unknown pathogenesis. Microorganisms. 2023;11(4):824.","journal-title":"Microorganisms"},{"issue":"15","key":"857_CR3","doi-asserted-by":"publisher","first-page":"2387","DOI":"10.1200\/JCO.2005.03.4009","volume":"24","author":"HL McArthur","year":"2006","unstructured":"McArthur HL, Dalal BI, Kollmannsberger C. Intravascular hemolysis as a complication of Clostridium perfringens sepsis. J Clin Oncol. 2006;24(15):2387\u20138.","journal-title":"J Clin Oncol"},{"issue":"5","key":"857_CR4","doi-asserted-by":"publisher","first-page":"212","DOI":"10.3390\/toxins10050212","volume":"10","author":"MA Navarro","year":"2018","unstructured":"Navarro MA, McClane BA, Uzal FA. Mechanisms of action and cell death associated with Clostridium perfringens toxins. Toxins (Basel). 2018;10(5):212.","journal-title":"Toxins (Basel)"},{"key":"857_CR5","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.713509","volume":"12","author":"A Suzaki","year":"2021","unstructured":"Suzaki A, Ohtani K, Komine-Aizawa S, Matsumoto A, Kamiya S, Hayakawa S. Pathogenic characterization of Clostridium perfringens strains isolated from patients with massive intravascular hemolysis. Front Microbiol. 2021;12: 713509.","journal-title":"Front Microbiol"},{"issue":"5","key":"857_CR6","doi-asserted-by":"publisher","first-page":"1702","DOI":"10.3390\/toxins7051702","volume":"7","author":"S Verherstraeten","year":"2015","unstructured":"Verherstraeten S, Goossens E, Valgaeren B, Pardon B, et al. Perfringolysin O: the underrated Clostridium perfringens toxin? Toxins (Basel). 2015;7(5):1702\u201321.","journal-title":"Toxins (Basel)"},{"issue":"2","key":"857_CR7","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1006\/anae.1999.0191","volume":"5","author":"RW Titball","year":"1999","unstructured":"Titball RW, Naylor CE, Basak AK. The Clostridium perfringens alpha-toxin. Anaerobe. 1999;5(2):51\u201364.","journal-title":"Anaerobe"},{"issue":"12","key":"857_CR8","doi-asserted-by":"publisher","first-page":"3409","DOI":"10.1172\/JCI25040","volume":"115","author":"PC Minneci","year":"2005","unstructured":"Minneci PC, Deans KJ, Zhi H, Yuen PS, et al. Hemolysis-associated endothelial dysfunction mediated by accelerated NO inactivation by decompartmentalized oxyhemoglobin. J Clin Invest. 2005;115(12):3409\u201317.","journal-title":"J Clin Invest"},{"issue":"6","key":"857_CR9","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1016\/j.kint.2019.08.026","volume":"96","author":"Z Dvanajscak","year":"2019","unstructured":"Dvanajscak Z, Walker PD, Cossey LN, Messias NC, et al. Hemolysis-associated hemoglobin cast nephropathy results from a range of clinicopathologic disorders. Kidney Int. 2019;96(6):1400\u20137.","journal-title":"Kidney Int"},{"issue":"11","key":"857_CR10","doi-asserted-by":"publisher","first-page":"e295","DOI":"10.1515\/cclm-2020-0676","volume":"58","author":"B Smit","year":"2020","unstructured":"Smit B, van der Helm MW, Bosma M, Hudig F, Russcher H. Massive hemolysis due to Clostridium perfringens: a laboratory\u2019s perspective. Clin Chem Lab Med. 2020;58(11):e295\u20137.","journal-title":"Clin Chem Lab Med"},{"issue":"13","key":"857_CR11","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1001\/jama.293.13.1653","volume":"293","author":"RP Rother","year":"2005","unstructured":"Rother RP, Bell L, Hillmen P, Gladwin MT. The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease. JAMA. 2005;293(13):1653\u201362.","journal-title":"JAMA"},{"issue":"82","key":"857_CR12","volume":"14","author":"F Cobo","year":"2023","unstructured":"Cobo F, P\u00e9rez-Carrasco V, Mart\u00edn-Hita L, Garc\u00eda-Salcedo JA, Navarro-Mar\u00ed JM. Comparative evaluation of MALDI-TOF MS and 16S rRNA gene sequencing for the identification of clinically relevant anaerobic bacteria. Crit Eval Discrepant Result Anaerob. 2023;14(82): 102754.","journal-title":"Crit Eval Discrepant Result Anaerob"},{"issue":"3","key":"857_CR13","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/j.cll.2019.05.003","volume":"39","author":"SL Mitchell","year":"2019","unstructured":"Mitchell SL, Simner PJ. Next-generation sequencing in clinical microbiology: are we there yet? Clin Lab Med. 2019;39(3):405\u201318.","journal-title":"Clin Lab Med"},{"issue":"1","key":"857_CR14","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1038\/s41426-018-0144-8","volume":"7","author":"R Kiu","year":"2018","unstructured":"Kiu R, Hall LJ. An update on the human and animal enteric pathogen Clostridium perfringens. Emerg Microbes Infect. 2018;7(1):141.","journal-title":"Emerg Microbes Infect"},{"issue":"1","key":"857_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.clinmicnews.2018.12.003","volume":"41","author":"MA Pence","year":"2019","unstructured":"Pence MA. Antimicrobial resistance in clinically important anaerobes. Clin Microbio Newsl. 2019;41(1):1\u20137.","journal-title":"Clin Microbio Newsl"},{"issue":"2","key":"857_CR16","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1128\/AAC.31.2.213","volume":"31","author":"DL Stevens","year":"1987","unstructured":"Stevens DL, Maier KA, Mitten JE. Effect of antibiotics on toxin production and viability of Clostridium perfringens. Antimicrob Agent Chemother. 1987;31(2):213\u20138.","journal-title":"Antimicrob Agent Chemother"},{"issue":"6","key":"857_CR17","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1586\/14787210.5.6.991","volume":"5","author":"I Brook","year":"2007","unstructured":"Brook I. Treatment of anaerobic infection. Expert Rev Anti Infect Ther. 2007;5(6):991\u20131006.","journal-title":"Expert Rev Anti Infect Ther"},{"key":"857_CR18","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-023-01637-5","author":"S De Rosa","year":"2023","unstructured":"De Rosa S, Marengo M, Fiorentino M, Fanelli V, Brienza N, Fiaccadori E, Grasselli G, Morabito S, Pota V, Romagnoli S, Valente F, Cantaluppi V. SIAARTI-SIN joint commission Extracorporeal blood purification therapies for sepsis-associated acute kidney injury in critically ill patients: expert opinion from the SIAARTI-SIN joint commission. J Nephrol. 2023. https:\/\/doi.org\/10.1007\/s40620-023-01637-5.","journal-title":"J Nephrol"},{"issue":"11","key":"857_CR19","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1007\/s00134-021-06506-y","volume":"47","author":"L Evans","year":"2021","unstructured":"Evans L, Rhodes A, Alhazzani W, Antonelli M, et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Intensiv Care Med. 2021;47(11):1181\u2013247.","journal-title":"Intensiv Care Med"},{"issue":"8","key":"857_CR20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0220444","volume":"14","author":"ME Broman","year":"2019","unstructured":"Broman ME, Hansson F, Vincent JL, Bodelsson M. Endotoxin and cytokine reducing properties of the oXiris membrane in patients with septic shock: a randomized crossover double-blind study. PLoS\u00a0ONE. 2019;14(8): e0220444.","journal-title":"PLoS\u00a0ONE"},{"key":"857_CR21","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1186\/s12882-018-1051-x","volume":"19","author":"D Cucchiari","year":"2018","unstructured":"Cucchiari D, Reverter E, Blasco M, Molina-Andujar A, et al. High cut-off membrane for in-vivo dialysis of free plasma hemoglobin in a patient with massive hemolysis. BMC Nephrol. 2018;19:250.","journal-title":"BMC Nephrol"}],"container-title":["CEN Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13730-024-00857-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s13730-024-00857-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s13730-024-00857-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T15:13:35Z","timestamp":1727795615000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s13730-024-00857-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,4]]},"references-count":21,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,10]]}},"alternative-id":["857"],"URL":"https:\/\/doi.org\/10.1007\/s13730-024-00857-3","relation":{},"ISSN":["2192-4449"],"issn-type":[{"value":"2192-4449","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,4]]},"assertion":[{"value":"22 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 February 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 March 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All the authors have declared no competing interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Informed consent for storing and sharing clinical data was obtained from the patient.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}